Anti-biotics hian hna a thawk lo em ni? Bacteria thattu virus i hre tawh em? (Phage Therapy hmanga enkawlna) .

Natna thenkhat tan chuan i doctor chuan antibiotics a pe ang che, a dik em? Bacteria infection damdawi kan hman ber an ni tlangpui. Mahse a chang chuan eng antibiotic pawh pe ila, kan do thei a, bacteria hlauhawm tak tak (hengte hi ‘superbugs’ kan ti bawk) kan taksaah hian a lut thei bawk. Chuti a nih chuan hetiang hunah hian eng nge kan tih? Vawiin hian hetiang huna tanpui thei tur enkawlna mak deuh mahse thiltithei tak tak kan sawi dawn a ni. Chu chu Phage Therapy a ni.

A awlsam zawngin Phage Therapy chu eng nge ni?

Phage emaw bacteriophage emaw hi virus chi khat a ni. "Virus a ni em?" Hei hi Corona emaw Dengue emaw ang virus, min ti na lo. Heng phage virus te hian an target leh ei tur awmchhun chu bacteria a ni. Mihring cell te an tichhe lo. Bacteria man tura trained commando bik ang maiin han ngaihtuah teh.

Phage hi mihring siam virus a ni lo. Khawvel hmun tinah - leiah te, tuiah te, mak tak maiin i taksaah te pawh a pianphungah a awm vek a ni. Chuvangin, phage therapy-ah chuan chu bacteria ‘hmêlma’ bik ni bawk he phage virus hi antibiotics pawhin a tihlum theih loh bacteria do nan a hmang a ni.

Chuti a nih chuan engtin nge he enkawlna hian hna a thawh?

Hei hi natural process ngaihnawm tak a ni. Phage virus chu a mah chauhin a piang chhuak thei lo va, chu chu a pung thei lo tihna a ni. Chutiang ti tur chuan bacterium a mamawh tak zet a ni.

1. Target recognition: Pakhatnaah chuan phage virus hian a tihchhiat theih bacterium bik a hmu a, a chung lamah a inbuntir a.

2. DNA dah luh: A dawtah phage virus chuan a genetic information, chu chu DNA chu bacteria cell-ah a inject leh a.

3. Control lak: Tunah chuan bacteria cell chu phage virus control hnuaiah a awm vek tawh. Bacteria chakna zawng zawng hmangin a lut DNA hmangin phage virus thar za tam tak a siam tan ta a ni.

4. Tihchhiat leh darh: Bacteria cell chhungah phage virus thar siamna tur hmun a awm tawh loh chuan bacteria cell chu a puak darh thin. Tichuan, chutiang phage virus lo piang thar sang tam tak chu an chhuak a, bacteria dang an zawng a, anmahni pawh tihchhiat cycle chu an tan ta a ni.

Doctor-te chuan hetiang hian an hmang thin: I taksaa natna thlentu bacteria dik tak chu an hmuchhuak thin. Tichuan, phage hrang hrang sang tam tak awmna ‘phage library’ atang chuan chu bacteria beitu phage dik tak chu an thlang a, enkawlna atan an hmang ta a ni.

He enkawlna hian a puih theihna tur dinhmun engemaw zat a awm a:

• Lung infection hi cystic fibrosis nena inzawm a ni
• Beng natna hi bacteria P. aeruginosa avanga lo awm a ni
• E. coli emaw P. aeruginosa bacteria avanga natna dang
• Ke ulcer dam lo atanga natna hrik
• Bacterial mit natna
• Nausen piang thar zingah sepsis (thisen natna) a awm
• Zun kawng natna a awm
• Operation hnua hliam natna

Phage therapy hian eng nge a thatna leh a that lohna?

Enkawlna dang ang bawkin he damdawi hian hlawkna a nei a, hlauhawmna engemaw zat a nei bawk. A pahnih hi han thlir ila. A thatna chungchang hi han sawi hmasa ila.

Hei hian harsatna a thlen thei em? Eng nge a hlauhawmna?

He enkawlna chungchang hi doctor-te’n an ngaihtuah hian thil engemaw zat a awm a.

• Thu chiang tawk lo: Russia leh Poland ang ramah hian hun engemaw chen chu phage therapy hman ni tawh mah se, khawvel pum huapa clinical trial lian leh tunlai tak takte chu a la hmasa ber a la ni. Chuvangin, he enkawlna hian hun rei lote leh hun rei tak chhunga nghawng a neih dan tur chu 100% chiang taka sawi theihna tur data a tlem hle.

• Septic Shock Risk: Hei hi a hlauhawm ber a ni. Phage virus hian bacteria cell te chu rang taka a tihchhiat chuan chu cell chhunga thil tha lo tak tak endotoxins an tih chu taksaah a chhuak thei a ni. Chungte chuan immune system a nghawng thei a, thisen sang a tlahniam nghal a, taksa peng hrang hrang a tichhe thei bawk. Mahse, antibiotics chak tak hman hian he risk hi a inang reng tih hre reng ang che.

• DNA transfer hlauhawmna: Phage virus te hian an pianphungah DNA chu bacteria pakhat atanga bacteria dang ah an transfer thei a. Chuvangin mi thenkhat chuan he DNA transfer hian bacteria chi thar, hlauhawm tak tak a siam thei niin an ngai. Mahse ngaihtuah buai a ngai lo, a chhan chu scientist-te chuan he enkawlna atana hman phage te hi uluk takin an screen a, toxin emaw gene tha lo emaw nei lo chauh an thlang thin.

Sri Lanka ramah hian he enkawlna hi a awm em?

Tun dinhmunah chuan phage therapy hi khawvel ram tam takah chuan mainstream treatment a la ni lo a, Sri Lanka pawh a tel. Research stage-ah a la awm a, a nih loh leh "compassionate use" category-ah a tla bawk. Chumi awmzia chu doctor-te chuan he enkawlna hi emergency-ah chauh an pe thei tihna a ni a, chutih hunah chuan enkawlna pawmpui dang zawng zawng a hlawhchham a, nunna chhanchhuahna tur kawng dang a awm tawh lo , phalna bik neiin.

Hetianga enkawl dan hi a takah chuan kum 100 chuang zet a upa tawh a ni. Kum 1940 chho vel khan America ramah pawh hman lar ni mah se, antibiotics hmuhchhuah a nih avangin a thi zauh zauh a ni. Mahse tunah chuan antibiotic-resistant bacteria buaina hi khawvel tan hlauhawmna lian tak a nih tawh avangin phage therapy lama ngaihvenna thar a awm ta a ni. Chuvangin khawvel hmun hrang hrangah hemi chungchanga zirchianna hi chak takin a thleng mek a ni.