Mucosal Melanoma chungchanga hriat tur awmte!

Skin cancer chungchang hi kan hre vek tawh a ni lawm ni? Mahse, a chang chuan heng cancer te hi kan taksa chhungah, pawn lam atanga hmuh theih loh hmunah te a lo awm thei tih i hria em? Chutiang cancer chi khat, hmuh tur awm lo mahse hlauhawm tak pakhat chu Mucosal Melanoma an ti a. Hei hi a pawi deuh niin a lang a nih chuan lungngai suh. Hemi chungchang hi i hriatthiam theih tur awlsam takin sawi ila.

He Mucosal Melanoma an tih hi eng nge ni?

A awlsam zawngin sawi ila, Mucosal Melanoma hi cancer chi khat hmuh tur awm lo tak, Melanoma . Kan taksa chhunga mucous membrane atang hian a intan thin. Tunah chuan mucous membrane chu eng nge ni tih i ngaihtuah mai thei. Kan taksa chhunga taksa peng hrang hrang, hnar chhung, ka chhung, hnute leh serh ang chite khuh tu, hnim hring, hnim hring a ni. Kan ka chhunga vun hring leh hnim hring ang maiin han ngaihtuah teh. Chutah chuan heng mucous membrane te hi hmuh tur a awm a ni.

Chuvangin, he mucosal melanoma an tih hi khawi hmunah pawh mucous membrane awmnaah i hmu thei a ni. Mahse a tam ber chu:

• Lu leh kawng lamah: a bik takin hnar, hmui, leh ka chhungah.
• The anorectal region: Hei hian i hnute chhehvel leh i bawlhhlawh chhuahna kawng a kawk a ni .
• Vulvovaginal region: Hmeichhe hnute pawn lam leh a chhehvel .

He natna hian kum 70 chunglam a vei tlangpui a, vanduaithlak takin cancer hi a hriat chhuah meuh chuan taksa hmun dangah a darh (metastasized) fo thei a ni. Doctor te chuan he mucosal melanoma chi hi operation hmangin an enkawl thei a ni. Mahse, a tam zawkah chuan doctor hrang hrang, multidisciplinary team- in an enkawl a, an thawkdun a, enkawlna chi hrang hrang an hmang a ni.

Hei hi thil awm dan tlangpui a ni em?

Ni lo, a tak takah chuan a ni lo. A rare hle mai . Ngaihtuah teh, American Cancer Society chuan kum 2022 chhung hian melanoma vei thar 99,000 vel an awm dawn niin an chhut a, mahse he melanoma chi, mucosal melanoma tia koh hi melanoma vei zawng zawng zinga 1% vel chauh a ni. Chu chu mi 990 vel a ni. Chuvangin hei hi a tlem zia chu i hmu thei ang.

Mucosal Melanoma natna lan chhuah dan chu engte nge ni?

Hei hi a buaithlak deuh thin. A chhan chu mucosal melanoma symptoms hi awlsam takin kan hmu lo thei a ni . Chu chu he cancer hi kan taksa chhunga hmun thup , kan check theih reng lohah a lo awm thin vang a ni. Kan hnar chhung emaw, kan hnute vel vun emaw ngaihtuah rawh. Chutiang hmunah chuan inthlak danglamna kan hmu fo lo.

Chubakah, heng symptoms te hi a chang chuan natna dang, na lo zawk te nen pawh a inang thei bawk. Chuvangin mi tam tak chuan heng inthlak danglamna te hi harsatna lian zawk chhinchhiahnaah an ngai lo. Cancer intanna hmun a zirin symptom pawh a inang lo.

Lu leh kawng kaihhnawih

Mucosal melanoma vei zawng zawng zinga 31% leh 51% inkar chu lu leh kawngah a awm a ni. A chi thum a awm a, a kaihhnawih symptoms te nen:

Oral mucosal melanoma a awm thin

He cancer hian i hmui chhung lam, i hmuiah a nghawng a ni. A lan chhuah dan chu:

• Lei chunga lump, dam lo leh lian zual zel.
• Kawngpuiah natna a dam tawh lovang.
• Kawng a na.
• Kawng atanga thisen chhuak.
• Ha lem hi a fit tha lo hle. (Ha lem vuah thiam i nih chuan)

Sinonasal mucosal melanoma a awm thin a ni

Hei hi hnar kawng leh hnar chhunga cancer lo awm a ni. A lan chhuah dan chu:

• Hnar pakhat atanga thisen chhuak chhunzawm zel (nosebleed - `epistaxis`) .
• Hnar chhunga thil awm (nasal obstruction) tih hriatna .
• Zun chhuah fo thin.
• Hmai natna.

A rilru a hah lutuk chuan a rilru a buai em em a

Hei hi mucosal melanoma chi khat zingah chuan a awm lo ber a ni. I rilru a nghawng a ni. A lan chhuah dan chu:

• Aw ri bengchheng tak.
• Chaw ei harsa (dysphagia) .
• Thlarau na emaw natna hrik (pharyngitis) .
• Kawng pawn lamah lump emaw tumor emaw a lo lang thin.

Anus chhung leh a chhehvel

Anorectal mucosal melanoma hi i rectum leh/ emaw i hnungzang ah a awm thin. Damlo zawng zawng zinga 17% leh 24% inkar a nghawng a ni. A lan chhuah dan chu:

• Rectum emaw anus emaw a na.
• Rectum emaw anus emaw a lump emaw tumor emaw a awm.
• Anus emaw rectum atanga thisen chhuak.
• Ek khal.
• Anus vel a natna (pruritus ani) .

Vagina leh pawn lam vaginal area-ah

Vulvovaginal mucosal melanoma hi hmeichhiaah chuan vagina leh vulva wall-ah a awm a. Damlo zawng zawng zinga 18% vel a nghawng a ni. A lan chhuah dan chu:

• Vaginal bleeding chu thlasik lai emaw, menopause hnu emaw (chu chu thlasik a tawp vek hnuah emaw a ni).
• Vaginal natna.
• Vaginal discharge pangngai lo a awm thei a, thisen chhuak pawh a awm thei.
• Vagina emaw pawn lam vaginal area-a lump emaw, lo thang lian emaw.
• Vagina emaw pawn lam vaginal area-a itching, enkawl ni mahse a tha lo.

Pawimawh tak: Heng symptoms te hi damdawi lam natna tlanglawn dang avanga lo awm thei a ni fo. Mahse, heng chhinchhiahnate hi i neih chuan, a bik takin a awm reng chuan doctor rawn rawh . A hmaa hmuhchhuah hi enkawlna hlawhtling tak neih nan a pui nasa hle fo thin.

Engvangin nge he mucosal melanoma hi a lo awm? A chhante chu engte nge ni?

A chhanna tawi chu medical researcher te hian mucosal melanoma awm chhan dik tak hi an la hre lo tih hi a ni. Melanoma zawng zawng ang bawkin, he cancer chi hi melanocytes an tih cell-ah a intan a ni. Melanocytes hi kan mit, sam leh vun rawng hriltu pigment melanin siamtu cell a ni. He melanin hian kan vun leh mit a venghim a, ni zungin a chhiat loh nan a venghim a ni.

Mahse mak tak maiin, zirchiangtute chuan engvangin nge heng ni êng laka vengtu melanocyte cells te hi ni êng hmu tlem tak, mucous membrane-ah an awm tih an la zirchiang reng a ni.

Mahse, zirchiangtute chuan heng mucosal melanoma thenkhat lo awm chhan hi genetic mutation pahnih hian a pui thei tih an hmuchhuak a ni. Hengte hi somatic mutations an ti a, chu chu kan pianpui thil ni lovin, kan dam chhunga kan cell-a inthlak danglamna a ni zawk tihna a ni. KIT gene leh BRAF gene -a mutation hi mucosal melanoma vei zinga za zela tlemteah hmuh a ni a:

• KIT gene: KIT gene hian cell thenkhat, melanocyte telin, an than chak dan a control a. BRAF gene ang bawkin KIT gene hian protein a siam a, chu chuan cell te chu a tichak a ni. KIT gene hi a inthlak danglam chuan KIT protein hian protein dangte chu a hruai sual a, chu chuan cell te chu a tlangpui aia rang zawkin an inthen darh a, an pung chak zawk thin. Zirna hrang hrangah chuan mucosal melanoma vei zawng zawng zinga 7% atanga 17% velah KIT mutations hmuh a ni tih hmuhchhuah a ni. Tin, vagina leh vulva-a mucosal melanoma vei zinga 30% velin an hmu bawk.

• BRAF gene: BRAF gene hian melanocyte te thanna control tu protein te a control a. Heng protein te hian BRAF gene atang hian cell te hi engtiang chiahin nge an inthen darh ang tih leh an pun chak dan tur chungchangah thupek an dawng thin. BRAF gene chu tihdanglam a nih chuan chu thupekte chu a danglam a, chu chuan cell-te chu thunun theih lohvin a tipung a, a tâwpah chuan cancer a ni ta a ni. Mahse, BRAF mutations hi za zela tlemte chauh hmuh tur a ni a, mucosal melanoma vei zawng zawng zinga 3% leh 15% inkar a ni.

Ni chhuahna hi vun melanoma thlentu a ni. Mucosal melanoma pawh chutiang bawk chu a ni em?

Ni lo, a ni lo. Mucosal melanoma hi ni chhuahna hmun, hnar chhungah, ka chhungah emaw, hnute chhungah emaw a lo awm thin. Chuvangin ni eng hi direct cause a ni lo.

He natna hi Doctor ten engtin nge an hriat chian?

Doctor-te chuan he natna hi hriat theih nan test hrang hrang an hmang a, chung zingah chuan:

• Imaging test hrang hrang pawh a tel thei a, chu chu CT scan (Computed Tomography scans) leh MRI scan (Magnetic Resonance Imaging scans) te hi a ni. Chungte chuan taksa chhunga tumor awmte, a lian leh te, a darh tawh leh tawh loh te a en thei a ni.
• Biopsies an ti thin. Chumi awmzia chu rinhlelh awmna hmun atanga cell emaw tissue emaw sample te tak te lak a ni a, microscope hmangin pathologist te chuan an enfiah tihna a ni. Hei hian cancer a nih leh nih loh leh eng chi nge a nih tih chiang takin a hril a ni.
• Genetic test pawh tih theih a ni a, genetic mutations a awm leh awm loh enfiah theih a ni bawk.

Mucosal Melanoma cancer staging hi eng nge ni?

Doctor-te chuan cancer staging system hmangin enkawl dan tur ruahmanna siamin, a hmalam hun tur, a nih loh leh a chhuah tur beisei dan tur an ruat thin. A tlangpuiin, early-stage mucosal melanoma hi cancer hi a bul tanna hmun atanga a darh lohna a ni.

Mahse, hei hi a buaithlak deuh a ni . A chhan chu mucosal melanoma chi hrang hrang (e.g., hmui, hnar, rectum) hian staging system an nei vek a, a chipchiar zawng pawh a inang lo hle. Cancer staging hi hriatthiam a harsa deuh thei. I doctor thusawi i chiang lo a nih chuan, emaw, ngaihtuahna emaw zawhna emaw i neih chuan, i doctor hnenah thu belhchian dawl zawk zawt ngei ang che .

Hei hi engtin nge enkawl a nih?

Mucosal melanoma hi natna khirh tak a nih avângin, enkawlna chu specialty hrang hranga doctor-te multidisciplinary team-in an enkawl fo ṭhîn . He team-ah hian surgical oncology specialist, radiation oncology specialist, leh medical oncology specialist te pawh an tel thei. Enkawlna kawng hrang hrangte chu:

• Cancer natna hrik leh a chhehvel tissue te surgery hmanga lakchhuah . Surgery chi hrang hrang hi tumor awmna hmunah a innghat nasa hle. Tumor thenkhat chu surgery hmanga lakchhuah a harsa hle.
• Radiation therapy hi cancer cell la awm zawng zawng tihchhiat nan operation hnuah adjuvant therapy angin pek thin a ni.

Tunah hian medical researcher te chuan cancer tan immunotherapy leh cancer tan targeted therapy te clinical trial an nei mek a ni . Clinical trial hi enkawlna thar a him leh hlawk loh endikna zirchianna a ni. Mucosal melanoma i neih chuan heng clinical trial zinga pakhatah hian i tling thei ang.I doctor zawh a tha.

Hetiang dinhmun nen hian eng nge i beisei theih ang?

Mucosal melanoma hi nunna atana hlauhawm thei natna a ni . Doctor-te chuan surgery leh enkawlna dang hmangin cancer lian tham tak takte chu paih chhuakin cancer cells te chu an that thin. Mahse, mucosal melanomas hi a lo let leh (recur) duh zawk . Mucosal melanoma i neih chuan operation dang emaw, enkawlna dang emaw i mamawh mai thei.

Natna hi eng prognosis nge ni?

Dam leh dam theihna chance chungchang sawi dawn chuan mi hrang hrangah a inang lo. Mahse, a pumpuiah chuan zirchianna hrang hrangah chuan mucosal melanoma vei kum nga chhunga dam rei zat chu 25% vel a ni . Hei hi a hniam angin a lang thei a, mahse a average a ni.

Heng damchhuahna rate pawh hi mucosal melanoma chi hrang hrang a zirin a inang lo bawk:

• Lu leh kawng: A tlangpuiin zirchianna atanga a lan dan chuan mi 30% aia tlem lo chu natna hmuhchhuah a nih atanga kum nga hnuah an dam leh thin. (Survival rates hi 14% atanga 48% inkar a ni).
• Vaginal leh vulva: Hetiang natna vei zinga 36% vel chu an hriat chhuah atanga kum nga hnuah an dam tawh a ni.
• Rectal leh anal cancer: Hetiang natna vei zinga 20% vel chu an hmuhchhuah atanga kum nga hnuah an dam leh thin.

Heng statistics te hian hlauthawng suh. Hengte hi natna bik nei pawl pakhat thil tawn atanga chhut chhuah mai a ni. An tan chuan thil dik tak chu i tan chuan a dik lo mai thei. Heng damchhuah zat chungchangah hian zawhna i neih chuan i doctor hnenah i dinhmun a zirin eng nge i beisei theih tih sawifiah turin hrilh rawh .

Engtin nge ka hriselna ka enkawl ang?

Mucosal melanoma hi nunna atana hlauhawm tak a ni a, enkawl hnuah pawh a lo lang leh thei a ni. Natna lo lang leh zel i neih chuan, enkawlna avanga symptoms leh side effects te enkawlna atana pui turin palliative care ngaihtuah i duh mai thei. Palliative care chu natna tihdam ai chuan damlo nunphung tihchangtlun leh natna tihziaawm tumna enkawlna a ni.

Engtikah nge Doctor ka hmuh ang?

Mucosal melanoma chi hrang hrang awm mahse, chi hrang hrang hi enkawl hnuah a lo kir leh thei tlangpui. I dinhmun a zirin i doctor chuan i hriselna zawng zawng enfiah tur leh a lo lang leh leh tawh loh enfiah turin checkup mumal tak a ruahman ang. Heng appointment-ah hian beat khat pawh hloh lova tel a pawimawh hle.

Doctor hnenah eng zawhna nge ka zawh ang?

Doctor i zawh theih tur zawhna thenkhat chu hetiang hi a ni:

• Eng ang mucosal melanoma nge ka neih?
• Ka natna hi eng stage nge ni?
• Eng enkawlna kawng nge ka neih?
• Engtin nge enkawl danin min nghawng ang? (Side effects ang chi thil)
• Ka natna hi eng prognosis nge ni?

Take-Home Thuchah a ni

Okay, chuvangin kan sawiho atang khan Mucosal Melanoma chungchangah hian ngaihdan i neih ka beisei. Hrereng:

• Hei hi cancer chi khat, kan taksa chhunga mucous membrane-a lo awm thin a ni.
• Symptoms hi awlsam taka hmuh loh theih a ni a, natna tlanglawn dang nen pawh a inang thei bawk. Chuvangin, i hmuiah, hnar-ah, i hmuiah emaw, i hnuteah emaw, natna lan chhuah dan danglam, awm reng i neih chuan doctor thurawn la rawh .
• Vawi tam tak chu hriat chhuah hma pawhin a darh tawh mai thei .
• Enkawlna atan chuan specialist medical team puihna a ngai a ni .
• Hun rei tak chhunga damdawi lam enkawlna a pawimawh a, natna hi a lo lang leh thei a ni .

He thu hi i tan a tangkai ngei kan beisei. Hetiang natna chi hi hriat chian chuan a tul chuan hma la thuai turin a pui ang che. I hriselna hi uluk reng ang che!

` Mucosal Melanoma, Cancer, Melanoma, Mucosal Cancer, Cancer Symptoms, Cancer Enkawlna, Cancer Rare