Mantle Cell Lymphoma hi eng nge ni? Kan sawi dawn nia!

Kan taksa chhungah hian a chang chuan ngawi renga indona a awm tih pawh i hre lo mai thei. Entirnan, Mantle Cell Lymphoma (MCL) hi cancer hmuh tur awm lo tak a ni a, kan thisen var cell lymphocyte an tih atanga intan a ni. A nihna takah chuan lymphoma chi khat non-Hodgkin lymphoma an tih a ni. Hemi chungchang hi awlsam takin, i hriatthiam theih dan tur angin sawi ila.

Engtin nge mantle cell lymphoma (MCL) hi a lo awm? Taksa chu eng nge thleng?

Ngaihtuah teh, he cancer MCL an tih hi a tir lamah chuan taksaah zawi zawiin leh ruk takin a darh tan thin. Mahse, rei vak lo hnuah chuan rang takin a thang chak thei a ni. Hei hi kan lymphatic system zawng zawngah a darh ber a ni. Lymphatic system hi kan taksaa tui chi khat a ni a, chu tui phurtu vessel network a ni. Kan taksa atanga bawlhhlawh paih chhuaktu system ang mai a ni. Natna a zual deuh chuan , heng cancer cell te hi lymph node atang hian an chhuak thei a, kan thisenah, ruhroah te, a chang chuan digestive system ang hmunah te pawh an darh thei bawk.

Pawimawh tak chu MCL vei hian remission period a nei thei a, recurrence pawh an nei thei bawk. Hei hi vawi tam tak a thleng thei. Enkawlna hian MCL chu a tidam kim thei lo nain, a remission hun chhung a ti rei thei a ni.

Mantle cell lymphoma hi cancer hmuh tur awm lo tak a ni . Mi 200,000 zinga pakhat velin a nghawng a ni. He cancer hi tu pawhin an vei thei a, mahse kum 60 leh 70 inkar te hi an hlauhawmna a sang deuh hlek a ni.

Mantle cell lymphoma (MCL) hi eng chi hrang hrang nge ni?

MCL hi chi hnih a awm a, chungte chu: 1. Classical MCL: Hei hi a tam ber a ni. Lymph node-ah a intan a, taksa peng dangah a darh zel a ni. A tlangpuiin aggressive zawk type a ni. 2. Leukaemic non-nodal MCL: Hetiang chi hi a tlangpuiin thisen leh ruh chhunga lymphoma cells lian tham leh lymphoma cells te a ni. Classical type aiin a thang zawi zawk .

He natna lan chhuah dan engte nge ni? Engtin nge i hriat chian?

MCL symptoms hi mi hrang hrangah a inang lo thei. A châng chuan natna tlanglawn tak chhinchhiahna angin an lang thei a, chuvangin cancer pawh i ngaihtuah lo mai thei. Chuvang chuan MCL hi a tlai fo thin a, chutih lai chuan natna hi a darh tawh a ni. Symptoms engmah i nei lo mai thei. Mahse, symptoms i neih chuan hengte hi a ni thei:

• Bruising a awm
• Lu na
• Chauhna awm reng ( Fatigue ) .
• Khawsik
• Pum natna a awm
• Chaw chakna
• Zan khat atanThawmhnaw hak
• Lymph node hring (kawng, kawr, kawrfual-a awm ang chi) .
• Chak lo anga inhriatna
• Chhan awm lovin taksa rihna tihtlem

Heng symptoms i neih vang mai mai hian MCL hi hlau suh. Mahse heng symptoms te hi a awm reng chuan doctor pan a tha ber .

Eng thilin nge mantle cell lymphoma (MCL) hi a thlen?

A tam zawkah chuan MCL hi kan gene thenkhat mutation vang a ni. He mutation hian kan B cells, lymphocyte chi khat hnathawh dan a tidanglam a ni. He mutation hi engvangin nge a lo awm tih hi zirchiangtute chuan an hre chiang lo. Mahse hei hi a thleng ta a ni: 1. B cells mutated danglam tak takte hian protein cyclin D1 an siam tam lutuk. He protein hian B cells te chu a ti thang lian thei a ni. 2. He cyclin D1 protein siam chhuah tam lutuk hian B cells te chu thunun theih lohvin a inthen darh a, a pung zel a. 3. Thunun theih loha inthen darh cell te chu an inzawm khawm a, tumor an siam thin.

Hetiang dinhmun hian eng harsatna nge a thlen?

Mantle cell lymphoma a lo zual zel chuan harsatna hrang hrang a awm a, chungte chu:

• Gastrointestinal atanga thisen chhuak
• A rilru a buai em em a
• Tumor lysis syndrome (cancer cells te a chhe chak lutuk avanga harsatna awm) .

Engtin nge mantle cell lymphoma (MCL) hi hmuhchhuah a nih?

I doctor-in MCL i neih a rinhlelh chuan test eng emaw zat an ti ngei ang.

• Lab test: Heng zingah hian thisen chhiar kimchang (CBC), comprehensive metabolic panel (CMP), LDH test, emaw uric acid level test te pawh a tel thei. Doctor-te chuan thisen test-a lymphocyte tamna an hmuh chuan rinhlelhna an nei tlangpui.
• Biopsies: I doctor chuan cancer cell a awm leh awm loh finfiah nan lymph node biopsy emaw, bone marrow biopsy emaw neih a rawt thei ang. Tissue sample chu pathologist ten an enfiah thin.
• Imaging test: Heng test te hian cancer hi eng chen nge a darh tawh tih hriat nan a pui thin. Cancer awmna hmun azirin colonoscopy, CT scan, EGD (esophagogastroduodenoscopy), emaw PET scan emaw tih a ngai mai thei.

Thisen test result a dik lo a nih chuan i doctor chuan a enfiah ang che a, i symptoms te a zawt ang che. I lymph nodes a hring em tih en turin i kawr leh i kawrfual ang chi hmun an hre thei bawk.

Mantle cell lymphoma (MCL) hi eng stage nge ni?

Doctor-te chuan natna a darh tawh dan azirin stage hrang hrangah an ṭhen a. Anni hian system bik Mantle Cell Lymphoma International Prognostic Index (MIPI) an tih chu an hmang a ni. Hei hian damlo pakhatin eng chen nge dam a beisei theih ang tih ngaihtuahna rough tak a pe a ni. A tlangpuiin natna hi a hma lam aiin a hnu lamah a lo lang leh duh zawk. Stage chu cancer a darh tawhna atanga teh a ni:

• Stage I: Hmun khata lymph node pakhat emaw tlemte emaw chauh a awm.
• Stage II: I diaphragm sir khatah lymph node pahnih emaw a aia tam emaw ah a darh tawh.
• Stage III: Diaphragm sir lehlamah a darh tawh a, a nih loh leh diaphragm chunglam spleen leh lymph node-ah te a darh tawh bawk.
• Stage IV: Mantle cell lymphoma hi taksa hmun hla tak takah a darh tawh a, a nih loh leh lymph node ni lo hmun dangah a darh tawh bawk.

Mantle cell lymphoma (MCL) hi engtin nge enkawl a nih?

MCL enkawl dan hi mi zawng zawng tan a inang vek lo. I tana enkawlna dik tak chu cancer awmna hmun leh a lo thang chak dan ang chi thilah a innghat a ni. MCL enkawlna tur thenkhat chu hetiang hi a ni:

• Chemotherapy: Cancer cell tihchhiatna atana damdawi pek thin.
• Immunotherapy: Cancer dona atana i taksa taksa chakna (immune system) tichaktu damdawi a ni.
• Radiation therapy: Energy sang tak nei rays hmanga cancer cell tihchhiat.
• Targeted therapy: Cancer cells te tihpun leh darh zel tura puitu molecule bik target tu damdawi.
• Stem cell transplant: Ruhro natna nei thlak nan stem cell hrisel tak tak thlak.

Heng enkawlna thenkhatah hian i tling thei a, thenkhatah chuan i tling lo thei bawk.

MCL i neih chuan enkawlna thar test-na clinical trial ngaihtuah pawh a tha hle. Heng enkawlna tharte hian MCL hi a tidam kim lo mai thei a, mahse nun hlim tak, symptom awm lohna nun atan hun tam zawk a pe thei che a ni. Hemi chungchang hi doctor zawt rawh.

Mantle cell lymphoma (MCL) hi a veng thei ang em?

Vanduaithlak takin MCL hi a dang thei lo. He natna i neih vang mai mai hian thil dik lo i ti tihna a ni lo. Kan taksaa genes te hi MCL ang cancer thlen thei tur kawng hrang hranga inthlak (mutate) chhan hi zirchiangtute chuan an la chhui chhuak mek a ni.

Mantle cell lymphoma (MCL) natna hi eng ang nge ni?

Mantle cell lymphoma hi lymphoma chi khat, tihdam theih vek a ni lo. Mahse, remission-a kal theihna tur enkawlna a awm. Remission-a awm hian cancer chu a dam vek tihna a ni lo. MCL hi thla emaw kum tam tak hnuah a lo lang leh thei a ni. MCL hmanga remission-a i awm chhung hi a rei zawk mai thei. Mahse, tun ṭumah hian targeted treatment thar a pung tih hmuhchhuah a ni. I prognosis chungchang hriat belh duh chuan i doctor nen inbia ang che.

Damchhuak zat

Mantle cell lymphoma vei kum nga chhunga dam rei zawng hi 50% vel a ni. Chumi awmzia chu he natna vei hmuhchhuah zinga a chanve vel chu hmuhchhuah a nih atanga kum nga hnuah pawh an la dam tihna a ni.

Mahse, heng damchhuah zat hi estimate mai a ni tih hre reng ang che. Eng chen nge i dam dawn tih leh eng enkawlna pawh i dawn dan tur chiang takin an sawi lo. Heng rates te hi engtin nge i tan a hman tih hriat tumin i doctor nen inbiakna neih a tha ber.

Engtin nge i in enkawl ang?

Mantle cell lymphoma natna vei hian taksa, rilru leh rilru lama in enkawl hi a pawimawh hle . I tanpui thei tur rawtna thenkhat chu hetiang hi a ni:

• I rilru put hmang pawm rawh: Lungngaihna leh hlauhna ang chi rilru put hmang thunun hian a ti bo lo vang. I rilru put hmang hriatthiam leh a lan chhuah theihna tura phalsak hi i mamawh ṭanpuina i hmuh theihna tura hmalakna hmasa ber a ni.
• Support dawng: Chutiang thil tawn tawhte nen support group-a tel chu a \angkai hle. I doctor hnenah i awmna hmuna group hrang hrangte emaw online emaw zawt rawh.
• Stress enkawl rawh: I chawlh hahdam theih dan tur zawng rawh. Mindfulness exercise, meditation ang chi te hi han ti ve teh.
• Thil tih dan pangngaiah lut rawh: Natna remission leh relapse cycle hian engkim a ti buai thei hle. Nitin thiltih tûra tih dân tûr siam a, chu chu zawm tlat chuan thununna engemaw chen i neih theih nân a ṭanpui thei che a ni.
• Counsellor nen inbia: I rilru hriselna enkawl a pawimawh. Counsellor emaw, therapist emaw chuan rilru natna khirh tak takte hmachhawn tûrin a ṭanpui thei che a ni.

Engtikah nge doctor i hmuh ang?

Mantle cell lymphoma vei enkawl i nih chuan doctor pan fo a ngai dawn a ni. I dinhmun an enfiah ang a, i enkawlna avanga side effects te pawh an enkawl thei ang. I natna chu remission-ah a awm a nih chuan a hun hunah doctor i pan a ngai dawn a ni (follow-ups). Heng appointment te hi eng chen nge i neih tur tih i doctor zawt rawh. Mantle cell lymphoma (MCL) i neih chuan natna, a bo tak tak ngai lo, rinhlelhna nen i nung a ni. Natna chu a lo let leh dawn em tih i ngaihtuah fo mai thei. A nih loh leh, a enkawlna chu i tân a ṭha em tih i ngaihtuah mai thei bawk. Heng rilru put hmangte hi hriat chu thil pangngai a ni . Mahse, he lungkhamna hian nun nuam tihna a dal che a nih chuan, i doctor nen inbiakna neihpui ngei ang che . I zinkawng zawh tura pui thei tur resources te an refer thei che a ni.

A tawp berah chuan take-home message:

Mantle cell lymphoma (MCL) hi thumal hlauhawm tak a ni thei. Amaherawhchu, fimkhur a pawimawh a, a natna lan chhuah dan ngaihven a, a hun taka damdawi lam thurawn lak a pawimawh. Nangmah chauh i ni lo tih hre reng ang che. Enkawlna dik leh puihna dik tak i neih chuan he natna hi tuar chhuak thei turin chakna i hmu ang. Zawhna leh ngaihtuahna i neih apiang chu i doctor hnenah sawi hreh suh. Mantle Cell Lymphoma, Cancer, Thisen Cancer, Lymphatic System, A lan chhuah dan, Enkawl dan