Tiyeni tidziwe za Primary Biliary Cholangitis (PBC), matenda osamveka bwino omwe amakhudza chiwindi.

Kodi nthawi zambiri mumamva kutopa kapena kuyabwa popanda chifukwa? Nthawi zina sitingasamale kwambiri zinthu izi ngati zinthu zachizolowezi m'miyoyo yathu ya tsiku ndi tsiku. Komabe, nthawi zina izi zingakhale chenjezo kuchokera m'thupi lathu. Makamaka, zitha kukhala zizindikiro zoyamba za vuto la chiwindi chathu. Lero tikambirana za matenda omwe angakhudze thupi mwakachetechete. Ndi Primary Biliary Cholangitis, kapena PBC mwachidule.

Mwachidule, kodi Primary Biliary Cholangitis (PBC) ndi chiyani?

Tangoganizani kuti mkati mwa chiwindi chanu muli njira ya machubu ang'onoang'ono komanso abwino kwambiri. Zili ngati nthambi za mtengo zomwe zimatuluka. Izi ndi zomwe timatcha ma duct a bile. Ntchito yayikulu ya ma duct awa ndikunyamula madzi otchedwa 'Bile' omwe amapangidwa ndi chiwindi kuchokera m'chiwindi, kutanthauza, kupita nawo m'thupi lathu. Bile iyi ndi yofunika kwambiri kwa ife, chifukwa ndi bile iyi yomwe imathandiza kusungunula mafuta omwe ali muzakudya zomwe timadya.

Tsopano, mu matenda otchedwa Primary Biliary Cholangitis (PBC), chitetezo chathu chamthupi chimalimbana molakwika ndi ma ducts a ndulu awa. Izi zimayambitsa kutupa, kapena kutupa, m'ma ducts a ndulu. Pakapita nthawi, kutupa kumeneku kumawononga ma ducts a ndulu ndikuwononga pang'onopang'ono.

Chimachitika ndi chiyani? Monga momwe chitoliro chamadzi chimatsekekera, ndulu singathe kuyenda ndipo imatsekeredwa mkati mwa chiwindi. ndulu yotsekeka imayamba kuwononga maselo a chiwindi. Pamene kuwonongeka kumeneku kukupitirira, minofu ya zipsera imayamba kupanga m'malo mwa minofu ya chiwindi yathanzi. Pamapeto pake, chiwindi chimalimba pang'onopang'ono ndipo ntchito yake imachepa. Matendawa timawatcha kuti cirrhosis . Kale, matendawa ankatchedwanso Primary Biliary Cirrhosis.

Kodi matendawa ndi oopsadi?

Matenda a PBC ndi matenda omwe amapitirirabe komanso osatha. Izi zikutanthauza kuti sachira usiku umodzi, ndipo zizindikiro zake zimatha kukulirakulira pakapita nthawi. Poyamba, sipangakhale zizindikiro zilizonse. Komabe, ngati matendawa sakulamuliridwa, pamapeto pake angayambitse kulephera kwa chiwindi. Pa nthawi imeneyo, akhoza kukhala pachiwopsezo chachikulu ngati sichinachitike choika chiwindi.

Ndani amene ali ndi mwayi waukulu wopeza matendawa?

Chinthu chimodzi chomwe chimaonekera kwambiri pokamba za matendawa ndichakuti ndi ofala kwambiri pakati pa akazi.Ndiko kuti. Kwa mwamuna aliyense amene amatenga matendawa, akazi pafupifupi 10 amadwala matendawa. Pali kusiyana kotere.

• Matendawa nthawi zambiri amapezeka munthu akakwanitsa zaka 40.
• Komanso, ngati wina m'banja mwanu ali ndi matenda ena odziteteza ku matenda a autoimmune , mungakhale pachiwopsezo chachikulu chotenga matenda ena, zomwe zikusonyeza kuti pakhoza kukhala kulumikizana kwa majini.

Kodi zizindikiro ndi zovuta za PBC ndi ziti?

Anthu ambiri saona zizindikiro zilizonse kumayambiriro kwa matendawa. Nthawi zina zimapezeka mwangozi akayesedwa magazi pazifukwa zina. Koma matendawa akamakula, zizindikiro zimayamba kuonekera.

Zizindikiro zofala zomwe zimabwera koyamba

• Kutopa: Ichi ndi chizindikiro chofala kwambiri. Kaya mugone kapena mupumule motani, kutopa komwe mumamva sikutha.
• Khungu loyabwa: Kuyabwa kumatha kuchitika, makamaka m'manja ndi m'mapazi. Komabe, kumatha kuchitika kulikonse mthupi. Kwa anthu ena, kuyabwako kumakhala kosapiririka.

Zizindikiro zimenezi sizimachitika mofanana kwa aliyense. Kwa ena, zimawonekera kumayambiriro kwa matendawa, pomwe kwa ena, zimawonekera mochedwa kwambiri.

Mavuto omwe angachitike pamene matendawa akupita patsogolo

Ngati ndulu siikuyenda bwino, imayamba kusonkhana m'magazi mwathu. Komanso, mavuto amayamba chifukwa chakuti dongosolo logaya chakudya sililandira ndulu. Pamene zipsera za chiwindi zikuwonjezeka, kuthamanga kwa magazi kumawonjezekanso pamitsempha yamagazi yomwe imadutsa m'chiwindi. Izi zingayambitse mavuto osiyanasiyana. Tiyeni tiwone izi patebulo.

Kodi chifukwa chenicheni cha PBC ndi chiyani?

Monga tanenera kale, matenda a PBC ndi matenda odziteteza okha . Mwachidule, "gulu lankhondo" la thupi lathu (chitetezo cha mthupi) limaukira molakwika maselo athu abwino. Zili ngati kuukira anthu a m'dziko lathu, poganiza kuti ndi adani. Mu PBC, "kuukira" kumeneku kumachitika pa ndulu m'chiwindi.

Madokotala sakudziwabe chifukwa chake izi zimachitika, koma amakhulupirira kuti pali zifukwa zingapo zomwe zingachitike:

1. Zinthu zokhudza majini: Ngati wina m'banjamo ali ndi matenda amenewa, enanso akhoza kudwala matendawa.

2. Zinthu Zachilengedwe: Pamene kachilombo, mabakiteriya, kapena mankhwala alowa m'thupi, chitetezo cha mthupi cha munthu amene ali ndi majini chingayambitse kusagwira ntchito bwino.

Kodi matendawa amapezeka bwanji? (Kuzindikira)

Mukauza dokotala wanu za zizindikiro zanu, adzakuyesani ndi kuyitanitsa mayeso angapo kuti atsimikizire kuti mwapezeka ndi matendawa.

1. Kuyezetsa Magazi: Iyi ndi njira yofunika kwambiri yoyezetsa magazi. Pali zinthu ziwiri zomwe zayang'aniridwa mwapadera.

• Ma antibodies: Pafupifupi 95% ya anthu omwe ali ndi PBC ali ndi antibody inayake yotchedwa Antimitochondrial Antibody (AMA) m'magazi awo.
• Ma Enzyme a Chiwindi: Chiwindi chikawonongeka, ma enzyme ena (makamaka Alkaline Phosphatase - ALP ) amawonjezeka m'magazi.

2. Kuyesa Zithunzi: Ngati mayeso a magazi akusonyeza kuti muli ndi PBC, dokotala wanu angakupatseni scan kuti aone chiwindi chanu ndi ndulu yanu. Izi zingathandizenso kupeza zifukwa zina zomwe zimayambitsa zizindikiro zanu. Kujambula kwa ultrasound nthawi zambiri kumakhala kuyesa koyamba. Kujambula kwa MRI kungachitike kuti mupeze zithunzi zomveka bwino.Mukhozanso kunena za chimodzi.

3. Kufufuza Chiwindi: Nthawi zina (makamaka kwa anthu omwe alibe ma antibodies a AMA m'magazi mwawo), chidutswa chaching'ono kwambiri cha minofu ya chiwindi chimatengedwa ndikuwunikidwa pansi pa maikulosikopu kuti atsimikizire matendawa ndikupeza kuchuluka kwenikweni kwa kuwonongeka kwa chiwindi.

Kodi mankhwala a PBC ndi otani?

Palibe mankhwala a PBC pakadali pano. Komabe, pali mankhwala othandiza kwambiri ochepetsa kuwonongeka kwa chiwindi komwe kumachitika chifukwa cha matendawa, kuwongolera kupitirira kwa matendawa, komanso kuthana ndi zizindikiro zake.

Mankhwala

• Ursodeoxycholic acid (UDCA): Iyi ndi mankhwala akuluakulu a PBC. Ndi bile acid yomwe imapezeka mwachibadwa. Mankhwalawa amathandiza kuchotsa bile m'chiwindi ndikuchepetsa kuwonongeka kwa chiwindi. Angakhale othandiza kwambiri akayamba msanga matendawa.
• Mankhwala ena: Kwa iwo omwe sayankha bwino ku UDCA, dokotala wanu angakulangizeni mankhwala ena, monga obeticholic acid . Kuphatikiza apo, mankhwala atsopano, monga seladelpar ndi elafibrinor, akugwiritsidwa ntchito tsopano.
• Mankhwala a zizindikiro:
• Pakhungu loyabwa: Mankhwala monga Cholestyramine, antihistamines, ndi chithandizo cha kuwala kwa ultraviolet amagwiritsidwa ntchito.
• Pakusowa kwa mavitamini: Zakudya zowonjezera zomwe zili ndi mavitamini A, D, E, ndi K zimaperekedwa.
• Pa kutopa: Anthu ena angapeze mpumulo kuchokera ku mankhwala opatsa mphamvu monga modafinil.

Opaleshoni

Ngati ntchito ya chiwindi chanu ikupitirira kuchepa ndipo sichikulamulidwa ndi mankhwala, dokotala wanu angakuikeni pamndandanda woyembekezera kuikidwa chiwindi . Kuika chiwindi cha PBC kumapambana kwambiri. Mutha kukhala moyo wabwinobwino mutaika chiwindi. Ngakhale kuti n'zotheka kuti PBC ibwerere ku chiwindi chatsopano, sizichitika kawirikawiri.

Kodi ndiyenera kudziwa chiyani pankhani yokhala ndi matendawa?

Matenda a PBC nthawi zambiri amakula pang'onopang'ono. Zingatenge zaka 15-20 kuti matendawa afike kumapeto. Ngati matendawa apezeka ndi kuchiritsidwa msanga, matenda oopsa amatha kupewedwa kapena kuchedwa. Anthu ambiri amatha kuchiza zizindikiro zawo ndi mankhwala ndipo amakhala zaka zambiri popanda kusokoneza kwambiri moyo wawo watsiku ndi tsiku.

Komabe, anthu ena akhoza kukhala ndi vuto la matendawa mofulumira kwambiri. Kutopa kwambiri komanso kuchuluka kwa bilirubin m'magazi kungakhale zizindikiro za matendawa kukulirakulira mofulumira.

Zinthu zomwe mungachite kuti muteteze chiwindi chanu

Kutsatira moyo wabwino komanso kudya zakudya zabwino kungathandize kuti chiwindi chanu chikhale ndi thanzi kwa nthawi yayitali.

• Siyani kusuta fodya, kumwa mowa, komanso kugwiritsa ntchito mankhwala osokoneza bongo mosayenera.Izi ndi zovulaza kwambiri chiwindi.
• Idyani zakudya zambiri zopanda mafuta monga ndiwo zamasamba zatsopano, zipatso, ndi zitsamba m'malo mwa zakudya zokonzedwa bwino, zopakidwa m'matumba.
• Chepetsani mafuta okhuta ndipo sankhani zakudya zomwe zili ndi mafuta osakhuta kapena "abwino" (monga mapeyala, mtedza, mafuta a azitona).
• Chitani masewera olimbitsa thupi tsiku lililonse. Ngakhale chinthu chosavuta monga kuyenda n'chothandiza. Kuchita masewera olimbitsa thupi kumathandiza kuti mafupa akhale olimba.

Kukhala ndi matenda osatha ngati awa kungakhale kotopetsa m'maganizo. Lankhulani ndi dokotala wanu za njira zochepetsera kupsinjika kwanu kwakuthupi, kwamaganizo, komanso kwamalingaliro. Funsani upangiri ngati pakufunika kutero. Kumbukirani kuti thanzi lanu lonse ndi lalikulu kwambiri kuposa matendawa.