Kodi mumamva ngati thupi lanu likulimbana nanu kuchokera mkati? Ikhoza kukhala Antisynthetase Syndrome!

Kodi nthawi zina mumamva ngati chinachake chikukuvutitsani kuchokera mkati? Mwina mafupa anu akungopweteka, mumamva kupuma pang'ono, kapena mungazindikire kusintha pang'ono pakhungu lanu. Musangonyalanyaza izi ngati chinthu chomwe chikuchitika. Nthawi zina pamakhala nkhani yovuta kwambiri kumbuyo kwawo. Lero tikambirana za vuto losowa, koma lotha kuthetsedwa lotchedwa Antisynthetase Syndrome.

Kodi Antisynthetase Syndrome ndi chiyani? Mwachidule...

Matenda a Antisynthetase Syndrome ndi matenda osowa kwambiri. Chomwe chimachitika pamenepa ndi chakuti pali kutupa m'thupi lonse, kutanthauza, matenda monga kutupa. Uwu ndi matenda a autoimmune. Tsopano mukufunsa kuti matenda a autoimmune ndi chiyani.

Tangoganizirani, thupi lathu lili ndi chitetezo chamthupi . Zili ngati gulu lankhondo lomwe limateteza dziko lathu. Maselo ndi ziwalo zomwe zili mu dongosololi zimatiteteza ku majeremusi, mabakiteriya, ndi mavairasi omwe amayambitsa matenda. Komabe, mu matenda odziteteza okha, chitetezochi chimasokonekera. Chimaganiza kuti maselo ndi minofu yathu yathanzi ndi "adani" ndipo chimayamba kuwaukira. Zili ngati gulu lathu lankhondo likuukira nyumba zathu. Ngakhale madokotala sakudziwa chifukwa chake izi zimachitika.

Mu Antisynthetase Syndrome, chitetezo chathu chamthupi chingakhudze madera otsatirawa a thupi lathu:

• Minofu
• Malumikizidwe
• Mapapu
• Khungu
• Mitsempha ya magazi

Chofunika kwambiri ndikuonana ndi dokotala ngati muwona kupweteka kwatsopano kwa mafupa, kusintha kwa khungu, kapena kupuma movutikira, osanyalanyaza.

Kodi matendawa ndi osowa bwanji?

Matendawa (Antisynthetase Syndrome) ndi matenda osowa kwambiri. N'zovuta kunena kuti ndi anthu angati omwe ali ndi matendawa. Chifukwa ndi anthu ochepa okha omwe amadwala matendawa chaka chilichonse. Nthawi zina, zizindikirozi zimakhala zofanana ndi zizindikiro za matenda ena, ndipo sizingadziwike.

Kodi zizindikiro za Antisynthetase Syndrome ndi ziti?

Zizindikiro zomwe mungakhale nazo zimadalira momwe chitetezo chanu cha mthupi chikugwira ntchito bwino m'thupi lanu komanso momwe chikuwonongera thupi lanu.

Kawirikawiri, anthu omwe ali ndi matenda a Antisynthetase Syndrome amakhala ndi zizindikiro zomwe zimakhala ndi matenda ena ambiri. Tiyeni tiwone zomwe zili:

• Myositis: Uku ndi kutupa kwa minofu kwa nthawi yayitali. Izi zimayambitsa kupweteka kwa minofu ndi kufooka.Zimachitika. Tangoganizirani, mumadzimva wofooka kwambiri moti simungathe ngakhale kukweza manja anu. Nthawi zina minofu ya pakhosi panu imafooka, zomwe zimapangitsa kuti zikhale zovuta kumeza chakudya ndi chakumwa. Timachitcha kuti (dysphagia) .

• "Manja a Makanika": Kodi dzina limeneli si lachilendo? Apa ndi pomwe khungu la m'manja ndi m'mbali mwa zala limakhuthala ndikusweka. Limaoneka ngati manja a makanika amene amagwira ntchito ndi mafuta tsiku lonse.

• Matenda a m'mapapo otchedwa Interstitial Lung Disease (ILD): Apa ndi pamene minofu pakati pa timatumba tating'onoting'ono ta mpweya (alveoli) m'mapapo mwathu ndi mitsempha yamagazi yozungulira imawonongeka. Izi zingayambitse kupuma movutikira (dyspnea) , chifuwa chouma , kutopa , komanso kupweteka pachifuwa . Zili ngati kugwa pansi pa masitepe.

• Matenda a nyamakazi: Izi zimachitika pamene mafupa asanu kapena kuposerapo amakhudzidwa nthawi imodzi. Izi zimayambitsa kupweteka, kuuma, ndi kutupa m'mafupa . Mungamve kuuma mukadzuka m'mawa.

• Matenda a Raynaud (matenda achiwiri a Raynaud): Pachifukwa ichi, zala za m'manja ndi zala za m'mapazi zimasintha mtundu (zimasanduka zotumbululuka, kenako zabuluu, kenako zofiira) ndipo zimakhala zamadzimadzi, makamaka zikakhudzidwa ndi kuzizira. Zili ngati zala zanu zimachita dzanzi mutatulutsa ayezi mufiriji.

• Malungo: Anthu ena amatha kungokhala ndi malungo popanda matenda m'thupi lawo. Izi zikutanthauza kuti kutentha kwa thupi kumakwera chifukwa cha chitetezo cha mthupi.

Kodi n’chiyani chimayambitsa matenda a Antisynthetase?

Choyambitsa chenicheni cha matendawa sichinadziwikebe . Koma madokotala apeza kuti anthu ambiri omwe ali ndi matendawa ali ndi mtundu wapadera wa ma antibodies m'magazi mwawo. Ma antibodies amenewa amasonyeza kuti chitetezo chawo cha mthupi chikuukira matupi awo m'malo mowateteza. Timatcha awa (autoantibodies) , zomwe zikutanthauza "self-antibodies".

Tsopano, taonani, ma antibodies ndi mapuloteni omwe amatiteteza pamene chinthu choipa chilowa m'thupi mwathu. Ali ngati zizindikiro za mankhwala zomwe chitetezo chathu cha mthupi chimagwiritsa ntchito. Ma antibodies amenewa amalemba olowa oopsa monga mabakiteriya ndi mavairasi ngati "ngozi." Koma ngati muli ndi matenda odziteteza okha, chitetezo chanu cha mthupi chimapanga molakwika ndikutulutsa ma antibodies omwe amaukira minofu yathanzi.

Anthu omwe ali ndi matenda a Antisynthetase Syndrome nthawi zambiri amakhala ndi ma autoantibodies omwe amaukira ma enzyme otchedwa tRNA synthetases . Ma tRNA synthetases amenewa ndi ma enzyme ofunikira komanso othandiza omwe matupi athu amafunikira kuti agwire ntchito bwino.

Sizikudziwikabe chifukwa chake chitetezo chathu cha mthupi chimayamba kupanga ma autoantibodies amenewa. Komabe, ngati muli ndi umboni wa ma autoantibodies amenewa m'magazi anu, n'zotheka kuti muli ndi Antisynthetase Syndrome.

Zili choncho, tangoganizirani wina akuyatsa zozimitsa moto patsogolo pa nyumba yanu. Mukayang'ana m'mawa wotsatira, pali zidutswa za zozimitsa moto ndi njira zopsereza zomwe zafalikira pansi. Simungadziwe bwino amene anayatsa zozimitsa moto, nthawi yomwe zinayatsidwa, kapena chifukwa chake. Koma pali umboni woti zinachitika. Mu Antisynthetase Syndrome, m'malo mwa phokoso lomwe mumamva mukayatsa zozimitsa moto ndipo agalu akuopa, mumakumana ndi zizindikiro zomwe tinakambirana kale.

Ndani amene ali pachiwopsezo chachikulu chotenga matendawa?

Aliyense akhoza kudwala matenda a Antisynthetase Syndrome. Komabe, akazi ndi anthu azaka zopitirira 50 ali ndi mwayi waukulu wodwala matendawa. Akazi ali ndi mwayi wowirikiza kawiri wodwala matendawa kuposa amuna.

Kodi Antisynthetase Syndrome imapezeka bwanji?

Dokotala amazindikira matendawa kutengera zizindikiro zanu, kuyezetsa thupi, ndi mayeso ena angapo.

Mungafunike kuonana ndi dokotala yemwe ndi katswiri wa matenda odziteteza ku matenda a autoimmune, wotchedwa rheumatologist . Iye adzakuyang'anirani ndikukufunsani za zizindikiro zanu. Muyenera kuuza dokotalayo zizindikiro zanu, nthawi yomwe munazizindikira koyamba, komanso ngati pali china chilichonse chomwe chikuzikulitsa.

Kuphatikiza apo, muyenera kuyesedwa kangapo kuti mutsimikizire kuti muli ndi Antisynthetase Syndrome komanso kuti mupeze matenda ena omwe angayambitse zizindikiro zofanana.

Ndi mayeso ati omwe amagwiritsidwa ntchito pozindikira matendawa?

Iyi si mayeso amodzi omwe angatsimikizire matendawa. Izi nthawi zambiri zimakhala gawo la njira yotchedwa differential diagnosis . Izi zikutanthauza kuti dokotala wanu adzachita mayeso angapo kuti adziwe chomwe chikukuyambitsani zizindikiro, kuchotsa matenda ena, ndikuzindikira kuti muli ndi Antisynthetase Syndrome. Mayeso ena omwe mungakhale nawo ndi awa:

• Kuyezetsa magazi: Kuyezetsa momwe chitetezo cha mthupi lanu chikugwirira ntchito komanso kuona ngati muli ndi ma autoantibodies, omwe ndi chizindikiro cha Antisynthetase Syndrome. Kuyezetsa magazi kungayezenso kuchuluka kwa ma enzyme ena omwe amatulutsidwa m'magazi minofu ikawonongeka.
• Kusanthula mkodzo: Kuwunika momwe impso zimagwirira ntchito komanso kuwona ngati pali matenda kapena mavuto ena mu mkodzo omwe angayambitse zizindikiro zanu.
• Mayeso a ntchito ya m'mapapo: Yang'anani ngati mapapu anu kapena dongosolo lanu lopumira lakhudzidwa.
• Kujambula zithunzi za CT scan kapena mayeso ena: Kujambula zithunzi za minofu ndi ziwalo mkati mwa thupi.
• (Electromyography - EMG):Yang'anani momwe minofu imagwirira ntchito.
• Kujambula kwa magnetic resonance imaging (MRI) kwa minofu yomwe yakhudzidwa: kuti muwone ngati pali kutupa.
• Kuyeza magazi (biopsy) ndi njira yoyezera yomwe imaphatikizapo kutenga chidutswa chaching'ono cha minofu kapena minofu ya m'mapapo.

Kodi Antisynthetase Syndrome imachiritsidwa bwanji?

Palibe mankhwala a Antisynthetase Syndrome. Komabe, dokotala wanu angakuthandizeni kupeza njira zosiyanasiyana zochiritsira zomwe zingathandize kuchepetsa zizindikiro zanu, kuchepetsa zotsatira zake pa moyo wanu watsiku ndi tsiku, komanso kuchepetsa kuwonongeka kwa ziwalo zanu.

Mtundu wa chithandizo chomwe mukufuna chidzadalira komwe zizindikiro zanu zili komanso momwe zilili zoopsa. Nazi zina mwa mankhwala omwe amagwiritsidwa ntchito kwambiri:

• Corticosteroids: Awa ndi mankhwala olembedwa ndi dokotala omwe amachepetsa ululu ndi kutupa. Madokotala nthawi zambiri amapereka mankhwala a corticosteroid pamodzi ndi mankhwala otchedwa immunosuppressants.
• Mankhwala Oletsa Kutupa kwa Thupi: Mankhwalawa amagwira ntchito poletsa chitetezo cha mthupi lanu kuti chisawononge maselo ndi minofu yathanzi. Mtundu wa mankhwala omwe mukufuna udzadalira ziwalo zomwe zakhudzidwa. Mankhwala oletsa kutupa kwa thupi omwe amagwiritsidwa ntchito kwambiri ndi methotrexate, azathioprine, ndi mycophenolate . Mungafunikenso cyclophosphamide, rituximab, kapena tacrolimus .
• Chithandizo cha Matenda a M'mapapo Omwe Ali Pakati pa Matenda (ILD): Mungapatsidwe mankhwala oti mupumule mosavuta, kapena chithandizo cha okosijeni ngati mukufuna mpweya wowonjezera. Muyenera kugwira ntchito ndi katswiri wa mapapu kuti muthane ndi mavuto anu opuma.
• Kuchiza ndi thupi: Katswiri wa thupi angakuthandizeni kukonza kayendedwe ka thupi lanu. Angakuthandizeni kuthana ndi zizindikiro zokhudzana ndi minofu kapena kukupatsani malangizo a masewera olimbitsa thupi opumira kuti mulimbikitse mapapu anu. Mungafunikenso chithandizo cha matenda a m'mapapo .

Kodi chimachitika ndi chiyani ngati ndili ndi matenda a Antisynthetase Syndrome?

Dokotala wanu angakuthandizeni kupeza njira zosiyanasiyana zochiritsira zomwe zingathandize kuthetsa zizindikiro zanu.

Matenda a Antisynthetase ndi matenda osatha . Izi zikutanthauza kuti muyenera kuthana ndi zizindikiro kwa nthawi yayitali (mwina moyo wanu wonse).

Kodi (Antisynthetase Syndrome) amafa?

Matenda a Antisynthetase nthawi zambiri sapha anthu . Nthawi yotsala ya moyo wa anthu omwe ali ndi matendawa nthawi zambiri simakhudzidwa kwambiri. Anthu ambiri amakhala ndi matendawa kwa moyo wawo wonse, koma amatha kuwongolera zizindikiro zawo ndi chithandizo.

Komabe, ngati muli ndi matenda aakulu a m'mapapo kapena vuto lina lomwe limakhudza dongosolo lanu la kupuma, likhoza kukupha. Koma nthawi zambiri silimachitika kawirikawiri. Dokotala wanu adzakuuzani zomwe mungayembekezere, komanso kusintha kwa zizindikiro zomwe zingakhale zizindikiro zoyambirira za mavuto aakulu a kupuma.

Kodi ndingapewe kudwala matenda a Antisynthetase Syndrome?

Palibe njira yopewera matenda a Antisynthetase Syndrome, chifukwa akatswiri sakudziwa bwino chomwe chimayambitsa matendawa kapena chomwe chimawonjezera chiopsezo chake.

Kodi ndiyenera kupita kwa dokotala liti?

Ngati mukupeza zizindikiro zatsopano, makamaka ngati zikuipiraipira, pitani kwa dokotala . Ngati mukuona kuti zizindikiro zanu sizikuwongoleredwa monga momwe zinalili kale ndi chithandizo chanu, kapena ngati zizindikiro zanu zikukupangitsani kukhala kovuta kuchita ntchito zanu za tsiku ndi tsiku, lankhulani ndi dokotala wanu.

Kodi ndiyenera kupita ku chipinda chadzidzidzi liti?

Ngati muli ndi zizindikiro izi, pitani ku chipinda chodzidzimutsa nthawi yomweyo kapena imbani 911 (kapena nambala yanu yadzidzidzi yapafupi) :

• Kuvuta kupuma mwadzidzidzi.
• Kupuma movutikira kwambiri (kumva ngati simungathe kupuma).
• Mtundu wabuluu wa khungu, milomo, kapena misomali (cyanosis).
• Kupweteka pachifuwa kapena kulemera.

Ndi mafunso ati omwe ndiyenera kufunsa dokotala wanga?

• Kodi ndili ndi matenda a Antisynthetase Syndrome kapena matenda ena a autoimmune?
• Ndi mayeso amtundu wanji omwe ndiyenera kuchita?
• Kodi ndi mankhwala ati abwino kwambiri oletsa zizindikiro zanga?
• Kodi ndikufunika chithandizo cha thupi kapena kupuma bwino?
• Kodi ndili pachiwopsezo chotani cha mavuto aakulu a m'mapapo?

Kodi mayina ena a Antisynthetase Syndrome ndi ati?

Madokotala nthawi zina amatcha Antisynthetase Syndrome ndi mayina ena. Mwachitsanzo:

• (Antisynthetase deficiency syndrome)
• (AS syndrome)
• (Matenda a Anti-Jo1)

Zonsezi ndi mayina osiyanasiyana a vuto lomwelo.

Pomaliza, zomwe muyenera kukumbukira (Uthenga Wopita Nawo Kunyumba)

Antisynthetase Syndrome ndi matenda osowa kwambiri omwe chitetezo cha mthupi lanu chimaukira thupi lanu m'malo mokutetezani. Lankhulani ndi dokotala wanu za mankhwala omwe angathandize kuchepetsa kukhudzidwa kwa zizindikiro zanu pa moyo wanu watsiku ndi tsiku.

Kukhala ndi matenda odziteteza ku matenda a autoimmune kungakhale kokhumudwitsa kwambiri - kungamveke ngati thupi lanu likukunyengani. Ngati mukufuna thandizo kuti muzolowere kusintha kwa moyo wanu kapena kuthana ndi vutoli, funsani dokotala wanu za njira zopezera upangiri wa zaumoyo wamaganizo. Kumva chisoni ndi kupsinjika maganizo ndikwachibadwa, koma simuyenera kudutsamo nokha.

'Matenda a Antisynthetase, matenda a autoimmune, myositis, matenda a m'mapapo amkati, chochitika cha Raynaud, ma autoantibodies, kupweteka kwa mafupa, kufooka kwa minofu