I taksa hian nangmah ngeiin thisen sen (red blood cells) a tichhia em? Autoimmune Hemolytic Anemia (AIHA) chungchanga hriat tur pawimawh te chu hetiang hi a ni!

A châng chuan chhan awm lovin i chau a, i chau bawk em? I vun chu a rawn sen deuh emaw, a sen deuh emaw pawh a ni mai thei. Hetiang thil a thlen chhan hi i ngaihtuah thiam loh chang a awm thin, a dik em? Heng symptoms te hi a chhan pakhat chu i taksa ngeia immune system, natna laka vengtu sipaite, nangmah ngeiin i thisen sen (red blood cells) an beih vang a ni thei. Chu chu damdawi lamah Autoimmune Hemolytic Anemia (AIHA) kan tih chu a ni. A awlsam zawngin, i taksa defense system hian nangmah ngeiin i thisen sen (red blood cells) chu "hmêlma" tiin a tisual a, a tichhe vek a ni. Hei hi a pawi deuh hlek nachungin, enkawl dan dik tak chuan a enkawl tha thei a ni . Mahse, enkawl loh chuan nunna atana hlauhawm a ni thei. Chuvangin, hei hi hriat chian a, a rang thei ang bera damdawi lam thurawn lak a pawimawh hle. Hemi chungchang hi chipchiar zawkin han sawi ila.

Autoimmune Hemolytic Anemia (AIHA) tih hi eng nge ni?

A awlsam zawngin, Autoimmune Hemolytic Anemia (AIHA) hi i immune system-in i thisen sen (red blood cells) chu "ram dang" anga a hriat sualna a ni a, chu chu taksa tana chhiatna thlen thei thil tihna a ni. Chumi avang chuan i taksa chuan thisen sen (red blood cells) tichhe thei antibody a siam chhuak a ni. Heng antibodies te hian red cells te hi an inzawm a, an tichhe vek a ni. Chuti a nih chuan eng nge thleng? I taksaa thisen sen (red blood cells) awm zat a tlahniam a. Chu chu "anemia" kan tih chu a ni.

Ngaihtuah teh, helaia thil thleng hi kan ram humhalhtu sipaite, kan khua leh tui ngeite bei sual ang mai a ni. Hei hi a takah chuan a buaithlak deuh a, mahse hriatthiam a harsa lo.

Primary leh secondary AIHA hi eng nge an danglamna?

AIHA hi a lo awm dan azirin chi hnih a awm a.

• Primary AIHA: A châng chuan, AIHA hi a bulpui ber damdawi lam dinhmun chiang tak awm lovin a lo awm thei a ni. Chumi awmzia chu doctor-te chuan engvangin nge a lo lang nghal tih an hre thei lo tihna a ni. Hei hi primary AIHA an ti a.
• Secondary AIHA: AIHA chi dang chu AIHA hi natna dang avanga lo awm a nih chuan a ni. Entirnan, virus infection thenkhat, autoimmune diseases (taksa immune system-in a tissue a beih na), damdawi thenkhat emaw, thisen cancer hnuaia awm lymphoma emaw avanga lo awm thei a ni.

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AIHA chi hrang hrangte chu engte nge ni?

AIHA hi chi hnih a awm a. Chungte chu Warm autoimmune hemolytic anemia leh Cold autoimmune hemolytic anemia te an ni. Hengte hi natna kaihhnawih antibody chi hrang hrang a zirin an thliar hrang a ni. Chu chu, he hming hi thisen sen (red blood cells) beitu antibodies te active nasat dan atanga lak a ni tihna a ni.

A rilru a buai em em a, a rilru a hah em em bawk a

Hei hi AIHA chi khat hman tlanglawn ber a ni. Hetah hian antibodies chi IgG te hian thisen sen (red blood cells) an inzawm khawm thin. Thil danglam bik chu heng antibodies te hi kan taksa temperature pangngai (i.e., "warm" environment-ah) ah an active a ni. A lan chhuah dan hi a tlangpuiin a lang zauh zauh a, kar tlemte chhungin a lang tan thin. Mahse, a then phei chuan ni reilote chhungin a natna lanchhuahna chu a na thei hle.

Cold autoimmune hemolytic thisen tlakchhamna (anemia) a awm

Hetiang chi hi AIHA vei zinga 10% atanga 20% chauh ah hmuh tur a awm. Autoantibody chi khat IgM tih a huam a ni. Heng autoantibodies te hi i thisen chu i taksa core temperature aia hniam zawka a awm chuan thisen sen (red blood cells) te nen an inzawm a, chu chu cold'' an ti a ni. He cold'' temperature hi mi hrang hrangah a danglam thei. Chumi awmzia chu mi thenkhat tan chuan heng antibodies te hi an vawt deuh laiin an thawk chhuak thei a, thenkhat tan chuan a lum zawk hle a ngai thei bawk.

He AIHA natna hian tute nge a nghawng ber?

AIHA hi tu pawhah a lo thang lian thei a, kum leh mipa leh hmeichhiaah pawh a lo thang lian thei. Mahse, he natna hi hmeichhia kum 40 chunglam zingah a tam ber a ni .

A awm fo ang bawkin AIHA hi a awm lo hle a ni . Kum tin mi sang za zelah mi pakhat emaw pahnih emaw vel a nghawng thin.

AIHA natna lan chhuah dan chu engte nge ni?

AIHA hian symptom hrang hrang a thlen thei. Ṭhenkhat chu a tam hle a, ṭhenkhat erawh chu AIHA i neih chi hrang hrang a zirin a danglam thung.

Heng a lan chhuah dan tlangpui thenkhat chu hetiang hi a ni:

• Khawsik
• Extreme fatigue (engkim ti tha thei lo khawpa chau lutuk) .
• Chaklohna
• Lung na tak tak
• Thâwk harsa (thawhrimna tlemte pawh nise) .
• Vun dum (thisen sang i neih lai ang chi) .
• Jaundice (vun leh mit sen) .
• Lu na (lu na) .
• Muscle na a na
• Zun dum (tea tui ang chi) .
• Luak chhuak leh luak chhuak
• Thâwk a tawi
• Kawthalo
• Lei hliam
• Palpitations (i thinlung a na lutuk tih hriatna) .

Heng symptoms zinga pakhat emaw pahnih emaw i neih hian AIHA i nei tihna a ni lo tih hre reng ang che. Mahse heng symptoms te hi a awm reng chuan doctor pan a tha ber.

A lan chhuah dan a inang lo thei a, a bik takin AIHA chi hrang hrang a zirin:

Warm AIHA hi a tam ber chu:

• Chau
• Luak chhuak thei
• Jaundice (vun sen) 1.1.
• Thinlung na tak tak hriatna

Cold AIHA hian natna lan chhuahna a thlen thei a, chungte chu:

• Chau
• Luak chhuak thei
• Kut leh ke lum (midang aiin a vawt zawka hriat) .
• Jaundice a awm
• A rilru a na
• Ke hnunglam a na
• Raynaud natna (khawsik a awm chuan kut zungtang leh ke ruhte chu a var/blue a, a hring vek) .
• Kut leh ke blue discoloration
• Thinlung thawk mumal lo (Arrhythmia)
• Thinlung mur ri hriatna
• Heart failure (hei hi a nasat chuan a ni) .

AIHA awm chhante chu engte nge ni?

AIHA vei zawng zawng zinga a chanve vel (50% vel) ah chuan a chhan dik tak chu hmuh theih a ni lo . Hei hi idiopathic autoimmune hemolytic anemia'' kan ti a, chu chu "a chhan hriat loh" tihna a ni.

A chanve dangah chuan AIHA hi damdawi lam thil dang nen a inzawm tlat a ni.

AIHA thlen thei damdawi lam thil dangte chu:

Secondary AIHA thlen thei autoimmune natna engemaw zat a awm. Chu chu taksa hrisel tak takte a beih nana natna dang a ni.

• Lupus : Hei hi taksa peng hrang hrang, vun, ruh, kal, leh thluak te a nghawng thei a ni.
• Rheumatoid arthritis : Ruh natna a ni ber a, ruh natna leh hliam a thlen thin.
• Sjogren’s syndrome : Mit leh hmui vawt hi a lan chhuah dan ber a ni.
• Thyroid natna : Thyroid hormone inthlauhna.
• Ulcerative colitis : Colon natna leh natna hrik awm.
• Hashimoto natna : Immune system-in thyroid gland a beih dan a ni.

A châng chuan, AIHA hi virus infection vang pawh a ni thei . Mahse, he thisen tlakchhamna hi virus infection a reh hnuah a reh fo thin. AIHA nena inzawm thei virus thenkhat chu:

• Epstein-Barr virus (mononucleosis thlentu virus) .
• Measles natna a ni
• Mumps a awm
• Rubella chuan a rawn ti a
• Atypical pneumonia a awm lo
• Varicella virus, chickenpox thlentu a ni
• HIV tih a ni
• Hepatitis (liver a bik taka nghawng thei virus) .
• Cytomegalovirus (Cytomegalovirus) hmanga natna hrik pai a ni

Damdawi thenkhat chuan AIHA a thlen thei bawk. I damdawi ei mek hian he natna hi a thlen nia rinhlelh a nih chuan i doctor chuan damdawi chu a titawp thei a ni.

• Antibiotics (a bik takin penicillin) .
• Nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g. ibuprofen) te hi a tha ber pawl a ni.
• Cancer dona damdawi

Engtin nge AIHA hi hmuhchhuah a nih?

I doctor chuan thisen tlakchhamna chhinchhiahna i neih a rinhlelh chuan thisen chhiar kimchang (CBC) a ti hmasa ang . Hei hian thisen tlakchhamna vaukhânna chhinchhiahna a hmu thei a ni. A bik takin, he test hian a tehna chu:

• I thisenah hian thisen sen, thisen var leh platelet engzat nge awm.
• I thisen zam (red blood cells) lian tham (lian, te, normal) te.
• Hemoglobin level - Hei hi i thisena protein awm, i taksa pum puia oxygen phurtu a ni.
• Hematocrit value (i thisenah i thisen sen (red blood cells) hian hmun engzat nge a luah)).

AIHA hriat theihna tura pui thei test dang

I doctor chuan thisen tlakchhamna (anemia) a rinhlelh chuan test tlemte tih belh leh turin a rawt ang che. Heng test te hian thisen tlakchhamna hi AIHA vang emaw, thil dang vang emaw a nih leh nih loh hriat theih nan a pui thei a ni.

• Peripheral smear: Hei hian i thisen sample lak a, microscope hmanga en a ni. Hei hian i thisen sen (red blood cells) a chhiat emaw, a pianzia a danglam em tih ang chi thil a zawng thei a ni.
• Reticulocyte count: He test hian i taksaa thisen sen (red blood cells) naupang (siam thar) awm zat a teh thin. Thisen sen (red blood cells) a chhiat chuan ruhro (bone marrow) hian a thlaktu atan thisen sen (red blood cells) tam zawk a siam tan tih hre reng ang che. Hei hian reticulocyte count a tipung a ni.
• Bilirubin test: Thisen sen (red blood cells) a chhiat chuan thil pakhat bilirubin an tih chu a lo piang chhuak thin. Hei hi a pun chuan jaundice (vun sen) a awm thin. Chuvangin, thisenah bilirubin level a sang a nih chuan thisen sen (red blood cells) a chhe vek tih chhinchhiahna a ni.
• Coombs’ test: Hei hi AIHA hriatchhuahna atana test pawimawh tak a ni. I taksain thisen sen (red blood cells) laka antibody a siam chhuak em tih a enfiah thin.
• Haptoglobin test: Haptoglobin hi thisen sen chhia atanga bawlhhlawh paih chhuaktu protein a ni. Thisen sen tam tak a chhiat chuan taksain he haptoglobin hi a hmang zo vek a ni. Hei hian thisen a haptoglobin level a tihhniam phah a ni.
• Lactate dehydrogenase (LDH): LDH hi thisen sen chhunga enzyme awm a ni. Thisen sen (red blood cells) a chhiat chuan he LDH enzyme hi thisenah a chhuak thin. Hei hian LDH level a tisang a ni.
• Cold agglutinin titer: I doctor chuan cold AIHA a rinhlelh chuan he test hi a order thei ang. Hei hian khaw lum laia thisen sen (red blood cells) beitu antibodies level a teh a ni.

AIHA hi engtin nge enkawl a nih?

AIHA enkawl hian a hmasa ber chu enkawl theih tur chhan bulpui a awm leh awm loh hriat a ni tlangpui. Entirnan, i AIHA hi lupus nen a inzawm a nih chuan i doctor chuan lupus hi a enkawl hmasa ngei ang. AIHA thlentu hi lymphoma ang chi natna a nih chuan chu natna chu enkawl a pawimawh hle. Damdawi pakhatin i AIHA a thlen a nih chuan chu damdawi chu i ei tawh loh a ngai mai thei.

Mahse, mi thenkhat tan chuan AIHA hi a nêm hle.. Chumi awmzia chu a symptoms chu chutiang chuan a na lo tihna a ni. Chutih hunah chuan enkawlna engmah a ngai lo mai thei.

Damdawi chi hrang hrang

• Corticosteroids: Hengte hi AIHA enkawlna hmasa ber a ni tlangpui. Heng damdawi te hian i taksa immune system a titawp a, chu chuan i thisen sen (red blood cells) a tihchhiatna chu a ti tlem a ni.
• Immunosuppressants: Corticosteroids ringawt hi natna control nan a tawk lo a nih chuan i doctor chuan heng damdawi chi hrang hrangte hi a pe thei ang. Hengte hian immune system-in ruhro (bone marrow) a beih loh nan a titawp a ni.

Splenectomy (spleen lakchhuahna surgery) tih a ni.

Damdawi chauh hmanga AIHA control theih loh chuan i spleen chu operation hmanga lakchhuah a ngai mai thei. Kan taksa chhunga taksa peng pakhat, thisen sen pangngai lo, thisen sen (red blood cells) te chu a filter chhuak a, chu chu antibody attached a ni. Spleen-ah hian antibody siamtu cell a awm bawk. Chuvangin spleen lakchhuah hian thisen sen tihchhiatna a ti tlem thei a, thisen tlakchhamna pawh a ti tlem thei bawk.

Thisen pek a ni

AIHA natna khirh takah chuan damlote chuan thisen pek an ngai mai thei a, chu chu pawn lam atanga thisen lak a ni. Hei hian thisen sen (red blood cells) a tipung thuai thei a, symptoms control-na kawngah a pui thei bawk.

‘Warm’ leh ‘cold’ AIHA enkawl dan a danglam em?

Ni e, primary ‘cold AIHA’ enkawl dan hi ‘warm AIHA’ nen a danglam a ni.

Corticosteroid emaw immunosuppressive damdawi emaw hi ‘warm AIHA’ atan hman a ni tlangpui. Chu chu a hlawhtling lo a nih chuan, a zung (spleen) lakchhuahna tur operation neih a ngai mai thei. Thisen tlakchhamna na tak a awm chuan thisen pek hi natna enkawl lai hian supportive therapy anga ngaih a ni bawk.

Mahse, ‘cold AIHA’ hian corticosteroid emaw splenectomy emaw a chhang tha lo. ‘AIHA lum’ hi a na lo a nih chuan taksa lumna (e.g., kut/ke lumna hman te, kutkawr, socks bun te, leh boruak lum zawka zin te) hmangin natna hi a thunun theih a ni. Enkawl a tul chuan damdawi Rituximab (a chang chuan immunosuppressant damdawi dang nen) hi first-line treatment a ni.

AIHA vei theihna hi a tlahniam thei ang em?

Autoimmune Hemolytic Anemia hi a veng thei ngai lo. A châng chuan chhan hriat lohvin a thleng ṭhin. Mahse, virus infection i neih emaw, AIHA nena inzawm nia hriat damdawi i ei a nih chuan i doctor chuan i dinhmun a enfiah thei a, natna i vei theihna tur a tihziaawm thei bawk.

AIHA hi natna khirh tak a ni em?

Autoimmune Hemolytic Anemia hi a chang chuan a na lo lutuk a, enkawlna engmah i mamawh lo mai thei. Mahse, a châng chuan a nasat êm êm a, zai emaw, thisen pêk emaw a ngai mai thei. AIHA i vei tih hmuhchhuah a nih chuan i doctor chuan i natna nasat dan leh i enkawl dan tur a sawipui thei che a ni.

A pawimawh ber chu AIHA hi enkawl loh chuan thihna thlen thei a ni a, chuvang chuan damdawi lam hmalakna rang tak neih a pawimawh em em a ni.

AIHA hi tihdam theih a ni em?

Awle. AIHA vei tam zawk chuan enkawlna an mamawh tlem hle emaw, enkawl ngai lo emaw a ni. Damlo 20% leh 30% inkar chuan damdawi, operation, emaw thisen pek emaw an mamawh a ni.

Engtikah nge Doctor ka hmuh ang?

Anemia symptoms i neih tan chuan – hah lutuk, chak lohna, jaundice (vun sen), emaw thawk harsatna emaw – doctor pan nghal rawh Diagnosis leh treatment i neih hma chuan i dam chak thei a, i nun pangngaiah i kir leh thei bawk.