Kodi munayamba mwaganizapo kuti kumva kutopa nthawi zonse, kutupa miyendo, komanso kuvutika kupuma ndi zachilendo? Nthawi zina, pakhoza kukhala vuto lina lovuta kwambiri kumbuyo kwa zizindikirozi lomwe sitinamvepo zambiri. Lero, tikulankhula za matenda osowa kwambiri, koma omwe muyenera kudziwa. Ndi AL Amyloidosis. Dzinali lingamveke ngati loopsa pang'ono, koma tiyeni tikambirane momveka bwino.
Mwachidule, kodi AL amyloidosis ndi chiyani?
Tangoganizani kuti tili ndi mafakitale ang'onoang'ono m'thupi mwathu, omwe timawatcha maselo a plasma . Awa ali m'mafupa athu. Ntchito yawo yayikulu ndikupanga asilikali otchedwa ma antibodies kuti amenyane ndi majeremusi omwe amalowa m'thupi mwathu. Ichi ndi gawo lofunika kwambiri la chitetezo chathu chamthupi.
Koma mu vuto lotchedwa AL amyloidosis, pali vuto laling'ono m'maselo a plasma awa. Chifukwa cha vutoli, maselo amenewo amapanga mtundu wa mapuloteni omwe amasokonekera, amasweka, komanso amasokonekera. Izi zimatchedwa puloteni yopepuka .
Mapuloteni opangidwa molakwika awa amasonkhana pamodzi, ndikupanga ma tangles ndi tinthu tating'onoting'ono ta ulusi. Izi zimasonkhana m'ziwalo zosiyanasiyana m'thupi lathu, monga mtima, impso, mitsempha, ndi matumbo. Monga momwe dothi limatsekera chitoliro, mapuloteniwa akamasonkhana, ziwalozo sizingagwire ntchito bwino. Ichi ndi chomwe timachitcha AL amyloidosis.
N’chifukwa chiyani izi zimatchedwa AL?
Pali mitundu ingapo ya amyloidosis. Mtundu uliwonse umatchedwa dzina la puloteni yosazolowereka yomwe imayambitsa matendawa. Chilembo A chimayimira Amyloidosis ndipo chilembo L chimayimira Light Chain .
Kodi matendawa amakhudza bwanji thupi?
M'thupi mwathu muli mitundu yambirimbiri ya maselo a plasma. Mtundu uliwonse umapanga mtundu winawake wa ma antibodies kuti amenyane ndi kachilombo kena.
Mu AL amyloidosis, selo limodzi la plasma limakhala ndi chilema, ndipo selo limenelo limagawikana mosalamulirika, ndikupanga maselo ambirimbiri olakwika. Selo lililonse limapanga puloteni yopepuka yolakwika yomwe tidakambirana kale.
Mapuloteni ambiri amenewa amayenda m'magazi mwathu ndipo amayamba kuikidwa m'ziwalo zathu. Ulusi wosungidwawu umatchedwa amyloid fibrils . Izi zimapangitsa kuti ziwalozo zikhale zokhuthala komanso zisagwire bwino ntchito. Pakapita nthawi, izi zingayambitse kuwonongeka kwakukulu komwe kungakhale koopsa ngakhale moyo.
Ndani amene ali ndi mwayi waukulu wopeza matendawa?
Uwu ndi matenda osowa kwambiri. Padziko lonse lapansi, umakhudza anthu ochepa, pakati pa 5 ndi 12 pa miliyoni.
- Zambiri kwa amuna kuposa akaziChizolowezi chomangirirana chimakhala chochulukira.
- Matendawa amapezeka kwambiri mwa anthu azaka zopitirira 60. Avereji ya zaka zomwe munthu amadwala matendawa ndi pafupifupi zaka 64.
Kodi zizindikiro zomwe zingathe kuzindikirika ndi ziti?
Vuto limodzi ndi matendawa ndilakuti zizindikiro zake nthawi zambiri zimakhala zofanana ndi za matenda ena ofala. Ndipo zizindikirozi zimawonekera pang'onopang'ono kwambiri. Chifukwa chake simungazindikire kusiyana kwakukulu poyamba. Tiyeni tiwone zizindikirozi mu tebulo ili m'munsimu.
| Chiwalo cha thupi chomwe chakhudzidwa | Zinthu zooneka |
|---|---|
| Mutu ndi khosi |
|
| Manja ndi mapazi | |
| Mtima ndi mapapo | |
| Dongosolo la m'mimba | |
| Impso ndi dongosolo la mkodzo |
Zizindikiro zimenezi zimapezekanso m'matenda ambiri, choncho musachite mantha ngati muli ndi amyloidosis chifukwa chakuti muli ndi chimodzi kapena ziwiri mwa izi. Koma ngati muli ndi zizindikiro zoposa chimodzi mwa izi, muyenera kuonana ndi dokotala kuti akupatseni upangiri.
Kodi dokotala amazindikira bwanji matendawa molondola?
Pambuyo pomvera zizindikiro zanu, ngati dokotala akukayikira kuti muli ndi matendawa, adzakuyesani mayeso angapo kuti atsimikizire.
Kuyezetsa kofunikira kwambiri pa izi ndi biopsy . Izi zimaphatikizapo kutenga chidutswa chaching'ono kwambiri cha minofu kapena chiwalo chomwe chikuganiziridwa kuti chakhudzidwa ndikuchiyang'ana pansi pa maikulosikopu. Izi zimatithandiza kuwona bwino ngati puloteni ya amyloid ilipo. Mayeso a biopsy nthawi zambiri amachitidwa kuti:
- Kufufuza za mafupa: Chitsanzo chaching'ono chimatengedwa kuchokera ku mafupa mkati mwa fupa.
- Kufufuza impso: Tizidutswa tating'onoting'ono ta minofu timatengedwa kuchokera ku impso.
- Kujambula mtima: Zidutswa zingapo zazing'ono za minofu ya mtima zimatengedwa.
- Kufufuza mafuta m'mimba: Kachidutswa kakang'ono ka minofu kamatengedwa kuchokera ku mafuta omwe ali pansi pa khungu la mimba.
Mayeso owonjezera
Kuonjezera pa izi, mayeso ena akuchitidwa kuti adziwe kuchuluka kwa kuwonongeka kwa ziwalo zanu.
- Mayeso a magazi: Izi zimathandiza kuona momwe impso, mtima, ndi chiwindi zikugwirira ntchito, komanso kuyeza kuchuluka kwa mapuloteni a unyolo wopepuka m'magazi.
- Kuyesa mkodzo: Chitsanzo cha mkodzo, chomwe nthawi zambiri chimatengedwa kwa maola 24, chimayesedwa kuti chione ngati pali kuwonongeka kulikonse ku impso.
- ECG (Electrocardiogram): Imayesa ntchito yamagetsi ya mtima.
- Echocardiogram: Kujambula mtima pogwiritsa ntchito ultrasound. Izi zimayang'ana zinthu monga kuyenda kwa mtima ndi kukula kwake.
- MRI ya Mtima: Kuyesa kumeneku kumachitika kuti mupeze chithunzi chomveka bwino komanso chatsatanetsatane cha mtima.
Kodi mankhwala ochizira izi ndi otani?
Pali zolinga zazikulu zingapo zochizira AL amyloidosis. Choyamba ndi kuwongolera zizindikiro. China ndikuwongolera kuwonongeka kwa ziwalo. Ndipo chofunika kwambiri, kuletsa kupanga mapuloteni osayenera .
Madokotala nthawi zambiri amagwiritsa ntchito mankhwala monga chemotherapy , immunotherapy , kapena steroids kuti awononge maselo a plasma omwe ali ndi vuto, zomwe zimaletsa kupanga mapuloteni atsopano a unyolo.
Chofunika kwambiri n’chakuti, ngakhale kuti mankhwala amenewa amatha kuletsa matendawa kuti asakule kwambiri, sachotsa ma amyloid fibrils omwe aikidwa kale m’ziwalo za thupi. Chithandizo chikayamba, chitetezo chathu cha m’thupi chimayamba kuchotsa mapuloteni amenewa.
Nthawi zina, kutengera ndi momwe wodwalayo alili , mungalimbikitse kuyika mafupa kapena kuyika maselo oyambira . Zonsezi zimasankhidwa ndi dokotala amene akukuthandizani.
Kodi mungakhale ndi matendawa kwa nthawi yayitali bwanji?
Ili ndi vuto kwa anthu ambiri. Ndipotu, mankhwala atsopano tsopano awonjezera kwambiri nthawi ya moyo wa anthu omwe ali ndi AL amyloidosis. Kwa anthu ena, lakhala matenda osatha omwe angathe kuthetsedwa ndi mankhwala.
Koma sitiyenera kuiwala kuti uwu ndi matenda oopsa kwambiri. Mkhalidwe wamtsogolo wa wodwalayo umatsimikiziridwa ndi zinthu zambiri, monga kuchuluka kwa kuwonongeka kwa ziwalo pamene matendawa apezeka, komanso momwe thupi limayankhira chithandizo.
Dokotala wanu angakupatseni chidziwitso chabwino kwambiri chokhudza matenda anu, zotsatira za chithandizo chanu, komanso tsogolo lanu. Choncho musaope kumufunsa mafunso aliwonse omwe muli nawo.
Kodi matendawa angapewedwe? Kodi ndingadzisamalire bwanji?
Mwatsoka, AL amyloidosis si matenda omwe tingathe kuwapewa. Amayambitsidwa ndi kusintha kwadzidzidzi mu selo la plasma. Koma matendawa akapezeka, pali zinthu zingapo zomwe mungachite kuti mudzisamalire nokha.
- Zakudya zabwino: Mankhwala ena angayambitse kulephera kudya. Koma zakudya zabwino ndizofunikira kuti thupi lanu likhale lamphamvu. Lankhulani ndi dokotala wanu za zakudya zoyenera kwa inu.
- Pumulani mokwanira: Perekani thupi lanu nthawi yoti lichiritse. Gonani mokwanira ndi kupuma.
- Maseŵero olimbitsa thupi oyenera:Kuchita masewera olimbitsa thupi n'kwabwino kwa maganizo komanso thupi. Koma funsani dokotala wanu kuti ndi masewera olimbitsa thupi ati omwe ndi otetezeka komanso oyenera thupi lanu.
- Chithandizo cha maganizo: Mukakhala ndi matenda osowa ngati awa, mungamve kuti muli nokha komanso kuti ndinu nokha chifukwa ena sakumvetsa. Zimenezo n'zachibadwa. Funsani dokotala wanu za magulu othandizira anthu omwe ali ndi vutoli. Kugawana zomwe mwakumana nazo ndi ena ndi mphamvu yaikulu.
Ngakhale kuti AL amyloidosis ndi matenda oopsa, n'zotheka kuthana ndi vutoli mwa kuzindikira msanga, kulandira chithandizo choyenera, ndikudzisamalira bwino.
Uthenga Wopita Nawo Kunyumba
- AL amyloidosis ndi matenda osowa omwe amayamba chifukwa cha kusungidwa kwa mapuloteni osazolowereka (maunyolo owala) opangidwa ndi maselo a plasma mu fupa la mafupa m'ziwalo.
- Izi zimakhudza kwambiri mtima ndi impso, koma zimatha kukhudza chiwalo china chilichonse m'thupi.
- Popeza zizindikiro monga kutopa, kutupa kwa miyendo, ndi kupuma movutikira zimatha kufanana ndi matenda ena, ndikofunikira kufunafuna upangiri wa dokotala ngati zikupitirira kwa nthawi yayitali.
- Kuyeza magazi m'thupi (biopsy) n'kofunika kwambiri kuti mudziwe bwino matendawa.
- Cholinga chachikulu cha chithandizo ndikuletsa kupanga mapuloteni osazolowereka kudzera mu chithandizo monga chemotherapy.
- Ndikofunikira kwambiri kulankhula momasuka ndi dokotala wanu za matenda anu ndi chithandizo chanu.
💬 Comments (0)
Palibe ndemanga zomwe zatumizidwa pano. Onjezani ndemanga yanu pano koyamba.
Onjezani ndemanga yanu