Ankylosing Spondylitis i nei em? TNF Inhibitors chungchang hi han sawi ila

I ni pawh hi hnungzang khauh tak leh zing i thawh hian na takin i tan thin em? I kal emaw, i che vel emaw a i ruhkawr atanga natna lo chhuak chu i chau tawh em? Chûngte chu ankylosing spondylitis , a tawi zawngin AS chhinchhiahna a ni thei. Hei hi hun rei tak chhunga inflammatory condition a ni a, ruh leh ruh dangteah a awm thin. Chuvangin he natna hi i neih chuan i doctor hian damdawi chi khat TNF Inhibitors tih chu a sawi tawh mai thei. Hemi chungchang hi vawiinah hian awlsam tak leh chiang takin sawi ila.

Engvangin nge AS ah hian joint a na? TNF chu eng nge ni?

Okay, hei hi a awlsam zawngin han sawi ila. Kan taksaah hian immune system kan nei vek a. Natna thlentu hrik dona hmanga min humhimtu a ni. Mahse AS ang dinhmunah chuan he immune system hi a overactive ta a ni. Guard pakhat, alert reng ang mai a ni.

Chutiang a nih chuan kan taksa hian protein bik Tumor Necrosis Factor, a nih loh leh TNF tih chu a siam chhuak tam tan ta a ni. He TNF protein hian kan ruhroah inflammation a siam a, chu chu inflammation, swelling, redness, leh pain tihna a ni. Hei vang hian i hnungzang leh i hip ang chi ruhte chu a nghet a, a hring a, a na bawk.

Chuti a nih chuan heng TNF Inhibitor te hi engte nge ni?

A awlsam zawngin sawi ila, TNF inhibitor hi damdawi chi khat a ni a, a hmaa kan sawi tawh TNF protein chu ‘block’ tu, inflammation thlentu a ni. Hengte hi natna tidamtu pangngai ang a ni lo. Painkiller hian natna hi rei lo te chhung chauh a titawp thin. Mahse TNF Inhibitor te hian chu aia thuk zawkin hna an thawk a ni.

Doctor-te chuan heng damdawi te hi ‘TNF blockers’, ‘biologics’, emaw ‘anti-TNF drugs’ an ti bawk. AS tan hian TNF inhibitor chi hrang hrang pawm a ni a:

• Adalimumab a awm bawk
• Certolizumab pegol a ni
• Etanercept tih a ni
• Golimumab a ni
• Infliximab a ni

I doctor chuan i natna lan chhuah dan chu painkiller (NSAID) hmanga control loh hunah he enkawlna hi a ngaihtuah tlangpui ang. TNF inhibitor zawng zawng hian mi zawng zawng tan hna an thawk vek lo. Damdawi pakhat hian mi thenkhat tan hna a thawk tha thei a, mi thenkhat tan erawh chuan a thawk tha lo. Chuvângin, i doctor chuan i tâna ṭha ber tûr an hmuh hma loh chuan damdawi chi hrang hrang a enchhin thei a ni.

Heng damdawi te hi engtin nge an hman?

There are two main ways to give this medication , chu chu damdawi chi hrang hrang i pek dan azirin a danglam ang.

1. Vun hnuaia injection angin (Injection) .

Damdawi thenkhat chu injection angin a lo thleng thin. A tha ber chu in lama i pek theih hi a ni. I doctor emaw, nurse trained emaw chuan dik taka pek dan tur a kawhhmuh ang che. I pum emaw i kekawr vunah emaw pek thin a ni tlangpui. A pawimawh ber chu injection site chu rotate a ni a, a vawi khatnaah a inang lo.

2. Vein chhunga saline solution pek ang chi (Intravenous Infusion) .

Damdawi Golimumab leh Infliximab te hi saline solution angin vein pakhatah an pe thin. Hei hian damdawi in emaw infusion center emaw pan a ngai a ni. He enkawlna hian darkar engemaw zat a daih thei. Doctor chuan darkar hnih vel damdawi chu a pe ang che a, darkar hnih dang chu allergy na tak i neih leh neih loh enfiah turin a enkawl leh ang che. A tir lamah chuan he damdawi hi kar hnih danah i ei a ngai mai thei a, mahse hun kal zelah he hun hi a tlahniam thei a ni.

TNF Inhibitors te hian eng hlawkna nge an neih?

Zirna hrang hrangah AS vei te hian he enkawlna atang hian hlawkna nasa tak an dawng tih hmuhchhuah a ni.

• A natna chu nasa takin a tlahniam a ni.
• Joint function leh flexibility a ti tha zawk.
• Zing lama ruh nghet leh hring ang chi symptoms te hi a tlahniam duh zawk.
• Spine leh ruh dangte vel inflammation a tihziaawm.
• Hun kal zelah ruh (joint) chhiatna awm reng chu a tikhawtlai.

Mi tam tak chuan damdawi vawi hnih emaw vawi thum emaw chauh an ei hnuah danglamna an hmu tan thin. Mahse, a chang chuan he damdawi hian a nghawng kimchang hmuh theih nan thla thum vel a ngai thei. Chuvang chuan a enkawl danah dawhthei taka kan awm a pawimawh.

Side effects pawh kan hre chiang hle.

Damdawi dang ang bawkin he damdawi hian side effect a nei thei bawk. Mahse, mi tam zawk chuan side effect tenau te chauh an nei thin. A pawimawh ber chu hei hi hriat chian a, harsatna i neih chuan doctor hriattir nghal tur a ni.

Heng damdawi te hian kan taksa chakna (immune system) hnathawh a tihtawp avangin natna hrik kan do theihna chu tlem a tlahniam thei a ni. Hei hian natna kai theihna a tipung deuh a ni .

Tuberculosis (TB) lo kir leh theihna a awm. Lungngai suh, he damdawi hi i tan hmain i doctor-in TB leh natna dang i neih leh neih loh a test ang che.

A hnuaia tarlan te hi side effects awm thei tlangpui te an ni.

A then phei chuan he damdawi hian vun cancer (non-melanoma skin cancer) vei theihna a tipung deuh thei a, chuvangin i doctor pawhin chu chu a hre chiang hle ang.

He damdawi hi tuin nge hmang lo tur?

TNF Inhibitor hi mi zawng zawng tan a tha lo. A hnuaia natnate hi i neih chuan i doctor chuan a pe lo thei ang:

• Nu hnute pe lai i nih chuan .
• Tunah hian active infection i nei a.Active infection a awm chuan.
• Lupus emaw multiple sclerosis emaw ang chi natna i neih tawh chuan .
• Cancer emaw precancerous cells emaw i neih chuan (hei hi kum 10 aia upa cancer vei, enkawl leh tihdam tawhteah chuan doctor thutlukna a zirin a danglam thei).
• Lung natna khirh tak i neih tawh chuan .

Naupai lai hian hengte hi hman theih a ni em?

Hei hi mi tam tak tan chuan zawhna pawimawh tak a ni. Zirchianna atanga a lan dan chuan heng damdawi tam zawk hi naupai laia hman a him a ni. Mahse, damdawi thenkhat, a bik takin naupai thla thum hnihna emaw, naupai lai hian nausen (placenta) chu naute hnenah a paltlang thei a ni.

Chuvangin naute i beisei a nih chuan i rheumatologist nen he thil hi sawipui ngei ang che. I tana tha ber damdawi, Certolizumab, nausen (placenta) paltlang lo ang chi chu a rawn rawt thei mai thei.