Kodi mwalangizidwa kuti mugwiritse ntchito mankhwala a PRRT? Tiyeni tikambirane za njira iyi yochizira khansa (Peptide Receptor Radionuclide Therapy - PRRT) mwachidule.

N'zovuta kufotokoza m'mawu zomwe mumamva mukazindikira kuti inuyo kapena munthu amene mumamukonda ali ndi khansa. Ndizachibadwa kuchita mantha komanso kufuna kudziwa zambiri dokotala wanu akakuuzani za mankhwala atsopano, monga PRRT, omwe ndi mawu osazolowereka. Koma musadandaule. Ngakhale kuti nkhaniyi ndi yovuta pang'ono, lero tikambirana za PRRT, zomwe imachita, komanso ubwino ndi kuipa kwake, m'njira yosavuta yomwe mungamvetse.

Kodi PRRT imatanthauza chiyani kwenikweni?

Mwachidule, PRRT ndi mankhwala apamwamba kwambiri omwe amalimbana, kufunafuna, ndikuwononga maselo a khansa, mofanana ndi 'chida chotsogozedwa' . Amagwiritsidwa ntchito makamaka pochiza mtundu wa khansa wotchedwa `Neuroendocrine Tumors (NETs).'

Ubwino wa chithandizochi ndi wakuti zinthu zotulutsa ma radiation (radioactivity) zomwe zimatulutsidwa nazo zimalowa mwachindunji m'maselo a khansa ndikuziwononga. Chifukwa chake, kuwonongeka kwa maselo athanzi kumakhala kochepa kwambiri poyerekeza ndi chithandizo cha radiation cha nthawi zonse.

Kodi chithandizochi chimagwira ntchito bwanji m'thupi?

Kuti timvetse izi, tiyeni tigwiritse ntchito chitsanzo chosavuta. Tangoganizani kuti maselo anu a khansa ndi zitseko zokhala ndi 'mabowo achinsinsi' ambiri apadera ('ma receptor'). Chitseko chilichonse chimangokwanira kiyi yokhala ndi mawonekedwe akeake.

Mankhwalawa, otchedwa PRRT, amapangidwa pophatikiza zigawo ziwiri:

1. Chinsinsi: Ichi ndi puloteni. Kiyi iyi imangolowa mu 'bowo la makiyi' a maselo a khansa. Sichilowa m'maselo athanzi.

2. Wokwera Ma Radioactive: Kiyi iyi ili ndi chinthu chaching'ono kwambiri cha radioactive (`radionuclide`) cholumikizidwa nacho.

Kotero, mukapereka mankhwala awa ku thupi lanu, 'kiyi' iyi imayenda m'thupi lonse, imapeza 'mabowo otsegulira' m'maselo a khansa, ndikudziphatika okha kwa iwo. Kenako, 'wokwera woyatsira' pa kiyiyo amalowa mkati mwa selo la khansa, amawononga DNA ya selo limenelo, ndikuwononga selo kuchokera mkati.

Mankhwala a PRRT omwe amagwiritsidwa ntchito kwambiri masiku ano ndi `lutetium Lu 177 dotatate (LUTATHERA®)`.

Kodi chithandizo cha PRRT chikulimbikitsidwa kwa ndani?

Mankhwalawa si oyenera odwala khansa onse. Pakadali pano, amalimbikitsidwa makamaka pa khansa yotchedwa `gastroenteropancreatic NETs`, yomwe ndi khansa ya m'mimba (matumbo, m'mimba, m'matumbo) ndi kapamba. Pali zochitika zingapo zomwe chithandizochi chingakhale choyenera kwa inu.

Kodi chimachitika ndi chiyani musanalandire chithandizo komanso mukalandira chithandizo?

Musanalandire chithandizo

Ngati mukumwa mankhwala ena a NET (makamaka somatostatin analogs), dokotala wanu angakulangizeni kuti musiye kumwa mankhwalawa milungu ingapo PRRT isanakwane. Dokotala wanu mwina adzayesanso magazi pafupifupi sabata imodzi musanalandire chithandizo kuti awone momwe impso zanu zimagwirira ntchito komanso kuchuluka kwa maselo a magazi kuti atsimikizire kuti thupi lanu lili bwino kuti lilandire chithandizocho.

Pa tsiku la chithandizo

Chithandizochi nthawi zambiri chimaperekedwa miyezi iwiri iliyonse kwa nthawi zinayi kwa miyezi 8. Ichi ndi chithandizo chakunja kwa dokotala, popanda kukhala m'chipatala. Njira yonseyi imatenga pafupifupi maola 5-6.

• Choyamba, chubu chaching'ono (cannula) chimayikidwa mu mtsempha womwe uli m'dzanja lanu ndipo mzere wa saline umapangidwa.
• Pafupifupi ola limodzi chithandizo chisanayambe, mankhwala amaperekedwa kuti apewe nseru ndi kusanza.
• Kenako, mudzapatsidwa mankhwala amchere okhala ndi ma amino acid kuti muteteze impso zanu kwa maola pafupifupi 4. Izi ndizofunikira kwambiri.
• Patatha mphindi 30 kuchokera pamene amino acid yayamba kuperekedwa, mankhwala a PRRT amaperekedwa m'thupi kudzera mu mchere kwa mphindi 30-45.
• Madzi onse amchere akaperekedwa, chubu chomwe chili m'dzanja chimachotsedwa.

Tsiku lotsatira chithandizo, mudzayesedwanso kuti muwone komwe mankhwala a radioactive apita m'thupi lanu, makamaka komwe kuli zotupa za khansa.

Kodi zotsatirapo zake ndi zoopsa zake ndi ziti?

Monga momwe zimakhalira ndi chithandizo chilichonse, pakhoza kukhala zotsatirapo zina.

Zotsatira zoyipa kwambiri:

Zotsatira zoyipa zomwe zimafala kwambiri ndi nseru ndi kusanza , koma izi zimatha kuthetsedwa ndi chithandizo choyambilira.

Mavuto ena omwe angakhalepo:

• Zotsatira zilizonse pa ntchito ya impso kapena chiwindi.
• Kuchepa kwa chiwerengero cha maselo a m'magazi (maselo oyera a m'magazi, maselo ofiira a m'magazi, ma platelet). Izi zingayambitse kupuma movutikira, kuwonjezeka kwa chiopsezo cha matenda, komanso chiopsezo chowonjezeka cha kutuluka magazi kapena kuvulala.
• Kawirikawiri, pamakhala chiopsezo chochepa kwambiri chotenga khansa zina zamagazi monga myelodysplastic syndrome kapena leukemia.

Dokotala wanu adzayang'anira kuchuluka kwa magazi anu nthawi zonse panthawi yonse ya chithandizo chanu. Ngati pabuka vuto lililonse, angasankhe kusintha mlingo kapena kusiya kulandira chithandizo chanu.

Vuto lalikulu kwambiri lomwe limafuna chisamaliro chachangu!

Moyo watsiku ndi tsiku pambuyo pa chithandizo

Anthu ambiri amavomereza chithandizochi bwino ndipo amachira msanga.

Chitetezo cha poizoni ndi ma radiation:

Mankhwalawa amagwiritsa ntchito mphamvu yochepa kwambiri ya kuwala. Izi zidzatuluka m'thupi lanu mu mkodzo ndi ndowe zanu masiku angapo otsatira. Panthawiyi, dokotala wanu adzakupatsani malangizo oti mupewe ena kukhudzidwa ndi kuwala kwa kuwala.

• Ndikofunikira kwambiri kukhala kutali ndi amayi apakati ndi ana aang'ono kwa masiku angapo.
• Sambani m'manja mwanu bwino ndi sopo mukatha kugwiritsa ntchito chimbudzi.

Kuyenda:

Pakhoza kukhala kuwala kochepa kwambiri m'thupi lanu kwa miyezi itatu mutalandira chithandizo. Izi zitha kuyambitsa zida zowunikira kuwala m'mabwalo a ndege kapena m'malire. Chifukwa chake, nthawi zonse sungani khadi lapadera lomwe mumalandira kuchokera kuchipatala ndi tsatanetsatane wa chithandizo chanu. Izi ndizofunikira kwambiri kuti mupewe zovuta zilizonse paulendo.