I taksa peng hrang hrangte hian zawi zawiin an thiltihtheihna an hloh tawh niin i hria em? Hei hi Motor Neuron Disease (MND) a ni thei!

Stairs i chhoh lai khan i ke a hrual ang maiin, i thusawi laiin i thusawi a hlim lo ang maiin, i kut atanga thil lo tla nghal ang maiin i inhriat ngai em? Hengte hi thil pangngaiah i ngai mai thei, mahse heng symptoms te hi a la awm reng a nih chuan tlem tal ngaihtuah a tha. A chhan chu hengte hi Motor Neuron Disease (MND) tih hming pu natna chhinchhiahna hmasa ber a ni thei a ni. Chuvangin, vawiinah hian he thu hi chipchiar deuhin han sawi ila.

Motor neurone natna (MND) hi eng nge ni?

A awlsam zawngin sawi ila, motor neurone disease (MND) hi kan nervous system tichhe thei natna chi khat a ni. Kan motor neurons te chu zawi zawiin a thi ta a ni. Tunah chuan heng motor neurons te hi eng nge an nih i ngaihtuah mai thei. Hengte hi kan taksa ruh (muscles) control tu nerve cells te an ni. Heng motor neurons te hi kan hnathawh zawng zawng atan a pawimawh hle a, thawk chhuah, thusawi, ei leh in leh kea kalna thlengin a pawimawh hle.

Ngaihtuah teh, kan thluak (chu chu upper motor neurons kan tih) atang hian kan ruhro (spinal cord) ah thuchah a lo thleng thin. Chuta tang chuan chu thuchahte chu motor neuron hnuai lam kaltlangin kan taksa peng hrang hrangah a kal a ni. Heng upper motor neurons te hi lower motor neurons te hnenah, "Okay, tunah chuan he muscle hi hetiang hian move rawh u," titu an ni.

Tunah chuan heng motor nerve hnuai lam hian taksa peng hrang hrangah thuchah an thawn thei lo a nih chuan eng nge thleng thin? Muscle te chu zawi zawiin a chak lo tan a , a tlahniam tan bawk (muscle atrophy) . Tin, upper motor nerve te hian lower motor nerve ah signal an thawn theih loh chuan taksa ruh te chu a nghet a, overreactive ( hyperreflexia ) a lo awm bawk. Hei hian tlawmngai taka chetna siam a harsat phah a, zawi zawiin a thleng thin. Hun a kal zel a, kea kal theihna leh chetna dangte thunun theihna pawh kan hloh thei a ni.

A pawimawh ber chu tun dinhmunah hian motor neurone natna hi damdawi a la awm lo . Hengte hi natna zual zel, hun kal zelah a zual zel a ni. Mahse, he natnain nghawng a neih lohna tura pui thei tur enkawlna a awm.

MND chi hrang hrang eng nge awm?

Doctor-te chuan MND hi upper motor nerve emaw, lower motor nerve emaw, a pahnih emaw a nghawng dan azirin an thliar hrang a. MND hi chi hrang hrang a awm a, chungte chu:

`Amyotrophic lateral sclerosis (ALS) natna avanga natna hrik awm hi a ni`

Hei hi MND chi khat a ni ber. Mi thenkhat chuan Lou Gehrig natna an ti bawk . ALS hian motor nerve chunglam leh hnuai lam a nghawng vek a ni. Hei hian taksa ruh thununna a hloh nghal thei a, a tâwpah chuan paralysis a thlen thei a ni . Doctor tam tak chuan ALS leh motor neurone disease tih thumal hi a inthlak danglam fo thin.

`Progressive bulbar palsy (PBP) a ni a, a rilru a hah lutuk a, a rilru a buai em em bawk a

Hei hi min beitu chu a ni.Thluak (bulbar region) nena inzawm motor nerve hnuai lam te. Kan thluak bul hian thusawi, ei leh in, ei leh in ang chi thila mamawh taksa ruhte chu a thunun a ni. PBP hming dang chu ``progressive bulbar atrophy`` tih a ni.

`Primary lateral sclerosis (PLS) natna hi a awm thei lo

Hei hian upper motor nerve chauh a nghawng a ni. A tam zawkah chuan he natna hian ke a nghawng hmasa ber a ni. Tichuan kut, kut leh ke ruh a nghawng a ni. A tawp berah chuan thusawi, ei leh ei tur ei nana hman thin ruh (muscles) te a nghawng thei a ni.

`Progressive taksa chakna (PMA)`

Motor nerve hnuai lam chauh a nghawng a ni. He natna hi mipaah ​​a tam zawk a, puitling atanga lo chhuak MND dangte aiin kum naupang zawkah a awm duh hle. A lan chhuah hmasak ber chu kutphah chak lohna a ni a, chu chu taksa hnuai lam thlengin a darh leh thin. Trunk leh thawk dan pawh a nghawng thei bawk.

Spinal muscular atrophy (SMA) a awm thei lo.

Hei hi hereditary condition a ni a, motor nerve hnuai lam a nghawng a ni. Nausen thihna thlentu genetic cause lian ber nia ngaih a ni bawk . `SMN1` gene a mutations a awm chuan `SMN` protein a hloh thin . Hei hian motor nerve hnuai lam a tichhe zauh zauh a, taksa ruh a tichhe a, a chak lo a, a tawpah chuan thihna a thlen bawk.

Kennedy natna a ni

Mipa X chromosome-a gene pakhat nen a inzawm tlat a ni. Androgen receptor gene a mutations avanga lo awm a ni. Hun a kal zel a, kut leh keah chak lohna a lo awm a, a tam zawkah chuan pelvic emaw shoulder area atanga tan a ni. Kut leh keah na leh ke na a awm thei bawk.

Polio hnu lama natna (PPS) .

Polio natna vei dam tawhte zingah a awm thin. An natna hmasa ber atanga kum sawmli thleng a awm thei. Polio hian motor nerve te nasa takin a tichhe thei a ni. PPS chhinchhiahna chu taksa ruh leh ruh chak lohna, hahna, hun kal zelah natna nasa zual, taksa ruh inthlak leh khawhral, ​​leh khawsik tuar thei lo te a ni.

MND natna lan chhuah dan chu engte nge ni?

MND symptoms hi a lo lang nghal lo va, zawi zawiin a lo lang thin. A tir lamah chuan an langsar vak lo mai thei.

A lan chhuah hmasak ber

• Stairs chhoh harsatna emaw, ke emaw ke emaw ke ruh chak lohna avanga tlu fo thin.
• Thusawi thiam lo (dysarthria) .
• Chaw ei harsat .
• I thil chelh lai grip chak lo. Entîr nân, kawr button chu a harsa thei a, bottle hawn a harsa thei a, i kuta thil awmte chu leiah a tla reng thei bawk.
• Muscle twitches leh cramps te a awm thin .
• Kut leh ke te tak te avanga taksa rihna tlahniam .
• Hun remchang lovah nuih emaw tap emaw tihtawp theih loh (pseudobulbar affect) . Hei hi i lungngaih laia nuih ang mai a ni a, a nih loh leh hlim taka i awm laia lungngaih ang mai a ni.

Symptom dang a awm bawk

Heng a tir lama a lan chhuah dan bakah hian natna dang a lo lang thei bawk:

• Thâwk harsa (thâwk lak loh) .
• Khumah mut laiin thawk harsa .
• Chest infection awm fo thin .
• Mut lama harsatna (mut buai) .
• Ngaihtuahna leh hriatrengna lama harsatna .
• Rilru tibuai .
• Zingkar lu na .
• Chau .

MND hi eng thilin nge a thlen?

Kan sawi tawh ang khan MND hi kan motor neurons-a harsatna awm vang a ni. Heng cell te hian hun kal zelah hna an thawk tha tawh lo zauh zauh a. Mahse, zirchiangtute chuan hetiang thil hi a thlen chhan chiang takin an la hre lo .

MND hi rochun a ni

MND natna thenkhat chu thlahtute atanga lo piang a ni a, chu chu chhungkaw member kaltlangin genes hmanga inkalpawhna a ni tihna a ni. Hetiang hunah hian natna hi gene pakhat inthlak danglam vang a ni. Chungte chu kawng pawimawh engemaw zatah rochun theih a ni:

• ``Autosomal dominant``: Hetiang a nih chuan, a natna vei nu leh pa pakhat chauh hnen atanga altered gene copy pakhat chauh i rochun pawhin natna vei theihna a la awm tho.
• ``Autosomal recessive``: Hetiang a nih chuan natna hi i lo vei theih nan nu leh pa pahnih hnen atangin altered gene copy pahnih i dawng tur a ni.
• `X-linked inheritance`: Hemiah hian nuin he gene hi X chromosome-ah a keng a, a fate mipa hnenah natna hi a pe chhuak thin.

Chhan dang

Non-hereditary MND condition hi thil chi hrang hrang avanga lo awm thei a ni. Chûng zîngah chuan virus, toxins, genetics, leh environment factors te pawh a tel thei a ni .

Tute nge MND vei theihna chance sang zawk?

MND hian kum 60 leh 70 inkar mi a vei tam ber a, mahse naupang leh puitling kum eng pawh a nghawng thei. I chhungte hnai tak pakhatin MND, a nih loh leh chutiang chi, frontotemporal dementia , a neih chuan MND vei theihna a sang hle.

Doctor-te hian engtin nge MND hi an hriat theih?

MND hi a hmaa hriat a harsa thei a, a chhan chu test bik a awm loh avangin. Natna leh hriatna hloh lovin i taksa ruh chak lohna zawi zawia i neih chuan i doctor chuan MND a ringhlel mai thei.

Doctor-in zawhna a zawh te

Zawhna hrang hrang i inzawt thei ang:

• Taksa peng engte nge a nghawng ?
• Engtik lai khan nge symptoms hi a lo intan?
• A lan chhuah hmasak berEngnge?
• Hun kal zelah a natna lan chhuah dan a danglam tawh em?

Test neih a ni

Natna hriat theihna turin test eng emaw zat tih theih a ni:

• Electromyography (EMG): Hei hian i taksa peng hrang hrangte electrical activity a record a. Hei hian buaina chu taksa ruh, nerve, neuromuscular junction-ah a awm em tih hriat theih nan a pui thei a ni.
• Nerve conduction study: Hei hian nerve-in impulse a thawn chhuah chak dan a teh a ni.
• Magnetic resonance imaging (MRI) scan: Thluak MRI te, a chang chuan ruhro MRI te hi thil danglam dang, chutiang bawka natna lan chhuah tir thei tur zawng chhuah nan tih a ni.

Damdawi lam thil dang tih loh nan doctor chuan test dang neih belh a dil thei ang:

• Thisen test a ni
• Zun test a ni
• Spinal tap (lumbar puncture) hmanga tihdam theih a ni.
• Genetic test neih a ni

Hun a kal zel a, MND symptoms hi a lang chiang em em a, test ngai lova natna hi hriat theih hun a awm thin.

MND enkawlna tur engte nge ni?

Motor neurone natna hi damdawi leh enkawlna bik a awm lo . Mahse, zirchiangtute chuan he natna enkawl dan him leh tangkai tak tak an zir chhunzawm zel a ni.

I natna lan chhuah dan tur enkawl turin doctor team nen thawhhona tha tak i neih a ngai dawn a ni. MND enkawlnaah hian:

• Physical therapy: Hei hian i taksa ruh chakna a vawng reng a, i ruh (joint) te a tidanglam thei bawk.
• If you have difficulty swallowing , i pum chhunga bang kaltlangin tube (gastrostomy tube) hmangin chaw ei tur pek i ni thei.

Damdawi chi hrang hrang

Damdawi thenkhat chuan MND vei tam tak chu an natna lan chhuah dan atanga hahdamna an hmuh theih nan a pui thin:

• Baclofen: Muscle stiffness tihziaawmna leh muscle spasms tihziaawmna.
• Phenytoin emaw quinine emaw: Muscle spasm tihziaawmna.
• Glycopyrrolate: Chaw chhuak tihtlem.
• Antidepressants: Depression tan a pui thin.
• Benzodiazepines: Natna a zual zel angin natna lo awm thin tan.

ALS vei tan chuan dam rei thei leh hnathawh tlahniam control thei damdawi pahnih a awm a, chungte chu riluzole leh edaravone .

Mi tam tak pawhin clinical trial ah an tel ve bawk .

Engtikah nge Doctor ka hmuh ang?

Muscle chak lohna ang chi i neih chuan, chu chu MND chhinchhiahna hmasa ber a ni thei a, doctor pan ngei ngei tur a ni. MND i nei lo mai thei, mahse i mamawh enkawlna leh puihna i hmuh theih nan a rang thei ang bera diagnosis dik tak neih hi a pawimawh hle.

Tin, MND emaw frontotemporal dementia vei i chhungte hnai tak i neih a, nang pawhin natna hi i vei thei tih i hlau a nih chuan doctor pan a tha. I doctor chuan i risk chungchang sawipui turin genetic counselor hnenah a refer thei bawk che.

Hetiang dinhmun nen hian eng nge i beisei theih ang?

Motor neurone natna hi natna zual zel a nih avangin i dinhmun hrethiam tur leh i dinhmun enkawl dan tur enkawlna dik tak zawng thei tur doctor zawn a pawimawh hle.

Support system neih a pawimawh bawk . I dinhmun a lo zual zel chuan, i tâna thil harsa tak tak ti tûrin mi dangte ṭanpuina i mamawh belh thei a ni. Ṭhiante leh chhungte nen inbiakna nei la, i doctor hnenah i khawtlang atanga tanpuina dawn dan tur zawt rawh. Nangmah chauh i ni lo tih hre reng ang che.

MND vei dam rei zawng chu engzat nge ni ang?

Vanduaithlak takin motor neurone natna hian i dam rei zawng chu nasa takin a ti tawi thei a ni . Chung natnate chu hun kal zelah a zual zel a, a tawpah thihna thlentu an ni. Mahse, chu lai hmun thlen theih nân eng chen nge a rei tih chu mi tin a inang lo. Mi thenkhat chu heng natnate nghawng avanga an thih hmain kum tam tak, a chang chuan kum sawm tam tak pawh an dam thin. I doctor hian i dinhmun prognosis/outlook chu a hrethiam zawk thei che a ni.

A pawimawh ber - i sawi tur chu

Motor neurone disease (MND) i vei tih hriat chu thil hlauhawm leh buaithlak tak a ni thei . I sualna a ni lo tih hre reng ang che . Thil dik lo i ti lo. Tin, i nihna a tidanglam lo – mahse nun chu tlem a danglam thei. Natna a zual zel angin harsatna i tawk thei a, mahse a nghawng dan tur enkawltu tur enkawlna a awm. I ṭhiante leh chhungte chu ṭanpuina atan innghat rawh. I tuar chhuah theih loh emaw, puihna tam zawk i mamawh emaw a nih chuan i doctor nen inbia ang che. I mamawh tur resources zawng turin an pui thei che a, hun kal zelah i mamawh tanpuina i hmuh ngei ngei tur a ni.

` Motor neurone natna, MND, thluak lam natna, thau chak lohna, ALS, nerve cells, thau tihchhiatna