Kodi mudamvapo za mtundu uwu wa mankhwala? Tiyeni tiphunzire mosavuta (Ma Phosphodiesterase Inhibitors)

Mwina mwamvapo za mankhwala monga Viagra. Anthu ambiri amadziwa kuti awa ndi mankhwala omwe amaperekedwa chifukwa cha zovuta zogonana. Koma kodi mumadziwa kuti mankhwala a gulu lina, otchedwa Phosphodiesterase Inhibitors, amagwiritsidwa ntchito pochiza matenda osiyanasiyana, kuyambira matenda a mtima mpaka matenda a m'mapapo, matenda a khungu, ndi matenda a mafupa? Lero, tiyeni tikambirane za mankhwala odabwitsa awa. Tiyeni timvetse bwino zomwe ali, momwe amagwirira ntchito, komanso zabwino ndi zoyipa zake.

Mwachidule, kodi Phosphodiesterase Inhibitors (PDE inhibitors) ndi chiyani?

Awa ndi mtundu wa mankhwala omwe amakulitsa mitsempha yamagazi m'thupi lathu, amachepetsa kuuma kwawo, komanso amapangitsa kuti magazi aziyenda mosavuta. Tangoganizirani kuti chitoliro chamadzi chikatsekedwa, ngati mutachikulitsa pang'ono, madziwo amayenda mosavuta. Izi zimachepetsa kuthamanga kwa magazi ndikukweza kuyenda kwa magazi m'malo osiyanasiyana a thupi. Chifukwa cha luso limeneli, mtundu uwu wa mankhwala umagwiritsidwa ntchito ngati mankhwala a matenda osiyanasiyana.

Kodi mankhwalawa amagwira ntchito bwanji?

Kuti timvetse izi, choyamba tiyenera kudziwa za kamtumiki kakang'ono ka mankhwala m'thupi lathu. Dzina lake ndi Phosphodiesterases , kapena PDE mwachidule. PDE iyi ndi mtundu wa enzyme . Ma enzyme ali ngati othandizira ang'onoang'ono omwe amafulumizitsa ndikuwongolera njira zina zamakemikolo m'thupi lathu.

Pali mitundu ingapo ya ma enzyme a PDE m'thupi lathu. Asayansi agwiritsa ntchito manambala kuti awasiyanitse. Chinthu chapadera ndichakuti mtundu uliwonse wa PDE umagwira ntchito kwambiri m'malo enaake a thupi.

• PDE-3: Mtundu uwu umapezeka makamaka mumtima mwanu ndi m'mitsempha yamagazi . Umathandizanso pakupanga magazi kuundana.
• PDE-4: Izi zimapezeka kwambiri m'mapapo . Zimagwira ntchito polimbitsa minofu m'njira zopumira.
• PDE-5: Mtundu uwu umapezeka m'mapapo ndi m'mimba mwa amuna .

Choncho, mankhwala otchedwa Phosphodiesterase Inhibitors (PDE inhibitors) amagwira ntchito poletsa ntchito ya ma enzyme a PDE omwe atchulidwa pamwambapa. Zili ngati kutseka chitseko. Mankhwala ena oletsa PDE amagwira ntchito mosankha kwambiri. Izi zikutanthauza kuti, amangoyang'ana mtundu winawake, monga PDE-5. Palinso mankhwala ena omwe amagwira ntchito mosasankha . Izi zikutanthauza kuti, amatha kukhudza mitundu yonse ya PDE mpaka pamlingo wina.

Ndi matenda ati omwe amachiritsidwa ndi mankhwalawa?

Gulu la mankhwala otchedwa PDE inhibitors lavomerezedwa ndi mabungwe monga U.S. Food and Drug Administration (FDA) kuti achiritse matenda oposa khumi ndi awiri. Nazi zina mwa izo.

Kodi ubwino wa PDE Inhibitors ndi wotani?

Mankhwala amtundu uwu ndi othandiza kwambiri pochiza matenda enaake. Pali zifukwa zingapo zomwe zimapangitsa izi.

• Zosavuta kugwiritsa ntchito: Mankhwalawa amabwera m'njira zosiyanasiyana. Amapezeka ngati mapiritsi omwa, mafuta opaka pakhungu, ndi jakisoni wa m'mitsempha. Mankhwala ena amafunika kumwedwa tsiku lililonse, pomwe ena amatha kumwedwa pokhapokha ngati pakufunika.
• Chithandizo Cholunjika: Monga ndanenera kale, mankhwala ena amangoyang'ana mtundu winawake wa PDE, kotero sangayambitse zotsatira zosafunikira (zotsatira zoyipa) pa ziwalo zina za thupi. Zili ngati mankhwalawo amagwira ntchito komwe kuli matendawa.
• Ubwino wosiyanasiyana wa mankhwala amodzi: Nthawi zina matenda awiri ofanana amatha kuchitika mwa munthu m'modzi. Mwachitsanzo, benign prostatic hyperplasia (BPH) ndi erectile dysfunction (ED) zimatha kuchitika pamodzi. Tadalafil woletsa PDE-5 ndi wovomerezeka kuti athetse matenda onse awiri. Mofananamo, pali mankhwala omwe amatha kuchiza gout ndi nyamakazi yogwirizana nayo.

Kodi zotsatirapo zake ndi zoopsa zake ndi ziti?

Zotsatirapo zake zazikulu zimadalira mtundu wa mankhwala oletsa PDE omwe ali nawo.

Ndani sayenera kumwa mankhwalawa?

Kwa anthu ena, mtundu uwu wa mankhwala otchedwa PDE inhibitors sungakhale woyenera chifukwa cha matenda ena omwe akumwa. Timatcha izi kuti ndi zoletsa . Pali mitundu iwiri ya izi:

1. Zotsutsana kwathunthu:

• Kwa mankhwala aliwonse oletsa PDE: Ngati mudayamba mwakhala ndi vuto lalikulu la ziwengo (hypersensitivity) ku mankhwala awa kapena ofanana nawo.
• Kwa Cilostazol: Ngati muli ndi vuto la mtima.
• Kwa oletsa PDE-5 (monga Sildenafil, Tadalafil): matenda aakulu a mtima, kupweteka pachifuwa kosakhazikika (angina yosakhazikika), kudwala kwa mtima kapena sitiroko komwe kwachitika posachedwapa.

2. Zotsutsana:

• Kwa oletsa PDE-5: Ngati mukumwa nitrates kapena alpha-blockers, muyenera kulankhula ndi dokotala wanu chifukwa angayambitse kutsika kwa kuthamanga kwa magazi anu moopsa.
• Kwa Cilostazol: Ngati muli ndi vuto la kutuluka magazi.
• Kwa Pentoxifylline: Ngati mwangoyamba kumene kutuluka magazi muubongo kapena m'diso.

Ngati muli ndi pakati, mukuyesera kutenga pakati, kapena kuyamwitsa, nthawi zonse lankhulani ndi dokotala musanamwe mankhwala aliwonse. Pali umboni wakuti zoletsa zina za PDE zingakhudze mwana wosabadwayo mu kafukufuku wa nyama.

Kodi muyenera kupita kwa dokotala liti?

Ngati zizindikiro zanu zasintha kapena zakhudza zochita zanu za tsiku ndi tsiku, ndi bwino kuuza dokotala wanu. Komabe, ngati mukukumana ndi zotsatirazi , pitani kuchipatala kapena kuchipinda chodzidzimutsa (ETU) nthawi yomweyo.

• Zizindikiro za matenda a mtima: kupweteka pachifuwa, kupuma movutikira, thukuta, chizungulire, nseru.
• Kukhwima maganizo: Kuuma kwa chiberekero komwe kumatenga maola opitilira 4 popanda chilakolako chogonana. Izi zitha kuwononga chiberekero kwamuyaya ngati sichikuthandizidwa mwachangu.
• Kutaya mwadzidzidzi masomphenya kapena kumva: Ngati mwataya mwadzidzidzi masomphenya, kutayika masomphenya, kapena kutayika kumva, pitani kuchipatala nthawi yomweyo. Kuchedwa kungayambitse kuwonongeka kosatha.