Cancer vei theihna tipungtu Lynch Syndrome chungchang hi kan sawi dawn em ni?

Lynch Syndrome hi i hre tawh em? He hming hi i tan chuan a thar deuh mai thei. Mahse kan taksaa cancer vei theihna nasa taka tipungtu genetic condition a ni. Hei hian cancer vei theihna a tipung a, a bik takin kum 50 i tlin hmain, "cancer i vei mai thei" tih thumal i hriat hian hlauhna tlem a awm hi thil pangngai a ni. Mahse a pawimawh ber chu chutiang dinhmun chungchang hriat chian hi a ni. Chuvangin vawiin hian he thu hi awlsam takin, in hriatthiam theih angin kan sawi dawn a ni.

A awlsam zawngin Lynch Syndrome hi eng nge ni?

Kan taksa hi instruction book lian tak (DNA) anga hnathawk machine complex tak ang mai a ni ang tih han ngaihtuah teh. Kan genes te hi he instruction book-a letter awm ang hi a ni. A châng chuan, he instruction bu-ah hian tihsual a awm a, a nih loh leh ‘typing tihsual’ a awm bawk. Damdawi lamah chuan hei hi genetic mutations an ti a.

Lynch syndrome hi genetic mutation avanga lo awm a ni. Kan taksa hian gene chi khat bik a nei a, chu chuan kan DNA-a tihsual awmte chu a hmuchhuak a, a siam \ha \hin. Hei hi ``mismatch repair (MMR)`` gene an ti a. Kan taksaah ''repair team'' ang mai a ni. Lynch syndrome vei chuan he ''repair team''-a gene pakhatah hian chhiatna a nei a. Chuvang chuan DNA-a tihsual awmte chu a siam \ha tawk lo. Heng tihsual nei cell te hi an pungkhawm a, hun kal zelah cancer an nih theihna a sang zawk.

Hetiang dinhmun hian tu pawh a nghawng thei a ni. A chhan chu genetic condition a nih vang a ni. A châng chuan he gene chhia hi i nu emaw, i pa emaw aṭangin i rochun thei bawk. A tlem hle a, he genetic mutation hi chhungkuaa tumah awm lovin mi thar taksaah a lo awm thei a ni. America ang ram statistics i en chuan mi 279 zinga pakhat velin he natna hi an vei nia chhut a ni.

Lynch syndrome vei mi pakhatin eng symptom nge a neih theih ang?

Hetah hian hriat tur pawimawh tak chu Lynch syndrome hian symptom bik a nei lo tih hi a ni. Chu ai chuan a natna avanga cancer awmte chhinchhiahna a ni zawk. Chung zinga a tam ber chu colorectal cancer a ni.

Chuvangin, colorectal cancer nena inzawm thei symptoms tlanglawn thenkhat chu hetiang hi a ni:

Hetiang dinhmun avang hian eng cancer chi nge lo awm thei?

Lynch syndrome hi cancer chi khat chauh kawng hawnsak thei a ni lo. Kan taksa peng hrang hrang tam takah cancer vei theihna a tipung a ni. Gene dik lo a zirin organ hlauhawm tak takte hi a inang lo thei. `MLHL`, `MSH2`, `MSH6`, `PMS2` leh `EPCAM` te hi gene pawimawh panga an ni.

A hnuaia tarlan te hi Lynch syndrome in a vei theihna tipung thei cancer chi hrang hrang tarlan a ni.

Lynch syndrome vanga colon cancer lo awm hi a danglam deuh hlek a. Cancer awm tlangpui aiin an thang chak zawk hle.Mi pangngai polyp te tak te cancer a nih theih nan kum 10 vel a ngai laiin, Lynch syndrome vei tan chuan kum khat emaw kum hnih emaw vel chauh a ngai thung.

Tin, he dinhmun avang hian mi pakhatin vawi khat chu colorectal cancer a vei a, a dam leh tawh chuan chutiang bawka cancer chi khat vei leh theihna a sang zawk bawk.

Engtin nge hei hi thlah kal zelah a lo kal zel?

Lynch syndrome hi ``autosomal dominant`` angin thlah khat atanga thlah dangah a lo inher chhuak thin a ni. Hei hian a awmzia chu nu leh pa pakhat chauh , nu emaw pa emaw pawhin gene dik lo nei mah se, naupangin a rochun theihna chance 50% a awm tihna mai a ni. Chumi awmzia chu naupang tin hian rochun theihna chance 50% an nei a, rochun loh theihna chance 50% an nei tihna a ni.

Chuvangin nangmah emaw, i chhungte zingah emaw Lynch syndrome vei nia hriat a nih chuan chhungkaw dangte hriattir a pawimawh hle. A bik takin i unaute, i fate leh i nu leh pate hnenah he hlauhawmna hi hrilh tur a ni. Genetic test leh counseling-a hruai hian an nunna pawh a chhanhim thei a ni.

Engtin nge he natna hi ka nei tih ka hriat theih ang? Eng test nge ka tih ang?

Lynch syndrome i neih leh neih loh hriat chian dan tha ber chu genetic testing tih hi a ni . Hei hian thisen sample lak a huam tlangpui. A nih loh leh i hmui chhung atang hian buccal swab lak a ni. He test hian kan sawi tawh ang chi genes, MLHL leh MSH2 te ah mutation i nei em tih dik takin a hre thei a ni.

Lynch syndrome i vei tih hmuhchhuah a nih chuan a dawt leh tur pawimawh ber chu cancer hriat hmasak nan screening neih fo hi a ni. I doctor chuan i tana tha tur screening schedule a siam ang.

Lynch syndrome hi engtin nge enkawl a nih?

Tunah hian genetic condition Lynch syndrome hi damdawi a la awm lo. Chuvangin, enkawlnain a ngaih pawimawh ber chu taksa atanga cancer cell awmte hriatchhuah a, surgery hmanga paih chhuah hi a ni. Cancer hi taksa peng dangah a darh hmaa hriatchhuah a, paih chhuah theih a nih chuan a rah chhuah chu a hlawhtling hle.

Hei hian doctor team hrang hrang, multidisciplinary team a mamawh a ni. Entirnan, gastroenterologist, surgeon, gynecologic oncologist leh oncologist te hian he natna hi enkawl turin an thawk ho thin.

Mi thenkhat, a bik takin hmeichhia chhungkaw zo tawhte chuan nakin lawka uterine emaw ovarian cancer an vei theihna tur tihtlem nan natna eng pawh a lo awm hmain hysterectomy emaw oophorectomy emaw neih an thlang thin. Chutiang bawkin colon cancer vei theihna sang tak nei te pawhin colectomy neih an thlang thei bawk. Hengte hi mimal thutlukna a ni hle a, doctor nen nasa taka sawiho hnuah siam tur a ni.

Lynch syndrome leh HNPCC hi thil inang an ni em?

`HNPCC (Hereditary Non-Polyposis Colorectal Cancer)` tih hming pawh i hre tawh mai thei. Lynch syndrome leh HNPCC hi a inthlak danglam fo thin a, mahse technical lama danglamna tlem a awm a ni.

A awlsam zawngin, HNPCC tih hming hi chhungkaw chanchin a zirin hman a ni. Chu chu chhungkaw pakhata mi engemaw zatin he cancer chi hi an vei a nih chuan chu chhungkua chuan HNPCC an nei nia sawi a ni. Mahse Lynch syndrome hi a thlentu gene mutation bik hriatchhuah a nih hnua an vuah a ni. Chuvangin, HNPCC vei chhungkaw member zawng zawng hian Lynch syndrome gene mutation hi an nei thei vek a ni. Tin, chhungkuaa mi dang awm lovin gene mutation thar nei mi pakhat pawhin Lynch syndrome a nei tih a ni thei bawk.

"Cancer i nei" tih thu hi tumahin an hre duh lo. Lynch syndrome vei tu emaw chuan an nunah engtik lai pawhin chu thu chu a hriat a ngai mai thei. Mahse khawvel tawp a ni lo. I dinhmun i hriat chian a, i doctor nena thawhhona i neih a, cancer screening neih fo chuan cancer eng pawh hi a hmasa berah hmuhchhuah leh tihdam theih a ni. Hriselna, hlim taka awm theihna tur chuan a hmaa hriatchhuah leh enkawl hi a tha ber a ni.