Cancer a vei tih hmuhchhuah a nih huna hlauhna leh lungkhamna a neih hi thumal hmanga sawi a harsa hle. Mahse damdawi lam thiamna a lo thang chho zel a, tunlai hian cancer enkawlna kawng changkang tak tak leh hlawhtling tak tak a awm ta. Tun hma ang lo takin tunah chuan cancer cell chauh target leh attack thei enkawlna bik a awm ta. Vawiin hian colorectal cancer enkawlna atana hmanraw pawimawh tak kan sawi dawn a ni. Chu chu Monoclonal Antibody Therapy a ni.
Heng Monoclonal Antibodies te hi engte nge ni?
Hei hi kan hriatthiam hma hian kan taksa ngeiin a natural defence system hi han thlir ila. Pawn lam atanga rawn lut, hrik emaw, virus emaw ang chi, kan taksaah a luh chuan kan taksa hriselna (immune system) hian protein bik a siam a, chu chu zawng chhuakin a tichhia a ni. Hengte hi antibody kan ti a. Sipaiin ram pakhat a humhalh ang mai a ni.
Tunah chuan he sipai hian "special forces team" a nei a, chu chu a bik taka training nei, target pakhat chauh beih dan thiam tak a ni tih han ngaihtuah teh. Monoclonal Antibodies hi chutiang thil chu a ni. Hengte hi laboratory-a artificial-a siam antibodies bik an ni. Target pakhat zawng chhuak tur, attach tur leh tihchhiat vek tura duan an ni. Chutiang a nih chuan chu target chu cancer cell a ni.
He treatment thatna lian ber chu a precision hi a ni . Traditional chemotherapy hi bomb ang mai a ni. Cancer cell a tihlum rualin kan taksaa cell hrisel te pawh a tichhe thei bawk. Chuvangin chemotherapy hian sam tlakchham leh hahna ang chi side effect a thlen thin. Mahse Monoclonal Antibody enkawlna hi "guided missile" ang mai a ni. Cancer cell-ah a kal nghal a ni. Chuvangin side effect tlem zawk i beisei thei.
Cancer "lifeline" titawp thei damdawi
Cancer chu cell bunch khat mai a ni lo. Factory tlemte ang mai a ni. A lo thanglian theih nan, a lian zawk theih nan nourishment a mamawh a ni. He chaw tha hi dawng tur hian cancer cell te hian anmahni tan thisen kalna kawng thar an siam thin. Damdawi lamah chuan he thil hi angiogenesis tiin kan sawi thin. Heng thisen kalna kawngte hmang hian cancer hian a dam khawchhuahna atana a mamawh ei tur a hmu thin.
Chuvangin, monoclonal antibodies thenkhatin an tih chu chu thisen kalna kawng siam chu a titawp a ni. Cancer tana fuel "supply" tihtawp ang mai a ni. He class-a damdawi lian ber chu Bevacizumab (Avastin) a ni.
Avastin hian engtin nge hna a thawh?
Cancer cells te hian signal bik Vascular Endothelial Growth Factor (VEGF) tih chu an tichhuak thin. He signal kan dawn hian taksain thisen kalna kawng thar a siam tan ta a ni. Damdawi Avastin hian chu VEGF signal chu block in hna a thawk a ni. Hei hian cancer hian thisen kalna kawng thar a siam loh nan a veng a ni. Tichuan, chaw ei loh chuan cancer chu a lo thang chak lo emaw, a tawp emaw a ni.
Avastin hi colon cancer, taksa peng dang a darh (metastasized) tawh enkawlna pawm a ni. Cancer hi a tidam kim lo nain, zirchianna atanga a lan dan chuan Avastin hi chemotherapy nena pek a nih chuan damlo dam rei zawng chu thla nga velin a tipung a ni.
He class-a damdawi thar zawk thenkhat chu `Fruquintinib (Fruzaqla), `ramucirumab (Cyramza)` leh `ziv-aflibercept (Zaltrap) te an ni.` Hengte hian VEGF signaling system tibuaituin hna an thawk bawk.
Avastin pek dan leh a side effects te
Avastin hi damdawi hi thisen zam emaw IV emawa pek thin a ni. Chemotherapy nen kar hnih atanga kar thum danah pek thin a ni. Hriat reng tur pawimawh tak chu he damdawi hian chemotherapy nghawng a tichak a, mahse colon cancer vei damlote tan a chauh pek a nih chuan a that tawk lo tih hmuhchhuah a ni.
He enkawlna i tan hma leh a enkawl lai hian i doctor nen inhawng taka inbiakna neih a pawimawh hle.
| Bevacizumab (Avastin) hian a nghawng tha lo awm thei | |
|---|---|
| Common side effects hmuh tur awm fo thin | |
| Chau leh nunna nei lo anga inhriatna | Lu na |
| Thisen sang a sang | Chaw chakna |
| Diarrhea (ril a na) . | |
| Side effect na tak tak, doctor hnena hriattir nghal tur | |
| Colon perforation (zai a ngai mai thei) . | Kidney a chhiat bakah zun a protein a pung bawk |
| Lung natna emaw, rilru natna emaw | Hliam damna a tlahniam (chuvangin operation zawh veleh hman nghal loh tur a ni) . |
| Thisen chhuah tam lutuk emaw, thisen zam harsatna emaw | |
Cancer cell-a "growth switch" titawp thei damdawi
Monoclonal antibody chi dang kan sawi dawn nia. Hengte hi a hmaa kan sawi tawh ang khan a thawk lo. Heng damdawi te hian cancer cell chunglama protein bik pakhat chu direct-in an target a ni. A hming chu Epidermal Growth Factor Receptor (EGFR) tih a ni.
A awlsam zawngin sawi ila, he EGFR hi "switch" ang mai a ni a, chu chuan cancer cell chu "grow, grow" turin a hrilh a ni. Colon cancer zinga 75% vel chuan he EGFR protein hi an nei a ni.
Damdawi cetuximab (Erbitux) leh panitumumab (Vectibix) te hian chu "switch" EGFR an tih chu attached a, off in hna an thawk a ni. Hei hian cell te lo thanglian tura hrilhtu natural signal chu switch nena inzawm lo turin a veng a ni. Chuvang chuan cancer cell te chu an lo thang lian tawh lo.
Erbitux leh Vectibix hi tute tan nge hman?
Heng damdawi pahnih hi colon cancer, taksa peng dang a darh (metastasized) tan phalsak a ni. Mahse thil pawimawh tak pakhat a awm . He enkawlna hi i tan hmain i cancer cells te chu special genetic test (`genetic mutation test`) i neih a ngai a ni. Chu test chuan heng damdawi te hian i cancer tan hna a thawk dawn em tih a tichiang a ni. Hei hi mi zawng zawng tan a inhmeh lo.
Erbitux hi kar khatah vawi khat thisenah pek thin a ni. Amah chauh emaw, chemotherapy damdawi irinotecan (Camptosar) nen emaw pek a ni. Vectibix hi kar hnih danah pek thin a ni a, a tlangpuiin chemotherapy damdawi dang engemaw zat nen pek thin a ni.
| Erbitux leh Vectibix te hian side effect a neih theih dan | |
|---|---|
| Vun lama harsatna: hmai vun ang chi blister, vun rawng, vun vawt. (Hriat reng tur chu, a chang chuan heng vun natna te hi damdawi hian cancer dona kawngah hna a thawk tih hriattirna a ni thei!) | Khawsik |
| Chau leh nunna nei lo anga inhriatna | Ek khal |
| Pum natna | Allergic reaction hrang hrang, thawk harsatna leh thisen sang hniam te |
| Damdawi taksaa pek a nih huna thil thleng (reactions) te | |
Heng enkawlna zawng zawng hi a chiang hle. I doctor chauh hian cancer chi leh i hriselna a zirin i tana enkawlna tha ber tur a ruat thei a ni. Internet-a i thil chhiar emaw, mi dangin a sawi emaw a\angin thutlukna siam suh.
Take-Home Thuchah a ni
- Monoclonal Antibody hi laboratory-a siam specialized treatment a ni a, cancer cell chauh target leh attack a ni.
- Hengte hian hnathawh dan hrang hrang a awm a. Damdawi ṭhenkhat chuan cancer-a thisen kalna chu a tikhawlo a, ṭhenkhat erawh chuan cancer cell-te’n an ṭhan theihna tura signal an pek chhuah chu a titawp thung.
- Heng enkawlnate hi mi zawng zawng tan a inang vek lo. Damdawi thenkhat pek hmain i cancer tan damdawi hian hna a thawk dawn em tih hriat nan special genetic test i neih a ngai mai thei.
- Damdawi zawng zawng ang bawkin he damdawi hian side effect a nei a. Hlau suh la, enkawl tan hmain doctor nen chiang takin sawi rawh.
- I cancer enkawlna chungchangah hian i enkawltu doctor chauhvin thurawn leh kaihhruaina tha ber ber a pe thei che a, chuvangin an thupek zawm a pawimawh hle.
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