Kodi pali ubale wotani pakati pa estrogen ndi khansa? Tiyeni tiphunzire za khansa zomwe zimadalira estrogen m'njira yosavuta!

Moni! Mwina mwamvapo za mahomoni otchedwa estrogen. Nthawi zambiri timamva dzinali pokhudzana ndi thanzi la akazi. Koma mwina simukudziwa kuti estrogen ingakhudzenso kukula kwa mitundu ina ya khansa. Ndicho chimene tikambirane lero, mwachidule, m'njira yomwe mungamvetse.

Kodi estrogen ndi chiyani? Tiyeni timvetse kaye!

Mwachidule, estrogen ndi mankhwala achilengedwe omwe matupi athu amapanga. Timatchanso kuti hormone. Homoni iyi ya estrogen imayenda m'magazi athu kupita ku maselo ndi minofu m'thupi lathu lonse.

Anthu ambiri amaganiza kuti estrogen ndi chinthu chomwe chimapezeka kwa akazi okha. Ndipotu, mazira, omwe ndi gawo la njira yoberekera ya akazi, amapanga mahomoni ambiri a estrogen. Koma zodabwitsa, aliyense, mosasamala kanthu za jenda, amapanga estrogen m'thupi lake, kuphatikizapo minofu ya m'mawere ndi maselo amafuta.

Mwa akazi, kutha msinkhu kumachitika chifukwa cha kuphatikiza kwa estrogen ndi mahomoni ena ogonana, progesterone. Izi zikutanthauza zinthu monga kukula kwa mabere ndi kukula kwa tsitsi m'mimba. Ndi mahomoni a estrogen omwe amalamulira nthawi ya msambo pamwezi.

Komabe, mahomoni otchedwa estrogen nawonso amagwira ntchito yofunika kwambiri mwa amuna. Amakhudza kukula kwa ubongo, magwiridwe antchito abwino ogonana, komanso chilakolako chogonana.

Ndiye, kodi khansa yodalira estrogen ndi chiyani?

Tsopano tiyeni tiwone zomwe khansa izi zomwe zimadalira estrogen zili. Nthawi zina mungamve zikutchedwa estrogen receptor-positive , hormone-dependent , hormone-positive , hormone receptor-positive , kapena hormone-sensitive . Mulimonsemo, amatanthauza chinthu chomwecho.

Mwachidule, izi zikutanthauza kuti mahomoni otchedwa estrogen amathandiza maselo a khansa kukula, kutanthauza kuti, kukula ndi kufalikira. Monga momwe chomera chimafunira madzi, mahomoni otchedwa estrogen ndi ofunikira pa mitundu iyi ya khansa.

Pali mitundu ingapo ya khansa yomwe imadalira kwambiri estrogen. Yaikulu ndi iyi:

• Khansa ya m'mawere
• Khansa ya m'chiberekero
• Khansa ya m'chiberekero - Iyi imatchedwanso khansa ya endometrial.

Kodi estrogen imayambitsadi khansa? Izi zikusokoneza pang'ono, sichoncho?

Nkhani imeneyi ndi yovuta kwambiri. Homoni ya estrogen nthawi zina imatchedwa kuti carcinogen. Izi zikutanthauza kuti ili ndi mphamvu zina zoyambitsa khansa. Koma tiyenera kumvetsetsa momwe zimachitikira.

Pafupifupi selo lililonse m'thupi lathu lili ndi mtundu wapadera wa mapuloteni otchedwa hormone receptors. estrogen m'magazi mwathu imabwera ndikugwirizana ndi ma receptor awa. Izi nthawi zambiri zimakhala zofunika pa ntchito zambiri m'thupi mwathu. Mu maselo athanzi, estrogen imathandiza maselo kugwira ntchito bwino ndikukula bwino.

Komabe, pazifukwa zina, zinthu zina zikagwirizana, maselo athanzi amatha kusanduka maselo a khansa. Zikatero, estrogen imayamba kugwira ntchito ngati chitsulo. Izi zikutanthauza kuti, estrogen imathandiza maselo a khansa omwe adapangidwa kale kugawikana mwachangu, kuchulukana, ndikufalikira kuchokera pamalo amodzi kupita kwina m'thupi.

Choncho, m'malo monena kuti estrogen yokha ndiyo imayambitsa khansa, n'kolondola kunena kuti estrogen, pamodzi ndi zinthu zina zomwe zimathandiza kuti khansa ikule, zimathandiza kuti khansa yomwe ilipo ikule .

Ndi zinthu ziti zomwe zimawonjezera chiopsezo chotenga khansa yodalira estrogen ngati iyi?

Pali zinthu zingapo zomwe zimawonjezera chiopsezo chotenga khansa yodalira estrogen mpaka pamlingo wina. Tiyeni tiwone zomwe zili:

• Kukhala ndi estrogen yochuluka kuposa yachibadwa m'thupi: Anthu ena mwachibadwa amakhala ndi estrogen yochuluka.
• Kutenga Mankhwala Obwezeretsa Mahomoni (HRT): Uwu ndi mankhwala omwe nthawi zambiri amaperekedwa pochiza kusasangalala kwa thupi (monga kutentha thupi, thukuta usiku) komwe kumachitika munthu akamaliza kusamba. Tangoganizirani kuti amayi anu kapena azakhali anu adapatsidwa mankhwala a mahomoni ndi dokotala chifukwa cha zizindikiro zawo atamaliza kusamba. Ndicho chimene HRT ili.
• Kunenepa Kwambiri: Pamene mafuta m'thupi akuwonjezeka, kupanga kwa estrogen kungawonjezekenso.
• Kukhala ndi vuto lotchedwa Polycystic Ovary Syndrome (PCOS): Izi zimagwirizananso ndi kusalinganika kwa mahomoni.
• Kugwiritsa ntchito Diethylstilbestrol (DES): Iyi ndi estrogen yopangidwa yomwe inaperekedwa kwa amayi apakati kuti apewe kutayika kwa mimba kuyambira 1938 mpaka 1971. Ngati mayi adagwiritsa ntchito DES panthawiyi, kapena ngati mayi adakumana ndi DES panthawi ya mimba ndikubereka mwana, mwanayo ali pachiwopsezo chotenga khansa yamtunduwu mtsogolo.

Kodi pali ubale wotani pakati pa estrogen ndi khansa ya m'mawere?

Ponena za khansa ya m'mawere, pafupifupi khansa zisanu ndi zitatu mwa khumi za m'mawere zimakhala ndi ma hormone receptor . Mwachidule, khansa imeneyi imafuna estrogen, progesterone, kapena mahomoni onsewa kuti ikule.

Chiwopsezo cha khansa ya m'mawere chimawonjezeka ngati munthu akumwa estrogen yambiri kwa nthawi yayitali. Zifukwa zazikulu za izi ndi izi:

• Mankhwala obwezeretsa mahomoni (HRT) pa kusamba.
• Kukhala ndi estrogen yambiri mwachibadwa m'thupi.
• Matenda a Klinefelter ndi matenda a majini omwe amakhudza amuna (amuna omwe ali ndi vutoli amakhala ndi estrogen yambiri).

Kale, amuna ena ankapatsidwa hormone ya estrogen ngati mankhwala a khansa ya prostate. Koma masiku ano madokotala samalimbikitsa chithandizo chimenecho chifukwa chimawonjezera chiopsezo cha khansa ya m'mawere mwa amuna.

Kodi pali ubale wotani pakati pa estrogen ndi khansa ya m'chiberekero?

Kumwa mankhwala a estrogen kwa moyo wonse kungapangitse kuti pakhale chiopsezo chotenga khansa ya m'chiberekero. Zinthu zomwe zingawopsezeke ndi izi:

• Kuyamba kusamba asanakwanitse zaka 12 (kutanthauza kutha msinkhu msanga).
• Osatenga mimba.
• Kusamba (kutanthauza kukhala ndi nthawi yosamba kwa nthawi yayitali) mutakwanitsa zaka 55.
• Kutenga mankhwala ophatikizana a mahomoni (mankhwala a mahomoni) pambuyo pa kusamba, komwe kumakhala ndi mahomoni a estrogen ndi progesterone.

Kodi pali ubale wotani pakati pa estrogen ndi khansa ya m'mimba?

Khansa ya m'chiberekero, kapena monga tanenera kale, khansa ya endometrial, imakula m'kati mwa chiberekero chanu. Azimayi ali ndi mwayi waukulu wopeza khansa iyi akamaliza kusamba.

Chiwopsezo chokhudzana ndi estrogen chikhoza kuwonjezeka chifukwa cha zinthu monga:

• Chithandizo cholowa m'malo mwa estrogen: Estrogen imathandiza kuchepetsa kusasangalala komwe kumachitika chifukwa cha kusamba, monga kutentha thupi, thukuta usiku, komanso kuuma kwa m'mimba. Komabe, kumwa mankhwala a estrogen okha kumawonjezera chiopsezo chokhala ndi khansa ya m'chiberekero. Izi zili choncho chifukwa estrogen imalimbikitsa kukula kwa chiberekero. Ichi ndichifukwa chake estrogen nthawi zambiri imaperekedwa ndi mahomoni otchedwa progesterone (mankhwala ophatikizana a hormone). Izi zimachepetsa chiopsezo cha khansa ya m'chiberekero. Komabe, ngati mwachitidwa opaleshoni yochotsa chiberekero, simudzakhala ndi khansa iyi chifukwa mulibe chiberekero.
• Kugwiritsa Ntchito Tamoxifen: Tamoxifen ndi mankhwala ofunikira kwambiri omwe amagwiritsidwa ntchito pochiza khansa ya m'mawere ndikuletsa khansa kuti isabwererenso. Imagwira ntchito ngati Selective Estrogen Receptor Modulator (SERM) ndipo imaletsa zotsatira za estrogen pa minofu ya m'mawere. Komabe, mwa akazi omwe asiya kusamba, tamoxifen imagwira ntchito ngati estrogen m'chiberekero. Izi zimapangitsa kuti chiberekero chikule, zomwe zimawonjezera chiopsezo cha khansa ya endometrial mpaka pamlingo wina. Koma musadandaule, chiopsezo chotenga khansa ya endometrial chifukwa cha tamoxifen nthawi zambiri chimakhala chochepera 1% pachaka. Palinso chiopsezo chochepa kwambiri chotenga sarcoma ya uterine, mtundu wosowa wa khansa womwe umayamba m'minofu kapena minofu ina ya chiberekero.

Kodi khansa yodalira estrogen imapezeka bwanji? Kodi madokotala amazindikira bwanji izi?

Ngati mukuganiza kuti muli ndi khansa, chinthu choyamba chomwe dokotala wanu angachite ndikutenga chidutswa cha minofu kuchokera ku chotupacho (chimenechi timachitcha kuti chotupa biopsy) ndikuchitumiza ku labu. Kumeneko, adzagwiritsa ntchito mayeso apadera kuti awone ngati maselowo ali ndi ma hormone receptors.

Ngati zotsatira za mayeso zikubwera ngati hormone receptor positive (HR+) , zikutanthauza kuti estrogen, progesterone, kapena mahomoni onsewa akuthandiza khansa yanu kukula, kutanthauza kuti, kuidyetsa.

Kodi khansa ngati imeneyi yomwe imadalira estrogen imachiritsidwa bwanji?

Ndikofunikira kuti madokotala adziwe momwe maselo a khansa alili, chifukwa mankhwala ena amagwira ntchito kokha pa khansa yokhala ndi mahomoni. Zina mwa njira zazikulu zothandizira mitundu iyi ya khansa ndi izi:

• Mankhwala oletsa aromatase: Mankhwalawa amagwira ntchito poletsa thupi kusintha ma androgens, mahomoni, kukhala estrogen. Mankhwalawa amagwira ntchito kokha kwa akazi omwe adutsa nthawi yosiya kusamba (monga momwe mazira awo asiya kupanga estrogen).
• Mankhwala ena a mahomoni: Izi zimachepetsa kapena kuletsa kupanga kwa estrogen m'thupi.
• Tamoxifen ndi mankhwala ena a SERM: Monga tafotokozera kale, izi zimagwira ntchito poletsa ma hormone receptors kuti asamamatire ku estrogen.
• Kuchotsa mazira m'mimba: Nthawi zina, mazira, omwe ndi ziwalo zazikulu zomwe zimapanga estrogen, amachotsedwa opaleshoni. Izi zitha kuchepetsa kwambiri kuchuluka kwa estrogen m'thupi.

Kodi mapiritsi oletsa kubereka angachepetsedi chiopsezo cha khansa iyi?

Yankho la izi likhoza kukhala 'inde' ndi 'ayi'. Kodi zimenezo zili bwanji?

Kafukufuku wina wasonyeza kuti akazi omwe amagwiritsa ntchito njira zolerera za mahomoni, monga mapiritsi, akhoza kukhala ndi chiopsezo chochepa kwambiri (pafupifupi 7%) chotenga khansa ya m'mawere .

Komabe, kumwa mapiritsi oletsa kubereka kungachepetse chiopsezo chotenga mitundu iyi ya khansa:

• Khansa ya pachibelekero
• Khansa ya m'matumbo
• Khansa ya m'chiberekero
• Khansa ya m'chiberekero

Kotero, monga mukuonera, izi n'zovuta pang'ono. Chifukwa chake, nthawi zonse ndi bwino kulankhula ndi dokotala wanu kuti musankhe njira yolerera yomwe ili yoyenera kwa inu, komanso yomwe ili yotetezeka kwambiri.

Kodi tingatani kuti tipewe kukula kwa khansa yodalira estrogen?

Khansa zambiri zimayamba popanda chifukwa chomveka. Izi zikutanthauza kuti nthawi zina khansa imatha kufalikira ngakhale titasamala bwanji. Komabe, pali zinthu zosavuta zomwe tingachite kuti tichepetse chiopsezo cha khansa pang'onopang'ono.

• Ngati n'kotheka, yamwitsani ana anu. Kuyamwitsa mwana kwapezeka kuti kumachepetsa chiopsezo cha khansa ya m'mawere.
• Chepetsani kumwa mowa kwambiri momwe mungathere ndipo pewani kusuta fodya kotheratu. Izi ndi zinthu zomwe zimayambitsa khansa zambiri.
• Yesetsani kudya zakudya zopatsa thanzi. Idyani ndiwo zamasamba ndi zipatso zambiri. Komanso, chita masewera olimbitsa thupi tsiku lililonse ndipo chita masewera olimbitsa thupi.
• Ngati muli onenepa kwambiri, ndiye kuti, onenepa kwambiri, yesani kuchepetsa thupi.
• Lankhulani ndi dokotala wanu za njira yotetezeka kwambiri yolerera.
• Ngati mukufuna kuthana ndi mavuto a kusamba, funsani upangiri wa dokotala wokhudza mankhwala ophatikizana a mahomoni kapena mankhwala osakhala a mahomoni.

Kodi ndi mafunso otani ofunika kwambiri omwe ndiyenera kufunsa dokotala wanga?

Ngati muli ndi nkhawa iliyonse yokhudza vutoli, kapena za chiopsezo cha khansa yokhudzana ndi estrogen, musazengereze kufunsa dokotala wanu. Ndikofunikira kuthetsa kukayikira kwanu. Nazi mafunso ena omwe mungafunse:

• Kodi khansa yomwe ndili nayo/yomwe ndili nayo imadalira estrogen kapena hormone-receptor?
• Kodi ndi mankhwala ati abwino kwambiri omwe alipo pakali pano a khansa yamtunduwu?
• Kodi zoopsa ndi zotsatirapo zake ndi ziti?
• Kodi ndi zinthu ziti zomwe ndingasinthe pa moyo wanga kuti nditeteze thanzi langa ndikuchepetsa chiopsezo cha khansa?
• Kodi ndisinthe njira yolerera yomwe ndikugwiritsa ntchito panopa? Ndi njira iti yomwe ili yabwino kwa ine?
• Kodi ndikoyenera kuti nditenge mankhwala a mahomoni? Kodi pali zoopsa zilizonse kwa ine?

Pomaliza, zomwe muyenera kukumbukira (Uthenga Wopita Nawo Kunyumba)

Nthawi zambiri, mahomoni otchedwa estrogen amathandiza kwambiri m'matupi athu, kuwathandiza kuti azigwira ntchito bwino. Komabe, khansa yodalira estrogen ndi yosiyana. Mu khansa izi, estrogen imathandizadi kuti khansa ikule, ndiko kuti, imadyetsa khansa.

Ngati mwapezeka ndi khansa ndipo dokotala wanu akukayikira kuti ikhoza kukhala ndi vuto la mahomoni, adzakuyesani mayeso ofunikira kuti adziwe ngati ikugwirizana ndi estrogen. Kutengera ndi zomwe zanenedwa, dokotala wanu adzatha kusankha chithandizo chothandiza komanso choyenera kwa inu.

Choncho, popanda mantha kapena kubisa chilichonse, kambiranani momasuka mafunso ndi kukayikira kwanu ndi dokotala wanu. Ndikofunikira kwambiri pa thanzi lanu komanso thanzi lanu la maganizo.

Estrogen , khansa, mahomoni, khansa ya m'mawere, khansa ya mazira, khansa ya uterine, thanzi la akazi