ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯃꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯅꯍꯥꯛꯅꯥ ꯈꯪꯂꯕ꯭ꯔꯥ? ꯃꯁꯤꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯋꯥꯔꯤ ꯁꯥꯁꯤ!

ꯅꯍꯥꯛꯀꯤ ꯌꯨꯔꯤꯅꯗꯥ ꯏ ꯈꯔꯥ ꯂꯩ ꯍꯥꯌꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯈꯪꯂꯕ꯭ꯔꯥ? ꯅꯠꯔꯒꯥ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯃꯇꯃꯗꯥ ꯅꯍꯥꯛꯀꯤ ꯇꯥꯕꯥ ꯉꯝꯕꯒꯤ ꯁꯛꯇꯤ ꯑꯗꯨ ꯈꯔꯥ ꯋꯥꯠꯂꯤ, ꯅꯠꯔꯒꯥ ꯅꯍꯥꯛꯀꯤ ꯃꯤꯠꯌꯦꯡ ꯑꯗꯨ ꯈꯔꯥ ꯇꯣꯉꯥꯜꯂꯤ ꯍꯥꯌꯅꯥ ꯈꯜꯂꯤꯕꯔꯥ? ꯍꯥꯌꯔꯤꯕꯥ ꯋꯥꯐꯃꯁꯤꯡ ꯑꯁꯤ ꯑꯩꯈꯣꯌꯅꯥ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯃꯇꯃꯗꯥ ꯑꯩꯈꯣꯌꯒꯤ ꯅꯨꯡꯇꯤꯒꯤ ꯄꯨꯟꯁꯤꯗꯥ ꯌꯥꯝꯅꯥ ꯃꯤꯠꯌꯦꯡ ꯆꯪꯗꯕꯥ ꯋꯥꯐꯃꯁꯤꯡꯅꯤ꯫ ꯑꯗꯨꯝ ꯑꯣꯏꯅꯃꯛ, ꯀꯔꯤꯒꯨꯝꯕꯥ ꯃꯇꯃꯗꯥ ꯑꯄꯤꯀꯄꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯑꯁꯤꯒꯤ ꯃꯇꯨꯡꯗꯥ ꯈꯔꯥ ꯍꯦꯟꯅꯥ ꯄꯨꯛꯅꯤꯡ ꯆꯪꯕꯥ ꯃꯊꯧ ꯇꯥꯕꯥ ꯀꯟꯗꯤꯁꯟ ꯑꯃꯥ ꯂꯩꯕꯥ ꯌꯥꯏ, ꯃꯗꯨꯗꯤ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗ꯭ꯔꯣꯝ . ꯑꯗꯨꯅꯥ ꯉꯁꯤ ꯑꯩꯈꯣꯌꯅꯥ ꯃꯁꯤꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯑꯗꯣꯝꯅꯥ ꯈꯉꯕꯤꯕꯥ ꯌꯥꯕꯥ ꯏꯆꯝ ꯆꯝꯕꯥ ꯃꯑꯣꯡꯗꯥ ꯋꯥꯔꯤ ꯁꯥꯅꯒꯅꯤ꯫

ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯍꯥꯌꯕꯁꯤ ꯀꯔꯤꯅꯣ?

ꯌꯥꯝꯅꯥ ꯂꯥꯏꯅꯥ ꯍꯥꯌꯔꯕꯗꯥ, ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯑꯁꯤ ꯅꯍꯥꯛꯀꯤ ꯀꯤꯗꯅꯤꯁꯤꯡꯅꯥ ꯅꯣꯔꯃꯦꯜ ꯑꯣꯏꯅꯥ ꯇꯥꯏꯞ IV ꯀꯣꯂꯥꯖꯦꯟ ꯄ꯭ꯔꯣꯇꯤꯅꯁꯤꯡ ꯄꯨꯊꯣꯀꯄꯥ ꯉꯃꯗꯕꯥ ꯖꯦꯅꯦꯇꯤꯛ ꯀꯟꯗꯤꯁꯟ ꯑꯃꯅꯤ꯫

ꯈꯟꯊꯕꯤꯌꯨ, ꯃꯁꯤꯒꯤ ``ꯇꯥꯏꯞ IV ꯀꯣꯂꯥꯖꯦꯟ'' ꯑꯁꯤ ꯔꯣꯞ ꯑꯃꯒꯨꯝꯅꯥ ꯀꯨꯄꯁꯤꯜꯂꯕꯥ ꯀꯣꯂꯥꯖꯦꯟ ꯆꯦꯟ ꯑꯍꯨꯝ (ꯑꯂꯐꯥ ꯆꯦꯟ) ꯑꯃꯅꯥ ꯁꯦꯝꯕꯅꯤ꯫ ꯆꯦꯅꯁꯤꯡ ꯑꯁꯤꯕꯨ ꯑꯥꯂꯐꯥ ꯳, ꯑꯥꯂꯐꯥ ꯴, ꯑꯃꯁꯨꯡ ꯑꯥꯂꯐꯥ ꯵ ꯍꯥꯌꯅꯥ ꯀꯧꯏ, ꯍꯧꯖꯤꯛꯇꯤ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯀꯤ ꯍꯀꯆꯥꯡꯅꯥ ꯆꯦꯅꯁꯤꯡ ꯑꯁꯤꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯑꯃꯠꯇꯥ ꯄꯨꯊꯣꯛꯠꯔꯕꯗꯤ ꯑꯇꯣꯞꯄꯥ ꯑꯅꯤ ꯑꯁꯤ ꯑꯃꯠꯇꯥ ꯑꯣꯏꯅꯥ ꯄꯨꯟꯁꯤꯅꯕꯥ ꯉꯝꯂꯣꯏ꯫ ꯃꯗꯨꯗꯥ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯃꯒꯤ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯁꯥꯊꯤꯕꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯊꯣꯀꯏ꯫

ꯀꯔꯤꯒꯨꯝꯕꯥ ꯃꯇꯃꯗꯥ, ꯆꯦꯟ ꯄꯨꯝꯅꯃꯛ ꯑꯁꯤ ꯅꯍꯥꯛꯀꯤ ꯍꯀꯆꯥꯡꯗꯥ ꯁꯦꯃꯒꯠꯂꯀꯏ, ꯑꯗꯨꯕꯨ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯃꯈꯣꯌꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯑꯃꯅꯥ ꯃꯑꯣꯡ ꯆꯨꯝꯅꯥ ꯁꯦꯃꯈꯤꯗ꯭ꯔꯕꯗꯤ, ꯀꯔꯤꯒꯨꯝꯕꯥ ꯃꯇꯃꯗꯥ ꯆꯦꯅꯁꯤꯡ ꯑꯗꯨ ꯄꯨꯟꯅꯥ ꯂꯥꯀꯄꯥ ꯉꯃꯗꯦ, ꯅꯠꯠꯔꯒꯥ ꯄꯨꯟꯅꯥ ꯂꯥꯀꯃꯤꯟꯅꯔꯕꯁꯨ ꯃꯈꯣꯌꯅꯥ ꯃꯑꯣꯡ ꯆꯨꯝꯅꯥ ꯊꯕꯛ ꯇꯧꯗꯦ꯫ ꯀꯦꯁꯁꯤꯡ ꯑꯁꯤꯗꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯑꯁꯤ ꯈꯔꯥ ꯍꯟꯊꯔꯀꯄꯥ ꯌꯥꯏ꯫

``ꯇꯥꯏꯞ IV ꯀꯣꯂꯥꯖꯦꯟ'' ꯍꯥꯌꯅꯥ ꯀꯧꯕꯥ ꯄ꯭ꯔꯣꯇꯤꯟ ꯑꯁꯤ ꯅꯍꯥꯛꯀꯤ ꯀꯤꯗꯅꯤꯗꯥ ꯂꯩꯕꯥ ꯐꯤꯜꯇꯔ ꯇꯧꯔꯤꯕꯥ ꯃꯦꯝꯕ꯭ꯔꯦꯅꯁꯤꯡ, ``ꯒ꯭ꯂꯣꯃꯦꯔꯨꯂꯥꯔ ꯕꯦꯖꯃꯦꯟꯇ ꯃꯦꯝꯕ꯭ꯔꯦꯅꯁꯤꯡ ꯅꯠꯠꯔꯒꯥ ꯖꯤ.ꯕꯤ.ꯑꯦꯝ.''ꯒꯤꯗꯃꯛꯇꯥ ꯌꯥꯝꯅꯥ ꯃꯔꯨꯑꯣꯏ꯫ ꯃꯁꯤꯒꯤ ``(GBM)'' ꯑꯁꯤꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯏ ꯑꯗꯨ ꯐꯤꯜꯇꯔ ꯇꯧꯏ, ꯍꯀꯆꯥꯡꯅꯥ ꯃꯊꯧ ꯇꯥꯗꯕꯥ ꯄꯣꯠꯁꯀꯁꯤꯡ ꯑꯃꯁꯨꯡ ꯑꯇꯩ ꯄꯣꯠꯁꯀꯁꯤꯡ ꯇꯣꯉꯥꯟꯅꯥ ꯇꯥꯍꯜꯂꯤ ꯑꯃꯁꯨꯡ ꯌꯨꯔꯤꯟ ꯁꯦꯝꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯏ꯫ ꯃꯁꯤꯅꯥ ꯏꯗꯥ ꯌꯥꯎꯔꯤꯕꯥ ꯕ꯭ꯂꯗ ꯁꯦꯂꯁꯤꯡ ꯑꯃꯁꯨꯡ ꯄ꯭ꯔꯣꯇꯤꯅꯁꯤꯡ ꯑꯁꯤꯅꯆꯤꯡꯕꯥ ꯄꯣꯠꯁꯀꯁꯤꯡ ꯑꯁꯤ ꯏꯗꯥ ꯆꯦꯟꯊꯔꯀꯄꯒꯤ ꯃꯍꯨꯠꯇꯥ ꯏꯗꯥ ꯊꯝꯕꯗꯁꯨ ꯃꯇꯦꯡ ꯄꯥꯡꯏ꯫

ꯍꯧꯖꯤꯛꯇꯤ, ꯃꯁꯤꯒꯤ `(GBM)` ꯑꯁꯤ ꯃꯑꯣꯡ ꯆꯨꯝꯅꯥ ꯊꯕꯛ ꯇꯧꯗꯕꯥ ꯃꯇꯃꯗꯥ, ꯏ ꯅꯠꯠꯔꯒꯥ ꯄ꯭ꯔꯣꯇꯤꯟ ꯑꯁꯤ ꯅꯍꯥꯛꯀꯤ ꯌꯨꯔꯤꯅꯗꯥ ꯂꯤꯛ ꯑꯣꯏꯕꯥ ꯌꯥꯏ꯫ ꯃꯇꯃꯒꯤ ꯃꯇꯨꯡꯏꯟꯅꯥ, ꯅꯍꯥꯛꯀꯤ ꯀꯤꯗꯅꯤꯁꯤꯡꯅꯥ ꯌꯨꯔꯤꯟ ꯐꯤꯜꯇꯔ ꯇꯧꯕꯒꯤ ꯃꯄꯥꯉ꯭ꯒꯂꯁꯨ ꯍꯟꯊꯔꯀꯏ꯫ ꯃꯁꯤꯅꯥ ꯀꯤꯗꯅꯤ ꯐꯦꯜ ꯑꯣꯏꯕꯒꯤ ꯔꯤꯁ꯭ꯛ ꯍꯦꯅꯒꯠꯍꯜꯂꯤ꯫

ꯑꯗꯨꯕꯨ ꯃꯁꯤꯅꯥ ꯀꯤꯗꯅꯤ ꯈꯛꯇꯗꯥ ꯑꯀꯥꯌꯕꯥ ꯄꯤꯗꯦ꯫ ꯃꯁꯤꯒꯤ ``ꯇꯥꯏꯞ IV ꯀꯣꯂꯥꯖꯦꯟ'' ꯑꯁꯤ ꯅꯍꯥꯛꯀꯤ ꯅꯥꯀꯣꯡ ꯑꯃꯁꯨꯡ ꯃꯤꯠꯇꯥꯁꯨ ꯌꯥꯎꯏ꯫ ꯃꯔꯝ ꯑꯗꯨꯅꯥ, ꯀꯤꯗꯅꯤꯒꯤ ꯄ꯭ꯔꯣꯕ꯭ꯂꯦꯃꯁꯤꯡꯒꯤ ꯃꯊꯛꯇꯥ, ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯂꯩꯕꯥ ꯃꯤꯑꯣꯏ ꯑꯃꯅꯥ ꯃꯤꯠ ꯑꯃꯁꯨꯡ ꯁꯣꯀꯄꯒꯤ ꯄ꯭ꯔꯣꯕ꯭ꯂꯦꯃꯁꯤꯡꯁꯨ ꯂꯩꯕꯥ ꯌꯥꯏ꯫

ꯃꯁꯤ ꯑꯩꯈꯣꯌꯅꯥ ꯀꯔꯝꯅꯥ ꯏꯅꯍꯦꯔꯤ ꯇꯧꯒꯅꯤ?

ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯃꯒꯤ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯖꯦꯅꯦꯇꯤꯛ ꯃꯈꯜ ꯑꯍꯨꯝ ꯂꯩ꯫ ꯃꯈꯣꯌꯁꯤꯡ ꯑꯁꯤ ꯀꯔꯤꯅꯣ ꯍꯥꯌꯕꯗꯨ ꯌꯦꯡꯁꯤ꯫

ꯑꯦꯛꯁ-ꯂꯤꯉ꯭ꯛ ꯇꯧꯔꯕꯥ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ (ꯑꯦꯛꯁ.ꯑꯦꯜ.ꯑꯦ.ꯑꯦꯁ.)

ꯃꯁꯤ ꯅꯍꯥꯛꯀꯤ X ꯀ꯭ꯔꯣꯃꯣꯖꯣꯃꯒꯥ ꯃꯔꯤ ꯂꯩꯅꯩ꯫ X ꯀ꯭ꯔꯣꯃꯣꯖꯣꯝ ꯑꯁꯤ ꯅꯍꯥꯛꯀꯤ ꯁꯦꯛꯁ ꯀ꯭ꯔꯣꯃꯣꯖꯣꯝ ꯑꯅꯤ (X ꯑꯃꯁꯨꯡ Y)ꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯑꯃꯅꯤ꯫ ꯃꯁꯤꯗꯥ ꯑꯥꯂꯐꯥ ꯵ ꯆꯦꯟ `(COL4A5)` ꯁꯦꯝꯂꯤꯕꯥ ꯖꯤꯟ ꯑꯁꯤ ꯌꯥꯑꯣꯏ꯫

ꯍꯧꯖꯤꯛ ꯌꯦꯡꯎ, ꯅꯨꯄꯥ ꯑꯃꯗꯥ X ꯀ꯭ꯔꯣꯃꯣꯖꯣꯝ ꯑꯃꯥ ꯑꯃꯁꯨꯡ Y ꯀ꯭ꯔꯣꯃꯣꯖꯣꯝ ꯑꯃꯥ ꯂꯩ꯫ ꯅꯨꯄꯤ ꯑꯃꯗꯥ X ꯀ꯭ꯔꯣꯃꯣꯖꯣꯝ ꯑꯅꯤ ꯂꯩ꯫ ꯅꯨꯄꯥꯁꯤꯡꯗꯥ ꯑꯁꯣꯌꯕꯥ X ꯀ꯭ꯔꯣꯃꯣꯖꯣꯝ ꯑꯃꯈꯛꯇꯃꯛ ꯂꯩꯕꯅꯥ ꯃꯔꯝ ꯑꯣꯏꯗꯨꯅꯥ ꯃꯈꯣꯌꯗꯥ ꯁꯥꯊꯤꯕꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯂꯩꯕꯒꯤ ꯆꯥꯡ ꯍꯦꯜꯂꯤ꯫ ꯅꯨꯄꯤꯁꯤꯡꯗꯥ ꯑꯁꯣꯌꯕꯥ X ꯀ꯭ꯔꯣꯃꯣꯖꯣꯝ ꯑꯃꯥ ꯑꯃꯁꯨꯡ ꯍꯀꯁꯦꯜ ꯐꯕꯥ X ꯀ꯭ꯔꯣꯃꯣꯖꯣꯝ ꯑꯃꯥ ꯂꯩꯕꯅꯥ ꯃꯔꯝ ꯑꯣꯏꯗꯨꯅꯥ ꯃꯈꯣꯌꯒꯤ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯑꯁꯤ ꯃꯍꯧꯁꯥꯅꯥ ꯍꯦꯟꯅꯥ ꯅꯦꯝꯃꯤ꯫

ꯅꯨꯄꯥ ꯑꯃꯅꯥ ꯃꯍꯥꯛꯀꯤ ꯋꯥꯏ ꯀ꯭ꯔꯣꯃꯣꯖꯣꯝ ꯑꯗꯨ ꯃꯍꯥꯛꯀꯤ ꯃꯆꯥꯁꯤꯡꯗꯥ ꯄꯤ꯫ ꯃꯔꯝ ꯑꯗꯨꯅꯥ ꯃꯈꯣꯌꯅꯥ ꯃꯈꯣꯌꯒꯤ ꯃꯆꯥꯁꯤꯡꯗꯥ `(XLAS)` ꯄꯤꯕꯥ ꯉꯃꯗꯦ꯫ ꯑꯗꯨꯕꯨ ꯅꯨꯄꯥ ꯑꯃꯅꯥ ꯃꯍꯥꯛꯀꯤ X ꯀ꯭ꯔꯣꯃꯣꯖꯣꯝ ꯑꯗꯨ ꯃꯍꯥꯛꯀꯤ ꯃꯆꯥꯅꯨꯄꯤ ꯄꯨꯝꯅꯃꯛꯇꯥ ꯄꯥꯁ ꯇꯧꯏ꯫ ꯃꯔꯝ ꯑꯗꯨꯅꯥ ꯃꯍꯥꯛꯀꯤ ꯃꯆꯥꯅꯨꯄꯤ ꯄꯨꯝꯅꯃꯛ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯂꯥꯀꯄꯥ ꯌꯥꯏ꯫

ꯅꯨꯄꯤ ꯑꯃꯅꯥ ꯃꯍꯥꯛꯀꯤ X ꯀ꯭ꯔꯣꯃꯣꯖꯣꯝ ꯑꯅꯤꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯑꯃꯕꯨ ꯃꯍꯥꯛꯀꯤ ꯑꯉꯥꯡꯗꯥ ꯄꯤꯖꯩ, ꯑꯉꯥꯡ ꯑꯗꯨ ꯅꯨꯄꯥꯃꯆꯥ ꯅꯠꯠꯔꯒꯥ ꯅꯨꯄꯤꯃꯆꯥ ꯑꯣꯏꯔꯕꯁꯨ ꯌꯦꯡꯗꯅꯥ꯫ ꯃꯔꯝ ꯑꯗꯨꯅꯥ ꯃꯍꯥꯛꯅꯥ ꯑꯉꯥꯡ ꯑꯃꯍꯦꯛꯇꯗꯥ `(XLAS)` ꯄꯤꯕꯒꯤ ꯆꯥꯡ 50% ꯂꯩ꯫

ꯃꯁꯤꯒꯤ `(XLAS)` ꯑꯁꯤ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯃꯒꯤ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯀꯃꯟ ꯑꯣꯏꯕꯥ ꯃꯈꯂꯅꯤ꯫ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯄꯦꯁꯦꯟꯇ ꯄꯨꯝꯅꯃꯛꯀꯤ 60% ꯑꯃꯁꯨꯡ 80%ꯒꯤ ꯃꯔꯛꯇꯥꯗꯤ ꯃꯈꯜ ꯑꯁꯤꯒꯤ ꯃꯅꯨꯡ ꯆꯜꯂꯤ꯫

ꯑꯣꯇꯣꯁꯣꯃꯜ ꯔꯤꯁꯦꯁꯤꯚ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ (ꯑꯦ.ꯑꯥꯔ.ꯑꯦ.ꯑꯦꯁ.)

"ꯑꯣꯇꯣꯁꯣꯃꯜ" ꯍꯥꯌꯕꯁꯤ ꯑꯣꯇꯣꯁꯣꯃꯜ ꯖꯤꯅꯒꯤ ꯄꯦꯔꯥ 23ꯕꯨ ꯈꯪꯅꯩ꯫ "ꯑꯣꯇꯣꯁꯣꯃꯜ ꯔꯤꯁꯦꯁꯤꯚ" ꯍꯥꯌꯕꯁꯤꯅꯥ ꯏꯅꯍꯦꯔꯤꯇꯦꯁꯅꯒꯤ ꯃꯑꯣꯡ-ꯃꯇꯧ ꯑꯗꯨꯕꯨ ꯈꯪꯅꯩ꯫ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯃꯃꯥ-ꯃꯄꯥ ꯑꯃꯅꯥ ꯑꯣꯇꯣꯁꯣꯃꯜ ꯔꯤꯁꯦꯁꯤꯚ ꯇ꯭ꯔꯦꯠ ꯑꯃꯥ ꯂꯩꯔꯕꯗꯤ ꯃꯈꯣꯌꯅꯥ ꯂꯥꯏꯑꯣꯡ ꯎꯠꯂꯣꯏꯗꯕꯅꯤ꯫ ꯃꯁꯤ ꯃꯈꯣꯌꯒꯤ ꯑꯉꯥꯡꯁꯤꯡꯗꯥ ꯌꯧꯍꯟꯅꯕꯒꯤꯗꯃꯛ ꯃꯃꯥ-ꯃꯄꯥ ꯑꯅꯤꯃꯛꯅꯥ ꯂꯃꯆꯠ-ꯁꯥꯖꯠ ꯑꯗꯨ ꯄꯨꯗꯨꯅꯥ ꯆꯠꯀꯗꯕꯅꯤ꯫ ꯑꯗꯨꯝ ꯑꯣꯏꯅꯃꯛ, ꯃꯈꯣꯌꯗꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯂꯩꯇꯕꯅꯥ ꯃꯔꯝ ꯑꯣꯏꯗꯨꯅꯥ ꯃꯈꯣꯌꯗꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯂꯩ ꯍꯥꯌꯕꯁꯤꯁꯨ ꯈꯪꯗꯦ꯫

ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯃꯗꯥ, ꯑꯥꯂꯐꯥ ꯳ (ꯁꯤ.ꯑꯣ.ꯑꯦꯜ.꯴ꯑꯦ.꯳) ꯑꯃꯁꯨꯡ ꯑꯥꯂꯐꯥ ꯴ (ꯁꯤ.ꯑꯣ.ꯑꯦꯜ.꯴ꯑꯦ.꯴) ꯄ꯭ꯔꯣꯇꯤꯅꯁꯤꯡ ꯑꯦꯅꯀꯣꯗ ꯇꯧꯕꯥ ꯖꯤꯅꯁꯤꯡ ꯑꯁꯤ ꯀ꯭ꯔꯣꯃꯣꯖꯣꯝ ꯲ꯗꯥ ꯂꯩ, "ꯔꯤꯁꯦꯁꯤꯕ" ꯍꯥꯌꯕꯁꯤꯅꯥ ꯂꯥꯌꯅꯥ ꯑꯁꯤ ꯊꯣꯀꯍꯟꯅꯕꯒꯤꯗꯃꯛꯇꯥ ꯖꯤꯟ ꯄꯦꯔꯥ ꯑꯃꯒꯤ ꯖꯤꯟ ꯑꯅꯤꯃꯛꯇꯥ ꯃ꯭ꯌꯨꯇꯦꯁꯟ ꯃꯊꯧ ꯇꯥꯏ ꯍꯥꯌꯕꯅꯤ꯫

ꯑꯗꯨꯅꯥ, `(ARAS)`ꯗꯥ, ꯀ꯭ꯔꯣꯃꯣꯖꯣꯝ 2ꯗꯥ ꯂꯩꯕꯥ ꯑꯥꯂꯐꯥ 3 ꯅꯠꯠꯔꯒꯥ ꯑꯥꯂꯐꯥ 4 ꯄ꯭ꯔꯣꯇꯤꯅꯁꯤꯡ ꯑꯦꯅꯀꯣꯗ ꯇꯧꯕꯥ ꯖꯤꯅꯁꯤꯡꯗꯥ ꯃ꯭ꯌꯨꯇꯦꯁꯟ ꯑꯃꯥ ꯂꯩ, `(ARAS)` ꯑꯁꯤ ꯖꯦꯟꯗꯔꯗꯥ ꯌꯨꯝꯐꯝ ꯑꯣꯏꯗꯦ, ꯃꯔꯝ ꯑꯗꯨꯅꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡꯒꯤ ꯏꯅꯍꯦꯔꯤꯇꯦꯁꯟ ꯑꯃꯁꯨꯡ ꯁꯣꯀꯍꯜꯂꯀꯄꯥ ꯑꯁꯤ ꯃꯤꯄꯨꯝ ꯈꯨꯗꯤꯡꯃꯛꯀꯤ ꯑꯣꯏꯅꯥ ꯃꯥꯟꯅꯩ꯫

ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ `(ARAS)` ꯂꯩꯔꯕꯗꯤ, ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡꯁꯤꯡꯅꯥ ꯑꯁꯣꯌꯕꯥ ꯖꯤꯅꯁꯤꯡ ꯑꯁꯤꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯑꯃꯕꯨ 50% ꯄꯤꯕꯒꯤ ꯆꯥꯡ ꯂꯩ꯫ ꯃꯁꯤꯅꯥ ꯃꯍꯧꯁꯥꯅꯥ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗ꯭ꯔꯣꯝ ꯊꯣꯀꯍꯟꯗꯦ꯫ ꯑꯗꯨꯝ ꯑꯣꯏꯅꯃꯛ, ꯑꯁꯣꯌꯕꯥ ꯖꯤꯟ ꯑꯅꯤꯃꯛ ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡꯁꯤꯡꯗꯥ ꯄꯤꯕꯒꯤ ꯆꯥꯡ ꯑꯁꯤ 25% ꯑꯣꯏ꯫ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯃꯁꯤ ꯑꯣꯏꯔꯕꯗꯤ, ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯗꯥ `(ARAS)` ꯂꯩꯒꯅꯤ꯫

(ꯑꯦ.ꯑꯥꯔ.ꯑꯦ.ꯑꯦꯁ.) ꯑꯁꯤꯅꯥ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯄꯦꯁꯦꯟꯇꯁꯤꯡꯒꯤ ꯆꯥꯎꯔꯥꯛꯅꯥ ꯱꯵% ꯑꯣꯏꯔꯤ꯫

ꯑꯣꯇꯣꯁꯣꯃꯜ ꯗꯣꯃꯤꯅꯦꯟꯇ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ (ꯑꯦ.ꯗꯤ.ꯑꯦ.ꯑꯦꯁ.)

"ꯗꯣꯃꯤꯅꯦꯟꯇ" ꯍꯥꯌꯕꯁꯤꯅꯥ ꯂꯥꯌꯅꯥ ꯑꯃꯥ ꯖꯤꯟ ꯄꯦꯔꯥ ꯑꯃꯗꯥ ꯖꯤꯟ ꯑꯃꯈꯛꯇꯗꯥ ꯃ꯭ꯌꯨꯇꯦꯁꯟ ꯇꯧꯕꯅꯥ ꯊꯣꯀꯍꯅꯕꯥ ꯌꯥꯏ ꯍꯥꯌꯕꯅꯤ꯫ ꯑꯦ.ꯗꯤ.ꯑꯦ.ꯑꯦꯁ.ꯇꯥ ꯀ꯭ꯔꯣꯃꯣꯖꯣꯝ ꯲ꯗꯥ ꯄ꯭ꯔꯣꯇꯤꯟ ꯁꯤ.ꯑꯣ.ꯑꯦꯜ.꯴ꯑꯦ.꯳ ꯅꯠꯠꯔꯒꯥ ꯁꯤ.ꯑꯣ.ꯑꯦꯜ.꯴ꯑꯦ.꯴ ꯑꯦꯅꯀꯣꯗ ꯇꯧꯕꯥ ꯖꯤꯅꯁꯤꯡꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯑꯃꯗꯥ ꯃ꯭ꯌꯨꯇꯦꯁꯟ ꯂꯩ꯫

ꯑꯦ.ꯗꯤ.ꯑꯦ.ꯑꯦꯁ.ꯅꯥ ꯖꯦꯟꯗꯔꯒꯤ ꯃꯈꯥ ꯄꯣꯜꯂꯤ, ꯃꯔꯝ ꯑꯗꯨꯅꯥ ꯍꯦꯔꯤꯇꯦꯕꯤꯂꯤꯇꯤ ꯑꯃꯁꯨꯡ ꯂꯥꯏꯑꯣꯡꯁꯤꯡꯒꯤ ꯌꯥꯝꯅꯥ ꯁꯥꯊꯤꯕꯥ ꯃꯑꯣꯡ ꯑꯁꯤ ꯃꯤꯄꯨꯝ ꯈꯨꯗꯤꯡꯃꯛꯀꯤ ꯑꯣꯏꯅꯥ ꯃꯥꯟꯅꯩ꯫

ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ADAS ꯂꯩꯔꯕꯗꯤ, ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡꯁꯤꯡꯅꯥ ꯑꯁꯣꯏ-ꯑꯉꯥꯝ ꯌꯥꯑꯣꯗꯕꯥ ꯖꯤꯟ ꯑꯁꯤ ꯄꯥꯁ ꯇꯧꯔꯀꯄꯒꯤ ꯆꯥꯡ 50% ꯂꯩ꯫

(ꯑꯦ.ꯗꯤ.ꯑꯦ.ꯑꯦꯁ.) ꯑꯁꯤꯅꯥ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯄꯦꯁꯦꯟꯇꯁꯤꯡꯒꯤ ꯲꯵% ꯑꯃꯁꯨꯡ ꯳꯵%ꯒꯤ ꯃꯔꯛꯇꯥ ꯑꯣꯏꯔꯤ꯫

ꯃꯁꯤꯅꯥ ꯀꯅꯥꯗꯥ ꯁꯥꯐꯨ ꯄꯤꯕꯒꯦ? ꯃꯁꯤ ꯀꯌꯥ ꯌꯥꯝꯅꯥ ꯀꯃꯟ ꯑꯣꯏꯕꯒꯦ?

ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯑꯁꯤ ꯀꯅꯥꯒꯨꯝꯕꯥ ꯑꯃꯠꯇꯗꯥ ꯁꯣꯀꯍꯅꯕꯥ ꯌꯥꯏ꯫ ꯃꯁꯤ ꯏꯅꯍꯦꯔꯤꯇꯦꯗ ꯀꯟꯗꯤꯁꯟ ꯑꯃꯅꯤ, ꯍꯥꯌꯕꯗꯤ ꯃꯃꯥ-ꯃꯄꯥ ꯑꯃꯅꯥ ꯅꯠꯠꯔꯒꯥ ꯑꯅꯤꯃꯛꯅꯥ ꯃꯈꯣꯌꯒꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯗꯥ ꯄꯤꯖꯩ꯫ ꯑꯗꯨꯝ ꯑꯣꯏꯅꯃꯛ, ꯆꯥꯎꯔꯥꯛꯅꯥ ꯀꯦꯁ 15%ꯗꯥ, ꯃꯃꯥ-ꯃꯄꯥ ꯑꯅꯤꯃꯛꯇꯥ ꯃ꯭ꯌꯨꯇꯦꯁꯟ ꯇꯧꯔꯕꯥ ꯖꯤꯟ ꯑꯗꯨ ꯂꯩꯇꯕꯁꯨ ꯌꯥꯏ꯫

ꯗꯣꯛꯇꯔꯁꯤꯡꯅꯥ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯑꯁꯤ ꯌꯥꯝꯅꯥ ꯊꯨꯅꯥ ꯊꯣꯀꯄꯥ ꯀꯟꯗꯤꯁꯟ ꯑꯃꯅꯤ ꯍꯥꯌꯅꯥ ꯈꯜꯂꯤ꯫ꯔꯤꯁꯔꯆꯔꯁꯤꯡꯅꯥ ꯍꯥꯌꯔꯤ ꯃꯗꯨꯗꯤ ꯑꯃꯦꯔꯤꯀꯥꯗꯥ ꯃꯤꯑꯣꯏ ꯂꯥꯈ ꯑꯅꯤꯗꯒꯤ ꯇꯥꯅꯥ ꯃꯁꯤ ꯂꯩꯔꯤ꯫ ꯃꯥꯂꯦꯝ ꯁꯤꯅꯕꯥ ꯊꯨꯡꯅꯥ, ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯑꯁꯤ ꯍꯤꯡꯅꯥ ꯄꯣꯀꯄꯥ ꯑꯉꯥꯡ 50,000ꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯆꯥꯎꯔꯥꯛꯅꯥ ꯑꯃꯅꯤ꯫ ꯑꯗꯨꯝ ꯑꯣꯏꯅꯃꯛ ꯔꯤꯁꯔꯆꯔꯁꯤꯡꯅꯥ ꯃꯁꯤꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯃꯈꯥ ꯇꯥꯅꯥ ꯊꯤꯖꯤꯅꯕꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯃꯈꯣꯌꯅꯥ ꯂꯥꯏꯑꯣꯡ ꯍꯟꯊꯕꯥ ꯃꯤꯑꯣꯏꯁꯤꯡ ꯊꯤꯔꯤ꯫ ꯃꯔꯝ ꯑꯗꯨꯅꯥ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯑꯁꯤ ꯍꯧꯖꯤꯛ ꯈꯪꯅꯔꯤꯕꯥ ꯑꯁꯤꯗꯒꯤ ꯍꯦꯟꯅꯥ ꯀꯃꯟ ꯑꯣꯏꯕꯥ ꯌꯥꯏ꯫

ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗ꯭ꯔꯣꯝ ꯑꯁꯤꯅꯥ ꯃꯇꯧ ꯀꯔꯝꯅꯥ ꯀꯤꯗꯅꯤ ꯐꯦꯜ ꯑꯣꯏꯍꯅꯕꯒꯦ?

ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯂꯩꯔꯕꯗꯤ, ꯑꯩꯅꯥ ꯃꯃꯥꯡꯗꯥ ꯍꯥꯌꯈꯤꯕꯥ ꯒ꯭ꯂꯣꯃꯦꯔꯨꯂꯥꯔ ꯕꯦꯖꯃꯦꯟꯇ ꯃꯦꯝꯕ꯭ꯔꯦꯅꯁꯤꯡ ꯑꯁꯤ ꯃꯑꯣꯡ ꯆꯨꯝꯅꯥ ꯐꯤꯜꯇꯔ ꯇꯧꯗꯦ꯫ ꯃꯔꯝ ꯑꯗꯨꯅꯥ ꯏ ꯑꯃꯁꯨꯡ ꯄ꯭ꯔꯣꯇꯤꯅꯁꯤꯡ ꯑꯁꯤ ꯌꯨꯔꯤꯅꯗꯥ ꯂꯤꯛ ꯑꯣꯏ꯫ ꯃꯁꯤ ꯈꯛꯇꯥ ꯅꯠꯇꯅꯥ, ꯃꯦꯝꯕ꯭ꯔꯦꯅꯁꯤꯡ ꯑꯗꯨꯒꯤ ꯅꯥꯀꯜ ꯑꯃꯔꯣꯃꯗꯥ ꯂꯩꯕꯥ ꯁꯦꯂꯁꯤꯡꯅꯥ ꯃꯇꯤꯛ ꯆꯥꯕꯥ ꯁꯄꯣꯔꯠ ꯐꯪꯗꯦ꯫ ꯑꯗꯨꯗꯒꯤ ꯁꯦꯂꯁꯤꯡ ꯑꯗꯨ ꯏꯔꯤꯇꯦꯠ ꯑꯃꯁꯨꯡ ꯏꯅꯐ꯭ꯂꯦꯃꯦꯁꯟ ꯑꯣꯏꯔꯀꯏ . ꯄꯣꯗꯣꯁꯥꯏꯠ ꯀꯧꯕꯥ ꯁꯦꯂꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯖꯤ.ꯕꯤ.ꯑꯦꯝ. ꯑꯀꯣꯌꯕꯗꯥ ꯂꯩꯕꯥ ꯁꯦꯂꯁꯤꯡꯅꯥ ꯏꯅꯐ꯭ꯂꯦꯃꯦꯁꯟ ꯇꯧꯕꯥ ꯃꯇꯃꯗꯥ, ꯄꯣꯗꯣꯁꯥꯏꯇꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯖꯤ.ꯕꯤ.ꯑꯦꯝ.ꯗꯥ ꯇꯥꯏꯞ IV ꯀꯣꯂꯥꯖꯦꯟ ꯍꯦꯟꯅꯥ ꯊꯥꯗꯅꯕꯥ ꯍꯣꯠꯅꯩ꯫ ꯃꯗꯨ ꯑꯣꯏꯔꯀꯄꯥ ꯃꯇꯃꯗꯥ ꯖꯤ.ꯕꯤ.ꯑꯦꯝ. ꯃꯁꯤꯅꯥ ꯄ꯭ꯔꯣꯇꯤꯟ ꯑꯁꯤ ꯌꯨꯔꯤꯅꯗꯥ ꯂꯤꯛ (proteinuria) ꯊꯣꯀꯍꯜꯂꯤ꯫

ꯃꯇꯃꯒꯤ ꯃꯇꯨꯡꯏꯟꯅꯥ, ꯌꯨꯔꯤꯅꯗꯥ ꯄ꯭ꯔꯣꯇꯤꯟ ꯍꯦꯟꯅꯥ ꯆꯪꯂꯀꯄꯒꯥ ꯂꯣꯌꯅꯅꯥ, ꯖꯤ.ꯕꯤ.ꯑꯦꯝ. ꯃꯁꯤꯒꯤ ꯃꯍꯩ ꯑꯣꯏꯅꯥ, ꯅꯍꯥꯛꯀꯤ ꯀꯤꯗꯅꯤꯁꯤꯡꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯏ ꯑꯗꯨ ꯁꯦꯡꯗꯣꯀꯄꯒꯤ ꯇꯧꯕꯥ ꯉꯝꯕꯗꯨ ꯃꯥꯡꯍꯅꯕꯥ ꯍꯧꯔꯀꯏ꯫ ꯃꯁꯤꯕꯨ ꯀ꯭ꯔꯣꯅꯤꯛ ꯀꯤꯗꯅꯤ ꯗꯤꯖꯤꯖ (CKD) ꯍꯥꯌꯅꯥ ꯀꯧꯏ꯫ ꯁ꯭ꯀꯥꯔ ꯇꯤꯁꯨ ꯍꯦꯟꯅꯥ ꯁꯦꯃꯒꯠꯂꯀꯄꯒꯥ ꯂꯣꯌꯅꯅꯥ, ꯀꯤꯗꯅꯤꯒꯤ ꯐꯉ꯭ꯀꯁꯟ ꯍꯦꯟꯅꯥ ꯐꯠꯆꯤꯜꯂꯀꯏ, ꯑꯃꯁꯨꯡ ꯑꯔꯣꯏꯕꯗꯥ ꯀꯤꯗꯅꯤꯁꯤꯡꯅꯥ ꯊꯕꯛ ꯇꯧꯕꯥ ꯂꯦꯄꯈꯤ (ꯀꯤꯗꯅꯤ ꯐꯦꯜ ꯑꯣꯏꯕꯥ)꯫

ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯃꯒꯤ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯑꯗꯨ ꯀꯔꯤꯅꯣ?

ꯅꯍꯥꯛꯅꯥ ꯂꯩꯔꯤꯕꯥ ꯃꯈꯜ ꯑꯗꯨꯒꯤ ꯃꯇꯨꯡꯏꯟꯅꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯑꯁꯤ ꯈꯦꯠꯅꯕꯥ ꯌꯥꯏ꯫ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡꯗꯤ:

• ꯅꯍꯥꯛꯅꯥ ꯎꯕꯥ ꯐꯪꯗꯕꯥ ꯌꯨꯔꯤꯅꯗꯥ ꯏ ꯊꯣꯀꯄꯥ (ꯃꯥꯏꯛꯔꯣꯁ꯭ꯀꯣꯄꯤꯛ ꯍꯦꯃꯦꯇꯔꯤꯑꯦꯜ)꯫
• ꯌꯨꯔꯤꯅꯗꯥ ꯄ꯭ꯔꯣꯇꯤꯟ ꯂꯩꯕꯥ (proteinuria)꯫
• ꯀ꯭ꯔꯣꯅꯤꯛ ꯀꯤꯗꯅꯤ ꯗꯤꯖꯤꯖ (CKD) ꯅꯠꯠꯔꯒꯥ ꯀꯤꯗꯅꯤ ꯐꯦꯜ ꯑꯣꯏꯕꯥ꯫
• ꯇꯥꯕꯥ ꯉꯃꯗꯕꯥ꯫
• ꯃꯤꯠꯀꯤ ꯁꯃꯁ꯭ꯌꯥ ꯂꯩꯕꯥ꯫

ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗ꯭ꯔꯣꯃꯒꯤ ꯑꯍꯥꯅꯕꯥ ꯈꯨꯗꯃꯗꯤ ꯃꯥꯏꯛꯔꯣꯁ꯭ꯀꯣꯄꯤꯛ ꯍꯦꯃꯦꯇꯔꯤꯑꯦꯂꯅꯤ꯫ ꯃꯁꯤꯅꯥ ꯇꯥꯀꯄꯗꯤ ꯅꯍꯥꯛꯀꯤ ꯑꯁꯣꯀꯄꯥ ꯖꯤ.ꯕꯤ.ꯑꯦꯝ.ꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯌꯨꯔꯤꯅꯗꯥ ꯔꯦꯗ ꯕ꯭ꯂꯗ ꯁꯦꯂꯁꯤꯡ ꯂꯤꯛ ꯑꯣꯏꯍꯜꯂꯤ꯫ ꯃꯁꯤ ꯃꯤꯠꯅꯥ ꯎꯕꯥ ꯐꯪꯗꯦ, ꯑꯗꯨꯕꯨ ꯃꯥꯏꯛꯔꯣꯁ꯭ꯀꯣꯄꯀꯤ ꯃꯈꯥꯗꯥ ꯈꯛꯇꯃꯛ ꯎꯕꯥ ꯐꯪꯏ꯫ XLAS ꯂꯩꯕꯥ ꯅꯨꯄꯥꯁꯤꯡ ꯑꯃꯁꯨꯡ ARAS ꯂꯩꯕꯥ ꯃꯤꯑꯣꯏ ꯑꯃꯍꯦꯛꯇꯗꯥ ꯄꯣꯀꯄꯗꯒꯤ ꯃꯥꯏꯛꯔꯣꯁ꯭ꯀꯣꯄꯤꯛ ꯍꯦꯃꯦꯆ꯭ꯌꯨꯔꯤꯌꯥ ꯂꯩꯕꯥ ꯌꯥꯏ꯫ XLASꯅꯥ ꯅꯥꯕꯥ ꯅꯨꯄꯤ ꯀꯌꯥꯗꯥ ꯃꯇꯃꯒꯤ ꯃꯇꯨꯡꯏꯟꯅꯥ ꯃꯥꯏꯛꯔꯣꯁ꯭ꯀꯣꯄꯤꯛ ꯍꯦꯃꯦꯆ꯭ꯌꯨꯔꯤꯌꯥ ꯊꯣꯀꯏ꯫ ꯑꯦ.ꯗꯤ.ꯑꯦ.ꯑꯦꯁ.ꯅꯥ ꯅꯥꯕꯥ ꯃꯤꯑꯣꯏ ꯈꯨꯗꯤꯡꯃꯛꯇꯥ ꯃꯥꯏꯛꯔꯣꯁ꯭ꯀꯣꯄꯤꯛ ꯍꯦꯃꯦꯆ꯭ꯌꯨꯔꯤꯌꯥ ꯅꯥꯕꯥ ꯉꯃꯗꯦ꯫

ꯀ꯭ꯔꯣꯅꯤꯛ ꯀꯤꯗꯅꯤ ꯗꯤꯖꯤꯖ (CKD) ꯑꯁꯤ ꯀꯤꯗꯅꯤꯒꯤ ꯐꯉ꯭ꯀꯁꯟ ꯍꯟꯊꯕꯥ ꯍꯧꯔꯀꯄꯥ ꯃꯇꯃꯗꯥ ꯊꯣꯀꯏ꯫ ꯃꯤꯑꯣꯏ ꯀꯌꯥꯅꯥ ꯃꯈꯣꯌꯒꯤ ꯀꯤꯗꯅꯤꯁꯤꯡ ꯑꯗꯨ ꯑꯣꯄꯔꯦꯁꯟ ꯇꯧꯗ꯭ꯔꯤꯉꯩꯗꯥ ꯁꯤ.ꯀꯦ.ꯗꯤ.ꯒꯤ ꯂꯥꯏꯑꯣꯡ ꯎꯠꯄꯥ ꯉꯃꯗꯦ꯫

ꯀꯤꯗꯅꯤ ꯐꯦꯜ ꯑꯣꯏꯕꯒꯤ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ:

• ꯃꯔꯨꯑꯣꯏꯅꯥ ꯈꯨꯠ ꯅꯠꯠꯔꯒꯥ ꯈꯨꯎꯒꯤ ꯑꯀꯣꯌꯕꯗꯥ ꯁꯣꯛ-ꯄꯅꯕꯥ (edema)꯫
• ꯑꯀꯅꯕꯥ ꯋꯥꯈꯜ ꯋꯥꯕꯥ꯫
• ꯅꯣꯡꯃꯩ ꯀꯥꯞꯄꯥ ꯑꯃꯁꯨꯡ ꯈꯣꯡ ꯍꯥꯝꯕꯥ꯫
• ꯃꯁꯜ ꯁꯣꯟꯊꯕꯥ꯫

XLAS ꯑꯃꯁꯨꯡ ARAS ꯂꯩꯕꯥ ꯅꯨꯄꯥꯁꯤꯡꯗꯥ ꯇꯥꯕꯥ ꯉꯃꯗꯕꯥ ꯑꯁꯤ ꯍꯦꯟꯅꯥ ꯀꯃꯟ ꯑꯣꯏ꯫ ꯑꯗꯨꯕꯨ ꯃꯁꯤ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯂꯩꯕꯥ ꯃꯤꯑꯣꯏ ꯑꯃꯍꯦꯛꯇꯗꯥ ꯊꯣꯀꯄꯥ ꯌꯥꯏ꯫ ꯇꯥꯕꯥ ꯉꯃꯗꯕꯥ ꯑꯁꯤ ꯇꯞꯅꯥ ꯇꯞꯅꯥ ꯊꯣꯀꯏ꯫ ꯃꯤꯑꯣꯏ ꯀꯌꯥ ꯑꯃꯅꯥ ꯃꯁꯤ ꯌꯥꯝꯅꯥ ꯊꯦꯡꯊꯗ꯭ꯔꯤꯐꯥꯑꯣꯕꯥ ꯈꯉꯕꯥ ꯉꯃꯗꯦ꯫ ꯃꯤꯑꯣꯏ ꯀꯌꯥꯅꯥ ꯑꯋꯥꯡꯕꯥ ꯈꯣꯟꯖꯦꯂꯁꯤꯡ ꯇꯥꯕꯗꯥ ꯑꯋꯥꯕꯥ ꯃꯥꯌꯣꯛꯅꯔꯤ, ꯑꯃꯁꯨꯡ ꯈꯔꯅꯥ ꯑꯔꯣꯌꯕꯗꯥ ꯇꯥꯕꯥ ꯄꯨꯝꯅꯃꯛ ꯃꯥꯡꯈꯤꯕꯥ ꯌꯥꯏ꯫ ꯅꯍꯥꯛꯅꯥ ꯑꯔꯣꯏꯕꯗꯥ ꯍꯤꯌꯥꯔꯤꯡ ꯑꯦꯗꯁꯤꯡ ꯁꯤꯖꯤꯟꯅꯕꯥ ꯃꯊꯧ ꯇꯥꯕꯥ ꯌꯥꯏ꯫ ꯁꯥꯊꯤꯕꯥ ꯀꯦꯁꯁꯤꯡꯗꯗꯤ, ꯅꯍꯥꯛꯀꯤ ꯁꯣꯛ-ꯄꯅꯕꯥ ꯑꯗꯨ ꯃꯄꯨꯡꯐꯥꯅꯥ ꯃꯥꯡꯈꯤꯕꯥ (deafness) ꯐꯥꯎꯕꯥ ꯌꯥꯏ꯫

ꯃꯤꯠꯀꯨꯄꯁꯤꯡꯗꯥ ꯇꯣꯉꯥꯟ-ꯇꯣꯉꯥꯅꯕꯥ ꯈꯨꯗꯣꯡꯆꯥꯗꯕꯁꯤꯡꯁꯨ ꯂꯩꯔꯤ꯫ ꯃꯤꯑꯣꯏ ꯈꯔꯗꯗꯤ ꯀꯣꯔꯅꯤꯑꯦꯜ ꯑꯦꯕꯔꯦꯁꯟ (cornial abrasions) ꯍꯦꯟꯅꯥ ꯊꯣꯀꯏ, ꯑꯃꯁꯨꯡ ꯃꯈꯣꯌ ꯑꯁꯤ ꯐꯒꯠꯂꯀꯄꯗꯥ ꯃꯇꯝ ꯍꯦꯟꯅꯥ ꯆꯪꯏ꯫ ꯃꯁꯤꯅꯥ ꯃꯤꯠ ꯎꯗꯕꯥ ꯑꯃꯁꯨꯡ ꯑꯅꯥꯕꯥ ꯊꯣꯀꯍꯅꯕꯥ ꯌꯥꯏ, ꯑꯗꯨꯕꯨ ꯃꯍꯧꯁꯥꯅꯥ ꯃꯤꯠ ꯎꯗꯕꯥ ꯊꯣꯀꯍꯟꯗꯦ꯫ ꯃꯤꯑꯣꯏ ꯈꯔꯗꯤ ꯃꯤꯠꯀꯤ ꯃꯌꯦꯛ ꯁꯦꯡꯕꯥ ꯁꯔꯨꯛ, ꯂꯦꯟꯁꯇꯥ ꯄ꯭ꯔꯣꯕ꯭ꯂꯦꯝ ꯂꯩ, ꯃꯗꯨꯅꯥ ꯃꯤꯠꯌꯦꯡꯗꯥ ꯃꯤꯠꯌꯦꯡ ꯊꯝꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯏ ꯑꯃꯁꯨꯡ ꯑꯔꯣꯏꯕꯗꯥ ꯀꯦꯇꯦꯔꯦꯛꯇ ꯂꯥꯀꯄꯥ ꯌꯥꯏ꯫

ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗ꯭ꯔꯣꯝ ꯂꯩꯔꯕꯗꯤ ꯑꯃꯁꯨꯡ ꯇꯥꯕꯥ ꯅꯠꯠꯔꯒꯥ ꯎꯕꯒꯤ ꯄ꯭ꯔꯣꯕ꯭ꯂꯦꯝ ꯂꯩꯔꯕꯗꯤ, ꯈꯨꯗꯛꯇꯥ ꯗꯣꯛꯇꯔ ꯑꯃꯒꯥ ꯇꯥꯟꯅꯧ꯫

ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯑꯁꯤ ꯀꯔꯤꯅꯥ ꯊꯣꯀꯍꯅꯕꯒꯦ?

ꯌꯥꯝꯅꯥ ꯂꯥꯏꯅꯥ ꯍꯥꯌꯔꯕꯗꯥ, ꯃꯁꯤ ꯅꯍꯥꯛꯀꯤ ꯀꯣꯂꯥꯖꯦꯟ ꯖꯤꯅꯁꯤꯡꯗꯥ ꯃ꯭ꯌꯨꯇꯦꯁꯅꯅꯥ ꯊꯣꯀꯍꯅꯕꯅꯤ꯫

ꯃꯁꯤ ꯂꯧꯅꯒꯅꯕꯥ ꯂꯥꯌꯅꯥ ꯑꯣꯏꯕꯔꯥ?

ꯅꯠꯇꯦ, ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯑꯁꯤ ꯂꯧꯅꯒꯅꯕꯥ ꯂꯥꯌꯅꯥ ꯑꯃꯅꯤ꯫ ꯃꯁꯤ ꯃꯤꯑꯣꯏ ꯑꯃꯗꯒꯤ ꯃꯤꯑꯣꯏ ꯑꯃꯗꯥ ꯀ꯭ꯂꯣꯖ ꯀꯟꯇꯦꯛꯇꯀꯤ ꯈꯨꯠꯊꯥꯡꯗꯥ ꯁꯟꯗꯣꯀꯄꯥ ꯅꯠꯇꯦ꯫ ꯃꯁꯤ ꯏꯅꯍꯦꯔꯤꯇꯦꯗ ꯀꯟꯗꯤꯁꯟ ꯑꯃꯅꯤ꯫

ꯃꯁꯤ ꯑꯗꯣꯝꯅꯥ ꯀꯔꯝꯅꯥ ꯈꯉꯕꯤꯔꯤꯕꯒꯦ?

ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯃꯥꯏꯛꯔꯣꯁ꯭ꯀꯣꯄꯤꯛ ꯍꯦꯃꯦꯆ꯭ꯌꯨꯔꯤꯌꯥ ꯅꯠꯠꯔꯒꯥ ꯀ꯭ꯔꯣꯅꯤꯛ ꯀꯤꯗꯅꯤꯒꯤ ꯂꯥꯌꯅꯥ ꯂꯩꯔꯕꯗꯤ, ꯗꯣꯛꯇꯔ ꯑꯃꯅꯥ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯆꯤꯡꯅꯕꯥ ꯌꯥꯏ꯫ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯀꯤ ꯏꯃꯨꯡꯒꯤ ꯃꯤꯑꯣꯏ ꯑꯃꯗꯥ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯂꯩꯔꯕꯗꯤ, ꯇꯦꯁ꯭ꯇꯁꯤꯡꯅꯥ ꯃꯁꯤ ꯈꯪꯗꯣꯀꯄꯥ ꯉꯃꯒꯅꯤ꯫ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯀꯤ ꯏꯃꯨꯡꯗꯥ ꯀꯅꯥꯒꯨꯝꯕꯥ ꯑꯃꯠꯇꯅꯥ ꯃꯁꯤ ꯂꯩꯠꯔꯕꯗꯤ, ꯗꯣꯛꯇꯔ ꯑꯃꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯃꯦꯗꯤꯀꯦꯜ ꯍꯤꯁ꯭ꯇꯔꯤ ꯑꯃꯁꯨꯡ ꯑꯍꯦꯅꯕꯥ ꯇꯦꯁ꯭ꯇꯁꯤꯡꯗꯥ ꯌꯨꯝꯐꯝ ꯑꯣꯏꯗꯨꯅꯥ ꯅꯍꯥꯀꯄꯨ ꯂꯥꯏꯑꯣꯡ ꯈꯪꯗꯣꯀꯄꯥ ꯌꯥꯏ꯫

ꯗꯣꯛꯇꯔꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯑꯗꯨ ꯌꯦꯡꯁꯤꯅꯒꯅꯤ ꯑꯃꯁꯨꯡ ꯅꯍꯥꯛꯀꯤ ꯏꯃꯨꯡꯒꯤ ꯃꯦꯗꯤꯀꯦꯜ ꯍꯤꯁ꯭ꯇꯔꯤꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯍꯪꯒꯅꯤ꯫ ꯇꯣꯉꯥꯟ-ꯇꯣꯉꯥꯅꯕꯥ ꯇꯦꯁ꯭ꯇꯁꯤꯡꯅꯥ ꯃꯁꯤꯕꯨ ꯈꯪꯗꯣꯀꯄꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯕꯁꯨ ꯌꯥꯏ꯫ ꯍꯥꯌꯔꯤꯕꯥ ꯇꯦꯁ꯭ꯇꯁꯤꯡ ꯑꯁꯤꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯃꯈꯥꯗꯥ ꯄꯤꯔꯤꯕꯁꯤꯡ ꯑꯁꯤ ꯌꯥꯑꯣꯔꯤ:

• ꯌꯨꯔꯤꯅꯂꯥꯏꯁꯤꯁ: ꯃꯁꯤꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯌꯨꯔꯤꯅꯒꯤ ꯃꯑꯣꯡ-ꯃꯇꯧ, ꯀꯦꯃꯤꯁ꯭ꯠꯔꯤ ꯑꯃꯁꯨꯡ ꯃꯥꯏꯛꯔꯣꯁ꯭ꯀꯣꯄꯤꯛ ꯄ꯭ꯔꯣꯄꯔꯇꯤꯁꯤꯡ ꯇꯦꯁ꯭ꯠ ꯇꯧꯏ꯫ ꯃꯁꯤꯅꯥ ꯌꯨꯔꯤꯅꯗꯥ ꯏ ꯅꯠꯠꯔꯒꯥ ꯄ꯭ꯔꯣꯇꯤꯟ ꯂꯩꯕ꯭ꯔꯥ ꯍꯥꯌꯕꯗꯨ ꯈꯪꯗꯣꯀꯄꯥ ꯉꯝꯃꯤ꯫
• ꯀ꯭ꯔꯤꯌꯦꯇꯤꯅꯤꯟ ꯀ꯭ꯂꯤꯌꯔꯦꯟꯁ ꯇꯦꯁ꯭ꯠ ꯅꯠꯠꯔꯒꯥ ꯁꯤꯁ꯭ꯇꯦꯇꯤꯟ ꯁꯤ ꯕ꯭ꯂꯗ ꯇꯦꯁ꯭ꯠ: ꯇꯦꯁ꯭ꯇꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯏꯗꯥ ꯀ꯭ꯔꯤꯌꯦꯇꯤꯅꯤꯟ ꯑꯃꯁꯨꯡ ꯑꯃꯣꯠꯄꯥ ꯄꯣꯠꯁꯛ ꯑꯃꯥ ꯑꯣꯏꯔꯤꯕꯥ ꯁꯤꯁ꯭ꯇꯦꯇꯤꯟ ꯁꯤꯒꯤ ꯆꯥꯡ ꯑꯗꯨ ꯂꯦꯄꯊꯣꯀꯏ꯫ ꯃꯁꯤꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯀꯤꯗꯅꯤꯁꯤꯡꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯏ ꯑꯗꯨ ꯀꯌꯥꯝ ꯐꯖꯅꯥ ꯐꯤꯜꯇꯔ ꯇꯧꯔꯤꯕꯒꯦ ꯍꯥꯌꯕꯗꯨ ꯎꯠꯄꯥ ꯉꯃꯒꯅꯤ꯫
• ꯑꯦꯁ꯭ꯇꯤꯃꯦꯠ ꯇꯧꯔꯕꯥ ꯒ꯭ꯂꯣꯃꯦꯔꯨꯂꯥꯔ ꯐꯤꯜꯠꯔꯦꯁꯟ ꯔꯦꯠ (eGFR): ꯃꯁꯤ ꯗꯣꯛꯇꯔ ꯑꯃꯅꯥ ꯀ꯭ꯔꯦꯇꯤꯅꯤꯟ ꯅꯠꯠꯔꯒꯥ ꯁꯤꯁ꯭ꯇꯦꯇꯤꯟ ꯁꯤ ꯑꯃꯗꯒꯤ ꯂꯧꯕꯥ ꯚꯦꯜꯌꯨ ꯑꯃꯅꯤ, ꯃꯁꯤꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯀꯤꯗꯅꯤꯁꯤꯡꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯏ ꯑꯗꯨ ꯀꯌꯥꯝ ꯐꯖꯅꯥ ꯁꯦꯡꯗꯣꯀꯄꯒꯦ ꯍꯥꯌꯕꯗꯨ ꯑꯦꯁ꯭ꯇꯤꯃꯦꯠ ꯇꯧꯏ꯫
• ꯀꯤꯗꯅꯤ ꯕꯥꯏꯑꯣꯞꯁꯤ: ꯗꯣꯛꯇꯔ ꯑꯃꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯀꯤꯗꯅꯤꯒꯤ ꯇꯤꯁꯨꯒꯤ ꯌꯥꯝꯅꯥ ꯑꯄꯤꯀꯄꯥ ꯁꯔꯨꯛ ꯈꯔꯥ ꯂꯧꯗꯨꯅꯥ ꯂꯦꯕ ꯑꯃꯗꯥ ꯃꯥꯏꯛꯔꯣꯁ꯭ꯀꯣꯄꯀꯤ ꯃꯈꯥꯗꯥ ꯌꯦꯡꯁꯤꯜꯂꯤ꯫ ꯁꯦꯝꯄꯂꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯀꯤꯗꯅꯤꯁꯤꯡꯗꯥ ꯁꯣꯀꯍꯜꯂꯤꯕꯥ ꯇꯣꯉꯥꯟ-ꯇꯣꯉꯥꯅꯕꯥ ꯃꯑꯣꯡ-ꯃꯇꯧꯁꯤꯡ ꯑꯗꯨ ꯎꯠꯂꯤ꯫ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯃꯗꯥ, ꯑꯁꯣꯀꯄꯥ ꯖꯤ.ꯕꯤ.ꯑꯦꯝ.ꯁꯤꯡ ꯑꯁꯤ ꯇꯞꯅꯥ ꯇꯞꯅꯥ ꯎꯕꯥ ꯐꯪꯏ, ꯑꯗꯨꯕꯨ ꯃꯈꯣꯌꯗꯨ ꯊꯤꯡꯖꯤꯅꯕꯥ ꯃꯐꯃꯁꯤꯡꯁꯨ ꯂꯩꯕꯥ ꯌꯥꯏ꯫ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯂꯥꯌꯅꯥ ꯑꯁꯤ ꯌꯥꯝꯅꯥ ꯁꯥꯊꯤꯕꯥ ꯑꯣꯏꯔꯕꯗꯤ, ꯃꯁꯤꯅꯥ ꯐꯤꯜꯇꯔ ꯌꯨꯅꯤꯠꯁꯤꯡ ꯑꯃꯁꯨꯡ ꯁꯄꯣꯔꯇꯤꯡ ꯁ꯭ꯠꯔꯀꯆꯔꯁꯤꯡꯗꯥ ꯁꯣꯀꯍꯜꯂꯀꯄꯥ ꯎꯠꯄꯥ ꯌꯥꯏ꯫
• ꯖꯦꯅꯦꯇꯤꯛ ꯇꯦꯁ꯭ꯇꯤꯡ: ꯃꯁꯤꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯀꯣꯂꯥꯖꯦꯟ ꯖꯤꯅꯁꯤꯡꯗꯥ ꯃ꯭ꯌꯨꯇꯦꯁꯅꯁꯤꯡ ꯈꯉꯗꯣꯀꯄꯥ ꯉꯃꯒꯅꯤ꯫ ꯃꯁꯤꯒꯤꯗꯃꯛꯇꯥ ꯑꯈꯟꯅꯕꯥ ꯖꯦꯅꯦꯇꯤꯛꯁ ꯀ꯭ꯂꯤꯅꯤꯛ ꯑꯃꯗꯥ ꯆꯠꯄꯥ ꯃꯊꯧ ꯇꯥꯒꯅꯤ꯫ ꯗꯣꯛꯇꯔ ꯑꯃꯅꯥ ꯃꯁꯤ ꯕ꯭ꯂꯗ ꯇꯦꯁ꯭ꯠ ꯅꯠꯠꯔꯒꯥ ꯁꯦꯂꯤꯚꯥ ꯁꯦꯝꯄꯜ ꯑꯃꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯇꯧꯒꯅꯤ꯫
• ꯍꯤꯌꯥꯔꯤꯡ ꯇꯦꯁ꯭ꯠ (ꯑꯣꯗꯤꯑꯣꯒ꯭ꯔꯥꯐ): ꯀꯔꯤꯒꯨꯝꯕꯥ ꯗꯣꯛꯇꯔ ꯑꯃꯅꯥ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯆꯤꯡꯅꯕꯥ ꯂꯩꯔꯕꯗꯤ ꯃꯈꯣꯌꯅꯥ ꯍꯤꯌꯥꯔꯤꯡ ꯇꯦꯁ꯭ꯠ ꯇꯧꯅꯕꯥ ꯑꯣꯔꯗꯔ ꯇꯧꯕꯥ ꯌꯥꯏ꯫ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯂꯩꯕꯥ ꯃꯤꯑꯣꯏ ꯑꯃꯅꯥ ꯇꯦꯁ꯭ꯠ ꯑꯁꯤ ꯇꯧꯒꯗꯕꯅꯤ꯫ ꯃꯁꯤꯒꯤ ꯇꯦꯁ꯭ꯠ ꯑꯁꯤ ꯆꯍꯤ ꯈꯔ ꯈꯨꯗꯤꯡꯒꯤ ꯇꯧꯒꯗꯕꯅꯤ, ꯃꯁꯤꯅꯥ ꯇꯥꯡꯕꯥ ꯍꯟꯊꯔꯀꯄꯥ ꯅꯠꯠꯔꯒꯥ ꯍꯦꯟꯅꯥ ꯐꯠꯆꯤꯜꯂꯛꯂꯤꯕ꯭ꯔꯥ ꯍꯥꯌꯕꯗꯨ ꯌꯦꯡꯒꯗꯕꯅꯤ꯫
• ꯃꯤꯠꯀꯤ ꯑꯦꯀꯖꯥꯃꯤꯅꯦꯁꯟ: ꯇꯦꯁ꯭ꯠ ꯑꯁꯤ ꯃꯤꯠꯀꯤ ꯂꯥꯌꯅꯥꯁꯤꯡ ꯈꯉꯗꯣꯀꯄꯥ ꯑꯃꯁꯨꯡ ꯂꯥꯌꯦꯡꯕꯗꯥ ꯑꯈꯟꯅꯕꯥ ꯃꯤꯠꯌꯦꯡ ꯆꯪꯕꯥ ꯃꯤꯠꯀꯤ ꯁ꯭ꯄꯦꯁꯤꯑꯦꯂꯤꯁ꯭ꯠ ꯑꯃꯅꯥ ꯄꯥꯡꯊꯣꯛꯀꯗꯕꯅꯤ꯫ ꯃꯈꯣꯌꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯃꯤꯠ ꯎꯗꯕꯥ ꯑꯗꯨ ꯌꯦꯡꯁꯤꯅꯒꯅꯤ ꯑꯃꯁꯨꯡ ꯅꯍꯥꯛꯀꯤ ꯃꯤꯠꯀꯤ ꯃꯊꯛꯇꯥ (ꯀꯣꯔꯅꯤꯌꯥ), ꯂꯦꯟꯁ ꯑꯃꯁꯨꯡ ꯅꯍꯥꯛꯀꯤ ꯃꯤꯠꯀꯤ ꯃꯈꯥ ꯊꯪꯕꯥ ꯁꯔꯨꯛꯇꯥ (ꯔꯦꯇꯤꯅꯥ) ꯌꯦꯡꯒꯅꯤ ꯑꯃꯁꯨꯡ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗ꯭ꯔꯣꯝ ꯑꯗꯨꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯃꯤꯠꯌꯦꯡꯗꯥ ꯑꯀꯥꯌꯕꯥ ꯄꯤꯕ꯭ꯔꯥ ꯍꯥꯌꯕꯗꯨ ꯌꯦꯡꯒꯅꯤ꯫ ꯃꯈꯣꯌꯅꯥ ꯑꯣꯞꯇꯤꯀꯦꯜ ꯀꯣꯍꯔꯤꯟꯁ ꯇꯣꯃꯣꯒ꯭ꯔꯥꯐꯤ (ꯑꯣ.ꯁꯤ.ꯇꯤ.) ꯀꯧꯕꯥ ꯏꯃꯦꯖꯤꯡ ꯇꯦꯁ꯭ꯠ ꯑꯃꯁꯨ ꯇꯧꯕꯥ ꯌꯥꯏ꯫

ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯑꯁꯤ ꯂꯥꯌꯦꯡꯕꯥ ꯉꯃꯒꯗ꯭ꯔꯥ? ꯂꯥꯏꯌꯦꯡꯕꯁꯤꯡ ꯑꯗꯨ ꯀꯔꯤꯅꯣ?

ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯃꯒꯤ ꯂꯥꯏꯌꯦꯡ ꯑꯃꯠꯇꯥ ꯂꯩꯇꯦ꯫ ꯔꯤꯁꯔꯆꯔꯁꯤꯡꯅꯥ ꯑꯁꯣꯏ-ꯑꯉꯥꯝ ꯌꯥꯑꯣꯗꯕꯥ ꯖꯤꯅꯁꯤꯡ ꯀꯣꯀꯍꯅꯕꯥ ꯉꯝꯕꯥ ꯖꯤꯟ ꯊꯦꯔꯥꯄꯤꯁꯤꯡꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯊꯕꯛ ꯇꯧꯔꯤ, ꯑꯗꯨꯕꯨ ꯃꯈꯣꯌ ꯍꯧꯖꯤꯛ ꯐꯥꯑꯣꯕꯥ ꯃꯥꯌ ꯄꯥꯀꯄꯥ ꯉꯃꯗ꯭ꯔꯤ꯫ ꯃꯥꯌ ꯄꯥꯛꯂꯕꯥ ꯖꯤꯟ ꯊꯦꯔꯥꯄꯤ ꯑꯃꯥ ꯄꯨꯊꯣꯛꯂꯕꯁꯨ ꯑꯩꯈꯣꯌꯅꯥ ꯐꯪꯗ꯭ꯔꯤꯉꯩꯗꯥ ꯆꯍꯤ ꯀꯌꯥ ꯁꯨꯔꯒꯅꯤ꯫ ꯑꯗꯨꯝ ꯑꯣꯏꯅꯃꯛ, ꯀꯤꯗꯅꯤꯒꯤ ꯐꯉ꯭ꯀꯁꯟ ꯍꯟꯊꯔꯀꯄꯥ ꯑꯃꯁꯨꯡ ꯀꯤꯗꯅꯤ ꯐꯦꯜ ꯑꯣꯏꯔꯀꯄꯥ ꯊꯦꯡꯊꯍꯅꯕꯥ ꯉꯝꯕꯥ ꯂꯥꯏꯌꯦꯡꯁꯤꯡ ꯂꯩ꯫

ꯗꯣꯛꯇꯔ ꯑꯃꯅꯥ ꯃꯈꯥꯗꯥ ꯄꯤꯔꯤꯕꯥ ꯋꯥꯐꯃꯁꯤꯡ ꯑꯁꯤ ꯄꯤꯕꯥ ꯌꯥꯏ:

• ꯑꯦꯟꯖꯤꯑꯣꯇꯦꯟꯁꯤꯟ-ꯀꯟꯚꯥꯔꯇꯤꯡ ꯑꯦꯅꯖꯥꯏꯝ (ACE) ꯏꯅꯍꯤꯕꯤꯇꯔꯁꯤꯡ: ꯃꯁꯤꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯕ꯭ꯂꯗ ꯄ꯭ꯔꯦꯁꯔ ꯍꯟꯊꯍꯜꯂꯤ, ꯅꯍꯥꯛꯀꯤ ꯌꯨꯔꯤꯅꯗꯥ ꯄ꯭ꯔꯣꯇꯤꯟ ꯍꯟꯊꯍꯜꯂꯤ ꯑꯃꯁꯨꯡ ꯅꯍꯥꯛꯀꯤ ꯀꯤꯗꯅꯤꯁꯤꯡ ꯉꯥꯀꯊꯣꯀꯄꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯏ꯫ (XLAS) ꯂꯩꯕꯥ ꯅꯨꯄꯥꯁꯤꯡ ꯑꯃꯁꯨꯡ (ARAS) ꯂꯩꯕꯥ ꯃꯤꯑꯣꯏ ꯑꯃꯅꯥ ꯗꯥꯏꯑꯦꯒ꯭ꯅꯣꯁꯤꯁ ꯇꯧꯔꯕꯥ ꯃꯇꯨꯡꯗꯥ ACE ꯏꯅꯍꯤꯕꯤꯇꯔꯁꯤꯡ ꯂꯧꯕꯥ ꯍꯧꯒꯗꯕꯅꯤ꯫ (XLAS) ꯅꯠꯠꯔꯒꯥ (ADAS) ꯂꯩꯕꯥ ꯅꯨꯄꯤꯁꯤꯡꯅꯥ ꯃꯈꯣꯌꯒꯤ ꯌꯨꯔꯤꯅꯗꯥ ꯄ꯭ꯔꯣꯇꯤꯟ ꯎꯕꯥ ꯍꯧꯔꯀꯄꯥ ꯃꯇꯃꯗꯥ, ꯅꯠꯠꯔꯒꯥ ꯂꯥꯏꯑꯣꯡ ꯈꯪꯗꯣꯀꯄꯥ ꯃꯇꯃꯗꯥ ACE ꯏꯅꯍꯤꯕꯤꯇꯔꯁꯤꯡ ꯂꯧꯕꯥ ꯍꯧꯒꯗꯕꯅꯤ꯫
• ꯑꯦꯟꯖꯤꯑꯣꯇꯦꯟꯁꯤꯟ II ꯔꯤꯁꯦꯄꯇꯔ ꯕ꯭ꯂꯣꯀꯔꯁꯤꯡ (ꯑꯦ.ꯑꯥꯔ.ꯕꯤ.ꯁꯤꯡ): ꯑꯦ.ꯑꯥꯔ.ꯕꯤ.ꯁꯤꯡ ꯑꯁꯤ ꯑꯦ.ꯁꯤ.ꯏ.
• ꯁꯣꯗꯤꯌꯝ-ꯒ꯭ꯂꯨꯀꯣꯖ ꯇ꯭ꯔꯥꯟꯁꯄꯣꯔꯠ ꯇꯧꯕꯥ ꯇꯥꯏꯞ 2 (SGLT-2) ꯏꯅꯍꯤꯕꯤꯇꯔꯁꯤꯡ: ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ CKD ꯅꯠꯠꯔꯒꯥ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯂꯩꯔꯕꯗꯤ, SGLT-2 ꯏꯅꯍꯤꯕꯤꯇꯔꯁꯤꯡꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯀꯤꯗꯅꯤ ꯐꯦꯜ ꯑꯣꯏꯕꯒꯤ ꯔꯤꯁ꯭ꯛ ꯍꯟꯊꯍꯅꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯏ꯫ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯅꯥ ꯍꯥꯌꯔꯤꯕꯁꯤꯡ ꯑꯁꯤ ꯅꯍꯥꯛꯀꯤ ACE ꯏꯅꯍꯤꯕꯤꯇꯔ ꯅꯠꯠꯔꯒꯥ ARBꯗꯥ ꯍꯥꯄꯆꯤꯅꯕꯥ ꯌꯥꯏ꯫ ꯑꯦꯁ.ꯖꯤ.ꯑꯦꯜ.ꯇꯤ.-꯲ ꯏꯅꯍꯤꯕꯤꯇꯔ ꯄꯨꯝꯅꯃꯛ ꯁꯤ.ꯀꯦ.ꯗꯤ. ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯀꯤ ꯏ.ꯖꯤ.ꯑꯦꯐ.ꯑꯥꯔ.ꯅꯥ ꯌꯥꯝꯅꯥ ꯅꯦꯝꯂꯕꯗꯤ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯅꯥ ꯍꯥꯌꯔꯤꯕꯁꯤꯡ ꯑꯁꯤ ꯄꯤꯗꯕꯥ ꯌꯥꯏ꯫
• ꯁꯣꯗꯤꯌꯝ ꯀꯟꯠꯔꯣꯜ ꯇꯧꯕꯥ ꯗꯥꯏꯠ: ꯅꯍꯥꯛꯀꯤ ꯗꯥꯏꯇꯇꯥ ꯁꯣꯜꯇ ꯑꯃꯁꯨꯡ ꯁꯣꯗꯤꯌꯃꯒꯤ ꯆꯥꯡ ꯍꯟꯊꯍꯅꯕꯅꯥ ꯕ꯭ꯂꯗ ꯄ꯭ꯔꯦꯁꯔ ꯍꯟꯊꯍꯅꯕꯗꯥ ꯑꯃꯁꯨꯡ ꯀꯤꯗꯅꯤ ꯑꯃꯁꯨꯡ ꯍꯥꯔꯇꯀꯤ ꯍꯀꯁꯦꯜ ꯉꯥꯛꯇꯨꯅꯥ ꯊꯝꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯏ꯫

ꯀꯤꯗꯅꯤ ꯇ꯭ꯔꯥꯟꯁꯞꯂꯥꯟꯇ ꯑꯃꯅꯥ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗ꯭ꯔꯣꯝ ꯐꯍꯅꯕꯥ ꯉꯃꯒꯗ꯭ꯔꯥ?

ꯍꯣꯌ ꯑꯃꯁꯨꯡ ꯅꯠꯇꯦ꯫ ꯀꯤꯗꯅꯤ ꯇ꯭ꯔꯥꯟꯁꯞꯂꯥꯟꯇ ꯑꯃꯒꯥ ꯂꯣꯌꯅꯅꯥ, ꯅꯍꯥꯛꯅꯥ ꯅꯣꯔꯃꯦꯜ ``ꯇꯥꯏꯞ IV ꯀꯣꯂꯥꯖꯦꯟ'' ꯑꯃꯁꯨꯡ ꯐꯤꯜꯠꯔꯦꯁꯟ ꯃꯦꯝꯕ꯭ꯔꯦꯅꯁꯤꯡ ꯂꯩꯕꯥ ꯀꯤꯗꯅꯤ ꯑꯃꯥ ꯐꯪꯏ꯫ ꯃꯔꯝ ꯑꯗꯨꯅꯥ ꯑꯅꯧꯕꯥ ꯀꯤꯗꯅꯤꯗꯥ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯍꯜꯂꯛꯂꯣꯏ꯫

ꯑꯗꯨꯝ ꯑꯣꯏꯅꯃꯛ, ꯀꯤꯗꯅꯤ ꯇ꯭ꯔꯥꯟꯁꯞꯂꯥꯟꯇ ꯇꯧꯕꯅꯥ ꯑꯇꯩ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ, ꯍꯥꯌꯕꯗꯤ ꯇꯥꯕꯥ ꯉꯃꯗꯕꯥ ꯑꯃꯁꯨꯡ ꯃꯤꯠꯀꯤ ꯄ꯭ꯔꯣꯕ꯭ꯂꯦꯃꯁꯤꯡꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯂꯣꯏ꯫

ꯃꯁꯤ ꯑꯩꯈꯣꯌꯅꯥ ꯀꯔꯝꯅꯥ ꯊꯤꯡꯒꯅꯤ?

ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯑꯁꯤ ꯊꯤꯡꯕꯥ ꯉꯃꯗꯦ꯫ ꯑꯗꯨꯝ ꯑꯣꯏꯅꯃꯛ, ꯅꯍꯥꯛꯀꯤ ꯏꯃꯨꯡꯒꯤ ꯍꯤꯁ꯭ꯇꯔꯤ ꯑꯗꯨ ꯈꯪꯖꯤꯅꯕꯅꯥ ꯅꯍꯥꯀꯄꯨ ꯃꯗꯨ ꯇꯣꯌꯅꯥ ꯈꯪꯗꯣꯀꯄꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯏ꯫ ꯃꯁꯤꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡꯁꯤꯡꯅꯥ ꯃꯁꯤ ꯄꯤꯖꯗꯕꯗꯁꯨ ꯃꯇꯦꯡ ꯄꯥꯡꯏ꯫

ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯑꯁꯤ ꯉꯟꯅꯥ ꯈꯪꯗꯣꯀꯄꯥ ꯑꯃꯁꯨꯡ ꯑꯦ.ꯁꯤ.ꯏ.

ꯀꯔꯤꯒꯨꯝꯕꯥ ꯗꯣꯛꯇꯔ ꯑꯃꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯌꯨꯔꯤꯅꯗꯥ ꯏ ꯂꯩꯔꯦ ꯍꯥꯌꯔꯕꯗꯤ, ꯃꯔꯨꯑꯣꯏꯅꯥ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯇꯥꯕꯥ ꯉꯃꯗꯕꯥ ꯅꯠꯠꯔꯒꯥ ꯀꯤꯗꯅꯤꯒꯤ ꯐꯉ꯭ꯀꯁꯟ ꯍꯟꯊꯔꯀꯄꯥ ꯑꯣꯏꯔꯕꯗꯤ, ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯃꯒꯤ ꯑꯍꯦꯅꯕꯥ ꯇꯦꯁ꯭ꯇꯁꯤꯡ ꯇꯧꯕꯥ ꯍꯥꯌꯕꯁꯤ ꯑꯐꯕꯥ ꯋꯥꯈꯜꯂꯣꯟ ꯑꯃꯅꯤ꯫

ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯀꯤ ꯏꯃꯨꯡꯒꯤ ꯀꯅꯥꯒꯨꯝꯕꯥ ꯃꯤꯑꯣꯏ ꯑꯃꯅꯥ ꯌꯨꯔꯤꯅꯗꯥ ꯏꯒꯤ ꯍꯤꯁ꯭ꯇꯔꯤ ꯂꯩꯔꯕꯗꯤ (ꯍꯦꯃꯆꯨꯔꯤꯌꯥ) ꯗꯣꯛꯇꯔ ꯑꯃꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯌꯨꯔꯤꯅꯗꯥ ꯏ ꯂꯩꯕ꯭ꯔꯥ ꯍꯥꯌꯕꯗꯨ ꯆꯦꯛ ꯇꯧꯒꯗꯕꯅꯤ ꯑꯃꯁꯨꯡ ꯅꯍꯥꯛꯀꯤ ꯀꯤꯗꯅꯤꯒꯤ ꯐꯉ꯭ꯀꯁꯟ ꯑꯗꯨ ꯌꯦꯡꯁꯤꯟꯅꯕꯥ ꯕ꯭ꯂꯗ ꯇꯦꯁ꯭ꯠ ꯇꯧꯒꯗꯕꯅꯤ꯫

ꯀꯔꯤꯒꯨꯝꯕꯥ ꯑꯩꯅꯥ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯂꯩꯔꯕꯗꯤ ꯑꯩꯒꯤ ꯄꯨꯟꯁꯤꯒꯤ ꯃꯇꯝ ꯑꯁꯤ ꯀꯔꯝꯅꯥ ꯑꯣꯏꯒꯅꯤ?

`(XLAS)` ꯂꯩꯕꯥ ꯅꯨꯄꯥꯁꯤꯡ ꯑꯃꯁꯨꯡ `(ARAS)` ꯂꯩꯕꯥ ꯃꯤꯑꯣꯏ ꯑꯃꯍꯦꯛꯇꯗꯥ ꯑꯌꯥꯝꯕꯅꯥ ꯆꯍꯤ 30ꯒꯤ ꯃꯃꯥꯡꯗꯥ ꯀꯤꯗꯅꯤ ꯐꯦꯜ ꯑꯣꯏꯕꯥ ꯑꯃꯁꯨꯡ ꯇꯥꯕꯥ ꯉꯃꯗꯕꯥ ꯊꯣꯀꯏ꯫

XLAS ꯂꯩꯕꯥ ꯅꯨꯄꯤꯁꯤꯡꯅꯥ ꯃꯍꯧꯁꯥꯅꯥ ꯅꯣꯔꯃꯦꯜ ꯑꯣꯏꯕꯥ ꯄꯨꯟꯁꯤ ꯃꯍꯤꯡ ꯑꯃꯥ ꯂꯩ꯫ ꯅꯍꯥꯛꯅꯥ ꯃꯥꯏꯛꯔꯣꯁ꯭ꯀꯣꯄꯤꯛ ꯍꯦꯃꯦꯆ꯭ꯌꯨꯔꯤꯌꯥ, ꯄ꯭ꯔꯣꯇꯤꯅꯌꯨꯔꯤꯌꯥ, ꯁꯤ.ꯀꯦ.ꯗꯤ., ꯅꯠꯠꯔꯒꯥ ꯀꯤꯗꯅꯤ ꯐꯦꯜ ꯑꯣꯏꯕꯥ ꯑꯃꯁꯨꯡ ꯇꯥꯕꯥ ꯉꯃꯗꯕꯥ ꯌꯥꯏ꯫ ꯃꯤ ꯈꯨꯗꯤꯡꯃꯛ ꯇꯣꯉꯥꯟ ꯇꯣꯉꯥꯅꯕꯥ ꯃꯑꯣꯡꯗꯥ ꯄꯥꯎꯈꯨꯝ ꯄꯤꯔꯤ꯫ ꯑꯗꯨꯕꯨ ꯅꯨꯄꯤ 16%ꯗꯤ ꯆꯍꯤ 60 ꯁꯨꯔꯀꯄꯗꯥ ꯀꯤꯗꯅꯤ ꯐꯦꯜ ꯑꯣꯏꯔꯛꯀꯅꯤ, ꯑꯃꯁꯨꯡ 20%ꯗꯤ ꯆꯍꯤ 80 ꯁꯨꯔꯀꯄꯗꯥ ꯀꯤꯗꯅꯤ ꯐꯦꯜ ꯑꯣꯏꯔꯒꯅꯤ꯫

`(ADAS)` ꯂꯩꯕꯥ ꯃꯤꯑꯣꯏꯁꯤꯡꯅꯥ ꯇꯣꯉꯥꯟ-ꯇꯣꯉꯥꯅꯕꯥ ꯔꯦꯁ꯭ꯄꯣꯟꯁꯁꯤꯡ ꯂꯩꯕꯥ ꯌꯥꯏ, ꯑꯃꯁꯨꯡ ꯃꯈꯣꯌꯅꯥ ꯅꯣꯔꯃꯦꯜ ꯑꯣꯏꯕꯥ ꯄꯨꯟꯁꯤ ꯃꯍꯤꯡ ꯑꯃꯥ ꯂꯩꯕꯥ ꯌꯥꯏ꯫ `(ADAS)`ꯗꯥ ꯇꯥꯕꯥ ꯉꯃꯗꯕꯥ ꯑꯃꯁꯨꯡ ꯀꯤꯗꯅꯤ ꯐꯦꯜ ꯑꯣꯏꯕꯥ ꯑꯁꯤ ꯌꯥꯝꯅꯥ ꯅꯦꯝꯃꯤ꯫

ꯀ꯭ꯔꯣꯅꯤꯛ ꯀꯤꯗꯅꯤ ꯗꯤꯖꯤꯖ (CKD) ꯑꯃꯁꯨꯡ ꯀꯤꯗꯅꯤ ꯐꯦꯜ ꯑꯣꯏꯔꯀꯄꯅꯥ ꯃꯍꯧꯁꯥꯅꯥ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗ꯭ꯔꯣꯝ ꯂꯩꯕꯥ ꯃꯤꯑꯣꯏꯁꯤꯡꯒꯤ ꯄꯨꯟꯁꯤꯒꯤ ꯃꯇꯝ ꯀꯨꯏꯅꯥ ꯂꯩꯍꯜꯂꯤ꯫ ꯁꯤ.ꯀꯦ.ꯗꯤ.ꯅꯥ ꯍꯥꯔꯇꯀꯤ ꯂꯥꯌꯅꯥ ꯑꯃꯁꯨꯡ ꯁ꯭ꯠꯔꯣꯀꯅꯥ ꯁꯤꯍꯅꯕꯒꯤ ꯔꯤꯁ꯭ꯛ ꯍꯦꯅꯒꯠꯍꯜꯂꯤ꯫ ꯀꯤꯗꯅꯤ ꯐꯦꯜ ꯑꯣꯏꯕꯥ ꯍꯥꯌꯕꯁꯤ ꯗꯥꯏꯑꯦꯂꯥꯏꯁꯤꯁ ꯅꯠꯠꯔꯒꯥ ꯀꯤꯗꯅꯤ ꯇ꯭ꯔꯥꯟꯁꯞꯂꯥꯟꯇ ꯇꯧꯗꯅꯥ ꯁꯤꯍꯅꯕꯥ ꯌꯥꯏ꯫ ꯂꯥꯏꯌꯦꯡꯕꯗꯁꯨ ꯀꯤꯗꯅꯤ ꯐꯦꯜ ꯑꯣꯏꯔꯀꯄꯅꯥ ꯍꯥꯔꯇꯀꯤ ꯂꯥꯌꯅꯥ, ꯁ꯭ꯠꯔꯣꯛ ꯑꯃꯁꯨꯡ ꯏꯅꯐꯦꯛꯁꯅꯁꯤꯡꯅꯥ ꯁꯤꯍꯅꯕꯒꯤ ꯔꯤꯁ꯭ꯛ ꯍꯦꯅꯒꯠꯍꯜꯂꯤ꯫ ꯇ꯭ꯔꯥꯟꯁꯞꯂꯥꯟꯇ ꯇꯧꯔꯕꯥ ꯀꯤꯗꯅꯤ ꯑꯃꯅꯥ ꯀꯌꯥ ꯌꯥꯝꯅꯥ ꯐꯖꯅꯥ ꯊꯕꯛ ꯇꯧꯕꯒꯦ ꯍꯥꯌꯕꯒꯤ ꯃꯇꯨꯡꯏꯟꯅꯥ, ꯀꯤꯗꯅꯤ ꯇ꯭ꯔꯥꯟꯁꯞꯂꯥꯟꯇ ꯑꯃꯅꯥ ꯅꯍꯥꯀꯄꯨ ꯅꯣꯔꯃꯦꯜ ꯑꯣꯏꯕꯥ ꯄꯨꯟꯁꯤ ꯑꯃꯥ ꯍꯤꯡꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯕꯥ ꯌꯥꯏ꯫

ꯑꯩꯅꯥ ꯃꯇꯧ ꯀꯔꯝꯅꯥ ꯏꯁꯥꯕꯨ ꯌꯦꯡꯁꯤꯅꯕꯤꯒꯅꯤ?

ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗ꯭ꯔꯣꯝ ꯂꯩꯔꯕꯗꯤ, ꯗꯣꯛꯇꯔ ꯑꯃꯅꯥ ꯅꯍꯥꯀꯄꯨ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯐꯕꯥ ꯂꯥꯏꯌꯦꯡꯒꯤ ꯄ꯭ꯂꯥꯟ ꯁꯦꯝꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯒꯅꯤ꯫ ꯃꯁꯤꯗꯥ ꯍꯤꯗꯥꯛ-ꯂꯥꯡꯊꯀꯁꯤꯡ ꯑꯃꯁꯨꯡ ꯄꯨꯟꯁꯤ ꯃꯍꯤꯡꯗꯥ ꯑꯍꯣꯡꯕꯥ ꯂꯥꯀꯄꯥ ꯌꯥꯏ꯫

ꯃꯦꯗꯤꯀꯦꯜ ꯇ꯭ꯔꯤꯠꯃꯦꯟꯇ꯫

• ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯅꯥ ꯄꯤꯕꯥ ꯃꯇꯨꯡꯏꯟꯅꯥ ACE ꯏꯅꯍꯤꯕꯤꯇꯔꯁꯤꯡ, ARBꯁꯤꯡ, ꯅꯠꯠꯔꯒꯥ SGLT-2 ꯏꯅꯍꯤꯕꯤꯇꯔꯁꯤꯡ ꯂꯧ꯫
• ꯄꯦꯅꯀꯤꯂꯔꯁꯤꯡ (ꯅꯟ-ꯁ꯭ꯇꯦꯔꯣꯏꯗ ꯑꯦꯟꯇꯤ-ꯏꯅꯐ꯭ꯂꯦꯃꯦꯇꯔꯤ ꯗ꯭ꯔꯒꯁꯤꯡ - NSAIDꯁꯤꯡ) ꯁꯤꯖꯤꯟꯅꯔꯣꯏꯗꯕꯅꯤ꯫ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯀꯤꯗꯅꯤꯒꯤ ꯐꯉ꯭ꯀꯁꯟ (abnormal kidney function) ꯅꯠꯠꯔꯒꯥ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗ꯭ꯔꯣꯝ ꯂꯩꯔꯕꯗꯤ ꯍꯥꯌꯔꯤꯕꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯀꯤꯗꯅꯤ ꯐꯦꯜ ꯑꯣꯏꯔꯀꯄꯥ ꯌꯥꯕꯒꯤ ꯆꯥꯡ ꯍꯦꯅꯒꯠꯍꯅꯕꯥ ꯌꯥꯏ꯫
• ꯅꯍꯥꯛꯀꯤ ꯇꯥꯕꯥ ꯉꯝꯕꯒꯤ ꯆꯥꯡ ꯑꯗꯨ ꯆꯦꯛ ꯇꯧ꯫ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯌꯥꯝꯅꯥ ꯁꯥꯊꯤꯅꯥ ꯇꯥꯕꯥ ꯉꯃꯗ꯭ꯔꯕꯗꯤ ꯑꯃꯁꯨꯡ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯅꯥ ꯍꯤꯌꯥꯔꯤꯡ ꯑꯦꯗꯁꯤꯡ ꯔꯤꯀꯃꯦꯟꯗ ꯇꯧꯔꯕꯗꯤ, ꯃꯈꯣꯌꯗꯨ ꯁꯤꯖꯤꯟꯅꯕꯁꯤ ꯑꯐꯕꯥ ꯋꯥꯈꯜꯂꯣꯟ ꯑꯃꯅꯤ꯫ ꯅꯠꯠꯔꯕꯗꯤ, ꯅꯍꯥꯛꯅꯥ ꯑꯇꯣꯞꯄꯁꯤꯡꯒꯥ ꯄꯥꯎ ꯐꯥꯎꯗꯣꯛ-ꯐꯥꯎꯖꯤꯟ ꯇꯧꯕꯗꯥ ꯑꯋꯥꯕꯥ ꯃꯥꯌꯣꯛꯅꯔꯀꯄꯥ ꯌꯥꯏ, ꯃꯗꯨꯅꯥ ꯅꯍꯥꯀꯄꯨ ꯇꯪꯗꯨ ꯂꯩꯇꯥꯕꯥ ꯑꯃꯁꯨꯡ ꯇꯣꯈꯥꯌꯅꯥ ꯂꯩꯕꯥ ꯐꯥꯎꯔꯀꯄꯥ ꯌꯥꯏ꯫ ꯑꯥꯏꯁꯣꯂꯦꯁꯅꯒꯤ ꯐꯤꯚꯃꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯗꯤꯞꯔꯦꯁꯟ ꯊꯣꯀꯍꯅꯕꯥ ꯌꯥꯏ꯫ ꯍꯤꯌꯥꯔꯤꯡ ꯑꯦꯗꯁꯤꯡꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯑꯀꯣꯌꯕꯗꯥ ꯂꯩꯔꯤꯕꯥ ꯃꯤꯑꯣꯏꯁꯤꯡꯒꯥ ꯂꯩꯅꯕꯥ ꯃꯔꯤ ꯐꯒꯠꯍꯅꯕꯥ ꯉꯝꯃꯤ, ꯅꯍꯥꯛꯀꯤ ꯋꯥꯈꯜ ꯐꯒꯠꯍꯅꯕꯥ ꯉꯝꯃꯤ ꯑꯃꯁꯨꯡ ꯅꯍꯥꯀꯄꯨ ꯋꯥꯈꯜ ꯅꯨꯡꯉꯥꯏꯇꯕꯥ ꯃꯦꯅꯦꯖ ꯇꯧꯕꯗꯥ ꯅꯠꯠꯔꯒꯥ ꯊꯤꯡꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯏ꯫
• ꯅꯍꯥꯛꯀꯤ ꯃꯦꯟꯇꯦꯜ ꯍꯦꯂꯊ ꯑꯗꯨ ꯌꯦꯡꯁꯤꯜꯂꯨ꯫ ꯖꯦꯅꯦꯇꯤꯛ ꯀꯟꯗꯤꯁꯟ ꯑꯃꯥ ꯂꯩꯕꯅꯥ ꯇꯪꯗꯨ ꯂꯩꯇꯥꯕꯥ ꯑꯣꯏꯕꯥ ꯌꯥꯏ, ꯑꯃꯁꯨꯡ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗ꯭ꯔꯣꯝ ꯑꯁꯤꯅꯥ ꯀꯤꯗꯅꯤ ꯐꯦꯜ ꯑꯣꯏꯕꯥ ꯅꯠꯠꯔꯒꯥ ꯇꯥꯕꯥ ꯉꯃꯗꯕꯥ ꯊꯣꯀꯍꯅꯕꯥ ꯌꯥꯏ ꯍꯥꯌꯕꯁꯤ ꯈꯪꯖꯤꯅꯕꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯗꯤꯞꯔꯦꯁꯅꯒꯤ ꯔꯤꯁ꯭ꯛ ꯍꯦꯅꯒꯠꯍꯅꯕꯥ ꯌꯥꯏ꯫ ꯅꯍꯥꯛꯅꯥ ꯊꯦꯡꯅꯔꯤꯕꯥ ꯃꯦꯟꯇꯦꯜ ꯍꯦꯂꯊꯀꯤ ꯏꯁꯨ ꯑꯃꯍꯦꯛꯇꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯒꯥ ꯋꯥꯔꯤ ꯁꯥꯅꯕꯥ ꯑꯃꯁꯨꯡ ꯅꯍꯥꯛꯅꯥ ꯃꯊꯧ ꯇꯥꯕꯥ ꯂꯥꯏꯌꯦꯡ ꯑꯗꯨ ꯂꯧꯕꯥ ꯍꯥꯌꯕꯁꯤ ꯌꯥꯝꯅꯥ ꯃꯔꯨꯑꯣꯏ꯫ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯂꯩꯕꯥ ꯃꯤꯑꯣꯏꯁꯤꯡꯒꯤ ꯁꯄꯣꯔꯠ ꯒ꯭ꯔꯨꯄꯁꯤꯡ ꯂꯩꯕ꯭ꯔꯥ ꯍꯥꯌꯕꯗꯨ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯗꯥ ꯍꯪꯎ꯫ ꯑꯁꯤꯒꯨꯝꯕꯥ ꯃꯤꯑꯣꯏꯁꯤꯡꯒꯥ ꯎꯅꯕꯅꯥ ꯅꯍꯥꯀꯄꯨ ꯇꯪꯗꯨ ꯂꯩꯇꯥꯕꯥ ꯍꯟꯊꯍꯅꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯏ꯫

ꯄꯨꯟꯁꯤ ꯃꯍꯤꯡꯗꯥ ꯑꯍꯣꯡꯕꯥ ꯂꯥꯀꯄꯥ꯫

• ꯅꯍꯥꯛꯀꯤ ꯆꯤꯟꯖꯥꯀꯁꯤꯡꯗꯥ ꯌꯥꯎꯔꯤꯕꯥ ꯁꯣꯂꯔꯒꯤ ꯆꯥꯡ ꯍꯟꯊꯍꯅꯒꯗꯕꯅꯤ꯫
• ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ CKD ꯂꯩꯔꯕꯗꯤ, ꯅꯍꯥꯛꯅꯥ ꯑꯈꯟꯅꯕꯥ ꯗꯥꯏꯠ ꯑꯃꯥ ꯆꯠꯄꯥ ꯃꯊꯧ ꯇꯥꯕꯥ ꯌꯥꯏ꯫ ꯃꯁꯤꯗꯥ ꯅꯍꯥꯛꯅꯥ ꯁꯥ-ꯁꯅꯒꯤ ꯄ꯭ꯔꯣꯇꯤꯟ ꯆꯥꯕꯥ ꯍꯟꯊꯍꯅꯕꯥ, ꯄꯥꯝꯕꯤꯗꯥ ꯌꯨꯝꯐꯝ ꯑꯣꯏꯕꯥ ꯗꯥꯏꯇꯇꯥ ꯍꯣꯡꯗꯣꯀꯄꯥ, ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯕ꯭ꯂꯗ ꯄꯣꯇꯥꯁꯤꯌꯃꯒꯤ ꯆꯥꯡ ꯋꯥꯡꯂꯕꯗꯤ ꯄꯣꯇꯥꯁꯤꯌꯝ ꯌꯥꯝꯅꯥ ꯌꯥꯎꯕꯥ ꯆꯤꯟꯖꯥꯀꯁꯤꯡ ꯊꯤꯡꯕꯥ, ꯑꯃꯁꯨꯡ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯕ꯭ꯂꯗ ꯐꯣꯁꯐꯔꯁ ꯅꯠꯠꯔꯒꯥ ꯄꯦꯔꯥꯊꯥꯏꯔꯣꯏꯗ ꯍꯣꯔꯃꯣꯟ (PTH)ꯒꯤ ꯆꯥꯡ ꯋꯥꯡꯂꯕꯗꯤ ꯅꯍꯥꯛꯀꯤ ꯄ꯭ꯔꯣꯇꯤꯟ ꯌꯥꯝꯅꯥ ꯌꯥꯎꯕꯥ ꯆꯤꯟꯖꯥꯀꯁꯤꯡ ꯌꯥꯎꯕꯥ ꯌꯥꯏ꯫
• ꯍꯥꯔꯇꯀꯤ ꯍꯀꯁꯦꯜ ꯐꯕꯥ ꯄꯨꯟꯁꯤ ꯃꯍꯤꯡ ꯑꯃꯥ ꯏꯅꯕꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯍꯥꯔꯇꯀꯤ ꯂꯥꯌꯅꯥ, ꯗꯥꯏꯑꯦꯕꯦꯇꯤꯖ ꯑꯃꯁꯨꯡ ꯀꯤꯗꯅꯤ ꯐꯦꯜ ꯑꯣꯏꯍꯅꯕꯥ ꯌꯥꯕꯥ ꯑꯇꯩ ꯀꯟꯗꯤꯁꯅꯁꯤꯡꯒꯤ ꯔꯤꯁ꯭ꯛ ꯍꯟꯊꯍꯅꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯏ꯫ ꯈꯣꯡꯖꯦꯜ ꯌꯥꯡꯅꯥ ꯆꯠꯄꯥ, ꯈꯣꯡꯅꯥ ꯆꯠꯄꯥ, ꯂꯝ ꯀꯣꯏꯕꯥ, ꯁꯥꯏꯀꯜ ꯊꯧꯕꯥ, ꯑꯃꯁꯨꯡ ꯔꯣꯞ ꯂꯥꯞꯅꯥ ꯆꯠꯄꯥ ꯑꯁꯤꯅꯆꯤꯡꯕꯥ ꯑꯦꯛꯁꯔꯁꯥꯏꯖꯁꯤꯡ ꯑꯁꯤ ꯑꯐꯕꯥ ꯑꯣꯏ꯫ ꯅꯍꯥꯛꯀꯤꯗꯃꯛꯇꯥ ꯆꯨꯅꯕꯥ ꯍꯀꯁꯦꯜ ꯐꯕꯥ ꯑꯔꯨꯝꯕꯥ ꯑꯃꯥ ꯊꯝꯕꯥ ꯑꯁꯤꯁꯨ ꯑꯐꯕꯥ ꯑꯃꯅꯤ꯫
• ꯊꯛꯅꯕꯥ ꯏꯁꯤꯡ ꯑꯃꯁꯨꯡ ꯑꯇꯩ ꯊꯛꯅꯕꯥ ꯏꯁꯤꯡꯗꯒꯤ ꯇꯣꯈꯥꯌꯕꯥ꯫ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯃꯩꯈꯨ ꯊꯥꯗꯣꯀꯄꯥ ꯊꯤꯡꯕꯗꯥ ꯃꯇꯦꯡ ꯃꯊꯧ ꯇꯥꯔꯕꯗꯤ ꯗꯣꯛꯇꯔ ꯑꯃꯒꯥ ꯇꯥꯟꯅꯧ꯫

ꯑꯩꯅꯥ ꯀꯗꯥꯏꯗꯥ ꯗꯣꯛꯇꯔꯒꯥ ꯎꯅꯒꯗꯒꯦ?

ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯀꯤ ꯌꯨꯔꯤꯅꯗꯥ ꯏ ꯂꯩꯔꯕꯗꯤ, ꯁꯣꯟꯊꯕꯥ ꯉꯃꯗꯕꯥ ꯅꯠꯠꯔꯒꯥ ꯃꯤꯠ ꯎꯗꯕꯥ ꯑꯣꯏꯔꯕꯗꯤ ꯗꯣꯛꯇꯔ ꯑꯃꯒꯥ ꯇꯥꯟꯅꯧ꯫ ꯍꯥꯌꯔꯤꯕꯁꯤꯡ ꯑꯁꯤ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯃꯒꯤ ꯈꯨꯗꯃꯁꯤꯡ ꯑꯣꯏꯕꯥ ꯌꯥꯏ꯫

ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗ꯭ꯔꯣꯝ ꯂꯩꯔꯕꯗꯤ, ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯅꯥ ꯅꯍꯥꯀꯄꯨ ꯀꯤꯗꯅꯤꯒꯤ ꯁ꯭ꯄꯦꯁꯤꯑꯦꯂꯤꯁ꯭ꯠ (ꯅꯦꯐ꯭ꯔꯣꯂꯣꯖꯤꯁ꯭ꯠ) ꯑꯃꯗꯥ ꯔꯤꯐꯔ ꯇꯧꯕꯥ ꯁꯣꯌꯗꯅꯥ ꯇꯧꯕꯤꯌꯨ꯫

ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯀꯤ ꯏꯃꯨꯡꯒꯤ ꯃꯤꯑꯣꯏ ꯑꯃꯗꯥ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗ꯭ꯔꯣꯝ ꯂꯩꯔꯕꯗꯤ, ꯅꯍꯥꯀꯁꯨ ꯃꯁꯤ ꯂꯩꯕ꯭ꯔꯥ ꯍꯥꯌꯕꯗꯨ ꯌꯦꯡꯅꯕꯥ ꯗꯣꯛꯇꯔ ꯑꯃꯒꯥ ꯇꯥꯟꯅꯧ꯫

ꯑꯩꯒꯤ ꯗꯣꯛꯇꯔꯗꯥ ꯀꯔꯤ ꯋꯥꯍꯪ ꯍꯪꯒꯗꯒꯦ?

ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯂꯩꯕꯥ ꯌꯥꯏ ꯍꯥꯌꯅꯥ ꯈꯜꯂꯕꯗꯤ, ꯅꯠꯠꯔꯒꯥ ꯅꯍꯥꯛꯀꯤ ꯏꯃꯨꯡꯒꯤ ꯃꯤꯑꯣꯏ ꯑꯃꯅꯥ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯂꯩꯔꯕꯗꯤ, ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯗꯥ ꯋꯥꯍꯪꯁꯤꯡ ꯑꯁꯤ ꯍꯪꯕꯤꯌꯨ:

• ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯑꯁꯤ ꯀꯔꯝꯅꯥ ꯈꯪꯗꯣꯀꯄꯥ ꯌꯥꯕꯒꯦ ꯍꯥꯌꯕꯗꯨ ꯅꯍꯥꯛꯅꯥ ꯈꯪꯂꯕ꯭ꯔꯥ?
• ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯑꯁꯤ ꯀꯔꯝꯅꯥ ꯂꯥꯌꯦꯡꯒꯅꯤ ꯍꯥꯌꯕꯥ ꯈꯉꯕꯥ ꯁ꯭ꯄꯦꯁꯤꯑꯦꯂꯤꯁ꯭ꯠ ꯑꯃꯗꯥ ꯅꯍꯥꯛꯅꯥ ꯑꯩꯕꯨ ꯔꯤꯐꯔ ꯇꯧꯕꯥ ꯌꯥꯒꯗ꯭ꯔꯥ?
• ꯑꯩꯒꯤ ꯌꯨꯔꯤꯅꯗꯥ ꯏ ꯂꯩꯕ꯭ꯔꯥ?
• ꯑꯩꯒꯤ ꯀꯤꯗꯅꯤꯒꯤ ꯐꯉ꯭ꯀꯁꯟ ꯍꯟꯊꯔꯛꯂꯤꯕ꯭ꯔꯥ?
• ꯑꯩꯅꯥ ꯍꯤꯌꯥꯔꯤꯡ ꯇꯦꯁ꯭ꯠ ꯑꯃꯥ ꯇꯧꯒꯗ꯭ꯔꯥ ꯅꯠꯠꯔꯒꯥ ꯑꯥꯏ ꯇꯦꯁ꯭ꯠ ꯑꯃꯥ ꯇꯧꯒꯗ꯭ꯔꯥ?
• ꯑꯩꯅꯥ ꯀꯤꯗꯅꯤ ꯕꯥꯏꯑꯣꯞꯁꯤ ꯇꯧꯒꯗ꯭ꯔꯥ?
• ꯑꯩꯅꯥ ꯖꯦꯅꯦꯇꯤꯛ ꯇꯦꯁ꯭ꯠ ꯑꯃꯥ ꯇꯧꯒꯗ꯭ꯔꯥ?

ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯂꯩꯔꯕꯗꯤ, ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯗꯥ ꯋꯥꯍꯪꯁꯤꯡ ꯑꯁꯤ ꯍꯪꯕꯤꯌꯨ:

• ꯑꯩꯍꯥꯛ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯂꯩ ꯍꯥꯌꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯀꯔꯝꯅꯥ ꯈꯉꯒꯅꯤ?
• ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯃꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯈꯪꯂꯕꯥ ꯀꯤꯗꯅꯤ ꯁ꯭ꯄꯦꯁꯤꯑꯦꯂꯤꯁ꯭ꯠ (ꯅꯦꯐ꯭ꯔꯣꯂꯣꯖꯤꯁ꯭ꯠ) ꯑꯃꯗꯥ ꯑꯩꯍꯥꯀꯄꯨ ꯀꯗꯥꯏꯗꯥ ꯔꯤꯐꯔ ꯇꯧꯕꯥ ꯌꯥꯕꯒꯦ?
• ꯑꯩꯉꯣꯟꯗꯥ ꯀꯔꯤ ꯃꯈꯂꯒꯤ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯂꯩꯕꯒꯦ?
• ꯑꯩꯅꯥ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯑꯁꯤ ꯑꯩꯒꯤ ꯑꯉꯥꯡꯁꯤꯡꯗꯥ ꯄꯥꯁ ꯇꯧꯒꯗ꯭ꯔꯥ?
• ꯑꯩꯒꯤ `(ꯖꯤ.ꯑꯦꯐ.ꯑꯥꯔ.)` ꯍꯥꯌꯕꯁꯤ ꯀꯔꯤꯅꯣ?
• ꯑꯩꯒꯤ ꯌꯨꯔꯤꯅꯗꯥ ꯄ꯭ꯔꯣꯇꯤꯟ ꯀꯌꯥ ꯂꯩꯕꯒꯦ?
• ꯅꯍꯥꯛꯅꯥ `(ACE ꯏꯅꯍꯤꯕꯤꯇꯔ)` ꯅꯠꯠꯔꯒꯥ `(ARB)` ꯑꯃꯥ ꯀꯗꯥꯏꯗꯒꯤ ꯍꯧꯒꯗꯒꯦ?
• ꯑꯦꯁ.ꯖꯤ.ꯑꯦꯜ.ꯇꯤ.-꯲ ꯏꯅꯍꯤꯕꯤꯇꯔ ꯑꯃꯗꯒꯤ ꯑꯩꯅꯥ ꯀꯥꯟꯅꯕꯥ ꯐꯪꯒꯗ꯭ꯔꯥ?
• ꯑꯗꯣꯝꯅꯥ ꯑꯇꯣꯞꯄꯥ ꯀꯔꯤ ꯍꯤꯗꯥꯛ-ꯂꯥꯡꯊꯀꯁꯤꯡ ꯔꯤꯀꯃꯦꯟꯗ ꯇꯧꯔꯤꯕꯒꯦ?
• ꯑꯩꯒꯤ ꯀꯤꯗꯅꯤꯒꯤ ꯍꯀꯁꯦꯜ ꯌꯦꯡꯁꯤꯟꯅꯕꯥ ꯑꯩꯅꯥ ꯀꯌꯥꯝ ꯀꯨꯏꯅꯥ ꯑꯦꯄꯣꯏꯟꯇꯃꯦꯟꯇꯁꯤꯡ ꯁꯦꯗ꯭ꯌꯨꯜ ꯇꯧꯒꯗꯒꯦ?
• ꯑꯩꯒꯤ ꯍꯤꯗꯥꯛ-ꯂꯥꯡꯊꯛ ꯑꯗꯨ ꯀꯌꯥꯝ ꯀꯨꯏꯅꯥ ꯇꯦꯁ꯭ꯠ ꯇꯧꯒꯗꯒꯦ?
• ꯑꯩꯒꯤ ꯃꯤꯠ ꯌꯦꯡꯁꯤꯟꯅꯕꯥ ꯑꯣꯐꯊꯥꯂꯃꯣꯂꯣꯖꯤꯁ꯭ꯠ ꯑꯃꯒꯥ ꯇꯥꯟꯅꯒꯗ꯭ꯔꯥ?
• ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯂꯩꯕꯥ ꯃꯤꯑꯣꯏꯁꯤꯡꯒꯤꯗꯃꯛ ꯁꯄꯣꯔꯠ ꯒ꯭ꯔꯨꯄꯁꯤꯡ ꯔꯤꯀꯃꯦꯟꯗ ꯇꯧꯕꯥ ꯌꯥꯕ꯭ꯔꯥ?

ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗ꯭ꯔꯣꯝ ꯍꯥꯌꯕꯁꯤ ꯅꯍꯥꯛꯀꯤ ꯀꯤꯗꯅꯤꯁꯤꯡꯗꯥ ꯂꯩꯕꯥ ꯕ꯭ꯂꯗ ꯚꯦꯁꯦꯂꯁꯤꯡꯗꯥ ꯑꯃꯥꯡ-ꯑꯇꯥ ꯊꯣꯀꯍꯅꯕꯥ ꯀꯟꯗꯤꯁꯟ ꯑꯃꯅꯤ꯫ ꯅꯍꯥꯛꯀꯤ ꯖꯤꯅꯁꯤꯡꯗꯥ ꯃ꯭ꯌꯨꯇꯦꯁꯅꯁꯤꯡꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯀꯤꯗꯅꯤꯁꯤꯡꯅꯥ ꯀꯔꯝꯅꯥ ꯊꯕꯛ ꯇꯧꯕꯒꯦ ꯍꯥꯌꯕꯗꯨꯗꯥ ꯁꯥꯐꯨ ꯄꯤ, ꯑꯃꯁꯨꯡ ꯅꯍꯥꯛꯀꯤ ꯇꯥꯕꯥ ꯑꯃꯁꯨꯡ ꯎꯕꯗꯥ ꯁꯣꯀꯍꯅꯕꯥ ꯌꯥꯏ꯫

ꯅꯍꯥꯛꯅꯥ ꯗꯥꯏꯑꯦꯒ꯭ꯅꯣꯁꯤꯁ ꯑꯁꯤ ꯑꯃꯁꯨꯡ ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯃꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯄꯨꯟꯁꯤꯗꯥ ꯁꯣꯀꯍꯅꯕꯒꯤ ꯃꯑꯣꯡ-ꯃꯇꯧ ꯑꯗꯨ ꯈꯪꯖꯤꯅꯕꯗꯥ ꯃꯈꯜ ꯀꯌꯥꯒꯤ ꯏꯃꯣꯁꯅꯁꯤꯡ ꯊꯦꯡꯅꯔꯀꯄꯥ ꯌꯥꯏ꯫ ꯅꯍꯥꯛꯀꯤ ꯀꯟꯗꯤꯁꯟ ꯑꯃꯁꯨꯡ ꯂꯥꯏꯌꯦꯡꯒꯤ ꯑꯣꯄꯁꯅꯁꯤꯡ ꯈꯪꯗꯣꯛꯅꯕꯥ ꯅꯍꯥꯛꯀꯤ ꯏꯁꯥꯗꯥ ꯃꯇꯝ ꯑꯃꯁꯨꯡ ꯃꯐꯝ ꯄꯤꯕꯥ ꯍꯥꯌꯕꯁꯤ ꯌꯥꯝꯅꯥ ꯃꯔꯨꯑꯣꯏ꯫ ꯅꯍꯥꯛꯀꯤ ꯑꯣꯄꯁꯅꯁꯤꯡ ꯑꯃꯁꯨꯡ ꯀꯔꯤ ꯑꯥꯁꯥ ꯇꯧꯒꯗꯒꯦ ꯍꯥꯌꯕꯗꯨ ꯈꯪꯕꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯏꯃꯣꯁꯅꯁꯤꯡ ꯑꯗꯨ ꯃꯦꯅꯦꯖ ꯇꯧꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯏ꯫ ꯅꯍꯥꯛꯀꯤ ꯍꯀꯁꯦꯂꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯑꯔꯣꯏꯕꯥ ꯋꯥꯔꯦꯞ ꯂꯧꯕꯥ ꯃꯤꯑꯣꯏ ꯑꯗꯨ ꯅꯍꯥꯛꯅꯤ, ꯑꯃꯁꯨꯡ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯅꯥ ꯅꯍꯥꯀꯄꯨ ꯏꯅꯐꯣꯔꯃꯦꯁꯟ ꯑꯃꯁꯨꯡ ꯒꯥꯏꯗꯂꯥꯏꯅꯁꯤꯡ ꯄꯤꯅꯕꯥ ꯂꯩꯔꯤ꯫ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯋꯥꯍꯪ ꯑꯃꯠꯇꯥ ꯍꯪꯂꯕꯗꯤ, ꯁꯄꯣꯔꯠ ꯃꯊꯧ ꯇꯥꯔꯕꯗꯤ ꯅꯠꯠꯔꯒꯥ ꯄꯥꯎꯇꯥꯛ ꯃꯊꯧ ꯇꯥꯔꯕꯗꯤ ꯃꯈꯣꯌꯒꯥ ꯋꯥꯔꯤ ꯁꯥꯕꯤꯌꯨ꯫

ꯌꯨꯃꯗꯥ ꯄꯨꯔꯀꯄꯥ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯄꯥꯎꯖꯦꯜ꯫

ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ ꯑꯁꯤ ꯌꯥꯝꯅꯥ ꯁꯥꯊꯤꯕꯥ, ꯄꯨꯟꯁꯤ ꯆꯨꯞꯄꯥ ꯖꯤꯅꯦꯇꯤꯛ ꯀꯟꯗꯤꯁꯟ ꯑꯃꯅꯤ ꯍꯥꯌꯔꯕꯁꯨ, ꯉꯟꯅꯥ ꯈꯪꯗꯣꯀꯄꯥ ꯑꯃꯁꯨꯡ ꯃꯑꯣꯡ ꯆꯨꯝꯅꯥ ꯃꯦꯅꯦꯖ ꯇꯧꯕꯅꯥ ꯃꯤꯑꯣꯏꯕꯕꯨ ꯑꯆꯧꯕꯥ ꯃꯑꯣꯡꯗꯥ ꯅꯣꯔꯃꯦꯜ ꯑꯣꯏꯕꯥ ꯄꯨꯟꯁꯤ ꯑꯃꯥ ꯍꯤꯡꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯏ꯫

ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯀꯤ ꯏꯃꯨꯡꯒꯤ ꯃꯤꯑꯣꯏ ꯑꯃꯅꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯑꯁꯤ (ꯃꯔꯨꯑꯣꯏꯅꯥ ꯌꯨꯔꯤꯅꯗꯥ ꯏ, ꯇꯥꯕꯥ ꯉꯃꯗꯕꯥ) ꯂꯩꯔꯕꯗꯤ, ꯅꯠꯠꯔꯒꯥ ꯅꯍꯥꯛꯅꯥ ꯃꯁꯥꯃꯛꯅꯥ ꯊꯦꯡꯅꯔꯕꯗꯤ, ꯃꯦꯗꯤꯀꯦꯂꯒꯤ ꯄꯥꯎꯇꯥꯛ ꯂꯧꯕꯗꯥ ꯀꯩꯗꯧꯉꯩꯗꯥ ꯊꯦꯡꯊꯕꯥ ꯑꯣꯏꯔꯣꯏ꯫ ꯑꯆꯨꯝꯕꯥ ꯇꯦꯁ꯭ꯠ ꯑꯃꯁꯨꯡ ꯂꯥꯏꯌꯦꯡꯅꯥ, ꯅꯍꯥꯛꯅꯥ ꯀꯤꯗꯅꯤꯒꯤ ꯑꯃꯥꯡ-ꯑꯇꯥ ꯍꯟꯊꯍꯅꯕꯥ ꯉꯃꯒꯅꯤ ꯑꯃꯁꯨꯡ ꯅꯍꯥꯛꯀꯤ ꯄꯨꯟꯁꯤꯒꯤ ꯃꯒꯨꯟ ꯑꯗꯨ ꯊꯝꯕꯥ ꯉꯃꯒꯅꯤ꯫ ꯅꯤꯡꯁꯤꯡꯕꯤꯌꯨ, ꯅꯍꯥꯛ ꯈꯛꯇꯅꯥ ꯅꯠꯇꯦ, ꯑꯃꯁꯨꯡ ꯗꯣꯛꯇꯔꯁꯤꯡ ꯑꯃꯁꯨꯡ ꯅꯍꯥꯛꯀꯤ ꯅꯨꯡꯁꯤꯖꯔꯕꯁꯤꯡꯅꯥ ꯅꯍꯥꯀꯄꯨ ꯃꯇꯦꯡ ꯄꯥꯡꯅꯕꯥ ꯂꯩꯔꯤ꯫

` ꯑꯂꯄꯣꯔꯠ ꯁꯤꯟꯗꯣꯝ, ꯀꯤꯗꯅꯤꯒꯤ ꯂꯥꯌꯅꯥ, ꯖꯦꯅꯦꯇꯤꯛ ꯂꯥꯌꯅꯥ, ꯀꯣꯂꯥꯖꯦꯟ, ꯌꯨꯔꯤꯅꯗꯥ ꯏ, ꯇꯥꯕꯥ ꯉꯃꯗꯕꯥ, ꯃꯤꯠꯀꯤ ꯂꯥꯌꯅꯥ꯫