Tiyeni tingophunzira zonse zokhudza Aromatase Inhibitors (AI) zomwe zimagwiritsidwa ntchito pochiza khansa.

Kodi dokotala wanu wakuuzani kapena wina m'banja mwanu kuti muyambe kumwa mankhwala oletsa aromatase? Ndizachilendo kumva mantha pang'ono komanso chidwi mukamva zimenezo. "Ndi mankhwala amtundu wanji awa?", "Ndikupatsidwa chiyani ichi?", "Ndi chiyani chidzandichitikire?", "Kodi padzakhala zotsatirapo zina?" Mwina muli ndi mafunso ambiri m'maganizo mwanu. Choncho musachite mantha. Lero, tikambirana za mankhwala otchedwa aromatase inhibitor m'chinenero chosavuta chomwe mungamvetse, ngati kuti mukulankhula ndi mnzanu.

Kodi Aromatase Inhibitor (AI) ndi chiyani mwachidule?

Mwachidule, Aromatase Inhibitor ndi mtundu wa mankhwala a mahomoni omwe amagwiritsidwa ntchito pochiza khansa. Amagwiritsidwa ntchito kwambiri pochiza mtundu wa khansa ya m'mawere yotchedwa Estrogen Receptor-Positive (ER+) .

Tsopano mwina mukudabwa kuti, "Kodi 'ER+` iyi ikutanthauza chiyani?" Ikutanthauza china chake chonga ichi. Maselo ena a khansa ya m'mawere amathandizidwa kukula ndi kufalikira ndi mahomoni otchedwa estrogen m'thupi lathu. Monga momwe chomera chimafunikira madzi ndi feteleza kuti chikule, maselo a khansa awa amagwiritsa ntchito mahomoni otchedwa estrogen ngati "chakudya" chawo. Chifukwa chake, khansa zomwe zimayambitsidwa ndi mahomoni awa a estrogen ndi zomwe timatcha khansa ya `ER+`.

Chomwe Aromatase Inhibitor imachita ndikuletsa maselo a khansa kuti asalandire "chakudya" chimenecho. Imachita izi mwa: Thupi lathu lili ndi enzyme yotchedwa Aromatase . Enzyme iyi imasintha mahomoni ena m'thupi kukhala estrogen. Chifukwa chake chomwe mankhwalawa amachita ndikuletsa ntchito ya enzyme ya Aromatase. Kenako kupanga estrogen m'thupi kumachepa kwambiri. Pamene estrogen yatha, maselo a khansa amataya "chakudya" chomwe amafunikira kuti akule, ndipo pang'onopang'ono amafa.

Mankhwalawa ndi othandiza kwambiri kwa akazi azaka zopitilira 50 omwe adasiya kusamba , chifukwa akasiya kusamba, estrogen m'thupi la mkazi imapangidwa makamaka kudzera mu aromatase enzyme iyi.

Kodi chithandizochi chimaperekedwa pazochitika ziti?

Pali zochitika zingapo zomwe madokotala angalimbikitse kugwiritsa ntchito mankhwala a Aromatase Inhibitor. Tiyeni tiwone zomwe zili.

• Pambuyo pa opaleshoni ya khansa ya m'mawere ya ER+: Mankhwalawa amaperekedwa kuti aletse khansayo kubwereranso, kutanthauza kuti, kuchepetsa chiopsezo chobwereranso.
• Ngati khansa yafalikira ku ma lymph nodes apafupi: Chithandizochi chimathandiza kuchepetsa kufalikira kwa khansa.
• Ngati khansa yafalikira (yomwe yafalikira) ku ziwalo zina m'thupi:Khansa ya m'mawere nthawi zina imatha kufalikira ku ziwalo zakutali monga mapapo, mafupa, ubongo, kapena chiwindi. Mankhwalawa amagwiritsidwanso ntchito pazochitika zotere.
• Ngati mutakhala ndi khansa ya m'mawere ya ER+ musanayambe kusamba: Popeza mazira a m'mimba akadali kupanga estrogen pa msinkhu uwu, muyenera kumwa mankhwala oletsa aromatase pamodzi ndi mankhwala ena omwe amaletsa mazira kupanga estrogen.
• Ngati muli ndi chiopsezo chowonjezeka cha khansa ya m'mawere ya `ER+`: Kafukufuku wina wasonyeza kuti mankhwala awa amachepetsa chiopsezo cha khansa ya m'mawere. Komabe, sanavomerezedwe mwalamulo pachifukwa ichi.
• Ngati mwamuna atenga khansa ya m'mawere ya `ER+`: Inde, amuna nawonso akhoza kutenga khansa ya m'mawere. Alinso ndi hormone yochepa ya estrogen m'thupi lawo. Chifukwa chake, pali nthawi zina pomwe amuna amathanso kupatsidwa chithandizochi.

Kodi mitundu ya Aromatase Inhibitors yomwe imagwiritsidwa ntchito kwambiri ndi iti?

Pali mitundu ingapo ya mankhwala amenewa pamsika. Dokotala wanu adzakulangizani yomwe ikuyenererani kwambiri. Awa ndi mitundu itatu yomwe imagwiritsidwa ntchito kwambiri.

Kodi ndingagwiritse ntchito bwanji mankhwalawa? Ndiyenera kumwa nthawi yayitali bwanji?

Mankhwala oletsa aromatase ndi mtundu wa mapiritsi omwe mumamwa tsiku lililonse . Mutha kupatsidwa mankhwalawa mukangoyamba kulandira chithandizo. Kapena, nthawi zina, dokotala wanu angakupatseni chithandizo china cha mahomoni chotchedwa tamoxifen kwa zaka zingapo kenako nkukusinthani ku mankhwala oletsa aromatase.

Kawirikawiri, chithandizochi chimapitirira kwa zaka pafupifupi zisanu . Pamapeto pa zaka zisanu, ngati mulibe zizindikiro za khansa ndipo mayeso sakusonyeza khansa, mumaonedwa kuti muli bwino.

Koma pali chinthu chofunikira kukumbukira. Kafukufuku wina wasonyeza kuti khansa ya m'mawere imatha kubwereranso pakatha zaka 20 kuchokera pamene chithandizo chaperekedwa. Izi zimatchedwa kubwereranso mochedwa . Chifukwa chake ndikofunikira kulankhula ndi dokotala wanu za chiopsezochi, kutengera momwe zinthu zilili.

Kodi ubwino ndi zoopsa za chithandizochi ndi ziti?

Monga momwe zimakhalira ndi chithandizo chilichonse, pali ubwino ndi zoopsa za zotsatirapo zina.

Ubwino waukulu

Ubwino waukulu komanso wofunika kwambiri wa chithandizochi ndi mwayi wochotsa khansa ya m'mawere ya `ER+` kwathunthu. Kafukufuku akusonyeza kuti 95% ya anthu omwe amalandira chithandizochi atachitidwa opaleshoni sadzakhala ndi zizindikiro za khansa konse patatha zaka zisanu. Ichi ndi chiŵerengero chachikulu kwambiri cha kupambana.

Zotsatirapo zomwe zingakhalepo (zoopsa)

Monga tafotokozera kale, mankhwalawa amagwira ntchito pochepetsa kuchuluka kwa estrogen m'thupi. Estrogen ndi mahomoni ofunikira pa thanzi la kubereka komanso thanzi la mafupa ndi mtima . Chifukwa chake kuchuluka kwa estrogen kukatsika, pakhoza kukhala zotsatirapo zina zokhudzana ndi izi.

Kodi mungatani ngati mukuvutika ndi zotsatirapo zake?

Zotsatirapo zake, makamaka kupweteka kwa mafupa, zimatha kukhala zoopsa kwambiri moti anthu ena sangathe kuchita zinthu za tsiku ndi tsiku. Koma simuyenera kuvutika chete . Pali njira zothetsera mavuto. Chofunika kwambiri ndikulankhula ndi dokotala wanu momasuka za vuto lililonse lomwe mukumva. Iye angakuthandizeni.

Dokotala wanu angakulangizeni zinthu monga:

• Mankhwala oletsa kutupa: Mankhwala oletsa kutupa omwe si a steroidal monga ibuprofen angaperekedwe kuti achepetse ululu. Komabe, awa ayenera kumwedwa pokhapokha ngati dokotala akuwalangiza.
• Kusintha kugwiritsa ntchito mankhwala ena a Aromatase Inhibitor: Nthawi zina zotsatira zoyipa za mtundu wina wa AI sizimachitika ndi mtundu wina. Choncho dokotala wanu angakuuzeni kuti muyese piritsi lina la AI.
• Kusinthana ndi Tamoxifen: Ngati zotsatirapo zake sizingapiririke, pakhoza kukhala njira yosinthira ku mankhwala ena a mahomoni otchedwa Tamoxifen.

Kodi muyenera kuyimbira dokotala liti?

Onetsetsani kuti mukulankhulana ndi dokotala wanu pazochitika zotsatirazi:

• Ngati zotsatira zake zili zoopsa kuposa momwe mumayembekezera ndipo n'zovuta kuzipirira.
• Ngati mankhwala omwe dokotala wapereka sathandiza pa zotsatirapo zake.
• Ngati muwona kusintha kulikonse m'thupi lanu komwe mukuganiza kuti kungakhale zizindikiro za khansa kubwerera (monga chotupa chatsopano, kupweteka kosazolowereka). (Funsani dokotala wanu zizindikiro zomwe muyenera kuyang'anira).

Kodi chithandizochi n'chofunika bwanji?

Mankhwala oletsa kutupa kwa aromatase amachepetsa kwambiri chiopsezo chobwereranso kwa khansa ya m'mawere yokhala ndi mahomoni. Kafukufuku wapeza kuti akazi omwe amamwa mankhwala oletsa kutupa kwa aromatase atachitidwa opaleshoni ali ndi chiopsezo chotsika cha 40% chomwalira ndi khansa ya m'mawere patatha zaka 10, poyerekeza ndi omwe samwa mankhwala aliwonse a mahomoni.

Kafukufuku wina wasonyeza kuti kumwa mankhwala a `Letrozole' kungachepetse chiopsezo cha kufa ndi khansa ndi 24% mpaka 35% .

Ziwerengero izi zikusonyeza kufunika kwa chithandizochi populumutsa moyo wanu. Mungafune kusiya chithandizochi chifukwa cha zotsatirapo zake. Koma musanachite izi, ndi bwino kulankhula ndi dokotala wanu za mavutowa, kuwathetsa, ndikuyesera kumaliza chithandizochi chopulumutsa moyo.