Doctor ten hnute cancer i vei tih an hriat chuan i doctor chuan chemotherapy a rawt thei ang. He thu i hriat hian tlemin hlauhna leh lungkhamna i neih hi thil pangngai a ni. Mahse heng enkawlna chungchang hi dik taka hriattir i nih chuan , chu hlauhna chu i hneh thei ang. Chemotherapy hmanga enkawlna chi hrang hrang a awm a. Alkylating agents hi hnute cancer atana damdawi chi hrang hrang hman ber pakhat a ni. Chuvangin, vawiin hian he thu hi chipchiar tak leh awlsam takin i sawi dawn nia.
Engtin nge heng damdawi Alkylating Agents tia koh te hian hna an thawh tak tak?
Hei hi hrethiam tur chuan cancer cell chungchang hi kan ngaihtuah hmasak a ngai a ni. Cancer cells hi cell inthen darh leh pung chak tak tak, thununna awm lovin an ni. Alkylating agents hi cancer laka damdawi hmuhchhuah hmasak ber zinga mi a ni. Tun thlengin an la hmang nasa hle.
A awlsam zawngin sawi ila, he damdawi chi hian cancer cell-te’n anmahni copy an siam loh nan, chu chu an inthen darh a, an lo thang lian lo tihna a ni. Hei hi hetiang hian a ti a ni:
Cell tin hian chu cell blueprint, a nih loh leh "blueprint" kimchang chu an nei vek a ni. Hei hi DNA kan ti a. Alkylating agents te hian an tih chu cancer cell DNA ah direct in an kal a, an inzawm khawm thin. Chabi pakhat chu a dang i stick chuan a thawk thei lo ang bawkin, he damdawi hian DNA a binding chuan chu cell chu a inthen thei lo.
Chutianga cell inthen darh a reh chuan cancer cell te chu an thi zauh zauh thin. Damdawi lamah chuan he thil hi apoptosis tiin kan sawi thin. Chu chu programmed cell thihna tihna a ni.
Heng damdawi danglamna dang chu cancer cell chu a nun chhung eng stage-ah pawh a bei thei a, a tichhia thei bawk. Hei hi `cell-cycle phase nonspecific` an ti a. Chuvangin cancer chi hrang hrang, a bik takin a thang chak zawkte lakah an thawk tha hle.
He damdawi hi pill angin emaw, vein (IV - intravenous) kaltlangin saline solution angin pek theih a ni. Vawi tam tak chu i doctor chuan he damdawi hi chemotherapy damdawi dang (combination therapy) nen a pe ang.
Alkylating Agents chi hrang hrangte chu engte nge ni?
He damdawi pawl hi chi hrang hrangah then a ni. Heng hming hi a buaithlak deuh a, mahse hriat a tha a, a chhan chu i damdawi sheet-ah heng zinga pakhat hi i hmu mai thei a ni.
| Ruihhlo Group | Chu category-a tel damdawi (Entirna) . |
|---|---|
| Nitrogen mustards hmanga siam a ni | bendamustine, chlorambucil, cyclophosphamide , ifosfamide, mechlorethamine, melphalan te a awm bawk |
| Ethylenamine leh methylenamine atanga chhuak te | altretamine, thiotepa tih a ni |
| Alkyl sulfonates a awm bawk | busulfan tih a ni |
| Triazenes a awm bawk | dacarbazine, procarbazine, temozolomide te a awm bawk |
| Platinum awmna agents te | carboplatin , cisplatin, oxaliplatin tih te hi a awm a |
| Nitrosoureas a awm bawk | carmustine, lomustine, streptozocin tih te hi a awm a |
Chung zingah chuan Nitrosoureas an tih damdawi class hi a danglam deuh hlek a ni. A chhan chu heng damdawi te hian kan thluak vengtu ‘blood-brain barrier’ an tih protective layer an paltlang thei a ni. Ruihhlo tam zawk chuan he daltu hi an paltlang thei lo. Chuvangin thluak kaihhnawih cancer enkawlnaah an pawimawh hle.
Hnute cancer atan hian eng chi nge hman tam ber?
Damdawi chi hrang hrang ` Nitrogen Mustards` leh `Ethylenamine leh methylenamine derivatives` te hi hnute cancer stage hrang hrang enkawlna atan hman a ni tlangpui.
Cytoxan (Cyclophosphamide) a awm bawk.
Hei hi damdawi `Nitrogen mustard` group-a tel a ni. Pill angin i ei thei a, IV angin vein-ah i pe thei bawk. A hman tlangpui chu:
- Operation hnua cancer hmasa ber lo kir leh tur venna .
- Cancer a lo zual tawh chuan operation hmain lump chu tihtlem hmasa phawt ang che .
- Surgery hnua cancer natna zual leh enkawlna dang enkawl .
Thiotepa chuan a ti a
Hei hi `Ethylenamine` atanga lo chhuak a ni. A tlangpuiin thisenah pek thin a ni. A hmanna tur chu:
- Cancer hmasa berah chuan a lo lang leh theihna tur a ti tlem .
- Cancer natna zual (advanced-stage cancer) enkawl .
Carboplatin a ni
Hei hi platinum awmna damdawi a ni. Hnute cancer enkawlna atana platinum damdawi phalsak awmchhun a ni. `Carboplatin` hi cancer natna zual zel tan pek a ni tlangpui a, chemotherapy damdawi dang nen pawh pek a ni bawk. IV angin pek a ni bawk.
He damdawi hian eng side effect nge a neih?
Chemotherapy-a harsatna lian ber pakhat chu cancer cell leh cell hrisel inthlauhna a hriat theih loh vang a ni. Heng damdawi te hian cell inthen darh chak tak takte chu an target a ni. Cancer cell te hi kan taksa chhunga cell hrisel thenkhat ang bawkin (entir nan, kan sam zung siamtu cell te, kan hmui leh kan chhungril lining line siamtu cell te, leh thisen cell te) te hi an inthen nghal vat thin. Chuvangin heng damdawi te hian chu cell hrisel te chu a nghawng bawk a, chuvang chuan side effect an nei thin.
Heng side effects te hi mi zawng zawngah a thleng dan inang vek lo. Mi thenkhat chuan an nei tam thei a, thenkhat chuan an nei tlem zawk mai thei. Hemi chungchangah hian lungngai suh. Heng thil tam zawk hi i doctor chuan a enkawl thei che a ni.
| Side effect chi hrang hrang |
|---|
| Mi tam takin an tawn theih side effects tlangpui |
| Nausea leh luak chhuak, chaw ei chak lohna, taksa rihna tlahniam, pum na, ril\am |
| Chau |
| Sam tlakchham, hmui emaw lei emaw a na |
| Kut zungtang leh ke ruh vun rawng, rawng emaw, a than dan inthlak danglam |
| Thisen var cell count tlahniam (hei hian natna kai theihna a tipung thei) . |
| Hmeichhiaah thlasik hun mumal lo |
| Symptom na tak tak, doctor hnena hriattir nghal tur |
| Khawsik, khawsik, ril na (infection chhinchhiahna) . |
| Hliam dam zawi zawi, hliam emaw thisen chhuahna danglam tak |
| Black or tarry stools, zun laiin natna, emaw zun chhunga thisen awm |
| Vun vun rawng, hives, itching |
| Thâwk harsa leh ei harsa, thawk hah, khuh |
| Ke, ke ruh, ke ruh hring, rilru na |
| Vun emaw mit emaw a sen (jaundice chhinchhiahna) . |
Rikrum!
A hnuaia symptoms te hi i neih chuan damdawi in hnai ber Emergency Department (ETU) ah kal nghal la , 1990 ambulance service ah call rawh:
* Thinrim dum
* Thisen chhuah tihtawp theih loh
* Thâwk harsa na tak
* A rilru a na
* Allergy na tak chhinchhiahna (hmai, hmui hring ang chi) .
A tlem hle a, heng alkylating agents te hian kan ruhro a tichhe thei a ni. Bone marrow hi kan taksain thisen cell thar a siamna hmun a ni. Hetiang chhiatna avang hian cancer chi dang, leukemia ang chi vei theihna a tlem hle. He risk hi damdawi dose a san chuan a sang deuh tlangpui. Hemi hi a tul lovah lungngai suh.Enkawlna i tan hmain hetiang cancer pahnihna vei theihna tur tihtlem dan tur i doctor nen zalen takin sawiho rawh. I mamawh thurawn zawng zawng a pe ang che.
Enkawlna neih huna ngaihtuah tur dang
Hengte hi damdawi chak tak tak an nih avangin i doctor hnenah i medical history kimchang hrilh a pawimawh a, chutiang chuan i doctor chuan i duh angin treatment plan a siam thei ang a, side effects a ti tlem thei ang. I doctor nen hian a hnuaia mite hi sawipui ngei ang che:
- Allergy i neih apiang (damdawi, ei tur) chungchang.
- Vitamin, supplement, emaw herbal remedies i hman apiang chungchang.
- I kal emaw, i liver emaw dinhmun chungchang.
- Tun hmaa chemotherapy treatment i lo dawng tawh a nih chuan min hrilh teh.
- Naupai i nih chuan, nau i hnute i pe a nih chuan, nau neih thuai i tum a nih chuan .
- Nakin lawkah surgery tih tur i neih chuan sawi rawh.
Doctor thupek dik takin zawm la, a bik takin pill i ei a nih chuan. Dose i ei theihnghilh chuan a hnuaia dose chu a ruahman angin ei leh rawh. Dose hloh tawh chu vawi khatah vawi hnih ei ngai suh. Enkawlna i chawlhsan hmain i doctor nen inbia fo ang che.
Take-Home Thuchah a ni
- Alkylating agents hi chemotherapy damdawi chak tak chi khat a ni a, cancer cell DNA a tichhia a, an inthen darh thei lo.
- Heng damdawi te hian cancer cell leh rang taka inthen darh cell hrisel te a nghawng avangin, natna tha lo tak tak, nausea leh sam tlakchhamna te a thlen thei a ni. Chungte chu enkawl theih a ni.
- I doctor nen i medical history kimchang, i ei tur damdawi dang, leh allergy chungchang te zalen taka inbiakna neih a pawimawh hle.
- Thâwk harsa emaw, thisen chhuak nasa emaw ang chi natna langsar tak tak i neih chuan damdawi-in Emergency Department (ETU)-ah kal nghal tur a ni.
- I doctor thurawn tel lo chuan damdawi ei tur hi i thlak ngai lo tur a ni a, enkawl pawh i chawlhsan tur a ni lo.
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