Infection na tak tak awm fo: He natna hmuh tur awm lo (Chronic Granulomatous Disease - CGD) hi kan hriat chian a ngai em?

I fa te chu a damlo reng em? Natna pakhat a dam chuan natna dang a lo thleng leh thin. A châng chuan vun, lung, a nih loh leh taksa chhûng lam thlengin natna khirh tak tak a nei em? Nu leh pa tam tak chuan chutiang harsatna chu an buaipui a. Vawiin hian hetiang natna hrik kai fo thei, genetic condition hmuh tur awm lo mahse pawimawh tak kan sawi dawn a ni. Hei hi doctor-te zingah chuan Chronic Granulomatous Disease, a tawi zawngin CGD kan ti thin.

A awlsam zawngin CGD chu eng nge ni?

Hei hi hrethiam tur chuan kan taksa invenna (defence system) chungchang tlem han sawi hmasa ila. Kan taksa hi ram ang maiin han ngaihtuah teh. Ram dang hmelma (germs) laka veng thei sipai a nei a ni. Chu chu kan immune system a ni . He sipai pawl bik pakhat chu thisen var (white blood cells) an ti a .

Tunah chuan, CGD vei chunga thil thleng chu hetiang hi a ni. Thisen var pawl bik sipai an tih a awm a, entirnan, `(neutrophils)`, `(monocytes)`, `(macrophages)` leh `(eosinophils)` te an ni. Heng cell-te hna ber chu taksaa bacteria leh fungi chi hrang hrang, taksaa lut a, man a, tihchhiat a ni.

Mahse CGD vei pakhatah chuan heng sipai bik emaw, thisen var emaw te hian an ralthuam an hmang tha thei lo. Chu natna hrik tihhlumna atana an mamawh enzyme bik chu an siam thei lo. Silai nei mahse bullet nei lo ang mai a ni. Chuti a nih chuan eng nge thleng? Kan immune system hi a buai hle a, taksaa lut bacteria leh fungi thenkhat chu a do thei lo.

Heng natnate hi vun, lung, lymph node, leh thin -ah te a awm fo thin . Tin, abscesses , taksa peng chhunga hnim hring (pus-filled lumps) an siam tam zawk bawk.

Hei hi natna tlanglawn tak a ni lo. Khawvel puma mi maktaduai hnih leh a chanve zinga pakhat velin he natna hi an vei a ni. Tin, mipa naupangte hian an vei tam zawk tih hmuhchhuah a ni bawk .

CGD vei hian eng symptom nge a lantir?

CGD symptoms hi naupan lai atanga tan a ni tlangpui. Mahse, a chang chuan kum eng pawhah an lo lang thei. A lan chhuah dan ber leh langsar ber chu bacteria leh fungal infection na tak tak lo lang leh thin hi a ni.

Heng symptoms te hi awlsam taka hrethiam turin han thlir ila.

Engvangin nge he CGD hi a lo awm? Eng nge a chhan?

A awlsam zawngin CGD hi genetic condition a ni.. Hei hi kan nu leh pate hnen atanga kan rochun a ni tihna a ni. Kan taksaa hnathawh zawng zawng hi gene an tih thilte hian a thunun vek a ni. A hmaa kan sawi tawh thisen var cell-ah chuan natna hrik tihhlumna atana enzyme mamawh siamtu ‘thupek’ a awm a.

CGD-ah hian heng thupekte awmna gene panga zinga pakhatah hian mutation a awm a. Hetiang mutation avang hian thisen var te hian enzyme hi an siam thei lo va, an siam a nih chuan a thawk tha lo hle bawk. Chumi rah chhuah chu hrik an do thei lo a ni.

He genetic defect hi engtin nge a awm tih a zirin CGD hi chi hnih ah then a ni.

• X-linked CGD: Hei hi a tam ber chi a ni. X chromosome-a gene (`CYBB` gene) a mutation vang a ni. Mipa hian X chromosome pakhat an nei a, hmeichhia erawh chuan X chromosome pahnih an nei thung. Hei vang hian he natna hi mipa naupangah a tam zawk a ni .
• Autosomal recessive CGD: Hei hi gene dang (`CYBA`, `NCF1`, `NCF2`, `CYBC1` emaw `NCF4`) a mutations avanga lo awm a ni. Hetiang chi hian mipa leh hmeichhia pawh inang tlangin a nghawng thei a ni.

He natna avanga hlauhawm leh harsatna awm thei te chu engte nge ni?

CGD vei chu an chhungkuaa mi pakhatin he natna hi a neih chuan a hlauhawm ber a ni. Mahse, a tlem hle a, he natna hi a takin a lo thleng a, chhungkaw chanchin engmah nei lovin a awm tih hmuhchhuah a ni.

CGD vang hian harsatna engemaw zat a awm thei.

• Chaw ei lama harsatna: Intestines-a ulcer leh inflammation awm hian chaw ei dan a tibuai thei a ni.
• Bowel diseases: Entirnan, Inflammatory Bowel Disease (IBD) ang chi natna vei theihna a sang hle a, chu chu intestine-a natna khirh tak a ni.
• Hmasawnna lama harsatna: Naupang te leh nausen te hian he natna hi an vei a nih chuan an taksa thanlenna a tlai thei hle.
• Natna dang: CGD thlentu genetic defect chi hrang hrang a zirin mi thenkhat chu thinlung natna, kal natna, zunthlum emaw, autoimmune condition dang emaw vei theihna an nei bawk.

Engtin nge CGD i vei tih i hriat theih ang?

I doctor chuan nang leh i fa chu i natna lan chhuah dan leh chhungkaw damdawi lam chanchin a zawt hmasa ang. Tichuan, an diagnosis finfiah nan test eng emaw zat an order ang.

• Taksa enfiahna: Doctor chuan taksa chu uluk takin a enfiah a, a hring, abscesses, leh granulomas a awm leh awm loh a enfiah thin.
• Thisen test: CGD dik taka hriat theihna tur thisen test bik a awm a. Hei hi DHR test (dihydrorhodamine test) an ti a. He test hian thisen var (white blood cells) te hian natna hrik an tihlum theih dan a teh a ni.
• Genetic testing neih dan tur: 1.1.Thisen sample emaw tissue sample emaw lak a ni a, CGD thlentu genetic defect bik chu zawn chhuah a ni. Hei hian natna chi dik tak hriat theihna turin a pui thei bawk.

CGD enkawlna tur engte nge ni?

CGD hi tihdam kim theih ni lo mah se, tunah chuan enkawlna tha tam tak a awm tawh a, chungte chuan natna lan chhuah dan thunun thei, natna khirh tak tak laka invenna leh mihring nun pangngaia nunpui thei tur a ni.

Damdawi hmanga enkawl

• Antibiotics: CGD vei tam tak chuan bacteria infection laka inven nan leh infection lo awm tak takte enkawl nan an dam chhung zawng antibiotics an ei a ngai dawn a ni.
• Antifungals: Damdawi `(itraconazole)` ang chi hi fungal infection venna atan leh enkawl nan hman a ni.
• Interferon-gamma injection: Hei hi kan taksa hriselna (immune system) siam protein siam chhuah (synthetic form) a ni. He injection hian natna kai tam leh nasat lohna a tiziaawm a ni.

Damlo ṭhenkhat, a bîk takin natna khirh tak neite chu stem cell transplant an nei thei a ni . Hei hian mi hrisel tak atanga stem cells te chu damlo taksaah inject a, chu chuan thisen var tha lo tak takte chu cell hrisel tak takin a thlak a ni. Mahse, hei hi eng emaw chen chu a buaithlak leh hlauhawm tak a nih avangin doctor-te chuan thil tam tak, damlo kum leh hriselna te a zirin an rawt a ni.

Hri kai laka inven nan eng nge kan tih ang?

• Tui lakah fimkhur rawh: Lui, tuifinriat leh luiah te tui chawi loh vek tur a ni. Hengte hi chlorinated an nih loh avangin natna hrik thlentu hrik te chu awlsam takin i taksaah an lut thei a ni. Chuvangin, tui chawi i tih chuan chlorinated pool chauh hmang rawh .
• I huan enkawl rawh: Huan bawlhhlawh, compost bawm, buhfai leh hnah hringte khawih emaw, innghah emaw loh tur. Heng zingah hian fungi hmuh theih thenkhat hian pneumonia na tak a thlen thei a, CGD damloin a hip chuan nunna atana hlauhawm thei a ni . Chuvangin he thil hi i fimkhur hle tur a ni.

He natna nena khawsak dan tur hriat tur

He natna chungchang hriat hi a hlauhawm thei hle. Mahse thudik tak chu, enkawl dan dik leh doctor nena inbiak reng chuan CGD vei tam zawk chu nun pangngai, active leh hlim takin an nung thei a ni. A pawimawh ber chu infection hriatchhuah a, enkawl tan hma, a na zual hmain.

Nang emaw i fa emaw hian chhan hriat loh natna i vei fo a nih chuan i doctor hmu nghal la, he thu hi sawipui rawh.

I fain CGD a neih chuan i sualna a ni lo tih hrethiam rawh. Genetic condition a ni. Damdawi lam thurawn dik tak i pek chuan i fa hian nun rei tak, hlim taka awm theihna hun tha tak a nei a ni. A pawimawh ber chu natna chungchang hriat chian a, doctor thupek uluk taka zawm a ni.