MGUS (Monoclonal Gammopathy of Undetermined Significance) hi cancer a ni em? A awlsam zawngin sawi ila.

Natna dang i neih leh neih loh thisen test i nei a ni mai thei. A nih loh leh kum tin medical checkup tih dan pangngai a ni mai thei. Chutih lai chuan doctor chuan, "I thisenah hian protein pangngai lo tak 'M protein' tih i nei a, hei hi MGUS kan ti a ni," a ti che a. Hetiang thil hi tu pawhin an hriat chuan an mangang deuh a, an hlauthawng deuh bawk. ‘Hei hi cancer a ni em?’, ‘Tunah hian eng nge ka chunga thleng ang?’, ‘Hei hi damdawi a awm em?’ tih ang chi zawhna tam tak rilruah a lo lang hi thil pangngai tak a ni. Mahse, lungngai suh. Vawiin hian MGUS hi eng nge a nih, a hlauhawm tak tak em, leh he dinhmun chungchangah hian eng nge kan tih tur tih te chu awlsam takin in hriatthiam theih turin kan sawi dawn a ni.

MGUS hi eng nge ni tak tak?

A awlsam zawngin, MGUS (Monoclonal Gammopathy of Undetermined Significance) hi i thisenin protein pangngai lo a siam chhuah theihna a ni. He protein pangngai lo hi M protein kan ti a . Hei hi thisen test hmangin emaw, a chang chuan zun test hmangin emaw hriat theih a ni.

Awle, tunah chuan tlem han thuk deuh ila, hetiang thil hi engtin nge a lo awm tih hi han en ila.

Kan taksa chhungah hian defence army kan nei ang tih han ngaihtuah teh. He sipaiah hian sipai chi khat bik chu plasma cells hi a ni . Hengte hi a takah chuan thisen var chi khat an ni. An hna ber chu kan taksaa natna thlentu hrik (bacteria, virus, etc.) lutte do turin antibodies an tih special protein weapons siam hi a ni. Heng antibodies te hian natna hrik te chu man leh tihchhiat hmanga natna laka min humhimtu an ni.

Mahse MGUS vei mi pakhatah chuan heng plasma cell thenkhat hi a ‘dik lo’ deuh thin. Chu chu, heng cell-te hian antibody pangngai, hrisel tak siam ai chuan protein inang, hmantlak loh, pangngai lo tam tak an siam tan tihna a ni. Chu chu M protein kan tih chu a ni.

MGUS natna lanchhuahna a awm em?

Hetah hian thil mak tak chu a awm. MGUS vei tam tak chuan symptom an nei lo . Chuvangin he natna hi a thleng mai mai a, chhan dang avanga thisen test an tih lai hian hmuhchhuah a ni fo thin. Danglamna i hre lo mai thei. Chuvangin MGUS i nei tih i hriat chuan "Ka tha e," tih ngaihtuah hi thil awmze nei tak a ni. Chu chu heng M proteins te hi thisenah chauh an awm tlangpui a, taksa tana chhiatna engmah thlen lovin an awm a ni.

Engvangin nge MGUS hi a lo thanglian? Risk factors te chu engte nge ni?

Dik tak chuan doctor-te chuan engvangin nge heng plasma cell-te hian hetiang hian an awm nghal thut tih chiang takin an la hre lo. Thuruk a la ni reng. Mahse zirchianna atanga a lan dan chuan mi thenkhat chu he natna hi an vei theihna chance a sang deuh hlek a ni.

MGUS vei theihna tipungtu thilte

• Kum: Kum upat deuh deuhin MGUS hi a hluar chho zel a. Kum 50 hnuah a awm fo thin a, kum 70 an tlin chuan mi 100 zinga 5 velin he natna hi an nei thei a ni.
• Gender: Hmeichhia aiin mipa hian MGUS an nei tam zawk.
• Hnam: Hetiang dinhmun hi hnam thenkhatah a tam zawk a, a bik takin mipa hring zingah .
• Chhungkaw chanchin: I chhungte hnai tak (nu, pa, unaupa) chuan thisen cancer MGUS emaw multiple myeloma ang chi a neih chuan, chu natna chu i vei theihna chance a sang deuh hlek a ni.
• Environment factors: Insecticide emaw pesticide emaw ei tawhna nei tawhte chu an hlauhawm zual thei.
• Natna dang: Autoimmune natna thenkhat nei te pawh an hlauhawm thei bawk.
• Radiation laka inhriatthiamna: Radiation tam lutuk avanga invenna pawh hi risk factor a ni thei bawk.

MGUS avanga harsatna awm thei te chu engte nge ni?

Hei hi mi zawng zawngin kan ngaihtuah leh hlauh ber a ni. Sawi tawh angin MGUS hi cancer a ni lo. Mahse, mi tlemte tan chuan he natna hi hun kal zelah natna khirh zawkah a chang thei a ni.

MGUS vei mi 100 zinga 20 atanga 25 vel chuan a tawpah thisen kaihhnawih natna khirh tak an nei dawn a ni. Chumi awmzia chu 100 zinga 75-80 chuan harsatna an nei dawn lo tihna a ni.

MGUS a kal zel a, natna lo awm thei lian ber berte chu:

• Multiple Myeloma: Hei hi harsatna awm tam ber a ni. Plasma cells cancer a ni.
• Amyloidosis: Natna pakhat, taksa peng hrang hrangah M protein a awm a, a tichhe thin.
• Waldenstrom macroglobulinemia: Hei hi thisen cancer chi khat hmuh tur awm lo tak a ni bawk.
• Chronic lymphocytic leukemia: Thisen cancer chi dang a ni.

Tin, MGUS hian hriselna lama harsatna dang a thlen theihna pawh tlem a tipung thei bawk:

• Thisen a chhuak thin
• Ruh hloh emaw, ruh tliak emaw
• Hri kai fo thin
• Kidney chungchangah harsatna a awm
• Nerve chhiatna (peripheral neuropathy): Hei hian ke ruh a ti na thei a, a ti na thei bawk.

Engtin nge doctor hian MGUS hi a hriat theih ang?

I doctor chuan thisen leh zun test a ti ang a, M protein a awm leh awm loh a enfiah ang. Chu chu an finfiah hnuah chuan he natna hi cancer-a a chan theih dan tur an zirchiang ang. Hei hian thil pawimawh pathum a en ang:

1. Thisenah M protein awm zat: M protein level 1.5 g/dL (grams per deciliter) aia tam a nih chuan a hlauhawmna chu a sang deuh hlek a ni.

2. M protein chi hrang hrang: M protein chi hrang hrang ( Immunoglobulin (Ig) chi hrang hrang an tih) a awm a. A chi thenkhat chuan a dang aiin natna khirh tak a thlen tam zawk.

3. Serum-free light chains (FLC) levels: Hei hi plasma cell siam protein dang a ni. Thisen test bik ( Serum-free light chains (FLC) test ) hmangin hengte hi a dik lo tih hriat theih a ni.

Heng thil pathumte nei vek mi chuan cancer vei theihna a sang hle. Mahse heng zinga pakhat mah nei lo mi chuan risk a nei tlem hle. I doctor chuan heng test result atang hian eng risk group-ah nge i awm tih a hrilhfiah ang che.

MGUS enkawl dan tur a awm em?

Hetah hian thu lawmawm chu a awm: MGUS vei tam zawk chuan enkawlna engmah an mamawh lo.

Chuti a nih chuan engtin nge i tih? Doctor chuan "watchful waiting" emaw "active surveillance" emaw an tih chu a ti thin. A awlsam zawngin, "watchful waiting."

Chumi awmzia chu, damdawi pe lovin i thisen M protein level leh thil dangte chu schedule ruat saah enfiah reng a ni tihna a ni.

• A tlangpuiin kum khatna atan thla 3 atanga thla 6 danah thisen test tura tih a ni.
• Tichuan, engkim a stable chuan thla 6 danah emaw kum khatah vawi khat emaw check-up i dil thei ang .

Hetiang check-up mumal tak neih chhan ber chu MGUS hi natna khirh takah a chan theihna tur chhinchhiahna hmasa ber hriatchhuah a ni. Hrilhfiahna eng emaw hmuh a nih chuan enkawl tan hma theih a ni. Chu chu advantage lian tak a ni.

MGUS bakah hian harsatna dang i neih chuan ruh chak lohna i nei a nih chuan i doctor chuan chutiang tur chuan enkawlna hran a pe ang che.

Engtik hunah nge Doctor ka hmuh ang?

MGUS i neih chuan i doctor chuan i check-up hun tur chiang tak a pe ang che. Chutiang date-ah chuan kal ngei ang che. Chu bâkah, natna lan chhuah dân danglam tak i neih chuan, i clinic appointment lo awm tûr chu nghah ai chuan, i doctor hmu nghâl rawh. Heng symptoms te hi i dinhmun a chhe zual zel tih hriattirna a ni thei.

A hnuaia symptom tarlan te hi a bik takin ngaihven rawh.

MGUS diagnosis hi a buaithlak deuh thei. A chhunga "undetermined significance" tih thumal tak tak hian kan hriat loh tam tak a la awm tih a hrilh che a ni. Mi thenkhat tan chuan a pawi em em a, thenkhat tan chuan a pawi lo tih hriat tumin zirchianna a la kal zel a ni.

Mahse a tha ber chu, tunlai medical science lama hmasawnna avang hian i risk chu i teh lawk thei a ni. Tin, enkawl reng reng i nih avangin, eng inthlak danglamna pawh a tir lamah man theih a ni. Chuvangin i tih theih tha ber chu i hlauhthawnna tihziaawm a, doctor thupek dik taka zawm hi a ni.