Heng lumps te hi eng nge ni? Rosai-Dorfman Disease chungchang hi i zir dawn teh ang!

Kan taksaa inthlak danglamna kan hmuh hian tlem a hlauhthawn hi thil pangngai a ni lawm ni? A bîk takin kan kawr, kan kawr, a nih loh leh kan kawchhungah hnim hring te te kan hmu a nih chuan, ‘Hei hi eng nge ni?’ tiin kan ngaihtuah thin. Vawiin hian hetiang lumps thlen thei dinhmun tlemte kan sawi dawn a, mahse mi tam takin an hre lo. Hei hi Rosai-Dorfman Disease an ti a.

Ross-Dorffman natna (RDD) hi eng nge a nih i hria em?

A awlsam zawngin kan taksa hian thisen var chi khat histiocytes , a nei a. Hengte hi kan taksaa police officer-te ang, natna thlentu hrik dotu an ni a, kan taksa hriselna atana pawimawh tak an ni. Mahse, heng histiocyte te hi an lo thang lian lutuk chuan Ross-Dorffmann disease (RDD) an ti a. Hei hi a takah chuan cancer (benign) , taksa peng khat atanga hmun danga darh thei natna hlauhawm a ni lo tihna a ni. Amaherawhchu, heng cell-te hi a tam lutuk hian an pungkhawm chuan lungawi lohna leh symptoms kan nei thei a ni.

A tam zawkah chuan heng histiocyte tam lutuk hi kan kawr chhunga lymph node-ah an pung khawm thin. Tichuan, an kawrfual (lump) ang maiin an lo hring chhuak ta a ni. Doctor-te chuan he hnah hring (swelling of the nodes) hi `(lymphadenopathy) an ti \hin.Mahse, kawr chauh ni lovin, taksa peng danga node-te pawh a nghawng thei a ni. A chang chuan node bakah hian heng cell te hi taksa peng dang (extranodal sites) ah pawh an awm khawm thei bawk.

He natna hi `sinus histiocytosis with massive lymphadenopathy` an ti bawk. Hei hi natna hmuh tur awm lo tak a ni a, `non-Langerhans cell histiocytosis` group-ah a tel a ni.

Ross-Dorffmann natna (RDD) chi hrang hrangte chu engte nge ni?

He natna hian mi zawng zawng a nghawng dan inang vek lo. Mi thenkhatin hmun khatah swelling an nei a, thenkhat erawh chuan hmun engemaw zatah swelling an nei thei bawk. Tin, heng histiocytes te hi lumps ah chauh ni lovin taksa hmun dangah pawh an pung khawm thei bawk. Hei hi classified dan a ni.

• Classic (Nodal) Ross-Dorffmann Disease (Classic/Nodal RDD): Hei hi a tam ber chi a ni. A bik takin kawr chhunga node awmte a hring (swelling) a ni. Mahse, node engzat nge a nghawng tih a zirin symptoms a inang lo thei.
• Extranodal RDD: Hetiang chi ah hian heng histiocyte te hi lymph node ni lo tissue dang ah an pung khawm thin. Vun hi a nghawng tam ber a ni. Hei hi cutaneous RDD (CRDD) an ti a. Chu bakah, he natna hian kan sinus, mit leh mitmeng, ruh, leh central nervous system (CNS) – chu chu thluak leh ruhro a nghawng thei bawk. A chang chuan thawkna lam leh chaw kawng lam pawh a nghawng thei bawk.

RDD vei zinga 40% vel chuan heng histiocyte cells te hi taksa hmun dangah an khawlkhawm thei a, chubakah chuan i sawi ang khan warts te pawh an nei thei bawk.

He natna hi tuin nge vei tam ber?

Ross-Dorffmann natna hian naupang, tleirawl, leh puitling naupangte a nghawng ber a ni . Kum 20 hnuai lam atanga hmuhchhuah a ni tlangpui. Amaherawhchu, kum 70 vela upa te pawhin he natna hi an vei nia hriat a ni.

RDD, testicles tichhe thei hi African hnam chhuak mipaah ​​a tam zawk. Mahse a hmaa kan sawi tawh angin vun natna ``CRDD`` hi Asian hnam chhuak hmeichhiaah a tam zawk. ``CRDD`` hi kum 20, 30, leh 40 inkar te zingah a tam ber.

Ross-Dorfman natna hi engtiang chiahin nge a tlem?

Hei hi natna hmuh tur awm lo tak a ni . Mi sang hnih zinga pakhat velin a nghawng a ni. Entîr nân, United States-ah chuan kum tin hri kai thar 100 vêl an awm a. Chumi awmzia chu Sri Lanka-ah chuan a tlem zawk tihna a ni.

Rose-Dorfman disease (RDD) natna lan chhuah dante chu engte nge ni?

I natna lan chhuah dan chu i taksaah hian khawiah nge histiocyte tam lutuk chu a awm khawm tih a innghat ang. I kawr chhunga lymph node chauh a nghawng chuan i natna lan chhuah dan chu a na lo emaw, a awm lo emaw pawh a ni thei. Mahse, heng cell te hi an pungkhawm a, taksa peng pakhat hnathawh a tibuai a nih chuan i natna lan chhuah dan chu a na zual thei a ni.

Classic (nodal) natna lan chhuah dan

Histiocytes hi kawr tissue-ah a awm khawm fo thin. Chuvangin, a lan chhuah dan tlangpui chu kawr sir lehlamah natna nei lo, hring dup lo lang hi a ni . A châng chuan khawsik emaw, flu emaw i neih laiin i kawngah hnah te tak te i lo awm ṭhin tih i hre reng mai thei, a dik em? Chu chu a dik a, mahse a hrehawm lo mai thei. Mahse, a natna hmun a zirin a hring chu hmun dangah pawh a awm thei bawk.

Histiocytes pung zel avanga inflammation awm thei ber berte chu:

• I kawr chu
• Groin area a ni
• Armpits a awm
• A rilru chhungril (mediastinum) .

Swelling tih loh chu symptom dang i nei lo thei a, a nih loh leh:

• Khawsik
• Vun dum (pale skin) a ni
• Chauhna nasa tak a awm
• Zan a thawk hah
• Hnar luang chhuak
• Sawifiah loha taksa rihna tlahniam

Extranodal symptoms a awm thei

Rose-Dorffmann natna (`CRDD`) hian vun a nghawng thei a, taksa khawi hmunah pawh a lang thei. Heng lumps te hi histiocyte cells inzawmkhawm atanga siam te hi an thang zawi zawi tlangpui. Vun a symptom hmuh theih te chu:

• Flat emaw raised emaw bumps a awm
• Pus-a khat emaw solid lumps emaw a awm
• Bumps sen, purple, red, emaw brown emaw a awm
• Vun zawng zawngah a darh thei a, hmun khatah chauh a darh thei bawk.

Heng histiocyte tam lutuk hian taksa peng emaw taksa system emaw a nghawng chuan symptom hrang hrang a awm thei a ni. Entirnan, RDD hian mit a nghawng chuan double vision a thlen thei a ni. Central nervous system a nghawng chuan seizures a thlen thei a ni. Lung a nghawng chuan khuh nghet tak a thlen thei a ni. Chutiang bawkin a natna hmun a zirin a natna lan chhuah dan pawh a inang lo.

Ross-Dorffman natna (RDD) hi eng nge thlen?

Scientist-te chuan he natna thlentu dik tak hi an la hre lo . RDD hian mi tin a nghawng dan a inang lo avangin a chhan hrang hrang a awm thei. Entirnan, tun hnaia zirchianna hrang hrangah chuan vun natna ``CRDD`` hi RDD pangngai thlentu thil inang lo thil dang vang a ni tih an sawi.

Tun hnaiah zirchiangtute chuan CRDD tih loh RDD chi dang dangah pawh gene mutation thenkhat hmuh tur a awm tih an hmuchhuak a. Heng mutations te hian cell te chu thunun theih lohvin a tipung thei a ni.

RDD vei tam tak chuan damdawi lam natna dang nen he natna hi an nei ve bawk. Chuvangin, chutiang dinhmun leh RDD inkarah hian inzawmna a awm thei. Hemi chungchangah hian zirchianna tam zawk neih a ngai a ni.

RDD hi a hnuaia dinhmunte nen hian a inzawm tih hmuhchhuah a ni:

• Viral infection: Entirnan, herpes, Epstein-Barr virus, cytomegalovirus, leh HIV infection te hi a ni.
• Cancer: Hodgkin lymphoma, non-Hodgkin lymphoma, leh vun cancer, cutaneous clear-cell sarcoma te a awm thei. (Mahse, RDD hi cancer a ni lo tih hre reng ang che.)
• Autoimmune natna: Lupus, Juvenile Idiopathic Arthritis, Autoimmune Hemolytic Anemia te a awm thei.

Ross-Dorffman natna (RDD) hi engtin nge an hriat theih?

I doctor chuan taksa enfiahna a nei hmasa ang a, i natna lan chhuah dan a zawt hmasa ang. RDD chhinchhiahna an zawng ang a, chu chu glands hring leh vun hring te hi a ni. RDD nena inzawm natna i neih leh neih loh en turin i medical history an zawt bawk ang.

Chu bakah, doctor chuan heng test te hi a ti thei bawk:

• Imaging procedures: Histiocytes awm nia rinhlelh tissue chi hrang hrang a zirin doctor chuan X-ray, ultrasound, MRI, CT, PET, PET/CT, emaw bone scan emaw a ti thei a ni. Hengte hmang hian taksa chhunga thil awmte chu kan hmu thei a ni.
• Thisen test: Thisen test eng emaw zat, complete blood count (CBC) leh comprehensive metabolic panel te hi taksaah eng inthlak danglamna nge thleng tih hriat theih a ni.
• Biopsy: Hei hi test pawimawh tak a ni.Hei hian tissue natna (e.g., lymph node hring) sample tlemte lak a, microscope hmanga cell te enfiah a, RDD characteristic an neih leh neih loh enfiah a ni. He biopsy hian natna dangin cell a tihpun dan pangngai lo a thlen em tih pawh a hriat theih bawk.

Ross-Dorffmann natna (RDD) hi engtin nge enkawl a nih?

A châng chuan RDD hi enkawlna engmah awm lovin spontaneous remission-ah a kal thei bawk . Chumi awmzia chu natna chu a mah chauhin a dam leh dawn tihna a ni. Amaherawhchu, a hun hman dan tur chu sawi lawk a har khawp mai. A dam theih nan thla tam tak emaw, kum tam tak emaw pawh a ngai thei. Mahse, a \henah chuan a mah chauhin a bo lo thei a, a lo let leh thei bawk. Enkawl loh chuan natna hi a na zual thei.

I enkawlna tur chu RDD-in a nghawng danah a innghat ang.

• Enfiahna: I nunah nghawng lian tak nei thei symptom i neih loh chuan i doctor chuan i dinhmun enfiah turin a rel mai thei. Hei hi "watchful waiting" approach nen a inang hle.
• Surgery: A lumps te hi surgery hmanga lakchhuah theih a ni. `CRDD` (cutaneous RDD) i neih chuan, emaw, lumps hian i thawkna kawng a tikhawlo emaw, i ruhro a nghawng emaw a nih chuan, operation tih theih a ni.
• Radiation therapy: Surgery hmanga histiocyte te lakchhuah theih loh chuan radiation therapy pek theih a ni. Hei hian machine hmanga targeted radiation beams chu cell-te lam hawia direct a, tihchhiat a huam a ni.
• Chemotherapy: Natna a nasat chuan, emaw, enkawlna dang, surgery ang chiah hian natna lan chhuahna a tlahniam lo a nih chuan, Chemotherapy hi ngaihtuah theih a ni. Hei hian cancer cell ang chi cell thang chak tak tak that thei damdawi hman a huam a ni.
• Corticosteroids: Corticosteroids, prednisone ang chi hian ruh natna a tiziaawm thei a, natna lanchhuahna a tiziaawm thei bawk. Hengte hi damdawi chi khat, inflammation tihziaawmna tur a ni.
• Immunotherapy: Heng enkawlnate hian nangmah ngeiin i immune system chu histiocyte cell tam lutuk zawng chhuakin a tichhe thei zawk a ni.

Ross-Dorffman natna (RDD) vei tan chuan hmalam hun eng nge ni ang?

I prognosis hi thil engemaw zat ah a innghat a ni. Cell a nghawng zat, i taksaah hian khawiah nge histiocyte tam lutuk awm tih te, enkawlna i dawn dan te. A tam zawkah chuan RDD hian a mah chauhin a resolve thin. Mahse, ṭhenkhatah chuan enkawl a ngai a, a nih loh leh harsatna lian tak a awm thei a ni.

A tlangpuiin, cell natna vei tlem poh leh a rah chhuah a tha zawk.. Extranodal RDD a awm a, chu chuan vun, rilru emaw, thawkna kawng chunglam emaw a nghawng a nih chuan a rah chhuah chu a tha zawk a ni. Mahse, histiocytes te hi thawkna kawng hnuai lam, kal emaw, thin emaw-ah a awm a nih chuan thil awmdan chu a chhe deuh thei a ni.

Doctor hnenah eng zawhna nge ka zawh ang?

Heng thilte hi i doctor nen sawi dun theihnghilh suh, i dinhmun hriatthiamna tha tak neih a pawimawh em em a ni:

• "Doctor, ka taksa peng eng chiah nge ka RDD natna hian a nghawng?"
• "Imaging test (scan ang chi) emaw thisen test emaw ka neih belh a ngai dawn em ni?"
• "Enkawlna ka mamawh em, a nih loh leh ka RDD dinhmun hi a mah chauhin a reh mai thei em?"
• "He RDD dinhmun hi engtiang chiahin nge ka ngaihtuah ang?"
• "Doctor in min rawn rawtna tha ber chu eng nge ni?"
• "Enkawl zawhah eng side effect nge ka beisei theih ang?"
• "Ka RDD condition hi enkawl hnuah a lo lang leh theihna chance engzat nge awm?"
• "Ka dinhmun enfiah turin engzat nge check-up neih ka mamawh?"

Ross-Dorffman natna (RDD) hi cancer a ni em?

Ni lo, hei hi mi tam takin an zawh thin zawhna a ni. Rose-Dorffman natna hi cancer (benign) a ni lo . Chu chu cancer (malignancy) angin taksa peng khat atanga hmun dangah a darh lo tihna a ni. Mahse, RDD avanga lumps lo awm hian taksa peng hrang hrang a nghawng thei a, an hnathawh a tibuai thei a, harsatna a thlen thei bawk. I RDD natna hian i taksa a nghawng dan leh i ngaihtuah tur em tih hriat nan i doctor hi a tha ber a ni.

Ross-Dorffman natna (RDD) hi tuin nge hmuchhuak?

Hei pawh hi hriat a tha khawp mai. Kum 1965 khan scientist pakhat Pierre Paul Louis Lucien Destombes chuan damlo pali zingah RDD symptoms a hmuchhuak a. Tichuan, kum 1969 khan scientist pahnih Juan Rosai leh Ronald Dorfman-a te chuan damlo pawl dang, natna lan chhuah dan inang tak takte chu an zirchiang leh a. Tunah chuan he natna hi Rosai-Dorfman natna tia hriat lar a ni ta a, an hming an inzawm khawm a ni. A tlem berah chuan Rosai-Dorfman-Destombes natna an ti bawk a, scientist pathumte chawimawina atan a ni.

A tawp berah chuan thil hriat reng tur (Take-Home Message) .

Ross-Dorffmann natna (RDD) hi a tlem em em a, mi tin a nghawng dan a inang lo em avangin hriatchhuah harsa tak a ni thei . RDD enkawlna tur kaihhruaina pakhat chauh a awm lo. Chuvangin i doctor nen zalen taka inbiakna neih a pawimawh a, i diagnosis hriatthiam a pawimawh a, i enkawl dan tur i hriat chian a pawimawh bawk.

Mild RDD i nei thei a, chu chu a mah chauhin a reh thei ang. A nih loh leh, enkawlna inzawmkhawm i mamawh mai thei bawk. I enkawl dan tur leh i result beisei chu i dinhmun ang zela siam dan tur i doctor zawt rawh.

Nangmah chauh i ni lo tih hre reng ang che . Chutiang natna hlauhawm tak kan hmachhawn hian damdawi lam thurawn zawm a, rilru lama chak taka awm reng a pawimawh hle. Zawhna emaw rinhlelhna emaw i neih chuan doctor nen sawiho rawh. Hlau suh, a chhan chu awareness hi chutiang thil do tur chuan ralthuam tha ber a ni.

` Rosai-Dorfman Disease, RDD, histiocytes, lymphadenopathy, kawng lum, vun natna, CRDD, natna rare, immune system