POEMS Syndrome hi eng nge ni? Hemi chungchang pawh i hriat duh em?

POEMS Syndrome tih hi i hre tawh em? Hei hi thil awm lo tak, hriat tur awm lo tak a ni. Amaherawhchu, a chanchin tlem tal hriat a pawimawh a, a chhan chu vawi khatah kan taksaa system tam tak a nghawng thei a ni. A awlsam zawngin kan thisen nena inzawm dinhmun khirh tak a ni. Vawiin hian POEMS Syndrome hi eng nge a nih, a natna lan chhuah dan te, engtin nge a hriat theih tih te, a enkawl dan tur a awm em tih te kan sawi dawn a ni.

POEMS Syndrome hi eng nge ni tak tak?

Awle, POEMS Syndrome hi eng nge a nih i en ang u. Hei hi thisen natna hmuh tur awm lo tak a ni. Kan taksaah hian thisen cell chi khat plasma cell an tih kan nei a. POEMS syndrome a lo awm hian heng plasma cell te hi a danglamin, thunun theih lohvin an inthen darh a, an pung chho thin. Heng plasma cell pangngai lote hian kan thisenah protein bik an chhuah chhuak thin. Monoclonal protein an ti a, a tawi zawngin M-protein an ti bawk. Tunah chuan i ngaihtuah thei tawh ang, a dik em? Heng plasma cell pangngai lo, M-protein te hi thisenah an pung lutuk chuan kan nerve leh chhungril peng te a tichhe thei a ni.

POEMS tih hming hi he natna lan chhuahna lian ber panga zinga hawrawp hmasa ber atanga lak a ni a:

• P - Polyneuropathy: Hei hian taksa pum puia nerve tihchhiatna a kawk a ni. POEMS-ah chuan he chhiatna hian i ke, i kut, kephah leh i kut ah natna emaw, thil dang nuam lo tak tak (tingling, burning, etc.) a thlen thei a ni.
• O - Organomegaly: Chumi awmzia chu chhungril taksa pengte chu a pangngai lo takin a lian tihna a ni. POEMS vei chuan taksa peng lian tak tak, liver, spleen, leh lymph nodes te a nei thei.
• E - Endocrinopathy: A awlsam zawngin sawi ila, hei hi hormone lama harsatna a ni. POEMS-ah chuan kan endocrine glands atanga hormone chhuah zat hi a danglam thei hle. Hormone thenkhat chu a tam lutuk emaw, a tlem emaw pawh a chhuak thei.
• M - Monoclonal protein (M-protein): Hei hi POEMS-a thisena protein bik awmkhawm a ni. Plasma cell pakhatin a copy (clone) tam tak a siam chuan, chu cell tin chuan he M-protein hi thisenah an dah tel a ni. A tawpah chuan thisena M-protein awm zat chu nasa takin a pung ta a ni.
• S - Vun inthlak danglam: POEMS vei te hian vun inthlak danglamna chi hrang hrang an nei thei a, chu chu vun a dum leh vun a thim a ni.

POEMS syndrome hi osteosclerotic myeloma , Crow-Fukase syndrome , PEP syndrome leh Takatsuki syndrome tia hriat a ni bawk .

Tute nge POEMS syndrome vei tam ber?

POEMS syndrome hi a awm lo hle a, a natna hi a awm lo hle. Khawvel puma mi tlemte chauh a nghawng a ni. Kum 50 leh 60 inkarah hmuh tur a tam ber a, mipa leh hmeichhia a nghawng thei a, mahse mipaah ​​a tam zawk niin a lang.

POEMS syndrome natna lan chhuah dan chu engte nge ni?

A hmaa kan sawi tawh ang khan POEMS tih hminga hawrawpte hian a lan chhuahna bulpui thenkhat a tarlang a ni. Chu chu Polyneuropathy, Organomegaly, Endocrinopathy, M-protein elevation, leh vun inthlak danglamna te hi a lan chhuahna ber a ni. POEMS vei zawng zawng deuhthaw hian polyneuropathy leh M-protein elevation an nei vek a. Symptom dangte chu mi hrang hrangah a inang lo thei.

Polyneuropathy avanga natna lan chhuah dan

He nerve chhiatna avanga symptoms awm hi POEMS-ah hian a tam ber a ni. A tam zawkah chuan ke leh keah a na ber. Mahse a chang chuan kut leh kut a nghawng thei. Hetiang natna i neih hian i rilru put hmang chu hetiang hi a ni:

• Chaklohna
• Tingling a ni
• Numbness a awm
• Prickling / Pins-and-needles tih hriatna
• Burning sensation a awm

Organomegaly - chhungril taksa peng lian zawk

Doctor-te’n imaging procedure an tih hian heng taksa peng hrang hrangte hi a lian em tih hriat theih a ni:

• Liver (Thin - `(Hepatomegaly)`) tih a ni.
• Spleen (Splenomegaly) tih hi a awm lo.
• Lymph nodes (Lymph nodes - `(Lymphadenopathy)`) te hi a tha hle a, a rilru a buai em em bawk a.

Endocrinopathy - hormone lama harsatna nei

POEMS nena lo awm hormonal problem ber chu sex hormone level tlahniam hi a ni. Heng sex hormone te hi mipaah ​​``Testosterone`` an ti a, hmeichhiaah chuan ``Estrogen`` an ti bawk. Chu bakah, symptoms te pawh i hmu thei bawk:

• Thisen sugar level control-na lama harsatna (e.g. zunthlum) .
• Thyroid lama harsatna (e.g. Hypothyroidism) .
• Addison natna (Adrenal insufficiency - `(Addison natna)`) a ni.

Mipa chuan nau neih chakna tlahniam leh hnute lian (Gynecomastia) an nei thei.

Hmeichhia tan chuan , thlasik hun a tawp thei (`(Amenorrhea)`), hnute a lian thei. Naupai lai hian bawnghnute siamna atana puitu hormone `(Prolactin)` hi a tam lutuk thei. Chuvangin naupai lo pawh nise, hnute atanga hnute tui a leak theih a ni.

M-Protein a tipung

POEMS thil langsar tak chu thisenah M-protein level sang tak a ni. Hetianga M-protein tam lutuk hian thisenah tumor a siam thei a ni. Tin, M-protein level sang tak avang hian iRuh chu a thim thei a, a nghet thei bawk (osteosclerosis) .

Vun a inthlak danglam thin

Vun inthlak danglamna chi hrang hrang a awm thei a, chungte chu:

• Vun dum zawk
• Vun thick zawk
• Kut zungtang dum
• I hmai leh kea sam sei tam
• Chhung vunah cherry te tak te ang maia thisen kalna kawng a lo thang lian

Symptom dang a awm bawk

Hei bakah hian symptom dang pawh hmuh tur a awm thei:

• Kut leh ke a hring chhuak
• Chhan awm lovin taksa rihna tihtlem
• Ruh leh ruhkawr natna
• Mit lama harsatna nei
• Thâwk harsa
• Chau
• Khawsik

POEMS syndrome vei thenkhat chuan Castleman Disease (CD) an tih pawh an nei thei a, chu chuan lymph nodes a tichhe thei a ni. Castleman Disease symptom i neih chuan i doctor pawhin POEMS a ringhlel thei bawk.

Eng thilin nge POEMS syndrome hi a thlen?

POEMS i neih hian monoclonal plasma cell disorder vangin symptom leh effect hrang hrang i nei thin . A awlsam zawngin, plasma cell pangngai lo chuan a copy tam lutuk a siam a ni. Heng cell te hi a tam poh leh tissue te a tichhia thei a ni. Heng cell te hian thisenah M-protein an dah belh a, chu chuan thisena M-protein awm zat a tisang a ni. Heng cell tam lutuk leh M-protein te hian taksa chhunga system hrang hrang a tichhe thin.

Mahse, scientist-te chuan engvangin nge heng plasma cell-te hi a tir lamah chuan a pangngai lo taka an than chhoh tan tih chiang takin an la hre lo.

Zirchiangtute chuan protein pakhat Vascular Endothelial Growth Factor (VEGF) an tih chu a inrawlh thei tih an hmuchhuak a. POEMS syndrome vei tam zawk hian an thisenah VEGF a sang hle. VEGF leh POEMS syndrome inzawmna chungchanga zirchianna chu kalpui mek a ni.

Engtin nge POEMS syndrome hi hriat theih? (Diagnosis) tih a ni.

I doctor chuan i medical history leh tuna i symptoms te a zawt hmasa ang che. Tichuan, taksa enfiahna an nei ang a, POEMS syndrome chhinchhiahna an neih leh neih loh an enfiah ang.

Chu bakah, doctor chuan test engemaw zat a ti thei bawk a, chungte chu:

• Thisen leh zun test: Heng test te hian i thisen emaw zun emaw ah M-protein emaw VEGF level sang tak a awm leh awm loh enfiah nan a pui thei a ni. Thisen cell count pangngai lo emaw, thisen cell pangngai lo anga lang emaw pawh an enfiah thei bawk. Hengte hi POEMS chhinchhiahna a ni thei.
• Imaging test: X-ray leh CT scan ang chi test te hian i ruh te chu a thim emaw, a nghet em tih emaw a hriat theih. Heng inthlak danglamna te hi M-protein level a san chuan a thleng thei a ni.
• Bone marrow biopsy: Hei hian i ruhroah plasma cell pangngai lo ang maia lang i neih leh neih loh a hriat theih a, plasma cell a tam lutuk em tih emaw a hriat theih bawk.
• Electromyogram (EMG): EMG hi nerve hnathawh dan tehna test a ni. I doctor chu polyneuropathy a hriat theih nan a pui thei a ni.

I natna lan chhuah dan azirin i doctor chuan test dang, thawk test, echocardiogram, emaw endocrine test te pawh a ti thei bawk.

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) tih natna i vei tih hmuhchhuah i nih chuan i doctor pawhin POEMS syndrome i neih leh neih loh a test thei bawk.

POEMS syndrome hi engtin nge enkawl emaw, enkawl emaw a nih?

POEMS syndrome hi damdawi a la awm lo. Mahse, enkawlna hian symptoms control leh management a pui thei a ni. Enkawlna kawng hrang hrangte chu:

• Radiation therapy: Hei hian plasma cell pangngai lote chu tihchhiat tumin radiation sang tak direct a ni.
• Chemotherapy: Cancer dona damdawi, ``Chemotherapy'' tia hriat bawk hi plasma cell pangngai lote tihlum emaw, tihkhawtlai emaw nan hman a ni. POEMS enkawlna atana chemotherapy hi multiple myeloma enkawlna nen a inang a ni. Heng enkawlnate hi a hlawk hle a, a tam zawkah chuan side effect na tak a thlen lo.
• Autologous stem cell transplant: Hetiang tih dan hian i plasma cell pangngai lo chu stem cell hrisel tak takin a thlak a ni. Stem cells chu plasma cell ang maia cell puitlingah a lo thang lian thin a ni. He transplant-ah hian i doctor chuan i taksa atanga stem cell hrisel thenkhat a la chhuak hmasa thin. Tichuan, chemotherapy emaw, radiation therapy emaw hmangin plasma cell pangngai lo chu an tichhia a ni. Enkawl zawhah stem cells lakchhuah te chu i taksaah dah leh a ni. Chumi hnuah chuan plasma cell hrisel takah an lo thang lian ta a ni.
• Physical therapy: Polyneuropathy avanga kea kal harsatna i neih chuan he enkawlna hian a pui thei ang.

Hei bakah hian doctor chuan natna lanchhuahna tihziaawmna tur steroid leh natna hrik tihziaawmna tur diuretics (tui pill) ang chi damdawi a pe thei bawk.

POEMS syndrome avanga harsatna awmte chu engte nge ni?

POEMS syndrome nen hian hun kal zelah nerve chhiatna leh chak lohna a pung thei a ni. Tin, kal kual a harsat phah thei bawk. Lung bulah emaw, rilru chhungah emaw tui tam lutuk a awm chuan rilru na a thlen thei a, thawk harsa a ti thei bawk.

Mahse, hre reng ang che, .Hlawhtling taka enkawl chuan nerve chhiatna a titawp thei a, a tikhawtlai thei bawk. Symptom dang tihziaawmna atan pawh a pui thei bawk. Nerve chhiatna pawh hi hun kal zelah zawi zawiin a dam thei.

POEMS syndrome vei theihna tur risk factor a awm em?

Tunah hian POEMS syndrome vei theihna tur risk factors hriatchhuah a la ni lo.

POEMS syndrome hi ven theih a ni em?

Vanduaithlak takin POEMS syndrome hi ven theih a ni lo.

POEMS syndrome vei te hian eng prognosis nge an neih?

I hriselna chu thil tam takah a innghat a, chung zingah chuan i taksa peng engte nge a nghawng tih te, natna hi engtiang chiahin nge a hriat chhuah a, enkawl tan a nih dan te, leh enkawlna i dawn danah te a innghat a ni.

POEMS enkawlna lak a pawimawh hle. POEMS syndrome hi enkawl loh chuan nunna atana hlauhawm tak a ni thei. Kawng lehlamah chuan, plasma cell pangngai lo tichhe thei enkawlna hlawhtling tak takte chuan dam rei zawkah a pui thei che a ni. Tin, enkawlna hian natna lan chhuah dan a tiziaawm thei a, i nunphung a ti tha thei bawk.

POEMS vei tam zawkte dam rei zawng chu kum 14 vel a ni. Chumi awmzia chu mi a chanve vel chu kum 14 hnuai lam an dam a, a chanve dang erawh chu an dam rei zawk tihna a ni. I dam rei zawng chu natna bik i tawn leh enkawl danah a innghat a ni.

POEMS syndrome vei mi i nih angin i hmalam hun tur chu i doctor hnenah zawt la.

POEMS syndrome chungchangah hian engtikah nge doctor i hmuh ang?

POEMS syndrome nena inzawm symptoms i neih chuan, a bik takin kut leh kea chak lohna , doctor pan nghal rawh.

POEMS syndrome chungchangah hian ka doctor hnenah eng zawhna nge ka zawh tur?

Hetiang zawhna hi i zawt thei ang:

• Ka dinhmun hi engtiang chiahin nge a nasat?
• Eng enkawlna kawng nge ka neih?
• Side effects tih tlem emaw, enkawl emaw turin eng nge ka tih ang?
• Eng support service nge ka tan a awm?
• Ka enkawlna kaihruai turin plasma cell disorder lama tui doctor ka pan a ngai em?

POEMS syndrome ka neih chuan engtikah nge ka hnathawh pangngaiah ka kir leh theih ang?

POEMS syndrome hian nitin hna i thawh theihna a nghawng thei a ni. I doctor chuan he natna hian i nitin nun a nghawng dan tur a hrilhfiah ang che.

POEMS syndrome hi autoimmune natna a ni em?

POEMS hi paraneoplastic syndrome a ni a.Autoimmune natna a ni lo. Paraneoplastic syndrome chu damdawi lam dinhmun hnuaia awm avanga symptoms awmkhawmna a ni. POEMS-ah chuan buaina bulpui ber chu plasma cell pangngai lote hian thisenah M-protein an siam tam lutuk (monoclonal plasma cell disorder) hi a ni. POEMS natna lan chhuah dan hi plasma cell pangngai lo leh M-protein-in taksa tissue a tihchhiat vang a ni.

POEMS syndrome hi multiple myeloma nen a inang em?

Multiple myeloma hi cancer natna a ni a, plasma cells a nghawng a ni. POEMS syndrome hi plasma cell pangngai lo leh M-protein tihpun avanga symptoms awmkhawm a ni. POEMS syndrome dam rei zawng hi multiple myeloma dam rei zawng aiin a tha zawk.

Mahse, POEMS leh multiple myeloma enkawlna chemotherapy hi a inang tlangpui. A lan chhuah dan thenkhat pawh a inang thei bawk.

POEMS syndrome hi hriat chian a harsa hle. I doctor-in i symptoms hi POEMS syndrome vang a ni tih hriat nan hun engemaw chen a la ngai thei a, condition dang vang a ni lo. I natna hmuhchhuah a nih hnuah, i damdawi lam team te nen thawk hovin, eng enkawlna nge i natna lan chhuah dan atanga hahdamna tam ber pe thei ang tih hriat rawh. I doctor hnenah POEMS syndrome ang chi diagnosis buaipuitu mimal leh chhungkaw tanpuitu pawl emaw, support group emaw chungchang zawt rawh.

Take-Home Thuchah a ni

Okay, chuvang chuan vawiin hian POEMS Syndrome chungchang kan sawi nasa hle. A pawimawh ber chu hei hi thil awm lo tak, mahse pawi tak a ni tih hriatthiam hi a ni . Kan taksaa system tam tak a nghawng thei a ni.

• POEMS tih hming hi English hminga a letter hmasa ber atanga lak a ni a, symptom lian panga (nervous disorders, internal organs lian tham, hormone lama harsatna, M-protein pung, leh vun inthlak danglamna) te hi a ni.
• Hei hi a chhan ber chu plasma cell pangngai lo leh an siam chhuah M-protein a ni.
• Damdawi famkim awm lo mah se, natna lan chhuah dan control leh nunphung tihchangtlunna tur enkawlna tha tak tak a awm.
• Natna hi hriatchhuah hmasak a pawimawh hle a .

Heng symptoms te hi i neih chuan doctor rawn la. Hlauthawng suh, thu dik leh damdawi lam puihna i neih chuan he dinhmun hi i tuar thei ang.

` POEMS syndrome, thisen natna, nerve chhiatna, hormone lama harsatna, M-protein, vun inthlak danglam, plasma cells