Kodi mankhwala omwe mumamwa angakhale oopsa kwa moyo wanu? Tiyeni tikambirane za Serotonin Syndrome

Kodi ndinu munthu amene mumamwa mankhwala a kuvutika maganizo, mutu waching'alang'ala, kapena ululu waukulu? Kapena mumamwa mankhwala kuchokera kwa madokotala angapo chifukwa cha matenda omwewo? Ndiye nkhaniyi idzakhala yofunika kwambiri kwa inu. Lero tikulankhula za vuto lomwe lingachitike m'thupi mwathu chifukwa cha mitundu ina ya mankhwala, omwe angakhale oopsa ngati sitikumvetsa bwino. Timatcha izi kuti 'Serotonin Syndrome' . Musadandaule, ngati tikudziwa bwino izi, tingapewe chiopsezo chachikulu.

Mwachidule, kodi Serotonin Syndrome ndi chiyani?

Kuti timvetse izi, choyamba tiyenera kudziwa kuti 'Serotonin' ndi chiyani. Taganizirani izi ngati mthenga waung'ono womwe umanyamula mauthenga pakati pa ubongo wathu ndi thupi lathu lonse. Mu zamankhwala, timatcha amithenga a mankhwala awa kuti 'neurotransmitters'. Serotonin ndi neurotransmitter yofunika kwambiri m'thupi lathu, yomwe imayang'anira zinthu zambiri monga momwe timamvera, kugona, komanso chilakolako chathu.

Kawirikawiri, mukamwa mankhwala omwe dokotala wakupatsani, kuchuluka kwa serotonin m'thupi kumakhala koyenera. Komabe, ngati pazifukwa zina mankhwala otchedwa serotonin awa akuwonjezeka kwambiri m'thupi lathu , ndiko kuti, ngati akusonkhanitsa kuchuluka komwe thupi silingathe kupirira, momwe thupi lathu limachitira ndi mankhwalawa amatchedwa 'serotonin syndrome'. Izi zitha kukhala zotsatira zoopsa zomwe zimachitika chifukwa cha mtundu wa mankhwala (mankhwala).

Ndani amene ali ndi mwayi waukulu wopeza vutoli?

Ndipotu, aliyense wa msinkhu uliwonse amene amagwiritsa ntchito mankhwala, zowonjezera zakudya, kapena mankhwala osaloledwa omwe amakhudza kuchuluka kwa serotonin m'thupi ali pachiwopsezo. Vutoli limapezeka kwambiri m'mikhalidwe ngati iyi:

• Mukayamba mankhwala atsopano: Mukangoyamba kumwa mankhwala atsopano omwe amawonjezera kuchuluka kwa serotonin m'thupi.
• Mukawonjezera mlingo wa mankhwala: Ngati dokotala wanu awonjezera mlingo wa mankhwala omwe mukumwa kale.
• Mukagwiritsa ntchito mankhwala angapo pamodzi: Ichi ndiye chifukwa choopsa kwambiri komanso chofala kwambiri. Tangoganizirani, mukupweteka mafupa. Mumamwa mankhwala ochepetsa ululu kuchokera kwa dokotala mmodzi chifukwa cha izi. Pakadali pano, chifukwa chakuti mukudera nkhawa pang'ono, mumapita kwa dokotala wina ndikumwanso mankhwala a zimenezo. Koma simumauza dokotala woyamba za mankhwala achiwiri, kapena dokotala wachiwiri za mankhwala oyamba. Apa ndi pamene pali mwayi waukulu wogwiritsa ntchito mankhwala awiri owonjezera serotonin pamodzi mosadziwa ndikuyambitsa vutoli.
• Ngati mwamwa mankhwala ochulukirapo: Ngati mwamwa mankhwala ochulukirapo kuposa mlingo wolembedwa, mwadala kapena mwangozi.

Kodi zizindikiro zake ndi ziti? Kodi tingazizindikire bwanji izi?

Zizindikiro za serotonin syndrome zimatha kusiyana malinga ndi munthu. Anthu ena amatha kukhala ndi zizindikiro zochepa kwambiri, pomwe ena amatha kukhala ndi zizindikiro zoopsa komanso zoopsa. Zizindikirozi nthawi zambiri zimayamba mkati mwa maola ochepa mutamwa mankhwala atsopano kapena kusintha mlingo.

Kuti timvetse bwino, tiyeni tigawane zizindikiro izi m'magulu atatu.

Kodi ndi mankhwala ati omwe amawonjezera kuchuluka kwa serotonin m'thupi?

Mndandanda uwu ndi wautali pang'ono, koma ndikofunikira kwambiri kuti chitetezo chanu chidziwe izi.

Mankhwala oletsa kuvutika maganizo

Mankhwala awa ndi omwe nthawi zambiri amagwirizanitsidwa ndi serotonin syndrome. Chiwopsezo chimakhala chachikulu makamaka akamwedwa limodzi ndi mankhwala ena (monga mankhwala a mutu waching'alang'ala).

• SSRIs (Selective serotonin reuptake inhibitors): Mankhwala monga Fluoxetine, Sertraline, Citalopram, Escitalopram, ndi Paroxetine.
• SNRIs (zoletsa kubwerezabwereza kwa Serotonin-norepinephrine): Mankhwala monga Venlafaxine, Duloxetine, Desvenlafaxine.
• Mankhwala oletsa kuvutika maganizo a Tricyclic: Mankhwala monga Amitriptyline, Nortriptyline, Imipramine.
• MAOIs (zoletsa monoamine oxidase): Ngakhale kuti izi sizigwiritsidwa ntchito kawirikawiri, nthawi zina zimaperekedwa.

Mankhwala ena

• Mankhwala ochepetsa ululu waukulu: Mankhwala ochepetsa ululu monga Tramadol, Pethidine (Meperidine), Fentanyl, ndi Methadone.
• Mankhwala a chifuwa: Mankhwala ena a chifuwa omwe amapezeka m'mafakitale ali ndi mankhwala otchedwa Dextromethorphan . Izi zingakhudzenso kuchuluka kwa serotonin.
• Mankhwala a mutu waching'alang'ala: Mankhwala a triptan monga Sumatriptan ndi Rizatriptan.
• Mankhwala ochizira kusanza: Mankhwala monga Metoclopramide ndi Ondansetron.
• Mankhwala ena opha tizilombo: Mankhwala opha tizilombo otchedwa linezolid.
• Mankhwala oletsa kusokonezeka maganizo: Lithium.

Zinthu zina

• Zowonjezera za zitsamba: Zinthu monga St. John's wort ndi Ginseng.
• Mankhwala osaloledwa: Zinthu monga Ecstasy (MDMA), LSD, Cocaine, Amphetamines.

Musachite mantha ndi mndandanda uwu. Si aliyense amene angadwale vutoli atamwa imodzi mwa mankhwala awa. Chiwopsezo chimabwera pokhapokha mutagwiritsa ntchito angapo mwa awa pamodzi, kuonjezera mlingo, kapena ngati thupi lanu limawaganizira.

Kodi dokotala amazindikira bwanji izi?

Palibe mayeso enieni a magazi kapena scan yotsimikizira serotonin syndrome. Dokotala adzazindikira vutoli kutengera zinthu zingapo:

1. Zizindikiro zanu: Mvetserani mosamala zomwe mukumva.

2. Kuwunika thupi: Kugunda kwa mtima wanu, kuthamanga kwa magazi, kutentha kwa thupi lanu, ndi momwe minofu yanu ilili kudzayezedwa.

3. Mndandanda wa mankhwala omwe mukumwa: Ichi ndiye chinthu chofunikira kwambiri.

Kuphatikiza apo, mungayesedwe magazi ndi mkodzo, X-ray pachifuwa, kapena CT scan kuti muwonetsetse kuti mulibe matenda ena (monga matenda) omwe amayambitsa zizindikiro zofanana.

Kodi mankhwala ochizira izi ndi otani?

Chithandizo chimadalira kuopsa kwa zizindikiro zanu.

• Ngati muli ndi zizindikiro zochepa: Chithandizo chachizolowezi ndi kusiya kumwa mankhwala omwe amayambitsa zizindikirozo. Izi nthawi zambiri zimathetsa zizindikirozo kwathunthu mkati mwa maola 24-72.
• Ngati muli ndi zizindikiro zochepa: Mudzasungidwa kuchipatala ndipo mudzayang'aniridwa kwa maola osachepera 24. Panthawiyi, mudzapatsidwa mankhwala amchere (IV fluids) ndi mankhwala monga benzodiazepines ochepetsa nkhawa.
• Ngati muli ndi zizindikiro zoopsa: Izi ndi zadzidzidzi zachipatala. Mudzaloledwa ku chipinda chosamalira odwala kwambiri (ICU) ndikupatsidwa chithandizo monga kuthandizira kupuma movutikira, kuwongolera kutentha thupi, ndi mankhwala oletsa kugunda kwa mtima ndi kuthamanga kwa magazi. Nthawi zina, mankhwala otchedwa Cyproheptadine, omwe amaletsa ntchito ya serotonin, angapatsidwenso.

Kodi tingadziteteze bwanji ku vutoli?

Pali zinthu zingapo zosavuta koma zofunika kwambiri zomwe tingachite kuti tipewe ngoziyi.

1. Dziphunzitseni za mankhwala anu: Lembani dzina, mlingo, ndi cholinga cha mankhwala aliwonse omwe mumamwa.

2. Uzani dokotala aliyense tsatanetsatane wake: Ngati mukulandira chithandizo ndi madokotala angapo, onetsetsani kuti mwauza dokotala mmodzi za mankhwala omwe ena onse akupatsani.

3. Musasiye kumwa mankhwala popanda kufunsa dokotala wanu: Ngakhale mutamva kusasangalala kulikonse, musasiye kumwa mankhwala kapena kusintha mlingo wake popanda kulankhula ndi dokotala.

4. Samalani mukamagula mankhwala ku pharmacy: Mukagula mankhwala a zinthu monga chifuwa ndi chimfine, pemphani mankhwala ogwirizana ndi mankhwala omwe mukumwa kale.

5. Samalani ndi zizindikiro: Samalani kwambiri kusintha kulikonse m'thupi lanu, makamaka mukayamba kumwa mankhwala atsopano kapena kuonjezera mlingo.