A châng chuan i chau hle a, i ruh a na a, i kut zungtang a lo hring bawk em? Ni engemaw zat chu vun rawng i nei a, ni dangah chuan thawk hah deuhin i awm bawk. Heng symptoms te hi natna dang nen a inang thei a, chuvangin, "Eng nge ka tihsual?" Hei hi natna pakhat nge natna inzawmkhawm a ni tih i chiang lo mai thei. Vawiin hian heng symptoms engemaw zat hi a awm dun theihna tur condition kan sawi dawn a, chu chu a buaithlak deuh a, mahse hriat a pawimawh hle. Hei hi Mixed Connective Tissue Disease (MCTD) an ti a.
A awlsam zawngin, MCTD chu eng nge ni?
MCTD hi autoimmune disorder hmuh tur awm lo tak a ni . Okay, chuti a nih chuan autoimmune disorder chu eng nge ni? A awlsam zawngin kan taksaah hian immune system kan nei a. Kan rama sipai awm ang mai a ni. A hna chu hmêlma hrik, virus, leh bacteria ang chi taksaa lut a, natna laka min humhim hi hriatchhuah leh beih hi a ni. Mahse, a chang chuan, keimahni ngei pawhin kan invenna hi a kal sual thin. Ram dang hmêlma ai chuan kan taksa hrisel leh cell hrisel tak takte chu "hmêlma" tiin an ngai sual a, an bei ṭan ta a ni. Chu chu autoimmune disease kan tih chu a ni.
MCTD-a thil thleng chu connective tissue natna lian pathum symptoms te hi a inzawm khawm a ni. Chuvangin "mixed" an ti a ni. Natna pathumte chu:
- Systemic lupus erythematosus (SLE): Hei hi a tawi zawngin "lupus" kan tih fo thin natna a ni.
- Scleroderma: Hei hi vun a thim leh a khauh vang a ni ber.
- Polymyositis: Hei hian taksa ruh chak lohna leh inflammation a thlen thin.
Hêng natna lian pathumte bâkah, mi ṭhenkhat chuan connective tissue natna dang, dermatomyositis , rheumatoid arthritis , a nih loh leh Sjögren’s syndrome te pawh an nei thei bawk. Chuvangin doctor-te chuan he natna hi "Overlap Syndrome" an ti a, a nih loh leh natna engemaw zat inzawmkhawmna dinhmun a ni.
MCTD natna lan chhuah dante chu engte nge ni?
Hemi chungchanga harsatna lian ber pakhat chu symptoms hi vawi khatah a lang vek lo tih hi a ni. Hun kal zelah an lo lang thei a, pakhat hnu pakhatin an lo lang thei bawk. Chuvangin a tir lamah chuan MCTD anga hriat a harsa deuh thei. I hmuh tur symptom lian ber berte hi han thlir ila.
| Symptom a ni | Hrilhfiahna awlsam tak |
|---|---|
| Chau lutuk leh nunna nei lo anga inhria | Engmah ti lo pawhin chau lutuk anga inhriatna. Nilengin khumah awm ang maia inhriatna. |
| Low-grade fever a ni | Khawsik sang tak nei lo mah la, i taksa chhung lam a\angin lumna lo chhuak ang maiin i inhria a, i taksa a na bawk. |
| Joint leh muscle natna | Joints hi chhan bik nei lovin a na a, a hring bawk. Muscle te chu a chak lo va, a na bawk. |
| Raynaud-a phenomenon chu a ni | Khua a vawt (e.g. AC room-a fridge atanga thil lak chhuah) a nih chuan kut zungtang, ke ruh, hnar leh beng zungbun-a thisen kal chu a tlahniam a, chu chuan a dum a, nunna nei lovin a siam a, chutah chuan blue/purple a lo ni ta a ni. An lum leh chuan an sen a, an normal leh thin. |
| Kut zungtang puffy | Kut zungtang chu sausage ang maiin a lang a, a hring bawk. A chang chuan hei hi ni engemaw zat hnuah a bo thin. Mahse, mi thenkhatah chuan hun kal zelah kut zungtang vun chu a nghet a, a hring a, a ben harsa (sclerodactyly) a ni. |
| Vun a hring chhuak | A bik takin knuckles-ah hian red emaw redish-brown emaw spot emaw patch emaw a lo lang thei. |
Flare-up a awm lai hian MCTD hi engtin nge a awm?
MCTD vei chuan a inhriat dan a inang reng reng lo. A chang chuan a natna lanchhuahna chu a reh thei a, a pangngaiin a awm thei bawk. Mahse hun dangah chuan natna hi a zual thut. Hei hi `flare-up` kan ti a. Heng hun chhung hian i symptoms te hi a na zual deuh mai thei.
- Ruhkawrteah natna nasa tak leh hliam na tak a awm thei bawk. Rheumatoid arthritis vei ang bawkin, ruh chu a khauh lutuk a, a na lutuk a, zing lamah kut zungtang pawh a ben thei lo.
- Raynaud-a phenomenon hi a na thei hle. Khawsik rei lo te pawh hian kut zungtangte chu rang takin a ti hlim thei a, nunna nei lovin a awm thei a, a rawng pawh a tidanglam thei bawk.
- I chau hle mai thei , ni tam tak chhung khawsik i nei tawh ang maiin, taksa ruh na leh engmah ti thei lo khawpa chak lo anga inhriatna nen.
MCTD hi eng thilin nge a thlen? Tu nge hlauhawm ber?
Dik tak chuan zirchiangtute chuan MCTD awm chhan dik tak hi an la hmuchhuak lo . Nu leh pa atanga fate hnena direct-a kai theih natna a ni lo va, rochun atanga lo chhuak a ni tihna a ni. Mahse, chhungkuaa mi tu emaw hian connective tissue natna dang a neih chuan midang pawhin he natna hi an vei theihna a sang deuh thei tih hmuhchhuah a ni.
Chu bakah chuan pawn lam thil thenkhat pawhin hei hi a nghawng ve mai thei niin ka ring.
- Viral infection thenkhat .
- Chemical thenkhat , polyvinyl chloride leh silica te nena inzawmna .
He natna hi kum eng pawhah a vei thei a, mahse hmeichhia kum 20 leh 30 inkar ah a lang tam ber .
MCTD vang hian eng harsatna nge thleng thei?
MCTD hi ruh natna mai a ni lo. Enkawl loh chuan taksa peng pawimawh tak tak a tichhe thei a, harsatna lian tham a thlen thei bawk. Chuvang chuan hei hi kan hriat chian a pawimawh hle a ni.
Heng harsatna zawng zawng hi damlo zawng zawngah a thleng vek dawn lo tih hre reng la, mahse a hlauhawmna hriat a pawimawh.
Harsatna lo awm thei ber chu:
- Pulmonary hypertension: Hei hi MCTD natna hlauhawm ber a ni. A awlsam zawngin sawi ila, thinlung atanga lung thlenga thisen phurtu thisen kalna kawng hrang hranga pressure tihpunna a ni. Hei hian thinlungah harsatna nasa tak a siam a, heart failure ang chi natna khirh tak tak a thlen thei bawk. Hetiang dinhmun hi MCTD vei thihna thlentu ber a ni.
- Interstitial lung disease: Lung tissue a inflammation leh scarring a awm a, chu chuan thawk harsatna a thlen thei.
- Lung natna
- Kidney a chhiat phah
- Digestive tract tihchhiat a ni
- Thisen tlakchhamna (Anaemia).
- Tissue thihna (necrosis) 1.1.
- Hriatna hloh
Engtin nge doctor-te hian he natna hi dik taka an hriat theih?
Kan sawi tawh ang khan MCTD symptoms hi hun kal zelah a hnungzuiin a lang thei a, doctor-te tan chuan hriat a harsa hle. MCTD a nih thu finfiah nan kum tam tak a ngai thei. Heng natna hrang hranga thiam doctor pakhat a awm a, chu chu rheumatologist an ti a ni. Heng symptoms te hi i neih chuan i doctor chuan heng specialist zinga pakhat hnenah hian a refer mai thei che.
MCTD hi connective tissue natna dang atanga thliar hran theihna tura puitu thil pawimawh pali a awm a:
1. Thisenah antibody anti-U1-RNP an tih sang: Hei hi thisen test bik hmanga hriat theih a ni. He antibody hi MCTD vei tan bik a ni.
2. Kidney leh central nervous system lama harsatna na tak awm loh: Heng harsatnate hi lupus (SLE)-ah hian a awm fo. Mahse, MCTD-ah chuan an tlem hle.
3. Arthritis na tak leh pulmonary hypertension awmna: Heng symptoms te hi lupus emaw scleroderma chauh aiin MCTD ah hian a tam zawk.
4. Raynaud-a phenomenon leh finger swelling: Lupus vei zinga 25% chauhvin heng symptoms hi nei mahse, MCTD vei zingah hian a hluar hle.
MCTD enkawlna tur engte nge ni?
A hmasa berah chuan MCTD hi damdawi a awm lo . Mahse, lungngai suh. I natna lan chhuah dan tur enkawl thei tur, harsatna lo awm tur venna tur leh nun pangngaia nunpui thei tur enkawlna tha tak tak a awm nual. Enkawlna chu i natna lan chhuah dan, i natna nasat dan leh a nghawng taksa peng hrang hrangah a innghat a ni.
| Ruihhlo chi hrang hrang | Function leh hman dan |
|---|---|
| Corticosteroid hmanga tihdam theih a ni Ex: prednisone tih hi a ni | Hengte hian taksaa inflammation tihziaawmna leh immune system malfunction control-na hmangin hna an thawk a ni. Natna a nat loh chuan a tlem zawkin pek theih a ni a, a nasat chuan a sang zawkin pek theih a ni bawk. |
| Malaria dona damdawi Entirnan: hydroxychloroquine tih hi a ni | Hengte hian flare-ups a veng thei a, symptoms na lo tak takte pawh a control thei bawk. |
| Calcium channel blocker a ni | Hengte hian thisen kalna kawng bang chhunga thau awmte chu a ti hahdam a, thisen chu awlsam zawkin a luang chhuak thei a, hei hian Raynaud-a thil thleng chu a thunun thei a ni. |
| Immunosuppressant dangte pawh a awm bawk | Lung leh kal (kidney) ang chi taksa peng lian tak takte a chhiat chuan, taksa hriselna (immune system) hnathawh dan tur thunun belh zel turin heng ang damdawi chak tak tak pek a ngai mai thei. |
| Antihypertensive damdawi hman tur | Hengte hi pulmonary hypertension control nan a pawimawh hle. |
Engtin nge i in enkawl theih ang?
I doctor-in a pek damdawi ei bakah hian i nunphungah inthlak danglamna tenau te siam hian he natna nena nun hi a ti awlsam hle thei a ni.
- Painkiller hman dan: Natna leh inflammation na lo tak tan chuan i doctor nen non-steroidal anti-inflammatory drugs (NSAIDs) - ibuprofen ang chi - entirnan ei chungchang i sawi thei ang. Mahse hengte hi doctor rawn hmasa lovin hmang chhunzawm ngai suh .
- Khaw lum lakah i kut venghim rawh: Hei hi Raynaud-a phenomenon i neih chuan a pawimawh hle. Ni lum lai chuan gloves vuah thin ang che. AC room-a i awm lai hian kut lum reng tur a ni. Fridge atanga thil i lak chhuah dawnin fimkhur hle ang che.
- Meizial zuk loh vek: Meizial zuk hian thisen kalna kawng a tikhawlo zual a, chu chuan Raynaud-a phenomenon chu a tizual thei a ni.
- Stress tihziaawm: Stress hi Raynaud natna thlentu lian tak a ni. Chuvangin thawk lakna exercise leh meditation ang chi thil tih hmangin i rilru tihlum tum ang che. A tul chuan rilru lam hriselna lama counselor te tanpuina lak a tha bawk.
MCTD hmanga hun rei tak dam
MCTD hi hun rei tak chhunga awm thei a nih avangin a nunpui zir a pawimawh hle. A bik takin damdawi corticosteroid ang chi hi rei tak ei hian side effect engemaw zat a awm thei.
- Osteoporosis avanga ruh chak lo.
- Tissue-a thisen supply tlahniam vanga tissue thihna.
- Muscle chak lohna.
- Hri kai awlsam takin a kai thei.
Heng side effects te hi enkawl leh enfiah turin hun ruat saah doctor i pan tur a ni . Doctor thupek dik takin zawm rawh.
MCTD vei hmeichhiain nau neih a tum a nih chuan a doctor nen inbiakna neih hmasak a pawimawh . Naupai lai hian a natna hi a zual thei hle. Tin, MCTD vei nu atanga naute piang te pawh hi nau piangah an rihna a hniam thei bawk.
Engtikah nge Doctor ka hmuh ang?
He thuziaka kan sawi tak symptoms te hi i neih chuan, a bik takin nitin hnathawhna tibuaitu a nih chuan doctor pan ngei ngei tur a ni. Joint emaw muscle na thar emaw, i kut zungtang a hring emaw, `Raynaud's phenomenon` chhinchhiahna emaw i neih chuan doctor rawn la.
Doctor hmu tura i kal hian heng zawhnate hi i zawt thei ang:
- Ka natna lan chhuah chhan hi eng nge ni?
- Connective tissue natna pakhat aia tam ka nei em?
- Eng ang test nge ka tih ngai?
- Ka dinhmun enkawl dan tur chu engte nge ni?
- Natna a zual zel loh nan enge ka tih theih ang?
He natna nena nung hian kum 10 hnuah i nun chu eng ang nge ni ang tih i ngaihtuah mai thei. Data atanga a lan dan chuan enkawl dan dik a nih chuan damlo 80% vel chu an natna hmuhchhuah atanga kum 10 tal an dam thei a ni. Mahse, nangmah ngeiin i doctor chauhvin hemi chungchangah hian thu tha ber leh dik ber a pe thei che a ni . A chhan chu thil tam takah a innghat a, chu chu i natna awm dan leh a nghawng taksa peng hrang hrangah a innghat a ni.
Take-Home Thuchah a ni
- MCTD hi autoimmune disease complex tak a ni a, natna dang engemaw zat, lupus, scleroderma, leh polymyositis te symptoms te a inzawm khawm a ni.
- A inzawm lo anga lang symptoms a lo lang thei a, chu chu ruh natna, hah lutuk, kut zungtang hring, leh khaw lum laiin kut zungtang rawng danglam (Raynaud’s) te hi a ni.
- He natna hi tihdam kim theih ni lo mah se, a natna lan chhuah dan thunun thei, harsatna lo thleng tur venna leh nun pangngaia awm theihna tur enkawlna tha tak tak a awm.
- Diagnosis leh treatment atan specialist, rheumatologist ang chi tanpuina lak a pawimawh.
- A hun taka doctor pan te, zu in loh te, khawsik laka invenna te, leh lungkhamna thunun te hi natna enkawl nan a pawimawh hle.
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