Castleman Disease chungchanga hriat tur awmte

I kawr, i kawrfual emaw, i kawrfual emaw-ah "lump" kan tih ang chi hi i nei tawh em? A châng chuan, khawsik emaw, natna chi khat emaw i neih chuan hetiang lumps hi a lo hring chhuak ṭhin. Chu chu thil pangngai a ni. Mahse hetiang hian chhan awm lovin, hun rei tak chhung, i chau a, i thau pawh i tlahniam a nih chuan tlem tal i ngaihtuah tur a ni. Vawiin hian hetiang huna rinhlelh theih tur dinhmun tlemte kan sawi dawn a ni. Chu chu Castleman Disease a ni.

A awlsam zawngin Castleman Disease hi eng nge ni?

Kan taksa hi ram ang maiin han ngaihtuah teh. Tichuan kan immune system chu chu ram venghimtu sipai chu a ni. Pawn lam atanga natna hrik (hmêlma) taksaa a luh chuan he sipaite hian indonaah an kal a, chu hmelma chu an hneh ta a ni. Indona a zawh chuan sipaite chu barrack-ah an kal leh a, an ngawi ta a ni. Hei hi mi hrisel taksaah a thleng thin.

Mahse Castleman natna vei tan chuan a danglam. Heta thil thleng hi indonaa kal sipai, immune system te hi indona a zawh hnuah pawh a reh lo. An active reng a ni. Indona atana an inpeih reng ang mai a ni. Hei hian taksaah hun rei tak chhung inflammation a thlen thin. Hei hian kan taksa peng hrang hrangte a tichhe thei a ni.

Chutih lai chuan kan lymph node te, chu thil te te te chu sipai hmunpui ang mai a ni. Hna tam tak an thawk a, chu chu natna hrik filter chhuah leh immune cells dahkhawm ang chi te hi a ni. Tunah chuan immune system hian hna a thawk reng avangin heng lymph node te pawh hian hna an thawk reng bawk. Chumi avang chuan an chhunga cell te chu an lo thang lian lutuk tan thin. Chuvangin Castleman natnaah hian lymph nodes a lo hring chhuak thin . A hring mai ni lovin, chu lymph node tissue-ah pawh a tidanglam thei a ni.

Castleman natna chi hrang hrangte chu engte nge ni?

Casselman natna hi chi hnih ah then a ni a. A natna lan chhuah dan leh enkawl dan pawh a inang lo hle. Chuvangin heng chi hnih hi chiang taka hriatthiam a pawimawh hle.

Multicentric Castleman disease (MCD) hi subtype hrang hrang a awm em?

Ni e, MCD hi subtype engemaw zatah then belh a ni. He classification hi a chhan leh a kaihhnawih thil dang awm dan atanga thlirin tih a ni.

• POEMS-associated MCD: POEMS hi thisen lama harsatna awm lo tak a ni. A châng chuan MCD hi POEMS nen a awm dun thei bawk.
• HHV-8-associated MCD: Hei hi Human Herpes Virus-8 (HHV-8) an tih virus kai avanga lo awm a ni. Hetiang chi hi HIV vei emaw, chhan dang avanga immunocompromised emaw te tan a tam hle.
• Idiopathic MCD (iMCD): Damdawi lam thumal " idiopathic " tih awmzia chu "a chhan hmuhchhuah a ni lo" tihna a ni. MCD vei tam zawk chuan hetiang chi hi an nei a ni. Chumi awmzia chu a chhan dik tak hriat a la ni lo tihna a ni.

Hetiang iMCD chi hi chi thum tenau zawkah then a ni leh a:

1. TAFRO nena inzawm iMCD: TAFRO tih hming hi symptom engemaw zat inzawmkhawm atanga lak chhuah a ni. Chu chu Thrombocytopenia (thisen platelet hniam), Anasarca (tui hmanga taksa hring), Fever (khawsik), Renal dysfunction (kidney hnathawh chak lohna) leh Organomegaly (liver emaw spleen emaw lian) te chu he natna atanga hmuh theih a ni.

2. iMCD with idiopathic plasmacytic lymphadenopathy (iMCD-IPL): Hetiang chi ah hian platelet count a sang thei. Thisen var hmanga antibody siam tam lutuk pawh a awm thei bawk.

3. iMCD, a danglamna tarlan loh (iMCD-NOS): iMCD vei damlo TAFRO nena inzawm lo, a chhan chiang dang hmuh theih lohte chu he category-ah hian an tel a ni.

He natna lan chhuah dan hi eng nge ni thei ang?

Castleman natna chi hrang hrang i neih dan azirin symptoms a inang lo.

Unicentric Casselman disease (UCD) hian a tlangpuiin a lan chhuahna a nei lo . A chhinchhiahna awm chhun chu lymph node (adenoid) a hring a ni. A châng chuan, symptoms (e.g., natna, thawk hahna) hi a hring node-in taksa peng dang a press chauhvin a awm ṭhin.

Mahse, multicentric Castleman disease (MCD) -ah chuan a lan chhuah dan a langsar zawk. Glands hring (swellen glands) bakah hian:

• Khawsik fo thin
• Chhan awm lova chau lutuk leh chau lutuk (hei hi thisen tlakchham vang pawh a ni thei) .
• Zanah thawk hah lutuk
• Nausea leh luak chhuak
• Beisei loh taka taksa rihna tlahniam
• Ke, ke ruh emaw, pum emaw a hring chhuak
• Spleen lian (splenomegaly) emaw, thin lian (hepatomegaly) emaw .
• Kut leh kea natna (peripheral neuropathy) .

Engvangin nge he natna hi a lo awm? Risk factors a awm em?

Dik tak chuan scientist-te chuan unicentric Castleman disease (UCD) awm chhan chiang tak an la hmu lo .

Multicentric Castleman disease (MCD) hi a chunga kan sawi tak HHV-8 virus nen hian a inzawm a ni . Mahse, zirchiangtute chuan iMCD chi hriat loh hi infection dang, gene mutations emaw, autoimmune response emaw avanga mawhphurtu a ni thei em tih an la zirchiang mek a ni.

Risk factors chungchang sawi dawn chuan UCD leh iMCD risk factors hriat tur a awm lo . Mahse, HIV infection emaw, immune system chak lo dang emaw i neih chuan HHV-8-associated MCD vei theihna i nei sang zawk a ni.

He natna hi kum eng pawhah a awm thei a, mahse kum 30 leh 60 inkar ah a tam ber .

He natna hian eng harsatna nge a thlen theih?

Castleman natna hian natna dang i neih theihna a tipung deuh thei a, a bik takin cancer , lymphoma, lymphatic system cancer ang chi te hi a tipung thei a ni.

Tin, UCD vei te hian vun natna hmuh tur awm lo mahse na tak, paraneoplastic pemphigus (PNP) an neih theihna a hlauhawm hle bawk. MCD vei te hian natna chi hrang hrang an vei theihna a sang hle. Enkawl loh chuan heng natnate hian taksa peng hrang hrang a tichhia a, thihna thlengin a thlen thei a ni.

Mahse lungngai suh, i doctor chuan he dinhmun hi a enfiah reng ang a, heng harsatnate hi a theih ang anga venna atana pui turin a tul angin hma a la ang.

Engtin nge doctor hian he natna hi dik taka a hriat theih ang?

Castleman natna lan chhuah dan chu natna dang, common cold emaw flu emaw ang chi nen a inang avangin doctor chuan natna tlanglawn a awm leh awm loh a enfiah hmasa ang. Chumi hnuah chauh chuan Castleman natna hi an ringhlel ang a, test bik an nei ang.

A hnuaia test te hi tih ber a ni:

• Lab test: I thisen chu microscope hmangin enfiah a ni ang a, i thisen cell count-ah thil dik lo leh thil dang dang a awm leh awm loh enfiah a ni ang. HHV-8 kaihhnawih MCD rinhlelh a nih chuan HIV test pawh tih theih a ni.
• Imaging test: CT scan leh PET scan hmangin taksa chhunga lymph node hring (swellen lymph nodes) awmna hmun hriat theih a ni. Tin, liver leh spleen ang chi organ lian tham a awm leh awm loh an enfiah thei bawk.
• Lymph node biopsy: Hei hi natna finfiahna awmchhun leh chiang ber a ni . Hei hian lymph node hring atanga tissue te tak te tak tak lak a, microscope hmanga enfiah a huam a ni. Chumi hnuah chuan Casselman natna nena inzawm cell inthlak danglamna bik a awm leh awm loh a hriat chian theih phah a ni.

Hei hi eng enkawlna nge ni?

Enkawl dan hi natna chi hrang hrang a zirin a inang lo vek.

Unicentric Casselman Disease (UCD) enkawl dan tur a ni.

UCD enkawlna ber leh hlawhtling ber chu a natna lymph node surgery hmanga lakchhuah hi a ni . A tam zawkah chuan he surgery hnuah hian natna hi a dam kim vek a ni.

A chang chuan tumor hi a lian a nih chuan operation hmain radiation therapy emaw immunotherapy emaw pek thin a ni a, chu chu a tihtlem nan leh lakchhuah awlsam zawk nan a ni.

Surgery hmanga lak chhuah theih lohna hmunah a awm a, symptom i neih loh chuan i doctor chuan enkawl loh a, en mai mai a tum mai thei. Mahse, zai tura candidate ni lo, symptom la nei tan chuan MCD enkawlna ang chiah hi pek theih a ni.

Multicentric Casselman natna (MCD) enkawl dan tur .

MCD hi taksa peng hrang hranga darh thei a nih avangin operation emaw radiation therapy emaw hmangin a tidam thei lo. Chuvang chuan inenkawlna dang hman a ni. Enkawlna chu HHV-8 i neih leh neih loh leh natna a nasat danah a innghat a ni.

A hnuaia enkawlna hrang hrangte hi an pe ber a ni:

• Corticosteroids: Heng damdawi te hian taksaa inflammation tihziaawmin symptoms control nan a pui thin.
• Chemotherapy damdawi: Hengte hian lymphatic system-a cell-te an lo thang chak lutuk rate control-in hna an thawk a ni. Rituximab hi HHV-8 nena inzawm MCD tan hman a ni tlangpui.
• Immunotherapy: Heng enkawlnate hian i taksaa overactive immune system chu a ti reh thei a ni. Siltuximab (Sylvant®) chauh hi iMCD atana phalna pek a ni.
• Antiviral drugs: HHV-8-associated MCD i neih chuan HIV emaw HHV-8 infection control nan heng damdawi te hi pek i ni thei.

Engtik hunah nge doctor ka hmuh ang?

I kawr, i kutphah emaw, i kawrfual emaw- ah i hriat theih tur lump emaw bump emaw i hmuh chuan i doctor hnenah hrilh ngei ang che.

Tin, he thuziaka târ lan lan dân, sawifiah theih loh khawpa khawsik, taksa rihna tlahniam, leh hah lutuk te hi kar engemaw zât chhûng a awm reng chuan, damdawi lam thurâwn la ngei ang che.

He natna nen hian nunpui theih a ni em?

He zawhna chhanna hi Casselman i neih chi hrang hrangah a innghat a ni.

UCD vei chuan result tha tak tak a beisei thei . Tumor chu surgery hmanga lakchhuah a nih chuan natna chu a dam kim vek fo thin. Enkawl hnuah hei hian i dam rei zawng a nghawng dawn lo.

MCD vei tan chuan prognosis hi a buaithlak deuh a ni . Natna chi leh nasat dan azirin a danglam thei. Ṭhenkhat tân chuan natna lan chhuah dân chu a nasat thut thei a, nunna atân pawh a hlauhawm thei bawk. Midang tan chuan symptoms hi rei tak a daih thei a, mahse beiseina a awm. MCD vei hmuhchhuah zinga 65% leh 75% inkar chu kum nga aia rei an dam . Hei hi enkawlna thar nen a tha chho zel a ni.

Casselman natna chungchangah hian chhanna awlsam tak, mi zawng zawng tan pakhat chauh a awm lo. I thil tawn, i natna chi hrang hrang, leh natna dang, HIV, TAFRO, emaw POEMS emaw i neih leh neih lohah a innghat ang. A châng chuan operation leh medical monitoring reng reng chu a tawk ang. A nih loh leh i dam chhung zawngin enkawlna tam tak i dawng a ngai mai thei bawk. Chuvangin i doctor nen i dinhmun te, i enkawl dan te, leh i hmalam hun te chu zalen taka sawipui a tha ber.