I damlo fo em? A chhan chu CVID (Common Variable Immunodeficiency) vang pawh a ni mai thei!

Khawsik, flu, leh khuh i nei fo em? A nih loh leh, beng, kawr, leh rilru natna nei lovin thla khat chhung i kal tam lo em ni? A chang chuan hei hi thil pangngaiah kan ngai thin, "Hetiang hian ka taksa hi a thawk thin." I ṭhiante chu an khawsik tlem a, ni hnih emaw ni thum emaw chhungin an dam chhoh laiin, kar tam tak chhung chu chutiang bawk chu i nei a, a ṭha lo va, pneumonia-ah pawh a kal mai thei em? Heng thilte chhan dik tak chu i taksa a ni lo mai thei. Vawiin hian natna pakhat, he hnung lama inthup, mahse tumahin an sawi tam loh chungchang kan sawi dawn a ni. Chu chu CVID a ni.

A awlsam zawngin CVID chu eng nge ni?

CVID hi Common Variable Immunodeficiency tih hming kimchang a ni a . Hei hi kan taksa hriselna (immune system) tichhe thei genetic condition a ni. A awlsam zawngin kan taksa hi ram ang a ni. Chu ram humhalh tur sipai a awm a. He sipai hi kan immune system a ni. He sipai hian hnam dang rawn lut, virus leh bacteria te chu a do a, kan taksa chu natna laka a venghim a ni.

He sipaiah hian sipai thenkhat training bik nei an awm a. Antibodies kan ti a . Heng antibody te hi protein chi khat an ni. He hrik taksaa a luh chuan heng antibody te hian chu natna hrik chu an hrechhuak a, an do a, an tichhia a ni.

Tunah chuan hei hi CVID vei chunga thil thleng a ni. An taksa hian heng sipai antibodies an tih hi a siam chhuak tlem hle. Chumi awmzia chu an taksa sipai a chak lo tihna a ni. Chuvangin hrik taksaah a luh chuan a do let tur sipai an tling lo. Chumi rah chhuah chu an damlo fo thin. Tin, an natna vei chu mi pangngai aiin a na zawk thei a, a dam leh theih nan hun rei tak a daih thei bawk.

He natna hi puitlingah hmuh chhuah tam ber ni mah se, a lan chhuah dan hi naupan lai atang pawhin a intan thei bawk.

CVID natna lan chhuah dan engte nge ni?

Hetiang natna lan chhuahna ber leh langsar ber chu natna kai fo hi a ni. Mahse, hei bakah hian symptom dang hmuh tur a awm nual. Eng nge an nih i han thlir teh ang.

Heng symptoms pakhat emaw pahnih emaw i neih chuan CVID i nei tihna a ni lo. Amaherawhchu, heng symptoms te, a bik takin hri kai fo thin te hi rei tak i neih chuan doctor pan vat a, thurawn lak a pawimawh.

Engvangin nge CVID hi a lo awm tak tak? Eng thilin nge hei hi a thlen?

Hei hi a chhan ber chu kan genes inthlak danglam vang a ni. Kan taksa chhunga thil awm zawng zawng hi kan DNA a thupek awm hian a thunun vek a ni . Heng thupekte hi gene kan ti a. CVID hi heng genes-a inthlak danglamna (mutations) engemaw zat avanga lo awm a ni.

A bik takin kan immune system-a B-cells te hian chutiang antibodies siam chu an thawk a ni. CVID thlentu genetic changes avang hian heng B-cells te hi an lo thanglian tha thei lo va, antibodies an siam theihna tur hmun an thleng thei lo. Chuvang chuan taksaa antibody chi thum, IgG, IgA leh IgM te level chu nasa takin a tlahniam a ni.

Sipai camp pakhat, sipaite zirtîrna hmun a awm ang tih han ngaihtuah teh. CVID-ah hian thil thleng chu he camp-ah hian eng emaw tlin lohna a awm avangin sipaite training mumal tak leh tirh chhuah theih an ni lo. Chuvangin ram humhalh tur sipai an awm tawk lo.

Tunah chuan i ngaihtuah mai thei, engtin nge heng genetic changes te hi ka neih?

• 10% velin: He natna hi nu leh pa atanga fate hnena rochun theih a ni.
• 90% ah chuan:Hetiang dinhmun hi a chhan dik tak hi hriat a la ni lo. Chumi awmzia chu mi tu emaw chuan an chhungkuaa tumahin an nei lo a nih pawhin a nei thei tihna a ni. Hemi kawngah hian boruak (environmental factors) hian chanvo a nei em tih hriat tumin zirchianna neih mek a ni bawk.

CVID vanga harsatna dang lo awm thei te

CVID hian natna tam zawk kan neih bakah hian hriselna lama harsatna lian tham dang kan neih theihna tur hlauhawmah min dah bawk. A chhan chu immune system hi kan taksa pumpui tichhe thei thil a nih vang a ni. A malfunction chuan system dang pawh a nghawng thei bawk.

Autoimmune Disorder awm thei te

Hei hi kan taksa hriselna (immune system) ngeiin kan cell hrisel tak takte a rawn beih tan hun a ni. Keimahni sipai ngeiin kan mite an beih ang mai a ni. CVID vei te hian heng natna chi hrang hrang hi an vei theihna chance a sang zawk a ni. Entirna tlemte chu hetiang hi a ni:

• Rheumatoid Arthritis natna a ni
• Autoimmune Hemolytic Anemia (Thisen sen hring tihchhiatna) .
• Thisen zam tichhe thei natna (Antiphospholipid Syndrome) .
• Thin natna thenkhat (Autoimmune Hepatitis) .

Lung natna rei tak awm thei

Chest infection fo hian hun kal zelah lung natna a tichhe thei a, chu chuan lung natna khirh tak tak, asthma, COPD, leh bronchiectasis te a thlen thei a ni.

Risk dang pawh a awm thei

• Cancer: CVID vei te hian mipui zawng zawng aiin lymphatic system (lymphoma) leh gastrointestinal system cancer vei an tam zawk.
• Splenomegaly: Hriselna (immune system) a tel ve thin, a hring (swelling) a ni.
• Granulomas: Lump leh thin ang chi taksa peng hrang hranga immune cells inzawmkhawm atanga lo awm, lump te tak te.
• Depression: Hun rei tak natna nena khawsakna avanga lungngaihna (depression) neih theihna a awm.

Doctor hian engtin nge CVID a hmuhchhuah?

I damlo fo vanga Doctor i pan chuan i symptoms te a zawt ang che a, a enfiah ang che. CVID rinhlelh a nih chuan a finfiah theih dan ber chu thisen test a ni .

He thisen test hian i thisena antibody awm zat a teh thin. A bik takin a chunga kan sawi tak IgG, IgA, leh IgM antibodies level a hniam hle a nih chuan CVID symptom pawimawh tak a ni.

Tin, a tul chuan genetic testing pawh tih theih a ni bawk. Damdawi lam dinhmun dang enfiah nan test hrang hrang pawh tih theih a ni bawk.

Hei hi eng enkawlna nge ni? Dam theih a ni em?

CVID hi natna tihdam theih tak a ni lo. Mahse hei hiDamdawi theih tak a ni. Hei hi enkawlna ber chu Immunoglobulin Replacement Therapy a ni .

A awlsam zawngin, hei hi i taksain a mah chauha a siam theih loh antibodies (immunoglobulins) i pekna hmun a ni. Antibody te hi mi hrisel thisen plasma atanga lakchhuah a ni. Hei hi ram pawn atanga sipai trained tak tak rawn luhtir ang mai a ni a, ram chhung sipai ngei pawh a tling tawk lo.

He enkawlna hi pek dan tlangpui pahnih a awm.

I doctor chuan heng enkawlna pahnih zingah hian eng nge i tan a tha ber tih a rel ang. He enkawlna hi i dam chhung zawnga i ei a ngai a ni . He enkawlna hi dik taka i ei chuan natna kai tam dan hi a tam zawkin i thunun thei a ni.

Tin, bacteria infection a lo awm chuan a enkawl nan antibiotics pek i ni thei bawk a, infection laka inven nan antibiotics ei chhunzawm zel turin an hrilh thei bawk.

CVID natna vei lai hian eng nge i hriat tur?

CVID vei nun hi harsatna ni thei mah se, enkawl dan dik leh hriatthiamna nen chuan nun pangngaiin i nung thei a ni.

• Enkawlna hi skip suh: I antiretroviral therapy hi a hun takah leh a dose dik takah ei a pawimawh hle.
• Infection chhinchhiahna awmte chu fimkhur rawh:Infection chhinchhiahna hmasa ber, khawsik, khuh, taksa na emaw i hmuh chuan doctor hnenah hrilh nghal rawh. Enkawl tan hma chuan natna a zual zel loh nan a pui thei a ni.
• Vaccine pek dan: Doctor rawn hmasa lovin vaccine engmah lak loh tur a ni. Live vaccine, a bikin virus nung awmna te hi CVID vei tan chuan a hlauhawm thei hle.
• Complication dang screening: CVID kaihhnawih natna cancer leh lung natna lan chhuah hmasak nan i doctor chuan a hun hunah screening neihpui turin a refer ang che Anmahni chu lo thlir ve suh ang che.
• Rilru hriselna: Hun rei tak natna nena kan nun lai hian stress neih hi thil pangngai a ni. I lungngaih emaw, i lungkham emaw a nih chuan i doctor emaw, i hnaih ber emaw hnenah sawipui rawh.

Engtik hunah nge doctor ka hmuh ang?

Hetiang thil hi i tawng a nih chuan Doctor pan ngei ngei tur a ni a, thurawn pawh la ngei ang che.

• Bacteria infection i neih fo chuan: Entirnan, kum khatah vawi tam tak pneumonia, sinusitis emaw beng natna emaw i vei a nih chuan.
• Hun rei tak chhunga natna lan chhuah dan a awm chuan: pum na fo, pum na, leh lung lama harsatna te ang chi thil.
• Vaccine nung i dawn hnua i damloh chuan.

Heng thilte hi i doctor nena in inbiak hian hei hi chhui chian belh ngai thil a nih leh nih loh a rel thei ang.