He aha te Glucagonoma? Me kōrero tātou mō tēnei mate onge!

He okana iti engari he tino nui te repe taiaki i roto i tō tinana. He maha ngā homoni e whakaputaina ana e ia e hiahiatia ana e tō tātou tinana. Nō reira, i ētahi wā, ka raru pea tētahi momo mate pukupuku onge e puta mai ana i roto i te repe taiaki. Koinei te ingoa o tēnei mate ko te Glucagonoma . Tērā pea kua pāngia koe e te mate huka, kua pāngia rānei koe e tētahi mea pērā i te ponana rerekē i tō kiri, he mea tino nui kia mōhio koe ki tēnei.

He aha te glucagonoma? He māmā noa iho...

He pukupuku matepukupuku tino onge te Glucagonoma e puta ana i roto i tō repeure. He nui rawa te homoni e puta mai ana i tēnei pukupuku e kiia nei ko te glucagon. Tērā pea kei te whakaaro koe he aha tēnei glucagon.

He tino hira te homoni o te glucagon e āwhina ana ki te whakahaere i te taumata huka o tō tātou tinana, arā, te taumata huka toto . Ka hangaia e ngā pūtau alpha, he momo pūtau motuhake i roto i tō repeure. Whakaarohia mēnā kāore koe i kai mō tētahi wā, mēnā he tino kaha tō whakakori tinana, mēnā rānei ka kai koe i tētahi kai nui-pūmua, ka taea e koe te heke i te taumata huka toto, tika? Ko te wā tēnā e puta mai ai tēnei glucagon, ka tukuna te huka e rongoatia ana i roto i tō ate, arā, te glycogen , ā, ka whakahokia mai te taumata huka toto ki runga. He rite ki tētahi e āwhina ana ki te pupuri i te taurite huka i roto i tō tātou tinana.

Heoi, ina he glucagonoma, ka nui rawa te hanga o tēnei homoni glucagon. Kātahi ka kore e taea e tō tātou tinana te whakahaere. Ko te huinga o ngā tohu e puta mai ana i tēnei ka kiia ko te Glucagonoma Syndrome . Ka taea e tēnei te arahi ki ngā raruraru maha pērā i ngā raruraru kiri me te mate huka.

Ko tēnei momo mate pukupuku, e kiia nei ko te glucagonoma, kei roto i te kāwai o ngā pukupuku neuroendocrine pancreatic, ngā pukupuku pūtau islet rānei. I te nuinga o te wā, ka puta ake ēnei i te hiku, i te wāhanga waenga rānei o te pancreas.

He mate pukupuku tūturu tēnei?

Ae, i te nuinga o te wā, he mate pukupuku te glucagonoma. Ko te mea pouri, ahakoa kua tautuhia, i roto i te 50% o ngā take, arā, tata ki te kotahi i roto i te rua, kua horapa pea tēnei mate pukupuku (metastasized) ki ētahi atu wāhanga o te tinana, inā koa te ate .

He pēhea te noa o tēnei āhuatanga?

He tino onge te mate huka. Neke atu i te kotahi i roto i te miriona ngā mate hou ka kitea i ia tau. Ko te nuinga o te wā ka pāngia te hunga i waenga i te 50 me te 70 tau te pakeke .

He aha ngā tohu o tēnei?

He puhoi te tipu o ngā glucagonoma. Nō reira, ki te kore tō tinana e whakaputa i te nui o te glucagon hei whakararuraru, tērā pea kāore he tohu e pā mai ana ki a koe.

Heoi, ina nui rawa te glucagon e whakaputaina ana e te glucagonoma, ā, kāore e taea e te tinana te whakahaere, ka puta te mate glucagonoma kua whakahuatia ake nei.Ka puta. Kātahi ka kitea ngā tohu mārama. Mena kei a koe ēnei tohu, he mea nui kia tere tonu te toro atu ki te tākuta.

Te ponana kiri (Necrolytic Migratory Erythema - NME)

Koinei te tohu matua me te tohu tino kitea o te mate glucagonoma. Tata ki te 90% o te hunga whai mate pēnei ka pāngia e tēnei raruraru kiri. Ka kiia ko te necrolytic migratory erythema (NME) .

Whakaarohia, ko tō kiri, inā koa i ngā wāhanga tūmataiti, i te papa, me ngā waewae o raro, ka tīmata te puta o ngā ira whero, mākūkū, ā, i ētahi wā ka mamae. Ka huri ēnei hei pupuhi, hei ngatata, hei kiripaka. Ahakoa kua ora, ka toe tonu he ira parauri. Ka puta pea tēnei i tētahi wāhi, ka ora, kātahi ka puta anō i tētahi atu wāhi. He rite ki te ponana e neke haere ana i tētahi wāhi ki tētahi wāhi.

Ētahi atu āhuatanga o te NME:

• Ka taea e tēnei te haere mai, te haere atu, ā, ka taea hoki te neke haere i te tinana .
• Ka tino mākūkū, ka mamae hoki i te tīmatanga.
• Ka whero te ponana, kātahi ka pupuhi, ka hanga he kirinuku. I muri i te ora, tera pea ka toe he ira parauri.
• Ka taea e tēnei te arahi ki ngā āhuatanga pēnei i te mate arero (glossitis ), ngā mate waha, ngā ngutu pakaru, me te angular cheilitis .
• Tērā pea ka pupuhi ngā kamo ( blepharitis ), ka ngaro te makawe, me ngā raruraru whao.

Ngā tohu o te mate huka

Ka hua ake i tēnei mate te nui o te huka toto ( hyperglycemia ), ka arahi pea ki te mate huka. Ko ngā tohu o te mate huka ko:

• Te hiroki noa iho , kāore he take.
• Te matewai nui tonu (Polydipsia) .
• Te mimi pinepine ( polyuria ), ina koa i te pō.
• Te hiakai nui rawa ( Polyphagia ).

Ētahi atu tohu o te (glucagonoma syndrome)

He maha atu anō ngā tohu:

• Te mate korere mau tonu .
• He iti te hemoglobin i roto i te toto (anemia ). Ka pā mai pea te ngenge me te whanoke.
• Ngā toto totoka, inā koa i roto i ngā uaua hohonu o ngā waewae ( Hōhonu o te Uaua Thrombosis (DVT) ).

Ngā tohu e pā ana ki te pūnaha hinengaro me te pūnaha io

I ētahi wā, ka kitea pea e koe ngā tohu e pā ana ki te pūnaha hinengaro me te pūnaha io, pēnei i:

• Te pouri
• Te mate wareware
• Te whakaohooho
• Te tere o te urupare a te tinana ( hyperreflexia )
• Te hikoi whakatewhatewha (ataxia )
• Ngā mate hinengaro ( Psychosis))
• Ngā wehi me ngā whakapae koretake ( Ngā Mānukanuka Paranoid )

He aha te take o te glucagonoma?

I te nuinga o te wā, kāore ngā tākuta e mōhio ki te tino take o te glucagonoma. Heoi, i roto i te 10% o ngā take, e hono ana tēnei mate pukupuku ki tētahi āhuatanga ira e kiia nei ko te Multiple Endocrine Neoplasia momo 1 (MEN momo 1) .

Heoi, kāore te katoa e pāngia ana e te MEN momo 1 ka pāngia e te glucagonoma. He iti noa iho hoki te ōrau o tēnā.

Me pēhea koe e mōhio ai ki tēnei?

Mena kei a koe te mate kiri necrolytic migratory erythema (NME) i whakahuatia i mua ake nei, ka whakapae pea te tākuta kei a koe te glucagonoma. Kātahi ka whakahaerehia e rātou ngā whakamātautau pēnei i:

• Whakamātautau Huka Toto Nohopuku: Mena he tiketike te taumata huka, ka taea te whakapae he glucagonoma, ā, ka taea te whakaū i te mate huka e pā ana.
• Whakamātautau Toto Glucagon Nohopuku: He tino teitei ngā taumata Glucagon i roto i te glucagonoma – he nui ake i te 500 pikokaramu ia miririta (pg/mL). Ko ngā taumata glucagon nohopuku noa he iti iho i te 150 pg/mL.
• Whakamātautau Toto Waikawa Amino: Ko te tikanga ka iti te taumata o ngā waikawa amino i roto i te toto ( hypoaminoacidemia ) i te nuinga o te wā ka puta mai i te Glucagonoma.
• Tatau Toto Katoa (CBC): Mā tēnei ka tirohia mēnā he anemia , nā te mea ka puta te anemia me te glucagonoma.

Mā ngā whakamātautau whakaahua pēnei ka āwhina i te whakaū mēnā kei reira he puku:

• Matawai CT
• Matawai MRI
• Te Ultrasound Endoskopiko

Me pēhea te rongoā?

Ko te maimoatanga o te glucagonoma e whakawhirinaki ana ki te mea kua horapa noa te mate pukupuku ki te repe taiaki (kua horapa ki te rohe), kua horapa rānei ki ētahi atu wāhanga o te tinana (kua horapa ki te toto) .

Me pēhea te whakahaere i ngā tohu i te tuatahi

Ko te taahiraa tuatahi ko te whakahaere i ngā tohu me ngā raruraru i puta mai i te nui rawa o te glucagon. Ka penei te rongoā mō tēnei:

• Ngā rongoā hei whakahaere i te nui rawa o te glucagon: Ka āwhina ngā werohanga e kiia nei ko Octreotide me Lanreotide ki te whakaiti i ngā pānga o te nui rawa o te glucagon me te aukati i te hanga glucagon. Ka taea e ēnei rongoā te whakaroa i te tipu o ngā pukupuku. Ka whakaora hoki i ngā tohu o te NME, te mate huka, te mate korere, me ngā mate pūnaha io.
• Te whakahaere i te mate huka: Me tango pea koe i te rongoā mate huka ā-waha, i te werohanga insulin rānei hei pupuri i te taumata huka toto ki te awhe tika.
• Tautoko kai:Ka taea te hoatu i te Kai Totika Katoa (TPN) , te waikawa amino me ngā tāpiringa konutea hei whakaiti i ngā pānga o te kore kai pai.
• Te rongoā mō te mate kiri NME: Ka taea e ngā paturopi me ngā corticosteroids te whakapai ake i te NME.
• Te rongoā ārai toto totoka: Mā ngā rongoā whakaiti toto pēnei i te heparin ka āwhina ki te aukati i te toto totoka o roto i te uaua hōhonu (DVT) .

Mena he iti noa iho ki te pancreas...

Mena kei roto i te repeure anake te mate pukupuku, ko te pokanga te maimoatanga matua . Mena ka taea e te taote pokanga te tango katoa i te pukupuku, ka ora te mate . I muri i te tangohanga o te glucagonoma, me hoki ō taumata glucagon ki te āhua noa. Me ngaro hoki ō tohu.

Mena kua horapa ki ētahi atu wāhi (kua horapa ki te pūtau)...

I ngā wā katoa e taea ai, ka tūtohu ngā tākuta kia tangohia ngā pukupuku mā te pokanga. Tērā pea ka uru atu ki tēnei te tango i ngā pukupuku i roto i te repe taiaki, i ngā kōpū waikura tata, me te ate.

Engari ki te kore e taea e te taote pokanga te tango i tetahi, i te katoa rānei o te puku, ka tūtohu pea tō tīma hauora i tētahi, i ētahi rānei o ēnei maimoatanga:

• Te rongoā matū: Mā te whakangaro i ngā pūtau matepukupuku me te ārai i tō rātou tipu ka mahi tēnei maimoatanga.
• Te Whakakorenga Auautanga Reo Irirangi: Ka whakamahia te wera mai i ngā ngaru reo irirangi hei patu i ngā pūtau matepukupuku.
• Te Whakakorenga Pokanga: Ka whakamahia ngā matū tino makariri, pērā i te hauota wai, hei whakangaro i ngā pūtau matepukupuku.
• Chemoembolization: Ka aukatihia e tēnei maimoatanga te rere o te toto ki te mate pukupuku.

He aha te matapae mō te whakaoranga mai i tēnei mate?

Ko te tirohanga mō te tangata whai glucagonoma e whakawhirinaki ana ki ētahi āhuatanga:

• Tō tau me tō hauora whānui .
• Te rahi o te pukupuku matepukupuku .
• Ahakoa kua horapa te mate pukupuku, kāore rānei .

Mena kei te repeure anake te mate pukupuku, he pai te āhua. He maha ngā wā ka ora te pokanga hei tango i te pukupuku, engari koinei te āhua mō te 20% anake o ngā tūroro glucagonoma.

Nā te mea he tino onge te glucagonoma, kāore i te rawaka ngā raraunga hei kī i te roa o te oranga, me te āhua o te mutunga mēnā ka horapa te mate pukupuku. Ka taea e tō rōpū hauora te whakarato atu i ētahi atu kōrero i runga i tō āhuatanga.

Ka taea te ārai i tēnei?

Nā te mea kāore ngā kaipūtaiao e mōhio ki te pūtake o te nuinga o ngā take glucagonoma, kāore rawa he mea ka taea e koe te mahi hei ārai i tēnei .

Heoi, ki te mea kua tāpaetia tētahi o ō whanaunga tuatahi (ngā mātua me ngā tuākana/teina) ki te mate MEN (Multiple Endocrine Neoplasia) , kōrero ki tō tākuta mō ngā whakamātautau ira. Mena kei a koe anō te MEN, ka taea e te whakamātautau ira te āwhina i te kimi i ngā mate pukupuku i ngā wā tōmua.

He wheako tino whakarihariha te tātaritanga o te mate pukupuku. Ina he mea onge pērā i te glucagonoma, he uaua ake. Engari kia mahara, kei reira tō tīma hauora hei whakautu i ō pātai me te tautoko i a koe. Ki te mea kei te noho mokemoke koe i te hinengaro me te kare ā-roto me te glucagonoma, pātai atu ki tō tākuta mō ngā kaupapa me ngā ratonga ka taea te āwhina i a koe.

Hei whakamutunga, ngā mea hei maumahara (Karere hei tango ki te kāinga)

Nō reira, ahakoa he tino onge te mate glucagonoma, he mea nui kia mōhio koe ki tēnei. Ina koa mēnā ka puta ohorere mai ngā tohu rite ki te mate huka me te kiri mākūkū (NME), e ai ki te kōrero, me toro atu ki te tākuta i runga i te wā tonu. Mēnā ka kitea wawetia, ka taea te rongoā. Ahakoa he onge tēnei, he maimoatanga kei reira.

Kaua e manukanuka, kāore koe i te mokemoke. Mā tō tākuta me tō tīma hauora koe e āwhina i roto i tēnei haerenga. Kia kaha, kia whai hoki i ngā tohutohu e homai ana e rātou ki a koe.

` Glucagonoma, matepukupuku repeure, glucagon, mate huka, tohu kiri, homoni, matepukupuku onge