Chordoma: He cancer hmuh tur awm lo, ruhro (spinal cord)-a lo awm thin hi i zir dawn teh ang.

‘Chordoma’ tih hming hi i hre ngai em? A ni lo mai thei. A chhan chu a rare hle a, chu chu malignant condition hmuh tur awm lo tak a nih vang a ni. He cancer natna hi kan taksa hmun pawimawh tak pahnih ah a lo thang lian thin. Pakhat chu kan ruhro a ni a, pakhat chu kan lu ruh bul a ni. Chutiang hmuna cancer tih thumal sawi a nih hian tlem a hlauhthawn hi a dik a ni. Mahse, lungngai suh. Engkim hi i tan awlsam, chiang tak leh hriatthiam awlsam takin kan sawi dawn a ni.

A awlsam zawngin, Chordoma chu eng nge ni?

Chordoma hi kan ruh chhunga cancer lo awm thin a ni. A dik tak chuan cancer pawl pakhat sarcomas an tih zinga mi a ni. Cancer a lo thang zawi hle a ni. Chumi awmzia chu a natna lanchhuahna nei lovin rei tak a awm thei tihna a ni.

He cancer hi ruhro hmun apiangah a lo awm thei a, mahse hmun pathum a awm tam ber a ni:

• Spine hnuai ber (Sacrum): Chordoma zawng zawng zinga 35% vel chu he hmunah hian a lo awm thin.
• Skull base: Hetah hian case dang 35% vel an lo awm leh thin. Hetih lai hian ruh hi ‘clivus’ an ti a. Hetiang chi hi ‘clival chordomas’ an ti bawk.
• Spine vertebrae dang: A bak 30% chu ruh hmun dangah a awm. Cervical vertebra pahnihnaah an tam ber a, lumbar leh thoracic vertebrae-ah an dawt leh a ni.

He cancer chungchanga harsatna lian ber chu, zawi zawiin lo thang mahse, a chhehvel nervous system hmun pawimawh tak tak a rawn lut a ni. Chumi awmzia chu thluak leh ruhro ang chi hmun sensitive tak tak a tichhe thei tihna a ni.

Thil dang chu a lo lang leh duhna a sang hle a, enkawl hnuah pawh a lo lang leh thin. A hmaa a awmna hmunah a rawn let leh tlangpui. Tin, 30% - 40% velin he cancer hi taksa peng dangah a darh (metastasize) thei bawk. A awm chuan a darh tam ber chu:

• Lung lam thlengin
• A chhehvel lymph node-ah te
• Ruh dangte hnenah
• Liver thlengin
• Vun thlengin

Chordoma chi hrang hrang a awm em?

Ni e, World Health Organization (WHO) chuan he cancer chi thum lian tak tak a hmuchhuak a. Heng classification te hi cancer cell te hi microscope (histology) hmanga an lan dan atanga siam a ni. Eng nge an nih i en ang u.

He natna hi tuin nge vei tam ber? Engtiang chiahin nge a hluar?

Chondroma hi kum eng pawhah a lo awm thei a, mahse puitling kum 50 leh 80 inkarah a awm tam ber a, za zela tlemte, 5% velin naupangah an vei thin. Tin, mipa hian hmeichhia aiin a let 1.5 velin he natna hi an vei tam zawk bawk.

Hei hi a tlem em em a, kum tin mipui maktaduai khat (100,000) zinga pakhat chauhvin he natna hi an vei thin . Chumi awmzia chu kan ram ang ramah pawh hian kum tin hri kai thar an tlem hle tihna a ni.

Hei hi eng symptoms nge ni?

Chordoma a lo lian chhoh zel chuan a chhehvel thluak emaw, ruhro emaw chu pressure a siam thin. He pressure hian symptoms a siam thin. Tin, tumor awmna hmun azirin symptoms a inang lo thei bawk.

A hnuaia table-ah hian lump awmna hmun azira symptoms a danglam dan hi i en ang u.

Engvangin nge hetiang cancer hi a lo awm? Eng nge a chhan?

Researcher-te chuan a chhan dik tak chu an la hmuchhuak thei lo a, mahse TBXT an tih gene-a mutations a awm niin an ngai.

Ngaihtuah teh, naute chu nu pum chhunga a lo seilian hmasak ber hian, ruhro a lo seilian hmain ruhro te tak te, notochord an tih chu a lo piang ta a ni. Hei hi a hnuah chuan spinal cord-ah a lo thang lian dawn a ni. A tlangpuiin he notochord hi naute kar 8 vel a nih meuh chuan a bo vek thin.

Mahse a tlem hle a, heng cell thenkhat hi luruh bul emaw, ruh ruh emaw-ah emaw an awm thei. A hnuah chuan kan sawi tawh TBXT gene-ah hian inthlak danglamna a awm a nih chuan heng cell la awmte hi thunun theih lohvin an lo thang lian tan thei a, chondroma cancer an ni thei niin an ngai.

Tin, genetic condition tuberous sclerosis vei te hi chordoma vei theihna chance a sang deuh hlek bawk.

Engtin nge natna hi kan hriat theih ang? (Diagnosis) tih a ni.

A chunga tarlan symptoms i neih chuan i doctor pan hmasa phawt tur a ni. Doctor chuan i symptoms leh i medical history te a zawt ang che. Tichuan, taksa enfiahna leh thluak lam enfiahna an nei ang.

Cancer lump nia rinhlelh a nih chuan doctor chuan imaging test turin a refer ang che.

• X-ray hmanga tih a ni
• Computed Tomography (CT) hmanga tihchhuah a ni
• Magnetic Resonance Imaging (MRI) hmanga enfiah a ni

Heng test te zawhah hian ruh cancer lama tui doctor hnenah refer i ni mai thei. He natna hi finfiah nan leh taksa peng dangah a darh tawh em tih hriat nan test dang neih belh a ngai mai thei.

Natna hi 100% a chiang thei tur awmchhun chu biopsy neih hi a ni a , chu chu a hnah atanga tissue sample tlemte tak tak, needle te tak te hmanga lak a, microscope hmanga enfiah a ni.

Engtin nge enkawl a nih?

Chordoma enkawlna ber leh tha ber chu operation hi a ni. Damlo tan result tha ber chu cancer lump a tam thei ang ber lakchhuah (en bloc resection) a ni.

Mahse, hei hi a awlsam angin a lang lo a, a chhan chu kan sawi tawh ang khan heng tumor te hi taksa peng leh nerve sensitive tak tak, pawimawh tak tak bulah an siam a ni.

• Luruh bul lama tumor awmte: Hengte hi thluak zung, nerve pawimawh tak tak, leh thisen kalna bul hnaia awm a nih avangin paih kim a harsa hle.
• Spinal tumors: Hengte hian ruhro, nerve leh thisen kalna kawng lian ber berte a rawn lut thei a ni. Hengte hi operation laiin a chhiat chuan permanent disability emaw thihna pawh a thleng thei.

Chuvangin neurosurgeon-te chuan damlo tichhe lovin a tam thei ang ber tumor chu paih chhuah an tum thin.

Chordoma cancer hian radiation therapy leh chemotherapy-ah a chhang tha lo tlangpui a, chuvangin hengte hi primary treatment atan hman a ni tlem hle. Mahse, operation zawhah radiation therapy pek a ni a, chu chuan cancer cell la awm zawng zawng a tichhia a, cancer lo kir leh theihna tur a ti tlem a ni.

Tunah hian zirchiangtute chuan tunlai damdawi, targeted therapy leh immunotherapy te an zirchiang mek a ni.

Natna hi eng prognosis nge ni?

"Prognosis" tih hi natna atanga dam leh dam theihna tur hrilhlawkna a ni. Chondroma-ah chuan hei hi thil engemaw zatah a innghat a ni:

• Tumor awmna hmun leh operation neih chhunga engzat nge lak chhuah: Tumor chu lak chhuah vek a nih chuan a result a tha zawk.
• Cancer hi a darh tawh em (metastasized):Taksa peng hla tak takah a darh tawh chuan damchhuahna rate a tlahniam thin.
• Diagnosis hunlai kum: Kum 60 chunglam zingah result a hniam deuh thei.
• Cancer chi: Kan sawi tawh "Dedifferentiated" ang chi aggressive zawkte aiin conventional type te hian outcome tha zawk an nei a.

Zirna pakhatah chuan chordoma vei damchhuah zat chu hetiang hi a ni:

• Kum 3 hnuah: 80.5%
• Kum 5 hnuah: 68.4%
• Kum 10 hnuah: 39.2%

He natna hi ven theih a ni em? Engtikah nge Doctor ka hmuh ang?

Chondroma lo awm tur venna tur hian engmah tih theih a awm lo. A tam zawk hi chu random takin a thleng thin. I chhungkuaa mi pakhatin chondroma emaw tuberous sclerosis emaw a neih chuan medical checkup neih fo a pawimawh.

A pawimawh ber chu enkawl hnua hun rei tak enkawl zui a ni. Chondroma hi cancer a ni a, kum tam tak enkawl hnuah pawh a lo lang leh thei a ni. Chuvangin i medical team-te thurawn angin regular check-up neih a pawimawh hle.

Symptom thar i neih chuan emaw, i symptoms a zual emaw chuan doctor pan nghal tur a ni.

Chutiang cancer hmuh tur awm lo tak chungchang i hriat chuan hlauhna leh rilru hah lutuk hi thil pangngai a ni. Mahse, i medical team te chuan i tan enkawlna tur ruahmanna tha ber siam turin an thawk ho ang che tih hre reng ang che a, i nunphung tihchangtlun nan theihtawp an chhuah ang.