Kodi mumaona kuti ngakhale ululu wamba sungapiririke? Tiyeni tikambirane za Hyperalgesia!

Tangoganizirani kuti dzanja lanu lapsa pang'ono pamene mukugwira ntchito kukhitchini. Kapena muli ndi kachikwapu kakang'ono pamene mukusewera cricket. Ndizachibadwa kumva ululu pang'ono nthawi zina ngati izi. Koma bwanji ngati ululuwo umakhala wosapiririka, woopsa kwambiri moti mukumva kufuula? Umenewo ndi mkhalidwe womwe tikukamba lero, `Hyperalgesia`. Ichi ndi chizindikiro osati matenda. Tiyeni tikambirane za izi mwatsatanetsatane .

Kodi hyperalgesia ndi chiyani kwenikweni?

Ululu kwenikweni ndi gawo labwinobwino la thupi lathu. Uli ngati belu lochenjeza. Ululu umatiuza kuti pali vuto, kuti pali vuto m'thupi lathu. Tikamva ululu, timayankha nthawi yomweyo, tikuyesera kuletsa ululuwo. Tangoganizirani kuchuluka kwa ngozi zazikulu zomwe tingakumane nazo tikanakhala kuti sitinamve ululu.

Kupweteka kwambiri kwa thupi ndi vuto lomwe ululu umamveka kwambiri kuposa momwe umakhalira, ngakhale pamene uyenera kutero. Mwachidule, kuyankha ululu kumawonjezeka. Izi zitha kuchitika chifukwa cha zifukwa zosiyanasiyana, ndipo nthawi zambiri zimatha kulamulidwa ndi chithandizo choyenera.

Kodi kusiyana pakati pa Hyperalgesia ndi Allodynia ndi kotani?

Ngakhale kuti mawu awiriwa ndi ofanana pang'ono, pali kusiyana koonekeratu pakati pa zochitika ziwirizi. Kuti mumvetse bwino izi, onani tebulo ili m'munsimu.

Kodi mukumvetsa kusiyana kwake? Mu hyperalgesia, ululu umachokera ku chinthu chomwe chiyenera kupweteka, koma chimakhala choopsa. Mu allodynia, ululu umachokera ku chinthu chomwe sichiyenera kupweteka.

Kodi chinthu ichi chotchedwa Hyperalgesia chimachitika bwanji m'thupi lathu?

Kuchuluka kwa ululu m'thupi kumasintha momwe thupi lathu limapangira ndikugwiritsa ntchito zizindikiro za ululu. Izi zitha kuchitika m'njira zingapo zazikulu:

• Kuchepetsa ululu: Kuchepetsa ululu komwe chinthu chomwe nthawi zambiri chimaonedwa kuti sichikusangalatsa chimakhala chopweteka kumachepa kwambiri mu mkhalidwe uwu. Izi zikutanthauza kuti ngakhale chinthu chaching'ono kwambiri chingayambitse ululu.
• Yankho limakhala lamphamvu kwambiri: Ma receptors a ululu m'thupi lathu amakhala ambiri komanso ogwira ntchito kwambiri kuposa masiku onse. Izi zimapangitsa ululu kukhala wovuta kwambiri.
• Zizindikiro za ululu sizimasiya: Ngakhale chifukwa cha ululu chitatha, zolandirira ululu zimakhala zokhudzidwa kwambiri ndipo zimapitiriza kutumiza zizindikiro za ululu ku ubongo.

Izi zitha kugawidwa m'magulu awiri akuluakulu:

1. Kupweteka kwapadera kwa thupi: Apa ndi pamene ululu umamveka pamalo pomwe pavulala. Mwachitsanzo, khungu lopsa ndi dzuwa limamva kupweteka kwambiri pamalo pomwe pavulala.

2. Kupweteka kwachiwiri kwa thupi: Apa ndi pamene ululu umamveka m'malo ozungulira kuvulalako, osati komwe kunachitika kuvulalako. Izi zimachitika chifukwa cha kusintha kwa momwe mitsempha yathu imagwirira ntchito pochiza zizindikiro za ululu.

Kodi ndi zinthu ziti zomwe zimayambitsa hyperalgesia?

Tsopano tikudziwa kuti vutoli limayamba chifukwa chakuti ma receptors a ululu m'thupi lathu amakhala ndi mphamvu zambiri. Pali zifukwa zambiri zomwe zingayambitse izi.

• Kupsa (kuphatikizapo kupsa ndi dzuwa)
• Kuluma kapena kulumidwa ndi tizilombo, zokwawa, kapena nyama zina
• Matenda a khansa
• Mavuto obwera chifukwa chogwiritsa ntchito mankhwala ena kwa nthawi yayitali (tikambirana izi pansipa)
• Kuwonongeka kwa mitsempha komwe kumachitika chifukwa cha matenda a shuga (Diabetic Neuropathy)
• Matenda a chitetezo chamthupi (monga Lupus, Multiple Sclerosis)
• Matenda omwe amakhudza dongosolo la mitsempha (monga Shingles, Herpes virus)
• Matenda monga mutu waching'alang'ala
• Matenda opweteka nthawi zonse monga `Complex regional pain syndrome`
• Kuvulala kulikonse kwakunja (monga mafupa osweka, minofu yosweka, kuvulala kwa mitsempha)

Kuwonjezeka kwa ululu chifukwa cha mankhwala ochepetsa ululu (Opioid-induced hyperalgesia - OIH)

Iyi ndi mfundo yofunika kwambiri komanso yofunika kuiganizira. Mukagwiritsa ntchito mankhwala ochepetsa ululu a opioid (okhala amphamvu pang'ono) kwa nthawi yayitali, nthawi zina zotsatira zoyipa zotchedwa `Opioid-induced hyperalgesia (OIH)` zimatha kuchitika. Izi zikutanthauza kuti thupi limamva kupweteka kwambiri chifukwa cha mankhwala ochepetsa ululu omwe amatengedwa kuti achepetse ululu, zomwe zimapangitsa ululuwo kukhala woipa kwambiri.

Ichi ndichifukwa chake madokotala amaganiza kawiri za kupereka mankhwala ochepetsa ululu a opioid kwa nthawi yayitali. Ngati wina akupeza OIH, dokotala nthawi zambiri amachepetsa pang'onopang'ono mlingo wa mankhwalawa kenako n’kusiya kwathunthu. Izi sizingachitike nthawi imodzi, chifukwa zingayambitse zotsatirapo zoopsa. Chifukwa chake, izi ziyenera kuchitika pokhapokha ngati dokotala akupereka upangiri ndi kuyang'aniridwa.

Kodi mankhwala a hyperalgesia ndi ati?

Chithandizo chimadalira chomwe chimayambitsa komanso mtundu wa hyperalgesia. Chithandizo chimodzi kapena kuphatikiza kwa mankhwala kungagwiritsidwe ntchito. Dokotala wanu yekha ndiye adzadziwe chithandizo chomwe chili choyenera pa vuto lanu.

Nazi njira zina zochiritsira zomwe zimagwiritsidwa ntchito kwambiri:

• Mankhwala: Mitundu yosiyanasiyana ya mankhwala imagwiritsidwa ntchito pa izi. Mwachitsanzo, `Acetaminophen` (Paracetamol), `NSAIDs` (mankhwala osagwiritsa ntchito steroidal oletsa kutupa), `Ma antidepressants`, mankhwala ena a khunyu, ndi mankhwala oletsa ululu am'deralo monga `Lidocaine`.
• Kuchotsa mitsempha: Izi zimaphatikizapo kuletsa kwakanthawi mitsempha yomwe ikutumiza zizindikiro zosayenera za ululu. Izi zitha kuchitika pogwiritsa ntchito radiofrequency ablation kapena pobayira mankhwala monga Botox.
• Kutsekeka kwa mitsempha: Kulowetsa mankhwala oletsa ululu mu mitsempha kuti zizindikiro za ululu zisafike ku ubongo.
• TENS (Transcutaneous electrical nerve stimulation): Njira yowongolera zizindikiro za ululu popereka mphamvu yamagetsi yochepa kwambiri kudzera pakhungu.

Kodi nthawi zabwino zokaonana ndi dokotala ndi ziti?

Ululu wochokera ku chinthu chochepa, monga kutentha pang'ono padzuwa, nthawi zambiri umatha pakatha masiku ochepa. Komabe, ngati ululuwo ndi waukulu kwambiri moti sungathe kupirira ndipo umakupangitsani kuti musamachite zinthu zanu za tsiku ndi tsiku , kapena ngati ululuwo ukupitirira kwa milungu ingapo , ndi chizindikiro chakuti muyenera kupita kwa dokotala.

Ndikofunikira kwambiri kufunafuna upangiri wa dokotala ngati muli ndi zilonda zopsereza kwambiri (zachiwiri kapena kupitirira apo), kapena kupsereza kumutu, kumaso, kapena kumaliseche. Dokotala wanu adzakulangizaninso ngati ululu wanu ndi waukulu mokwanira kuti mupite ku Dipatimenti Yothandiza Anthu Odwala Zadzidzidzi (ETU).

Anthu omwe ali ndi vutoli samadzinamiza kuti akumva ululu kapena kuchita zinthu zosonyeza ululu wawo. Chifukwa chakuti pali vuto ndi momwe thupi lawo limachitira ndi ululu, ululuwo umamveka kwambiri. Chifukwa chake ngati inu kapena munthu amene mumamudziwa akukumana ndi ululu wosazolowereka komanso woopsa chonchi, chinthu chabwino komanso chotetezeka kuchita ndikupempha upangiri kwa dokotala.