"Waldenström Macroglobulinemia" tih hi i hre tawh em? A ni lo mai thei. Hming sei tak, sawi harsa tak a ni lawm ni? Mahse, lungngai suh. Thisen cancer chi khat a awm lo hle a, mahse a awm fo hle. Vawiin hian he dinhmun hi i hriatthiam theih tur tawng awlsam tak hmangin kan sawi dawn a, chu chu i thianpa nena inbiakna ang chi hi a ni. Eng nge a nih tak tak te, a natna lan chhuah dan te, engtin nge a enkawl tih te i lo en ang u.
Waldenström Macroglobulinemia (WM) hi eng nge ni tak tak?
A awlsam zawngin sawi ila, hei hi i thisen tichhe thei cancer a ni. A dik tak chuan cancer pawl pakhat Lymphoma an tih zingah a tel a, non-Hodgkin lymphoma chi khat a ni. Lymphoplasmacytic lymphoma an ti bawk. A tlem hle. America ang ramah pawh hian mi maktaduai khat zinga mi pathum atanga pali chauh a nghawng a ni. Chuvangin a tlem zia chu i ngaihtuah thei ang.
Tunah chuan hei hi taksa chhungah engtin nge a lo insiam tih i en ang u.
Kan immune system-a cell chi hrang hrang pawimawh ber pakhat chu ``B cells`` an ti a, hengte hi kan ruhro (bone marrow)-ah hian siam chhuah a ni. Bone marrow hi kan ruh chhunga hmun pakhat, thisen cell siamna factory ang mai a ni tih i hria a.
Chuvangin, WM-ah chuan heng B cell hrisel tak takte hi cancer cell-ah an chang a, thunun theih lohvin an inthen darh a, an pung chho tan ta a ni. Heng cancer cells te hian ruhro an luah khat chuan kan thisen cell hrisel te chu an crowd out thin.
Chuvangin thisen cell chi thum a tihtlem theih a ni:
- Thisen sen (Red Blood Cells) tlahniam: Hei hi ``anemia'' an ti. Hei hian i chau hle a , nunna nei lo ang maiin i inhria .
- White Blood Cells tlahniam: Hei hi ``neutropenia`` an ti a.`` White blood cells hi kan taksaa sipai ang an ni. Heng cell te hian natna lakah min venghim a ni. Chuvangin heng cell te hi an tlahniam chuan infection a awm fo thei a ni .
- Platelets tlahniam: Hei hi `(thrombocytopenia) an ti a.` Hengte hi thisen zam tichhe theitu an ni. Hliam te tak te atanga thisen chhuah titawptu an ni. Chuvângin, platelet a tlem chuan hliam tê tê pawhin thisen a chhuah chu a titawp thei lo va, i taksaah hliam i nei thei a ni .
Tin, heng cancer cell te hian protein pangngai lo tak `(immunoglobulin M)` emaw `(IgM)` emaw an siam tam hle. He `(IgM)` protein hi thisenah a awm khawm chuan kan thisen hi a thim ta a ni. Tui ang ni tur thisen chu syrup angin a thim tih han ngaihtuah teh. Hei hi medical science-ah chuan `(hyperviscosity syndrome)` an ti a.
Hetianga thisen a thim hian kan taksa chhunga thisen kalna kawng te tak te, te tak te tak te zingah hian a kal harsa thin. Hei hian symptom na tak tak, luak chhuak leh hnar thisen chhuak te a thlen thei a ni.
WM hi damdawi a la awm lo. Amaherawhchu, a hluar em avangin , enkawlna tha tak a awm chuan a natna lanchhuahna te chu thunun theih a ni a, a chang chuan a bo vek thei bawk a, mite chu kum tam tak chhung chu dam takin an dam thei a ni.
WM natna lan chhuahna awm thei te chu engte nge ni?
Mak tak mai chu he natna vei mi pali zinga pakhat vel hian symptom an nei lo. Natna dang avanga doctor pan tura an kal hian test an neih laiin accident-in an hmuchhuak thin. Symptoms a lo lang tak tak a nih chuan zawi zawiin, zawi zawiin a lo lang thin.
Hetiang symptoms tlanglawn tak takte hi han thlir ila.
| Symptom a ni | A awlsam zawngin... |
|---|---|
| Chak lohna leh hah lutuk | Eng ang pawhin mut mah ila chau tih hriatna, thisen sen (red blood cells) tlakchhamna (anemia) avanga lo awm. |
| Chhan awm lova khawsik | Hri kai lo khawsik. |
| Chaw ei chakna hloh leh taksa rihna tlahniam | Thawhrimna awm lovin, hriat lohvin taksa rihna tihtlem. |
| Zanah thawk hah lutuk | Mut theih loh khawpa thawmhnaw hak, sheet te chu a hnim vek. |
| Hriatrengna leh hriatna lama harsatna (Confusion) . | Stroke hi thisen zam avanga thluaka thisen kal that loh vang a ni thei. |
| Liver, spleen emaw lymph node emaw a hring chhuak | Heng taksa peng hrang hrangah hian cancer cell te chu an pung khawm a, chu chuan a ti lian a ni. |
| Ke ruh leh ke ruh natna (Peripheral Neuropathy) . | Kut zungtang leh ke ruh a tingling sensation, rulhut tlan kual ang maia awm. |
| Thisen zam natna lanchhuahna | Hnar thisen chhuak, ha sil laiin hmui thisen chhuak, luak chhuak, lu na fo , mitdel. |
Engvangin nge hetiang natna hi a lo awm?
Hei hi a chhan ber chu genetic mutations a ni. Chu chu kan genes inthlak danglamna tihna a ni. WM vei mi 10 zinga 9 chuan ``MYD88`` tih gene-ah mutation an nei a. Tin, mi 10 zinga pali vel chuan ``CXCR4`` tih gene-ah hian inthlak danglamna an nei bawk. Heng gene pahnih inthlak danglamna hian cancer cell pangngai lote chu a inthen darh a, a lo thang chak hle.
Mahse hetah hian thil pawimawh leh thlamuanthlak ber chu heng genetic changes te hi rochun a ni lo tih hi a ni.
Chumi awmzia chu, hei hi i nu emaw, i pa emaw hnen atanga i dawn thil a ni lo tihna a ni. Tin, i fate hnena i hlan chhawn thin thil a ni lo bawk. Chûngte chu dam chhûnga taksa chhûnga thil danglam thar lo thlengte an ni.
Mahse zirchiangtute chuan heng genetic mutations te hi a awm chhan chiang tak an la hmu thei lo.
He natna vei theihna tur risk factors te chu engte nge ni?
He natna vei theihna hi tlem a tipungtu thil thenkhat a awm. Mahse, he thil hi a awm chuan natna hi a lo awm dawn tihna a ni hauh lo.
| Risk factor a ni | Hrilhfiahna |
|---|---|
| Kum | He natna hi kum 65 chunglam zingah hmuhchhuah a ni ber. |
| Hnam | Mihring var zingah hmuh tur a awm fo. |
| Mipa leh hmeichhe thliarna | Hmeichhia aiin mipain an vei tam zawk. |
| Damdawi lam thil dang | Hepatitis C, AIDS, Sjögren’s Syndrome ang chi natna vei te hi an hlauhawm zawk a ni. ``(MGUS)`` tih condition pawh hi WM hmahruaitu a ni thei bawk. Mahse, MGUS nei zawng zawng hian WM an nei vek dawn lo. |
| Chhungkaw damdawi lam chanchin | Thisen zawmpui pakhatin WM emaw lymphoma chi dang emaw a neih chuan a hlauhawmna chu a sang deuh thei a ni. |
He natna hi Doctor hian engtin nge a hriat chian?
Symptoms i neih chuan i doctor chuan test eng emaw zat a nei ang a, natna i vei em tih a finfiah ang. Test ber chu cancer cell leh i thisena protein pangngai lo ``(IgM)`` te zawn a ni.
- Thisen leh zun test: Hengte hian thisen cell count hniam (red cells, white cells, platelets) leh protein ``(IgM)'' level danglam tak tak a awm leh awm loh an enfiah thin.
- Imaging test: ``CT scan'' emaw ``PET scan'' ang chi test hmangin lymph node hring leh taksa peng lian, liver leh spleen te enfiah theih a ni.
- Mit enfiah: A chang chuan, thisen zam vangin mit chhungah, mit hnung lamah thisen chhuak te te a awm thei. Mit lam doctor pawhin hei hi a check thei a ni.
- Bone Marrow Biopsy: Hei hi natna finfiah nan test pawimawh ber a ni. Hetah hian hip ruh ang chi hmun atang hian ruhro sample tlemte tak tak lak a ni a, microscope hmangin an enfiah thin. Chumi hnuah chuan a chhungah cancer cell a awm leh awm loh hriat theih a ni.
WM enkawlna tur engte nge ni?
A hmaa kan sawi tawh ang khan he natna hi tihdam kim theih ni lo mah se, a natna lan chhuah dan thunun theihna tur damdawi tha tak tak a awm a. I doctor chuan i dinhmun a zirchiang ang a, i tana tha tur leh side effects tlem ber nei tur treatment plan a siam ang.
| Enkawl dan tur | Eng thil nge thleng? |
|---|---|
| Fimkhur taka nghah | Symptom i neih loh chuan i doctor chuan damdawi engmah ei tan lovin a lo en mai mai mai thei che a ni. Mi thenkhat chuan kum tam tak chhung chu enkawl ngai lovin an ti tha hle. |
| Plasmapheresis (plasma inthlak danglamna) . | Hei hi thisen zam symptom i neih chuan tih a ni. Machine hian i thisen atanga plasma an tih liquid part chu a then a, IgM protein tha lo tak chu a paih chhuak a, plasma thianghlim chu i taksaah a rawn thawn kir leh thin. |
| Immunotherapy hmanga enkawl a ni | Hei hian cancer cell tihchhiat nan nangmah ngeiin immune system hman a huam a ni. Hei atan hian damdawi ``Rituximab`` hi hman a ni tlangpui. |
| Chemotherapy hmanga enkawl a ni | Cancer cells that thei damdawi pek. A chang chuan hei hi immunotherapy nen an inzawm khawm thin. |
| Targeted Therapy hmanga tih a ni | Hei hi enkawlna chi thar a ni. Heng damdawi te hian cancer cell te inthen darh leh thanlenna tura puitu protein bikte chu an target a, an hnathawh a titawp thin. `(Ibrutinib)` leh `(Zanubrutinib)` te hi chutiang damdawi chu a ni. |
| Stem Cell thlak danglam a ni | Hei hi enkawlna a tlem hle a, damlo thlan bikte chauh tih thin a ni. Hemiah hian cancer vanga bone marrow tihchhiat chu ruh hrisel takin an thlak a ni. |
He natna nen hian nun hi eng ang nge ni ang?
Natna hmasawn tak a nih avangin mi zawng zawng tawn dan hi a inang vek lo. Research atanga a lan dan chuan mi 100 zinga 66 (chu chu mi 3 zinga 2 aia tam a ni) chu an natna hmuhchhuah atanga kum 10 hnuah pawh an la dam reng a ni. Mahse, hei hi kum a zirin a danglam thin. A tam zawkah chuan kum 65 hnua natna hmuhchhuah te hi WM vang ni lovin, an kum upat deuh deuha lo awm thin natna dang vangin an thi thin.
I kal dan tur chu thil engemaw zatah a innghat a ni:
- i kum zat
- I thisen test report result
- Genetic mutation i neih chi hrang hrang
Hemi chungchanga zawhna i neih chuan doctor nen inbia ang che. Nangmah leh i hriselna tichhe thei ber zawng zawng chu a hre vek a ni.
Hrisel taka awm theih nan eng nge i tih theih?
WM ang chi hun rei tak chhunga natna neia nun hian i nunah inthlak danglamna lian tak tak i siam thei a, mahse i tanpui theih tur thil tam tak a awm.
- Doctor zawt rawh: Eng ei leh in nge i tana tha tur, eng exercise nge i tana tha tur, leh rilru hrisel taka awm theihna tura i tih tur te.
- Midang nena inzawmna siam: Hetiang natna hmuh tur awm lo tak i neih hian mahni chauha awm i ni thei a, "Khawvela he natna hi keimah chauh hi ka vei" tih ang chi hi a ni. Mahse, nangmah chauh i ni lo. Hetiang natna vei te tan hian support group a awm bawk. I doctor hnenah pakhat nen connect turin hrilh rawh. Nangmah ang bawka thil tawn tawhte nena inbiakna chu chakna nasa tak a ni thei.
Take-Home Thuchah a ni
- Waldenström Macroglobulinemia (WM) hi thisen cancer a awm fo a, enkawl theih a ni.
- He natna vei nia hriat tam tak hian a tir lamah chuan symptoms an nei lo va, chuvangin kum tam tak chhung chu enkawl lohvin an dam tha thei a ni.
- Hei hi thlahthlam natna a nih loh avangin i fate hnena pek chhuah chungchangah lungngai suh.
- Enkawlna tum ber chu natna tihdam a ni lo va, a natna lan chhuah dan control a, i nunphung (quality of life) vawng reng tur a ni.
- Zawhna, hlauhthawnna, rinhlelhna i neih apiang chu i enkawltu doctor nen zalen takin sawipui rawh. Ani emaw, ani emaw chuan a pui ang che.
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