I ke pawh a hring vek ang tih i hria em? Hei hi Lambert-Eaton Myasthenic Syndrome (LEMS) a ni thei!

A chang chuan i ke a chak lo ang maiin i inhria em, ṭhutphah aṭanga tho chhuah harsa i ti a, stairs i chhoh dawnin i chau tih i inhria em? A nih loh leh mitmeng rit, hmui vawt, leh mit hmuhna pahnih ang chi symptoms neiin i chau tih i hria em? Chûngte chu hahna mai pawh a ni lo mai thei. Vawiin hian i hriat loh, mahse hriat hlawh tak, Lambert-Eaton Myasthenic Syndrome, emaw a tawi zawnga kan sawi angin ``(LEMS)`` emaw dinhmun kan sawi dawn a ni.

Lambert-Eaton Myasthenic Syndrome (LEMS) hi eng nge ni?

A awlsam zawngin sawi ila, Lambert-Eaton Myasthenic Syndrome (LEMS) hi autoimmune disorder a ni. Tunah chuan autoimmune disorder chu eng nge ni tih i ngaihtuah mai thei . Kan taksa hian immune system a nei a. Hei hian pawn lam atanga natna thlentu hrik doin min venghimtu a ni. Kan rama sipai awm ang mai a ni. Mahse a chang chuan he immune system hi a kal sual thin. Tichuan kan cell hrisel tak takte chu a rawn bei tan ta a ni. Chu chu LEMS-ah chuan a thleng thin.

He `(LEMS)` ah hian kan immune system hian kan motor nerve leh muscle inzawmna chu a bei thin . A dik tak chuan he inzawmna hi `neuromuscular junction` an ti a. He junction hi a chhiat chuan nerve atanga taksa peng hrang hranga thuchah thehdarh chu a tichhe thin. Hei hi taksa ruh chak lohna a awm lai a ni.

He chak lohna hi i kekawr chunglam atanga tan a ni tlangpui , mahse zawi zawiin i kut, thawk, ei leh in, leh thusawi thauah te a darh thei a ni.

He `(LEMS)` hi tute nge nei tam zawk?

`(LEMS)` siamtu pawl lian pahnih an awm a.

1. Cancer nena inzawm: LEMS vei zinga 60% velin cancer chi khat emaw an nei a. A chi tlangpui chu small-cell lung cancer a ni . Mak tak maiin, a chang chuan LEMS natna lan chhuah dan hi cancer a lo awm hma thla tam tak emaw, kum tam tak emaw pawh a ni thei. Heng mite zinga a tam zawk hi kum 60 chunglam an ni a, mipa an ni a, zuk leh hmuam an lo hmang tawh bawk.

2. Cancer nei lo: LEMS vei zinga 40% dang chuan cancer hmuhchhuah an nei lo. Heng mite hi kum 35 vel ah hmuhchhuah an ni tlangpui a, kum 60 vel ah hmuhchhuah leh thin an ni.

LEMS hi naupang tê tê zingah chuan a tlem hle.

Hemi nen hian small cell lung cancer (LEMS) chauh hi a inzawm em?

No. Small-cell lung cancer hi cancer chi khat a ni ber a, mahse cancer chi dang pawh hi LEMS nen hian a inzawm thei bawk. Entirnan, prostate cancer, thymoma, leh lymphoproliferative disorder te hi a ni. LEMS natna lan chhuah dan hi cancer lan chhuah hmain a lo lang thei a, chuvangin i doctor-in LEMS i vei tih a hriat chuan cancer enfiahna tur test dik tak neih a pawimawh hle.

LEMS hi genetic changes avanga lo awm a ni em?

Scientist-te chuan autoimmune natna a tlangpuiin genetic link engemaw zat a nei thei niin an ngai. LEMS pawh hi autoimmune disease a nih avangin genetic influence pawh a nei thei a, mahse hei hi hriat chian a la ni lo.

`(LEMS)` hi engtiang chiahin nge a awm?

LEMS hi natna hmuh tur awm lo tak a ni . He natna hian khawvel pumah mi maktaduai 2.8 vel a nghawng nia chhut a ni. United States-ah chuan LEMS vei hi mi 400 vel an awm tawh a ni. Kan ramah hian mi engzat nge awm tih hi statistics dik tak awm lo mah se, hei hi thil awm lo tak a ni tih a chiang hle.

`(LEMS)` natna lan chhuah dan chu engte nge ni?

`(LEMS)` symptoms pakhat hnu pakhatin han thlir ila. Heng symptoms zawng zawng hi mi zawng zawngah hian a rualin a awm vek lo va, symptom thenkhat chu a hmain a lang thei a, thenkhat chu a hnuah a lang thei bawk.

• Muscle chak lohna leh hahna: a bik takin ke chunglam.
• Kal harsa: Stairs chhoh harsa emaw, chair atanga tho emaw.
• Muscle na emaw, a nghet lo emaw.
• Ke ruh leh ke ruh (limbs) a awm tih hriat.
• Mitmeng tla (ptosis): Hei hi mutthilh ang maiin a lang thei.
• Thil pahnih vawi khata hmuh (diplopia).
• Kawng leh mit a vawt (xerostomia): hmui chhuah tlem, mittui tlak tlem.
• Ek khal.
• Thawmhnaw a tlahniam.
• Rihna tihtlem.
• Zun harsatna.
• Mipaah ​​chuan erectile dysfunction a awm thin.
• Thusawi harsa (dysarthria) leh ei harsa (dysphagia): Hengte hi natna hnu lama lo lang chhuak a ni tlangpui.
• Thâwk harsa (dyspnea) leh thawk lama harsatna: Hei pawh hi natna lan chhuahna a awm lo, na tak a ni a, natna hnuhnung ber a lo awm thei bawk.

Pawimawh: Heng symptoms pakhat emaw a aia tam emaw i neih chuan LEMS a ni tih ngaihtuah suh. Mahse, heng chhinchhiahnate hi a la awm reng a nih chuan damdawi lam thurawn lak chu a finthlak hle.

Engtin nge LEMS hi a lo lang tlangpui a, a kal zel?

LEMS hian a tlangpuiin thighs muscles a nghawng hmasa ber thin . Chumi hnuah chuan shoulder muscle te, kut leh ke ruh te, thusawi leh ei leh in lama puitu muscle te, mit ruh te a nghawng thei a ni.

Natna i neih tirh lamah chuan ṭhutphah aṭanga tho emaw, stairs emaw, tlâng emaw lawn emaw, i ke hman ngai hna hahthlak tak tak thawh emaw i harsat thei a ni.

A lan chhuah dan chu zawi zawiin a lo lang tlangpui a, kar tlemte atanga thla engemaw zat chhungin a lo lang thin . Mahse, cancer nei LEMS i neih chuan a symptoms a lo lang thuai thei.

Eng thilin nge LEMS hi a thlen?

Kan sawi tawh ang khan LEMS hi autoimmune disease a ni . Chumi awmzia chu i taksa invenna (antibodies) te hian nangmah ngeiin i taksa hrisel tak takte chu a bei tihna a ni. LEMS-ah chuan heng antibodies te hian nerve cell leh muscle fiber te inzawmna hmun chu an bei a, chu chu neuromuscular junction an ti a ni. A bik takin chutah chuan calcium channel te chu an bei thin. Heng calcium channel te hi nerve message kal tlang nan a pawimawh hle.

Domino row ang maiin han ngaihtuah teh. He beihna hian thil thleng hrang hrang a tichhuak a:

1. Antibody te hian nerve cell tawp lama calcium channel te chu an binding a, an block thin.

2. Calcium channel a tihtlem chuan neurotransmitter pakhat acetylcholine chhuah zat a tlahniam a. He acetylcholine hi taksa ruh hnathawhna atana chemical pawimawh tak a ni.

3. Acetylcholine a chhuah tlem chuan taksa peng hrang hranga "thuchah" te chu a kal tlang tha lo. Tichuan i taksa ruhte chu a thawk kim thei tawh lo.

4. Chumi avang chuan taksa ruhte chu a thawk tha lo a, chak lohna a awm thin.

Hetiang hian small-cell lung cancer vei te hian LEMS an vei thin: I taksaah cancer i neih hian antibodies te hian "indonaah kal" tih signal an dawng thin. Mahse cancer cells (a bik takin, cancer cells chunglama calcium channels) te chu beih ai chuan heng antibodies te hian nerve cells tawp lama calcium channels te chu an bei sual a ni. Tichuan, chutiang bawka thil thleng chu a thleng ta a ni.

Scientist-te chuan lung cancer nei lote LEMS thlentu chu taksa hriselna (immune system) a thawh that loh vang mai a ni an ti. Mahse hei hi engvanga lo awm nge tih erawh hriat chian a la ni lo.

Engtin nge `(LEMS)` hi kan hriat theih ang?

LEMS hriatchhuahna atana hmalakna hmasa ber chu i doctor-in uluk taka a enfiah che hi a ni. Hei hian neurologist, emaw, nerve leh muscle natna lama tui doctor emaw a huam fo ang. Hetiang kalphung thenkhatah hian i natna lan chhuah dan te, i damdawi lam chanchin te, leh damdawi i ei zawng zawng te zawh a ni. LEMS nena inmil chak lohna pattern leh signs te zawn nan detailed neurological examination an nei thin.

A dawt leh tur chu testing a ni. `(LEMS)` test-naah hian:

• Thisen test: Hei hian i thisenah anti-calcium channel antibodies i nei em tih a enfiah thei a ni. LEMS vei zinga 85% vel chuan an thisenah heng antibodies te hi an nei a ni.
• Electromyography (EMG): He test hian i taksa ruh leh nerve te an thawh dun dan a enfiah thin. LEMS-ah chuan EMG test hian thil hmuhchhuah chiang tak tak a nei a, chuvangin diagnosis tih chian nan a pui thei a ni.
• Lung X-ray `(X-ray)` emaw CT scan `(CT scan)` emaw MRI scan `(MRI)` (of the chest): Small cell lung cancer vei te zingah `(LEMS)` an tih natna a lo awm theih avangin heng test te hian lung cancer chhinchhiahna a zawng thin.

LEMS natna lan chhuah dan hi cancer a lo awm hma thla atanga kum ruk chhungin a intan thei a ni. Chuvangin LEMS hmuhchhuah a nih hnuah thla thum atanga thla ruk danah kum hnih tal cancer screening neih thin tur a ni. I doctor chuan i tan a tha tur screening schedule a rawn rawt ang che.

LEMS hi engtin nge enkawl a nih?

LEMS hi enkawlna hrang hrang a awm a.

• Cancer hnuaia awm enkawl dan: LEMS hi cancer, small cell lung cancer ang chi nen a inzawm a nih chuan, chu cancer enkawl chuan LEMS symptoms a tihziaawm thei bawk. Cancer enkawlnaah hian chemotherapy, radiation therapy, leh/ emaw surgery te pawh a tel thei. Hei hi cancer chi leh doctor-in a rawt danah a innghat a ni.
• (LEMS) enkawlna bik: Chung zingah chuan natna lanchhuahna tihziaawmna damdawi leh taksa hriselna (immune system) control thei damdawi te pawh a tel.

Symptoms te enkawl dan

• Amifampridine (Firdapse®), Guanidine: Heng damdawi te hian taksa ruh chakna a tipung a. Neuromuscular junction-a neurotransmitter acetylcholine chhuahna an tipung a, chu chuan taksa peng hrang hranga signal a ti \ha \hin.
• Pyridostigmine (Pyridostigmine - Mestinon®): Pyridostigmine hian neuromuscular junction-a acetylcholine a chhe lo tur venna hmangin hna a thawk a. Hei hian acetylcholine signaling a tipung bawk a, taksa ruh chakna a ti sang bawk. Pyridostigmine hi amifampridine nen hian taksa ruh hnathawh that nan leh LEMS natna lanchhuahna, hmui vawt, mit vawt, chaw ei kham, mipat hmeichhiatna lama harsatna, leh thawk hahna tihtlem te enkawlna atan pek thin a ni. Mahse, LEMS atana pyridostigmine hman hi off-label hman a ni a, hei hian U.S. Food and Drug Administration (FDA) chuan he natna atana damdawi hi a pawm lo tihna a ni.

Immune-modulating hmanga enkawl a ni

• Immunosuppressants te chu: 1.1.Heng damdawi te hian i immune system "defense" function tihtawp emaw control emaw a pui thin. Damdawi dangin i natna lan chhuah dan a thunun loh chuan i doctor chuan heng damdawi te hi a pe thei ang. Entirnan, damdawi prednisone an tih chu azathioprine emaw cyclosporine emaw nen emaw, tel lo emaw pawh nise pek theih a ni.
• Plasma exchange: Hetiang tih danah hian machine hian i thisen a liquid part (plasma) chu thisen cell atang hian a then hrang a. I antibodies te hi he plasma ah hian a awm a. Inthen hnuah thisen chu i taksaah dah leh a ni. I doctor chuan he enkawlna hi a ngaihtuah mai thei a, natna lan chhuahna na tak i neih a, enkawl vat ngai i nih chuan.
• Immunoglobulins: Mi thenkhat tan chuan immunoglobulin dose sang taka enkawlna hian natna a zual zel loh nan a pui thei a ni.

LEMS hi ven theih a ni em?

LEMS awm chhan dik tak hi hriat chian a la ni lo a, chuvangin he natna laka inven dan tur a awm leh awm loh hriat a la ni lo.

Mahse, LEMS hi lung cancer vei zingah a lo awm thei a, chuvangin lung cancer venna atan hian hetiang hian i pui thei ang:

• Meizial zu suh. Zuk leh hmuam i hman chuan zuk leh hmuam i hman loh nan i doctor hnenah tanpuina dil rawh.
• Second-hand smoke hi pumpelh rawh.
• I in chhungah radon gas a awm leh awm loh enfiah rawh. Hun rei tak chhung radon gas i tawrh hian lung cancer vei theihna a tipung thei a ni.

Nunphung hrisel vawng reng turin hma i la thei bawk:

• Thlai leh thlai ei tam zawk rawh. Mediterranean emaw DASH diet emaw zawm tur a ni.
• I taksa rihna hrisel tak vawng reng rawh.
• Doctor thurawn angin exercise la.
• Mut tlem - a tlangpuiin darkar sarih atanga darkar kua vel.
• I stress tihziaawm rawh. Stress hian symptoms a ti na zual thei.
• Tui lum a inbual loh tur. Khua lum hian LEMS symptoms a ti na zual thei.
• I doctor hmu fo la, i hriselna a inthlak emaw, symptom thar i neih chuan hriattir nghal rawh.

LEMS hi a dam kim thei em?

Vanduaithlak takin LEMS hi damdawi a awm lo . LEMS nena inzawm cancer hnuaia awm enkawl hian LEMS symptoms a ti tha tih hmuhchhuah a ni. Immunosuppressive drugs hian autoimmune attack a control thei a, nerve endings-a acetylcholine awm zat tihpun leh muscle chakna tichaktu symptoms tihziaawmna tur enkawlna pawh a awm bawk.

Cancer nei lo LEMS i neih chuan dam rei zawng pangngai i beisei thei a ni. LEMS leh cancer i neih chuan cancer hi a hmaa hriatchhuah leh enkawl a nih chuan hun kal zelah (a pum pui ni lo mah se) i symptoms a lo tha chho thei a ni.

I nunphung chu i natna lan chhuahna nasat danah a innghat nasa hle.

`(LEMS)` ka neih chuan engtikah nge doctor ka biak ang?

I hriselnaah inthlak danglamna a awm a nih chuan, emaw, i natna lan chhuah dan a na zual a nih chuan engtik lai pawhin i doctor hnenah zawhfiah rawh . Hlau suh, hlau suh. Doctor te tanpui turin an awm reng a ni.

`(LEMS)` leh `(Myasthenia Gravis - MG)` te hi eng nge an danglamna?

Lambert-Eaton myasthenic syndrome (LEMS) leh myasthenia gravis (MG) te hian natna lan chhuah dan inang deuh deuh an nei a. An pahnih hian taksa chak lohna leh hahna a thlen a ni.

Mahse, myasthenia gravis (MG) hian i mit chhehvel thau leh ei tur atana hman thin ruh te a nghawng hmasa ber thin. A hnuah chuan taksa ruh tlangpui zawk a nghawng thei a, chutah chuan thawkna thau leh ke ruhte pawh a nghawng thei a ni.

LEMS hi i kekawr chunglam chak lohna atanga tan a ni tlangpui a, chutah chuan i kut ah a kal leh thin. LEMS hian i mit ruh chak lohna a thlen thei bawk a, mahse a tlangpuiin myasthenia gravis (MG) aiin a na zawk.

Myasthenia gravis (MG)-ah chuan thawkna ruh (thâwk chhuahna ruh) chak lohna nasa tak chuan thihna a thlen thei a ni. Hei hi LEMS-ah chuan a tlem hle.

Myasthenia gravis (MG) vei te hian autonomic nervous system dysfunction symptom tam tak an lantir lo tlangpui (e.g., mit a vawt, hmui a vawt, constipation, thawk hahna tlahniam, sexual dysfunction). Chumi danglamna chu LEMS vei te hian heng complaint te hi an nei fo thin a, heng symptoms te hian natna pahnih thliar hrang turin a pui thei bawk.

A tawp berah chuan thil hriat reng tur (Take-Home Message) .

Tunah chuan Lambert-Eaton Myasthenic Syndrome (LEMS) hi immune system chak lutuk avanga lo awm a ni tih i hre tawh mai thei. I nerve cells te hian i muscle fibers te hnenah "contract" turin message an thawn tawk lo. Chumi rah chhuah chu taksa ruh chak lohna leh symptom dangte a ni.

LEMS vei zinga 60% vel chuan small-cell lung cancer an nei tih hre reng ang che. LEMS i nei a, mahse cancer i nei lo a nih chuan, i doctor nen cancer screening neih thin chu i hriat chhuah hnu kum hnih tal chu thla engemaw zat danah neih thin tur a ni.

Enkawlna hrang hrang a awm. Chung zingah chuan cancer a awm chuan enkawl te, nerve cell leh muscle fiber inbiakpawhna tichaktu damdawi ei te pawh a tel. Inbiakpawhna tihchangtlun hian taksa chakna leh symptom dangte a ti tha thei a ni.

He thu hi i tan a tangkai ngei ka beisei.Hriselna lama harsatna i neih chuan doctor hriatna nei tak nen inbiakna neih a tha ber tih hre reng ang che.

` Lambert-Eaton myasthenic syndrome, LEMS, autoimmune natna, thau chak lohna, small cell lung cancer, neuromuscular junction, acetylcholine