Kodi thupi lanu silikuyankha bwino ku Parathyroid Hormone? Tiyeni tikambirane za vuto lachilendoli (Pseudohypoparathyroidism)!

Kodi nthawi zina mumamva ngati chinachake m'thupi mwanu sichikugwira ntchito bwino? Pali matenda ena achilendo, omwe mayina ake amatha kukhala oopsa pang'ono. Matenda ena omwe samveka kawirikawiri, koma ndi ofunikira kudziwa, ndi Pseudohypoparathyroidism (PHP). Ngakhale dzinalo lingawoneke lalitali pang'ono, tiyeni tipitirizebe kulimvetsa.

Kodi pseudohypoparathyroidism ndi chiyani?

Mwachidule, iyi ndi matenda osowa kwambiri a majini . Tili ndi tiziwalo tating'onoting'ono m'thupi mwathu totchedwa parathyroid glands. Tizipanga timadzi totchedwa Parathyroid Hormone (PTH). Timadzi totereti ta PTH ndi tofunikira kwambiri m'thupi lathu. Chifukwa timadzi totereti timathandiza kusunga Calcium, Phosphorus, ndi Vitamini D m'magazi mwathu.

Kodi mukudziwa zomwe zimachitika kwa munthu amene ali ndi pseudohypoparathyroidism (PHP)? Ngakhale kuti ma glands awo a parathyroid amapanga hormone ya PTH mwachibadwa, maselo m'thupi lawo sayankha bwino, zomwe zikutanthauza kuti sangathe "kuizindikira". Zili ngati munthu akulankhula nanu koma simungamve. Timatcha Parathyroid Hormone Resistance .

Zotsatira zake n’zakuti, kuchuluka kwa calcium m’magazi kumachepa, pomwe kuchuluka kwa phosphorous kumawonjezeka. Kusalinganika kumeneku kungayambitse kugwedezeka kwa minofu, dzanzi, khunyu, ndi mavuto a mano.

Chofunika kwambiri, vuto limeneli lotchedwa PHP ndi losiyana ndi vuto lotchedwa Hypoparathyroidism. Anthu omwe ali ndi hypoparathyroidism sapanga mahomoni okwanira a PTH poyamba. Komabe, mu PHP, mahomoniwo amapangidwa, koma thupi siligwiritsa ntchito.

Kodi mitundu ikuluikulu ya PHP ndi iti?

Pali mitundu ikuluikulu ingapo ya PHP status iyi. Tiyeni tiwone zomwe zili.

Mtundu wa PHP-1

Uwu ndiye mtundu wofala kwambiri wa PHP . Kuwonjezera pa kukana kwa mahomoni a PTH omwe atchulidwa kale, kusintha kwina kwa mafupa kumatha kuwoneka. Mwachitsanzo:

• Kuzungulira kwa nkhope
• Kuchepa kwa kutalika (kufupika kwa msinkhu)
• Kupweteka kwa khosi
• Kusweka kwa manja ndi mapazi

Madokotala amatcha izi kuphatikiza kwa zizindikiro kuti Albright Hereditary Osteodystrophy (AHO) . Anthu omwe ali ndi PHP-1 ali ndi vutoli chifukwa cha mtundu wina wa jini wotchedwa `GNAS` womwe amalandira kuchokera kwa m'modzi mwa makolo awo.

Pseudopseudohypoparathyroidism (PPHP)

Iyi ndi njira yochepa ya PHP-1. Anthu omwe ali ndi PPHP (Pseudopseudohypoparathyroidism) akhoza kukhala ndi mawonekedwe akuthupi omwe amawonedwa mu AHO (monga nkhope yozungulira ndi kutalika kochepa), koma alibe kukana kwa mahomoni a PTH . Izi zikutanthauza kuti kuchuluka kwa calcium ndi phosphorous m'thupi lawo ndi kwabwinobwino.

Mtundu wa PHP-2

Anthu omwe ali ndi PHP-2 ali ndi vuto la PTH hormone, zomwe zikutanthauza kuti ali ndi calcium yochepa komanso phosphorous yambiri. Koma alibe mawonekedwe akuthupi (monga nkhope yozungulira ndi kutalika kochepa) omwe amapezeka mu AHO. Ofufuza sanapezebe vuto lenileni la majini lomwe limayambitsa mtundu uwu wa PHP-2.

Kodi zizindikiro za PHP ndi ziti?

Zizindikiro za PHP zimatha kusiyana pakati pa munthu ndi munthu . Izi zikutanthauza kuti si aliyense amene adzakumane ndi zizindikiro zomwezo. Zizindikiro zina zodziwika bwino ndi izi:

• Kupweteka kwa minofu
• Kupweteka kwa minofu pafupipafupi : Kumva ngati mwendo ukukokedwa.
• Kusanza kapena kumva kuwawa m'miyendo
• Kugwidwa ndi khunyu
• Kuchedwa kutulutsa mano
• Kufooka kwa enamel ya dzino
• Kuthamanga kwa magazi kotsika
• Tsitsi ndi misomali yofooka
• Nkhawa
• Kuvutika maganizo

Anthu omwe ali ndi PHP-1 amatha kukhala ndi zizindikiro zina zomwe zimayenderana ndi vuto la Albright hereditary osteodystrophy (AHO) lomwe latchulidwa kale. Anthu ena omwe ali ndi PHP amathanso kukhala ndi zizindikiro izi:

• Kuzungulira kwa nkhope
• Kutalika kwa msinkhu (kufupika kwa msinkhu)
• Kupweteka kwa khosi
• Mafupa m'manja ndi m'mapazi : Makuponi, makamaka a chala chachinayi ndi chachisanu, angaoneke ngati akutembenukira mkati.
• Kunenepa kwambiri : Kumatanthauza kunenepa kwambiri.
• Kulephera kuona bwino : zinthu monga ma cataract, kusawona bwino, komanso kusamva kuwala.
• Mafupa otupa pansi pa khungu lanu
• Kuchedwa kwa chitukuko : Ana ena angakumane ndi kuchedwa kwa chitukuko.

Kodi zifukwa za PHP ndi ziti?

Chifukwa chachikulu cha matendawa ndi kusiyana kwa majini athu, makamaka mu jini yotchedwa `GNAS` . Anthu ena amalandira matendawa kuchokera kwa makolo awo . Izi zikutanthauza kuti ndi cholowa. Koma nthawi zina vutoli limatha kuchitika popanda mbiri ya banja ndipo palibe chifukwa chomwe chingapezeke.

PHP nthawi zambiri imapezeka ali mwana kapena ali mwana , koma nthawi zina imatha kupezeka ali wamkulu.

Kodi mavuto omwe angakhalepo chifukwa cha PHP ndi ati?

Ngati muli ndi PHP, muli ndi mwayi waukulu wokhala ndi matenda ena a endocrine system . Mavuto okhudzana ndi mahomoni awa angayambitse zizindikiro monga kuchepa kwa mphamvu komanso kusakhala ndi chilakolako chogonana.

Anthu ena omwe ali ndi PHP ali pachiwopsezo chachikulu chotenga matenda monga:

• Matenda a Parkinson: Kuwonetsa zizindikiro zofanana ndi matenda a Parkinson.
• Kuvuta ndi luso lotha kugwira ntchito bwino : Izi zikutanthauza kuvutika ndi ntchito zabwino monga kulemba kapena kukanikiza mabatani.
• Matenda a Carpal Tunnel : Makamaka kwa iwo omwe ali ndi PHP-1. Imeneyi ndi vuto lomwe mitsempha m'dzanja imapanikizika, zomwe zimapangitsa dzanzi ndi kupweteka m'dzanja.
• Kupweteka kwa msana
• Kulephera kupuma mokwanira : Makamaka kwa ana.

Kodi madokotala amazindikira bwanji PHP?

Ngati mukuganiza kuti muli ndi PHP, dokotala wanu ayamba kaye wakuyezani thupi . Adzakufunsaninso za mbiri ya banja lanu. Kenako angachite mayeso ena angapo kuti atsimikizire matendawa. Izi zikuphatikizapo:

• Kuyezetsa magazi : Yesani kuchuluka kwa mahomoni, makamaka calcium, phosphorous, ndi PTH.
• Kuyesa mkodzo : Yang'anani kuchuluka kwa calcium ndi phosphorous mu mkodzo.
• Kuyesa majini : Yang'anani kusintha kwa majini a `GNAS`.
• Electrocardiogram (EKG) : Imayang'ana ngati pali vuto pa kugunda kwa mtima.
• Ma X-ray a m'manja : Yang'anani ngati mafupa asweka ndi kusintha kwina kuli koyenera.
• Kujambula kwa CT (CT - Computed Tomography scan) : Kuti muwone ngati pali kusintha kulikonse mu ubongo.

Kutengera ndi zomwe zapezeka kuchokera ku mayesowa, dokotalayo amatha kutsimikizira molondola momwe PHP ilili.

Kodi PHP imathandizidwa bwanji?

Palibe mankhwala a vutoli pakadali pano . Koma musadandaule. Ndi chithandizo choyenera komanso kuyang'aniridwa bwino, mutha kuwongolera zizindikiro zanu ndikukhala moyo wabwinobwino.

Cholinga chachikulu cha chithandizo ndikukhala ndi calcium ndi phosphorous m'magazi mwanu . Kusunga calcium ndi phosphorous m'magazi anu kungathandize kuchepetsa zizindikiro. Ichi ndi chithandizo cha moyo wonse .

Njira zochiritsira zingaphatikizepo:

• Zakudya zowonjezera za calcium ndi vitamini D : m'mapiritsi kapena m'madzi.
• Makapisozi a Calcitriol : Iyi ndi mankhwala omwe amawonjezera kuchuluka kwa calcium m'thupi.
• Jakisoni wa Calcitriol
• Chithandizo cha kukula kwa mahomoni kapena mahomoni a chithokomiro : ngati pakufunika.
• Zakudya zokhala ndi calcium yambiri komanso phosphorous yochepa : Monga momwe katswiri wa zakudya amalangizira.

Chofunika kwambiri ndikutsatira malangizo a dokotala mosamala ndikupita kukayezetsa magazi nthawi yake.

Kodi ndiyenera kupita kwa dokotala liti?

Ngati muli ndi PHP, ndikofunikira kupita kwa dokotala nthawi zonse kuti akafufuze kuchuluka kwa calcium ndi phosphorous m'thupi lanu . Kuwunika kumeneku nthawi zonse kudzakuthandizani kuti chilichonse chiyende bwino.

Ngati mukukumana ndi zizindikiro zoopsa monga kupuma movutikira mwadzidzidzi, kugwedezeka kwa minofu kwambiri, kapena khunyu , pitani kuchipatala chapafupi nthawi yomweyo kapena imbani 1990.

Kodi mungayembekezere chiyani mukakhala ndi vuto la PHP?

Ngati muli ndi PHP, muyenera kupitiriza kugwira ntchito ndi Dokotala Wanu Woyang'anira Chisamaliro Chachikulu . Popeza PHP ingakhudze ziwalo zosiyanasiyana za thupi, mungafunike kuonana ndi akatswiri angapo kuti akuthandizeni ndi zizindikiro zanu. Gulu lanu lachipatala likhoza kuphatikizapo:

• Akatswiri a Endocrinologists : Akatswiri a mahomoni.
• Madokotala a mafupa : Pa mavuto okhudzana ndi mafupa.
• Madokotala a ana : Ngati ndi mwana.
• Akatswiri a za ubongo : Pa mavuto okhudzana ndi dongosolo la mitsempha.
• Akatswiri a zamaganizo
• Akatswiri a zamaganizo pantchito
• Akatswiri a zakudya
• Madokotala a mano
• Akatswiri a majini
• Akatswiri osamalira ululu

Mwina mudzayenera kumwa mankhwala owonjezerawa moyo wanu wonse .

Luso la kukula ndi nzeru zimatha kusiyana kwambiri kutengera mtundu ndi kuopsa kwa matendawa. Komabe , nthawi zambiri, anthu omwe ali ndi PHP amakhala ndi moyo wabwinobwino poyerekeza ndi anthu omwe alibe PHP . Dokotala wanu angakuuzeni zomwe mungayembekezere kutengera matenda anu.

Popeza PHP ndi matenda osowa kwambiri, zimakhala zovuta kupeza ena omwe ali ndi vuto lomwelo ngati lanu . Nthawi zina limathanso kusungulumwa. Ngati inu kapena mwana wanu mwapezeka ndi PHP, lankhulani ndi dokotala wanu za magulu othandizira ndi maphunziro . Izi zingakuthandizeni kupeza njira zowongolera zizindikiro zanu komanso moyo wanu wonse.

Uthenga Wopita Nawo Kunyumba

Chabwino, tiyeni tione zinthu zina zofunika kukumbukira zokhudza pseudohypoparathyroidism (PHP) yomwe takhala tikukambirana.

• PHP ndi matenda osowa kwambiri omwe thupi siliyankha bwino ku hormone ya parathyroid (PTH).
• Izi zimapangitsa kuti calcium m'magazi ichepe komanso kuti phosphorous iwonjezeke.
• Pali mitundu ikuluikulu ingapo : PHP-1, PHP-2, ndi PHP-3.Inde. PHP-1 ingayambitse kusintha kwa mafupa kotchedwa AHO.
• Zizindikiro zosiyanasiyana zimatha kuchitika, monga kugwedezeka kwa minofu, dzanzi, khunyu, mavuto a mano, kutalika kochepa, ndi nkhope yozungulira .
• Chifukwa chachikulu ndi kusintha kwa majini a `GNAS` .
• Ngakhale kuti palibe mankhwala athunthu, zizindikiro zimatha kuthetsedwa ndi chithandizo cha moyo wonse (calcium, vitamini D, ndi zakudya zapadera).
• Kupimidwa nthawi zonse ndi dokotala komanso thandizo la madokotala odziwa bwino ntchito n’kofunika kwambiri.
• Anthu ambiri akhoza kukhala ndi moyo wabwinobwino .
• Thandizo lochokera ku magulu othandizira ndilofunika kwambiri kuti munthu akhale wolimba m'maganizo.

Musaiwale kuti simuli nokha. Ngakhale kuti vutoli ndi losowa, lingathe kuthetsedwa bwino ndi upangiri ndi chithandizo choyenera chachipatala. Kumbukirani kuti madokotala, abale, ndi abwenzi alipo kuti akuthandizeni mukafuna mphamvu.

Pseudohypoparathyroidism , PHP, parathyroid hormone, calcium, phosphorous, matenda a majini, AHO