I taksa hian nangmah ngeiin thisen sen (red blood cells) a tichhia em? Autoimmune Hemolytic Anemia (AIHA) chungchanga hriat tur pawimawh te chu hetiang hi a ni!

A châng chuan chhan awm lovin i chau a, i chau bawk em? I vun chu a rawn sen deuh emaw, a sen deuh emaw pawh a ni mai thei. Hetiang thil a thlen chhan hi i ngaihtuah thiam loh chang a awm thin, a dik em? Heng symptoms te hi a chhan pakhat chu i taksa ngeia immune system, natna laka vengtu sipaite, nangmah ngeiin i thisen sen (red blood cells) an beih vang a ni thei. Chu chu damdawi lamah `Autoimmune Hemolytic Anemia` (AIHA) kan tih chu a ni. A awlsam zawngin, i taksa defense system hian nangmah ngeiin i thisen sen (red blood cells) chu "hmêlma" tiin a tisual a, a tichhe vek a ni. Hei hi a pawi deuh hlek nachungin, enkawl dan dik tak chuan a enkawl tha thei a ni . Mahse, enkawl loh chuan nunna atana hlauhawm a ni thei. Chuvangin, hei hi hriat chian a, a rang thei ang bera damdawi lam thurawn lak a pawimawh hle. Hemi chungchang hi chipchiar zawkin han sawi ila.

`Autoimmune Hemolytic Anemia` (AIHA) tih hi eng nge ni?

A awlsam zawngin, `Autoimmune Hemolytic Anemia` (AIHA) hi i immune system-in i thisen sen (red blood cells) chu "ram dang" anga a hriat sualna a ni a, chu chu taksa tana chhiatna thlen thei thil tihna a ni. Chumi avang chuan i taksa chuan thisen sen (red blood cells) tichhe thei antibody a siam chhuak a ni. Heng antibodies te hian red cells te hi an inzawm a, an tichhe vek a ni. Chuti a nih chuan eng nge thleng? I taksaa thisen sen (red blood cells) awm zat a tlahniam a. Chu chu "anemia" kan tih chu a ni.

Ngaihtuah teh, helaia thil thleng hi kan ram humhalhtu sipaite, kan khua leh tui ngeite bei sual ang mai a ni. Hei hi a takah chuan a buaithlak deuh a, mahse hriatthiam a harsa lo.

Primary leh secondary AIHA hi eng nge an danglamna?

AIHA hi a lo awm dan azirin chi hnih a awm a.

• Primary AIHA: A châng chuan, AIHA hi a bulpui ber damdawi lam dinhmun chiang tak awm lovin a lo awm thei a ni. Chumi awmzia chu doctor-te chuan engvangin nge a lo lang nghal tih an hre thei lo tihna a ni. Hei hi primary AIHA an ti a.
• Secondary AIHA: AIHA chi dang chu AIHA hi natna dang avanga lo awm a nih chuan a ni. Entirnan, virus infection thenkhat, autoimmune diseases (taksa immune system-in a tissue a beih na), damdawi thenkhat emaw, thisen cancer hnuaia awm lymphoma emaw avanga lo awm thei a ni.

AIHA chi hrang hrangte chu engte nge ni?

AIHA hi chi hnih a awm a. Chungte chu ``Warm autoimmune hemolytic anemia`` leh ``Cold autoimmune hemolytic anemia`` te an ni. Hengte hi natna kaihhnawih antibody chi hrang hrang a zirin an thliar hrang a ni. Chu chu, he hming hi thisen sen (red blood cells) beitu antibodies te active nasat dan atanga lak a ni tihna a ni.

A rilru a buai em em a, a rilru a hah em em bawk a

Hei hi AIHA chi khat hman tlanglawn ber a ni. Hetah hian antibodies chi `IgG` te hian thisen sen (red blood cells) an inzawm khawm thin. Thil danglam bik chu heng antibodies te hi kan taksa temperature pangngai (i.e., "warm" environment-ah) ah an active a ni. A lan chhuah dan hi a tlangpuiin a lang zauh zauh a, kar tlemte chhungin a lang tan thin. Mahse, a then phei chuan ni reilote chhungin a natna lanchhuahna chu a na thei hle.

Cold autoimmune hemolytic thisen tlakchhamna (anemia) a awm

Hetiang chi hi AIHA vei zinga 10% atanga 20% chauh ah hmuh tur a awm. Autoantibody chi khat `IgM` tih a huam a ni. Heng autoantibodies te hi i thisen chu i taksa core temperature aia hniam zawka a awm chuan thisen sen (red blood cells) te nen an inzawm a, chu chu ``cold'' an ti a ni. He ``cold'' temperature hi mi hrang hrangah a danglam thei. Chumi awmzia chu mi thenkhat tan chuan heng antibodies te hi an vawt deuh laiin an thawk chhuak thei a, thenkhat tan chuan a lum zawk hle a ngai thei bawk.

He AIHA natna hian tute nge a nghawng ber?

AIHA hi tu pawhah a lo thang lian thei a, kum leh mipa leh hmeichhiaah pawh a lo thang lian thei. Mahse, he natna hi hmeichhia kum 40 chunglam zingah a tam ber a ni .

A awm fo ang bawkin AIHA hi a awm lo hle a ni . Kum tin mi sang za zelah mi pakhat emaw pahnih emaw vel a nghawng thin.

AIHA natna lan chhuah dan chu engte nge ni?

AIHA hian symptom hrang hrang a thlen thei. Ṭhenkhat chu a tam hle a, ṭhenkhat erawh chu AIHA i neih chi hrang hrang a zirin a danglam thung.

Heng a lan chhuah dan tlangpui thenkhat chu hetiang hi a ni:

• Khawsik
• Extreme fatigue (engkim ti tha thei lo khawpa chau lutuk) .
• Chaklohna
• Lung na tak tak
• Thâwk harsa (thawhrimna tlemte pawh nise) .
• Vun dum (thisen sang i neih lai ang chi) .
• Jaundice (vun leh mit sen) .
• Lu na (lu na) .
• Muscle na a na
• Zun dum (tea tui ang chi) .
• Luak chhuak leh luak chhuak
• Thâwk a tawi
• Kawthalo
• Lei hliam
• Palpitations (i thinlung a na lutuk tih hriatna) .

Heng symptoms zinga pakhat emaw pahnih emaw i neih hian AIHA i nei tihna a ni lo tih hre reng ang che. Mahse heng symptoms te hi a awm reng chuan doctor pan a tha ber.

A lan chhuah dan a inang lo thei a, a bik takin AIHA chi hrang hrang a zirin:

Warm AIHA hi a tam ber chu:

• Chau
• Luak chhuak thei
• Jaundice (vun sen) 1.1.
• Thinlung na tak tak hriatna

Cold AIHA hian natna lan chhuahna a thlen thei a, chungte chu:

• Chau
• Luak chhuak thei
• Kut leh ke lum (midang aiin a vawt zawka hriat) .
• Jaundice a awm
• A rilru a na
• Ke hnunglam a na
• Raynaud natna (khawsik a awm chuan kut zungtang leh ke ruhte chu a var/blue a, a hring vek) .
• Kut leh ke blue discoloration
• Thinlung thawk mumal lo `(Arrhythmia)`
• Thinlung mur ri hriatna
• Heart failure (hei hi a nasat chuan a ni) .

AIHA awm chhante chu engte nge ni?

AIHA vei zawng zawng zinga a chanve vel (50% vel) ah chuan a chhan dik tak chu hmuh theih a ni lo . Hei hi ``idiopathic autoimmune hemolytic anemia'' kan ti a, chu chu "a chhan hriat loh" tihna a ni.

A chanve dangah chuan AIHA hi damdawi lam thil dang nen a inzawm tlat a ni.

AIHA thlen thei damdawi lam thil dangte chu:

Secondary AIHA thlen thei autoimmune natna engemaw zat a awm. Chu chu taksa hrisel tak takte a beih nana natna dang a ni.

• Lupus : Hei hi taksa peng hrang hrang, vun, ruh, kal, leh thluak te a nghawng thei a ni.
• Rheumatoid arthritis : Ruh natna a ni ber a, ruh natna leh hliam a thlen thin.
• Sjogren’s syndrome : Mit leh hmui vawt hi a lan chhuah dan ber a ni.
• Thyroid natna : Thyroid hormone inthlauhna.
• Ulcerative colitis : Colon natna leh natna hrik awm.
• Hashimoto natna : Immune system-in thyroid gland a beih dan a ni.

A châng chuan, AIHA hi virus infection vang pawh a ni thei . Mahse, he thisen tlakchhamna hi virus infection a reh hnuah a reh fo thin. AIHA nena inzawm thei virus thenkhat chu:

• Epstein-Barr virus (mononucleosis thlentu virus) .
• Measles natna a ni
• Mumps a awm
• Rubella chuan a rawn ti a
• Atypical pneumonia a awm lo
• Varicella virus, chickenpox thlentu a ni
• `HIV` tih a ni
• Hepatitis (liver a bik taka nghawng thei virus) .
• Cytomegalovirus `(Cytomegalovirus)` hmanga natna hrik pai a ni

Damdawi thenkhat chuan AIHA a thlen thei bawk. I damdawi ei mek hian he natna hi a thlen nia rinhlelh a nih chuan i doctor chuan damdawi chu a titawp thei a ni.

• Antibiotics (a bik takin penicillin) .
• Nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g. ibuprofen) te hi a tha ber pawl a ni.
• Cancer dona damdawi

Engtin nge AIHA hi hmuhchhuah a nih?

I doctor chuan thisen tlakchhamna chhinchhiahna i neih a rinhlelh chuan thisen chhiar kimchang (CBC) a ti hmasa ang . Hei hian thisen tlakchhamna vaukhânna chhinchhiahna a hmu thei a ni. A bik takin, he test hian a tehna chu:

• I thisenah hian thisen sen, thisen var leh platelet engzat nge awm.
• I thisen zam (red blood cells) lian tham (lian, te, normal) te.
• Hemoglobin level - Hei hi i thisena protein awm, i taksa pum puia oxygen phurtu a ni.
• Hematocrit value (i thisenah i thisen sen (red blood cells) hian hmun engzat nge a luah)).

AIHA hriat theihna tura pui thei test dang

I doctor chuan thisen tlakchhamna (anemia) a rinhlelh chuan test tlemte tih belh leh turin a rawt ang che. Heng test te hian thisen tlakchhamna hi AIHA vang emaw, thil dang vang emaw a nih leh nih loh hriat theih nan a pui thei a ni.

• Peripheral smear: Hei hian i thisen sample lak a, microscope hmanga en a ni. Hei hian i thisen sen (red blood cells) a chhiat emaw, a pianzia a danglam em tih ang chi thil a zawng thei a ni.
• Reticulocyte count: He test hian i taksaa thisen sen (red blood cells) naupang (siam thar) awm zat a teh thin. Thisen sen (red blood cells) a chhiat chuan ruhro (bone marrow) hian a thlaktu atan thisen sen (red blood cells) tam zawk a siam tan tih hre reng ang che. Hei hian reticulocyte count a tipung a ni.
• Bilirubin test: Thisen sen (red blood cells) a chhiat chuan thil pakhat bilirubin an tih chu a lo piang chhuak thin. Hei hi a pun chuan jaundice (vun sen) a awm thin. Chuvangin, thisenah bilirubin level a sang a nih chuan thisen sen (red blood cells) a chhe vek tih chhinchhiahna a ni.
• Coombs’ test: Hei hi AIHA hriatchhuahna atana test pawimawh tak a ni. I taksain thisen sen (red blood cells) laka antibody a siam chhuak em tih a enfiah thin.
• Haptoglobin test: Haptoglobin hi thisen sen chhia atanga bawlhhlawh paih chhuaktu protein a ni. Thisen sen tam tak a chhiat chuan taksain he haptoglobin hi a hmang zo vek a ni. Hei hian thisen a haptoglobin level a tihhniam phah a ni.
• Lactate dehydrogenase (LDH): LDH hi thisen sen chhunga enzyme awm a ni. Thisen sen (red blood cells) a chhiat chuan he LDH enzyme hi thisenah a chhuak thin. Hei hian LDH level a tisang a ni.
• Cold agglutinin titer: I doctor chuan cold AIHA a rinhlelh chuan he test hi a order thei ang. Hei hian khaw lum laia thisen sen (red blood cells) beitu antibodies level a teh a ni.

AIHA hi engtin nge enkawl a nih?

AIHA enkawl hian a hmasa ber chu enkawl theih tur chhan bulpui a awm leh awm loh hriat a ni tlangpui. Entirnan, i AIHA hi lupus nen a inzawm a nih chuan i doctor chuan lupus hi a enkawl hmasa ngei ang. AIHA thlentu hi lymphoma ang chi natna a nih chuan chu natna chu enkawl a pawimawh hle. Damdawi pakhatin i AIHA a thlen a nih chuan chu damdawi chu i ei tawh loh a ngai mai thei.

Mahse, mi thenkhat tan chuan AIHA hi a nêm hle.. Chumi awmzia chu a symptoms chu chutiang chuan a na lo tihna a ni. Chutih hunah chuan enkawlna engmah a ngai lo mai thei.

Damdawi chi hrang hrang

• Corticosteroids: Hengte hi AIHA enkawlna hmasa ber a ni tlangpui. Heng damdawi te hian i taksa immune system a titawp a, chu chuan i thisen sen (red blood cells) a tihchhiatna chu a ti tlem a ni.
• Immunosuppressants: Corticosteroids ringawt hi natna control nan a tawk lo a nih chuan i doctor chuan heng damdawi chi hrang hrangte hi a pe thei ang. Hengte hian immune system-in ruhro (bone marrow) a beih loh nan a titawp a ni.

Splenectomy (spleen lakchhuahna surgery) tih a ni.

Damdawi chauh hmanga AIHA control theih loh chuan i spleen chu operation hmanga lakchhuah a ngai mai thei. Kan taksa chhunga taksa peng pakhat, thisen sen pangngai lo, thisen sen (red blood cells) te chu a filter chhuak a, chu chu antibody attached a ni. Spleen-ah hian antibody siamtu cell a awm bawk. Chuvangin spleen lakchhuah hian thisen sen tihchhiatna a ti tlem thei a, thisen tlakchhamna pawh a ti tlem thei bawk.

Thisen pek a ni

AIHA natna khirh takah chuan damlote chuan thisen pek an ngai mai thei a, chu chu pawn lam atanga thisen lak a ni. Hei hian thisen sen (red blood cells) a tipung thuai thei a, symptoms control-na kawngah a pui thei bawk.

‘Warm’ leh ‘cold’ AIHA enkawl dan a danglam em?

Ni e, primary ‘cold AIHA’ enkawl dan hi ‘warm AIHA’ nen a danglam a ni.

Corticosteroid emaw immunosuppressive damdawi emaw hi ‘warm AIHA’ atan hman a ni tlangpui. Chu chu a hlawhtling lo a nih chuan, a zung (spleen) lakchhuahna tur operation neih a ngai mai thei. Thisen tlakchhamna na tak a awm chuan thisen pek hi natna enkawl lai hian supportive therapy anga ngaih a ni bawk.

Mahse, ‘cold AIHA’ hian corticosteroid emaw splenectomy emaw a chhang tha lo. ‘AIHA lum’ hi a na lo a nih chuan taksa lumna (e.g., kut/ke lumna hman te, kutkawr, socks bun te, leh boruak lum zawka zin te) hmangin natna hi a thunun theih a ni. Enkawl a tul chuan damdawi `Rituximab` (a chang chuan immunosuppressant damdawi dang nen) hi first-line treatment a ni.

AIHA vei theihna hi a tlahniam thei ang em?

Autoimmune Hemolytic Anemia hi a veng thei ngai lo. A châng chuan chhan hriat lohvin a thleng ṭhin. Mahse, virus infection i neih emaw, AIHA nena inzawm nia hriat damdawi i ei a nih chuan i doctor chuan i dinhmun a enfiah thei a, natna i vei theihna tur a tihziaawm thei bawk.

AIHA hi natna khirh tak a ni em?

Autoimmune Hemolytic Anemia hi a chang chuan a na lo lutuk a, enkawlna engmah i mamawh lo mai thei. Mahse, a châng chuan a nasat êm êm a, zai emaw, thisen pêk emaw a ngai mai thei. AIHA i vei tih hmuhchhuah a nih chuan i doctor chuan i natna nasat dan leh i enkawl dan tur a sawipui thei che a ni.

A pawimawh ber chu AIHA hi enkawl loh chuan thihna thlen thei a ni a, chuvang chuan damdawi lam hmalakna rang tak neih a pawimawh em em a ni.

AIHA hi tihdam theih a ni em?

Awle. AIHA vei tam zawk chuan enkawlna an mamawh tlem hle emaw, enkawl ngai lo emaw a ni. Damlo 20% leh 30% inkar chuan damdawi, operation, emaw thisen pek emaw an mamawh a ni.

Engtikah nge Doctor ka hmuh ang?

Anemia symptoms i neih tan chuan – hah lutuk, chak lohna, jaundice (vun sen), emaw thawk harsatna emaw – doctor pan nghal rawh Diagnosis leh treatment i neih hma chuan i dam chak thei a, i nun pangngaiah i kir leh thei bawk.

A tawi zawngin (Take-Home Message) .

Autoimmune Hemolytic Anemia (AIHA) hi nangmah ngeiin i immune system-in i thisen sen (red blood cells) a bei a, thisen tlakchhamna a thlen thin.

• Symptoms hi a na lo emaw, na tak emaw pawh a ni thei. Chauhna, paleness, jaundice, leh thawk harsatna te hi a pawimawh ber a ni.
• A chhan pawh a inang lo hle. A châng chuan chhan engmah hmuh theih a ni lo (primary), a châng chuan natna dang, hri kai, damdawi (secondary) vang pawh a ni thei.
• Enkawlna kawng hrang hrang a awm. Chûng zîngah chuan damdawi te, rilṭâm lak chhuah te, leh thisen inthlâk te a tel a ni. ‘Warm’ leh ‘cold’ chi hrang hrangah enkawl dan a inang lo.
• AIHA hi natna enkawl theih tak ni mah se, enkawl loh chuan a na hle thei a, nunna atana hlauhawm tak pawh a ni thei .

Chuvangin heng symptoms te hi i neih chuan hlauthawng suh la, tihkhawtlai lo la, doctor thurawn zawng zawk rawh. I doctor chuan a tul angin test a ti thei a, i dinhmun dik takin a hmu thei a, enkawlna dik ber a pe thei bawk. Tichuan i dam thuai thei tawh ang a, nitin hna i thawk chhunzawm thei tawh ang!

` autoimmune hemolytic anemia, AIHA, thisen tlakchhamna, thisen sen, antibody, immune system, jaundice, hahna