Damdawi thenkhat i ei avangin i hmui a vawt reng a, i mit a hring deuh emaw, i pum a vawt reng emaw tih i hmu ngai em? Hei hi i natna avanga lo awm thil dang niin i ngai mai thei. Mahse, a chhan chu i hriat lohvin anticholinergic property nei damdawi i ei vang a ni thei. Ngaihtuah buai suh, hei hi a hluar hle. Vawiin hian he thu hi i hriatthiam theih tur awlsam takin kan sawi dawn a ni.
Heng anticholinergic damdawi te hi eng tak nge ni?
He hming hi a buaithlak deuhin a lang thei. Mahse a thawnthu hi a awlsam khawp mai. Kan taksa nervous system hi network mak tak mai a ni. Hei hian kan ngaihtuahna, kan che vel, kan thawk, leh kan thinlung thawk zawng zawng a thunun vek a ni. He nervous system-ah hian thuchah phur chhuak leh chhuak tur "messenger" an awm a. Post office-a miten lehkha an thawn ang bawkin. Heng tirhkohte hi `(Neurotransmitters)` kan ti a.
Chutiang thuchah pawimawh tak pakhat chu acetylcholine a ni .
Tunah chuan he `Acetylcholine` hnathawh ber chu eng nge ni tih i lo en ang u. Kan autonomic nervous system hi a bulpui ber pahnih a awm a.
1. Sympathetic system: Hei hi kan "fight-or-flight" system a ni. A awlsam zawngin, he system hian emergency, hlauhna, a nih loh leh hlauhawm hmachhawn turin min buatsaih a ni. Car chhunga accelerator awm ang mai a ni. A activate chuan kan thinlung a thawk chak zawk a, kan mit a zau a, kan thawk hah bawk.
2. Parasympathetic system: Hei hi kan "rest-and-digest" system a ni. Chumi awmzia chu he system hian taksa a ti thlamuang a, ei tur a digest a, a hahdam thei tihna a ni. Car brake ang a ni. Kan palai `Acetylcholine` tih hian he system-ah hian hna a thawk ber a ni.
Okay, tunah chuan thawnthu background i hrethiam tawh a ni lawm ni? Anticholinergic damdawi hian chu tirhkoh `Acetylcholine` tia koh hnathawh tibuaituin hna a thawk a ni. Chumi awmzia chu chu palai chu a thuchah a thlenna hmuna a kal chuan chu hmun (receptor) chu a block ta tihna a ni. Tichuan chu "calming" system (Parasympathetic) hnathawh chu tlem a tlahniam ta a ni.
A awlsam zawngin, anticholinergic damdawi hian kan taksaa thil tih hahdam leh tihlumtu (relaxing and calming process) control tu messenger hnathawh chu rei lo te chhung atan a tikhawlo a ni.
He damdawi hi eng ang natna atan nge hman a nih?
Anticholinergic property nei damdawi 600 chuang a awm a. Damdawi thenkhat chu he anticholinergic property hmang tangkaia natna enkawlna atana siam a ni. Damdawi thenkhat chuan side effect angin he property hi an nei a.
A hnuaia table-ah hian natna enkawlna atana he anticholinergic property hmang ber damdawi chi hrang hrang kan en ang.
| Damdawi hming (entirnan) . | Case leh sawifiahna awlsam tak hmang rawh |
|---|---|
| Atropine a ni | Hei hi Emergency Department (ETU)-a hman fo thin damdawi a ni. Heart rate a hniam lutuk laiin bradycardia enkawlna atan hman a ni a, pesticide thenkhat atanga poisoning enkawlna atan pawh hman a ni bawk. Poisoning a awm chuan i doctor chuan National Hospital-a National Poisons Information Center-ah thurawn dang a dil ang. |
| Ipratropium / Tiotropium tih a ni | Hengte hi thawkna lama natna vei, asthma leh COPD te hnena pek thin inhaler-ah te a awm a ni. Heng damdawi te hian thawkna kawng a tizau a, thawk a ti awlsam bawk. |
| Oxybutynin / Solifenacin hmanga siam a ni | Hengte hi urge incontinence enkawlna atana pek a ni a, chu chu zun tam a ngai a, i zun kal dan tur control harsat a ni. Heng damdawi te hian bladder chhunga muscle te contraction tihziaawmna hmangin hna an thawk a ni. |
| Scopolamine hmanga siam a ni | Hengte hi bus leh lawnga zin vanga luak chhuak leh luak chhuak (motion sickness) enkawlna atan hman a ni. A chang chuan patch angin an lo kal thin. |
| Benztropine / Trihexyphenidyl hmanga siam a ni | He damdawi hian Parkinson natna vanga khur ang chi symptoms te chu a control thei a ni. |
| Diphenhydramine hmanga siam a ni | Allergy atana hman damdawi tam tak (e.g., piritan)-ah hian hengte hi a awm a. He anticholinergic property hi hengte i ei hian i mut a, i hmui a vawt chhan ber a ni. |
Hetiang property nei damdawi te hi side effect atan an hmang thin
Damdawi thenkhat chu an hnathawh ber chu thil dang ni mahse, side effect angin anticholinergic effect nei an awm.
- Damdawi hlui thenkhat chu depression ang chi natna enkawlna atana hman thin (Tricyclic antidepressants). Damdawi thenkhat (`Antipsychotic medications`) hi rilru lam natna khirh tak tak, schizophrenia ang chi tan pek thin a ni.
- Allergy damdawi tam tak (`Antihistamines`).
Anticholinergic damdawi hian eng side effect nge a neih?
Tunah chuan heng damdawi te hian hmui a vawt a, mit a ti fiah lo tih i hrethiam tawh mai thei. Chu "calming" system hnathawh kan tihtlem chuan chu system-in a thunun thil tam tak chu a nghawng a ni.
Heng side effects te hriatrengna atana doctor ten an hman thin English thufing pakhat a awm a. "Hare ang maia lum, bat ang maia mitdel, ruh ang maia vawt, beet ang maia sen, hatter ang maia mad". Hei hian "Hare ang maia lum, bat ang maia mitdel, ruh ang maia vawt, beetroot ang maia sen, lukhum siamtu ang maia â" tihna a ni . Hei hian a side effect lian ber berte hriatreng a ti awlsam hle.
Heng side effects leh a chhan hrang hrangte hi a hnuaia table-ah hian awlsam takin han thlir ila.
| Side Effect a awm thei | A awlsam zawngin, eng nge thleng? |
|---|---|
| Kawng & mit a vawt | "Calm" system hian hmui leh mittui siam chhuahna a tichak a ni. A active lo deuh chuan hmui leh mittui pawh a chhuak tlem bawk. |
| Mit hmuh a fiah lo | Mitmeng lian leh te tidanglamtu thau te chu a nghawng a, hnai tak atanga thil hmuh a harsa hle. Pupil te chu a lian zawk (dilated pupils). |
| Zun harsatna (Urinary retention) . | Bladder muscle te chu a flexible lo deuh deuh chuan bladder chu a hring vek a harsa ta hle. |
| Ek khal | Digestive process nena inzawm intestinal movement a slow thin. |
| Lung natna chak tak (Tachycardia) . | Heart rate hi a normal level aia sangin a sang a, a chhan chu heartbeat control tu "brake" a chak loh vang a ni. |
| Buaina / Rilru dinhmun danglam | Acetylcholine hi thluaka hriatrengna leh ngaihtuahna kalphung atan pawh a pawimawh hle. A tihbuai chuan, a bik takin kum upa lamteah chuan buaina a thlen thei a ni. |
| Hyperthermia & Vun a rawn sen chhuak | Sweating hi taksain temperature a tihdanglam theih dan a ni. Heng damdawi te hian thawmhnaw a tiziaawm thei a, chu chuan taksa lumna a tisang thei a ni. |
Engtik lai nge doctor pan tur i mamawh?
Anticholinergic damdawi pek i nih chuan i ei hlawkna chuan a nghawng tha lo aiin a hlawkpui zawk daih. Mahse, a hnuaia mite hi i tawn chuan doctor nen inbia ngei ang che.
- Damdawi hmanga i natna a dam loh chuan.
- Doctor-in a tih angin damdawi ei harsatna i neih chuan (e.g. side effects avanga harsatna i neih chuan).
- Damdawi side effects a nasat lutuk chuan nitin hnathawh (hnathawh, lirthei khalh, lehkha zir) tibuaitu a nih chuan.
Ngaihtuah teh, Asthma i nei a, inhaler an pek che hian thawk a ti awlsam a, mahse i hmui erawh a vawt hle thung. A nih loh leh i zun i control harsat a, damdawi an pek che hian i mit a ti fiah lo deuh bawk. Chutiang hunah chuan i doctor nen in inbia a, damdawi hman dan tur chu a thlak danglam thei a, a nih loh leh a result inang pe thei damdawi dang a pe thei bawk.
A pawimawh ber chu, harsatna i neih chuan i damdawi ei kha bansan suh la, nangmah chauhin a dose pawh thlak suh. Doctor nen inbia fo la, an thurawn zawm rawh.
Take-Home Thuchah a ni
- Anticholinergic damdawi hian kan taksa "calming" system-a thawk chemical messenger (Acetylcholine) hnathawh chu a tikhawlo a ni.
- He damdawi hi natna chi hrang hrang enkawlna atan hman a ni a, chungte chu Asthma, Parkinson’s disease, leh urinary incontinence te hi a ni.
- Allergy leh depression damdawi thenkhat pawh hian he anticholinergic property hi side effect angin an nei bawk.
- Side effect awm tlangpui chu hmui a vawt, mit a fiah lo, pum a na, thinlung na rang, leh buaina te a ni.
- Damdawi i ei tur side effects i ngaihtuah a nih chuan sawi emaw, mahni chauha thutlukna siam emaw hlau suh, mahse i doctor nen inbia ngei ang che.
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