Ese ufite PTCL (Peripheral T-cell Lymphoma)? Ntugahangayike, reka tubiganireho!

Hari igihe dushobora kwandura indwara tutanatekerezaho, si byo se? Mu magambo make, Lymphoma ya T-cell, cyangwa PTCL , ni indwara igoye, ariko ni ngombwa cyane kuyimenya. Mu by'ukuri si indwara imwe, ahubwo ni uruvange rw'indwara nyinshi. Ese twavuga kuri ibi mu buryo bworoshye, mu buryo ushobora gusobanukirwa?

Lymphoma ya T-cell lymphoma (PTCL) mu by'ukuri si indwara imwe. Ni itsinda ry'ubwoko bwinshi bwa kanseri y'amaraso ikaze . By'umwihariko, igira ingaruka ku sisitemu yacu ya lymphatic . Ushobora kuba warumvise ivuga ko ari "lymphoma itari Hodgkin", kandi ni ko imeze. Ikintu kimwe kuri PTCL ni uko ishobora gukwirakwira (ikwirakwira) kuva mu gice kimwe cy'umubiri ijya mu bindi bice . Ibi bivuze ko ishobora kugira ingaruka ku gice icyo ari cyo cyose cy'umubiri, bityo ibimenyetso biratandukanye.

Inkuru nziza ni uko abaganga bashobora kugenzura neza ubwoko bwinshi bwa PTCL. Ariko, rimwe na rimwe indwara ishobora kugaruka . Niyo mpamvu abashakashatsi mu by'ubuvuzi bahora bashaka uburyo bushya bwo kuvura bushobora gufasha abantu kubaho igihe kirekire bakoresheje PTCL.

Ese iyi ndwara yitwa PTCL isanzwe?

Oya, iyi si indwara ikunze kugaragara cyane . Ubushakashatsi bwakozwe ku isi yose bwerekana ko abantu bagera ku bihumbi magana abiri barwara PTCL. Abagera kuri 10% by'abarwara `(non-Hodgkin lymphoma)` bafite PTCL.

Iyi ndwara ikunze kugaragara cyane mu bihugu byacu bya Aziya, Afurika, no muri Karayibe kurusha muri Leta Zunze Ubumwe za Amerika. Ikunze kugaragara cyane mu bantu barengeje imyaka 60. Ariko, hari ubwoko bumwe na bumwe bushobora no kugaragara mu bana bato no mu rubyiruko .

Ni ubuhe bwoko bw'ingenzi bwa PTCL?

Umuryango Mpuzamahanga wita ku Buzima (OMS) wagaragaje ubwoko burenga 20 bwa PTCL. Buri bwoko bufite ibimenyetso byabwo byihariye by’uturemangingo. Reka turebe bumwe mu bwoko bukunze kugaragara.

Lymphoma y'uturemangingo twa T two mu gice cy'imbere, itavuzwe ukundi (PTCL-NOS)

Iyi ni yo nyuguti ikunze kugaragara cyane . ``(PTCL-NOS)`` ni icyiciro kirimo abantu badashobora gusobanurwa neza kandi badahuye n'izindi nyuguti zisobanutse neza. Hafi 30% by'abarwayi bose ba PTCL bari muri iki cyiciro. Ishobora kugira ingaruka cyane cyane ku mitsi yawe, umwongo , urwagashya , cyangwa umwijima .

Lymphoma ya T-cell angioimmunoblastic (AITL)

Ibi kandi bibaho kuri 15% kugeza kuri 30% by'abarwayi ba PTCL ku isi yose. AITL ishobora no kugira ingaruka ku gahanga kawe, ku musokoro w'amagufwa, ku gahanga, cyangwa ku mwijima.

Lymphoma nini ya Anaplastic (ALCL)

Hariho kandi ubwoko butandukanye bwa `(ALCL)`.

• Hari imwe yitwa ALCL y'ibanze y'uruhu , igira ingaruka ku ruhu .
• Hari indi imwe.ALCL y’umubiri, igira ingaruka ku bihaha, uruhu, n’izindi ngingo. Iyi ALCL y’umubiri rimwe na rimwe ishyirwa mu byiciro birambuye hashingiwe ku mpinduka mu ngirabuzimafatizo runaka yitwa ALK (anaplastic lymphoma kinase) . Hafi 15% bya PTCL biri muri ubu bwoko bwa ``(ALCL)```.

Umwicanyi w’umwimerere utari uw’inyuma y’urugingo/lymphoma y’uturemangingo twa T, ubwoko bw’izuru

Iyi ni umwihariko. Iyi ndwara ikunze kugaragara mu ngingo z'izuru ryawe , mu mwobo wa sinus , no mu muhogo wo hejuru . Ariko rimwe na rimwe ishobora gukwirakwira ku ruhu, mu nzira y'igogora , no mu zindi ngingo. Ubwo bwoko bugira hafi 10% bya PTCL.

Limfoma y'uturemangingo twa T two mu mara

Izina ribigaragaza, sibyo? Ibi bigira ingaruka ku buryo bw'igogora . Bifite hafi 6% bya PTCL. Bifite kandi ubwoko bwitwa enteropathy-associated T-cell lymphoma (EATL) na monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) .

Lymphoma/leukemia y'uturemangingo twa T tw'abantu bakuru (ATLL)

Ishobora kugira ingaruka ku ruhu no ku magufwa. Hari ubwoko bune bwa ATLL: acute, lymphoma, chronic, na smoldering . Ubwoko bubiri bukunze kugaragara ni acute na lymphoma, butera ubukana. Ubwoko budakira n'ubutera butera ubukana butera buhoro buhoro. Buri bwoko bwa ATLL bugira ingaruka ku bice bitandukanye by'umubiri.

Ni ibihe bimenyetso bya PTCL?

Nubwo buri bwoko bwa PTCL bufite ibimenyetso byihariye, hari bimwe na bimwe bikunze kugaragara. Reka turebe ibyo ari byo:

• Utunyangingo tw’imitsi tubyimba: Ushobora kubyimba mu ijosi, mu kwaha, cyangwa mu kibuno nta bubabare . Tekereza akantu gato mu ijosi ryawe wumva kagenda kakura uko igihe kigenda gihita, ariko katababaza. Nguko uko byagenda kose.
• Kugabanya ibiro mu buryo butunguranye: Niba ugabanyije hafi 10% by'ibiro byawe byose mu mezi atandatu, utihatiye cyane, ni ikintu cyo guhangayikishwa na cyo.
• Kubabara mu nda cyangwa kubyimba: Ibi bishobora kubaho iyo urwagashya rwawe rwagutse. Bishobora kugorana, nk'aho inda yawe yuzuye.
• Umunaniro uhoraho: Kumva ufite umunaniro udasanzwe iminsi myinshi nta mpamvu igaragara. Ni nk'aho umunaniro udashira uko waba usinziriye kose.
• Umuriro udasobanutse: Akenshi, umuriro uba iyo umubiri urimo kurwanya indwara. Ariko, niba umuriro urenze dogere selisiyusi 39.5 (103 Fahrenheit) ukomeje amasaha arenga abiri nyuma yo kuvurwa mu rugo, cyangwa niba umuriro ukomeje iminsi irenga ibiri, bishobora kuba ikimenyetso cy'ikintu gikomeye kurushaho.

Igikuru ni uko udakwiye guhangayikishwa no kugira PTCL kubera ko ufite ibi bimenyetso. Bishobora guterwa n'izindi mpamvu zoroshye. Ariko niba ibi bimenyetso bikomeje,Ni ngombwa cyane kubonana na muganga no kugisha inama.

Noneho reka turebe ibimenyetso biza hamwe n'ibindi bimenyetso byihariye.

Ibindi bintu bifatika bya lymphoma ya T-cell lymphoma yo mu gice cy'imbere, bitavuzwe ukundi (PTCL-NOS)

Uretse ibimenyetso bisanzwe, ushobora no kubona:

• Kugabanuka kw'uturemangingo dutukura tw'amaraso (Anemia) - Ibi bishobora gutera ububobere no kwiyongera k'umunaniro.
• Umubare muto wa platelets mu maraso (Trombocytopenia) - Ibi bishobora gutera akamenyero ko kuva amaraso.
• Uduheri dutukura dushyuha ku ruhu.
• Iyo kanseri iri mu gituza , ububabare mu gituza cyangwa guhumeka bigoranye (dyspnea).

Ibindi bintu bifatika bya lymphoma ya T-cell angioimmunoblastic (AITL)

Uretse ibimenyetso bisanzwe:

• Kubira ibyuya nijoro - Kubira ibyuya byinshi mu gihe usinziriye ku buryo amashuka abira.
• Uduheri ku ruhu.
• Indwara z’ubudahangarwa bw’umubiri nka "Autoimmune hemolytic anemia "

Ibindi bintu bifatika ku ndwara ya lymphoma nini ya anaplastic (ALCL)

ALCL y'ibanze y'uruhu (ubwoko bw'uruhu rugira ingaruka ku ruhu)

• Ibintu nk'ibara ridasanzwe ry'uruhu ritukura cyangwa umutuku wijimye, ibibyimba birushaho kwiyongera uko igihe kigenda gihita.
• Udusebe twinshi, tunini kandi twizengurutse .
• Utu tubyimba dushobora kubabara no kuzuramo igituza.

ALCL yo mu mubiri (ubwoko bw'indwara zifata ingingo z'imbere)

Muri iki gihe, ibimenyetso bisanzwe kuri PTCL biragaragara.

Umwicanyi w’umwimerere utari uw’inyuma y’urugingo/lymphoma y’uturemangingo twa T, ubwoko bw’izuru

• Kuziba izuru , kumva nk'aho izuru ryazibye.
• Kuva amaraso mu mazuru .
• Imbere mu mazuru hahinduka nk'ibicurane .
• Kubyimba mu maso kubabaza .
• Ibibazo by'amaso nko kuva mu maso no kubabara mu maso.

Lymphoma/leukemia y'uturemangingo twa T tw'abantu bakuru (ATLL)

Ibimenyetso bya PTCL ni ibisanzwe ku bwoko bune bwose bwa ATLL.

Ni izihe mpamvu za PTCL?

Muri make, lymphoma y’uturemangingo twa T ibaho iyo uturemangingo twa T mu mubiri wacu twihinduye (`(mutate)`) tukaba uturemangingo twa kanseri. Nkuko mubizi, utwo turemangingo twa T ni ubwoko bw’uturemangingo tw’amaraso twera tuturinda abadutera nk’udukoko twinjira mu mubiri wacu. Rero, iyo utwo turemangingo twa T twihinduye, tuba uturemangingo twa kanseri tugatangira kwiyongera mu buryo budasubirwaho . Iyo twiyongera gutya, twirundanya mu bihaha byacu, mu mugongo, mu mwijima no mu zindi ngingo z’umubiri maze tugakora ibibyimba bya kanseri .

Impuguke ntizirabona impamvu ifatika ituma izi selile T zihinduka gutya.Ariko, ubushakashatsi bwagaragaje ko bifitanye isano n'indwara zimwe na zimwe.

Urugero:

• Ubushakashatsi bwakozwe ku isi bwagaragaje ko abantu bafite indwara yitwa indwara ya celiac bashobora kugira ibyago byinshi byo kurwara ubwoko butandukanye bwa PTCL, harimo na ALCL.
• Nanone, abantu banduye virusi ya Epstein-Barr bashobora kugira ibyago byinshi byo kurwara lymphoma y’uturemangingo tw’inyuma y’uturemangingo/uturemangingo twa T.
• Abantu bafite virusi `(Human T-cell lymphotropic virus Type 1 (HTLV-1))` bari mu kaga ko kurwara `(accute T-cell lymphoma/leukemia)`.

Ni gute PTCL ipimwa?

Abaganga bashobora gukenera gukora ibizamini bitandukanye kugira ngo bamenye ubwoko bwihariye bwa PTCL butera ibibazo by'ubuzima bwawe. Ibi bishobora kuba bikubiyemo ibizamini by'amaraso, ibizamini byo gufata amashusho, ibizamini bya biopsy , n'ibizamini bya genetiki kugira ngo bige imiterere y'uturemangingo twa kanseri.

Gupima amaraso

Abaganga bakora ibizamini by'amaraso kugira ngo barebe niba nta virusi zishobora kuba zifitanye isano na PTCL. Ibi bishobora kuba birimo:

• Umubare w'amaraso yuzuye (CBC)
• Urusobe rw'imikorere y'umubiri (CMP)
• Ikizamini cya Lactate dehydrogenase (LDH)
• Ibipimo bya Hepatite B na Hepatite C
• Ikizamini cya virusi itera SIDA (HIV)
• Ibipimo bya virusi ya T-cell lymphotropic Type 1 (HTLV-Type 1) y'abantu

Ibizamini byo gushushanya

Izi scan zituma abaganga babona amakuru y’imbere mu mubiri wawe, cyane cyane aho ibibyimba bya kanseri biherereye.

• Isuzuma rya mudasobwa (CT)
• Isuzuma rya Positron emission tomography (PET)
• Isuzuma rya MRI (magnetic resonance imaging)

Isuzuma ry'ubuzima bw'umuntu

Ibi bisaba gufata agace gato k'urugingo mu gace gakekwaho indwara no kugasuzuma hifashishijwe mikorosikopi. Ubu ni bwo buryo bw'ingenzi bwo kwemeza neza indwara .

• Isuzuma ry'uturemangingo tw'imitsi
• Isuzuma ry'uruhu
• Kuvura umwongo w'amagufwa

Ni izihe ntambwe za PTCL?

Abaganga bakoresha uburyo bwo gupima kanseri kugira ngo bategure uburyo bwo kuvura no kuguha igitekerezo cy'icyo ushobora kwitega mu buvuzi (prognosis). Iki cyiciro kigenwa n'ubwoko bwa PTCL n'aho uturemangingo twa T twa kanseri twakwirakwiriye. Dore ibyiciro bine by'ingenzi bya PTCL:

• Icyiciro cya mbere: Uturemangingo twa T twa kanseri tuba mu turemangingo kamwe cyangwa mu itsinda rimwe ry'uturemangingo.
• Icyiciro cya Kabiri: Kanseri yafashe imiyoboro ibiri cyangwa irenga ya lymph ku ruhande rumwe rw'umubiri wawe (urugero, ku mpande zombi z'ijosi ryawe, cyangwa ku rundi ruhande ruri hejuru cyangwa munsi y'umuyoboro).
• Icyiciro cya gatatu: Kanseri yakwirakwiriye mu ngingo ziri hejuru no munsi y'igitambaro cyawe.
• Icyiciro cya kane: Uretse amabya, kanseri yanagize ingaruka ku zindi ngingo, nko mu bihaha, umwijima, umwotsi w'amagufwa, cyangwa mu buryo bw'igogora.

Ni ubuhe buryo bwo kuvura PTCL?

Kubera ko hari ubwoko bwinshi bwa PTCL n'icyiciro cya kanseri, nta buryo bumwe bwo kuvura bushobora gutandukana bitewe n'umuntu ku giti cye. Muganga wawe ni we uzaguhitiramo uburyo bwiza bwo kuvura. Dore bumwe mu buryo busanzwe bwo kuvura:

• Ubwivumbure: Uruvange rw'ubwoko butandukanye bw'imiti ya chimiotherapie. Ubu ni bwo buryo bukunze gukoreshwa cyane mu kuvura.
• Ubuvuzi bushingiye ku mirasire: Hari igihe bukoreshwa hamwe na chemotherapy, cyane cyane iyo kanseri iherereye ahantu runaka.
• Ubuvuzi bwibanda ku mpinduka mu buryo bwihariye mu ngirabuzimafatizo (mutations) zituma uturemangingo tuzima tuba uturemangingo twa kanseri. Ibi bitandukanye n'imiti isanzwe ya chimiotherapie.
• Uburyo bwo kuvura hakoreshejwe imiti igabanya ubukana n'uburyo bwo gutera uturemangingo tw'umubiri: Ubu buryo bwo kuvura bushobora gukoreshwa kuri PTCL idakira imiti igabanya ubukana n'imirasire, cyangwa ikongera kubaho nyuma yo kuvurwa. Ubu buryo ni uburyo bugoye cyane.

Hari igihe ushobora kwitabira igeragezwa ry’ubuvuzi ku miti mishya ya PTCL. Vugana na muganga wawe kuri ibi.

Ni izihe ngaruka mbi zikunze kugaragara zo kuvurwa?

Uburyo bwinshi bwo kuvura kanseri bushobora gutera ingaruka zimwe na zimwe. Ariko, si buri wese ubona izi ngaruka zose, kandi uburemere bwazo bushobora gutandukana. Urugero, ingaruka mbi za chimiotherapie na radiation therapy zishobora kuba zirimo:

• Umunaniro
• Igihu cyo mu bwonko giterwa na chimiotherapie - kumva ko ubwonko bumeze nk'igihu, kwibagirwa, no kugorwa no kwibanda ku bintu.
• Isesemi no kuruka
• Gutakaza umusatsi
• Ibisebe byo mu kanwa
• Bikunze kugaragara ko barwaye indwara

Ubu hari uburyo bwinshi bwo kugenzura izi ngaruka mbi, bityo vugana na muganga wawe kuri ibyo.

Ni iki giteganyijwe ku ndwara ya PTCL?

Ibi biterwa cyane n'ubwoko bwa PTCL, aho kanseri igeze, ubuzima bwawe muri rusange, ndetse niba kanseri iri mu nzira yo koroherwa (``remission``) iyo ivuwe."Kuremurura" bivuze ko nta bimenyetso ufite kandi ko nta bimenyetso bya kanseri biboneka mu bipimo. Hari ubwo PTCL ishobora gukira burundu hakoreshejwe uburyo busanzwe bwo kuvura.

Ariko, ubwoko bwinshi bwa lymphoma ya T-cell lymphoma ishobora kugaruka (`(isubira)`) . Ibi bibaye, ushobora gukenera ubundi buvuzi cyangwa ubundi bwoko bw'ubuvuzi.

Ni ibisanzwe gushaka kumenya icyo wakwitega mu buvuzi bwawe. Muganga wawe ni we muntu mwiza wo kumenya ku bijyanye n'uburwayi bwawe. Bityo rero, mubwire ukuri kandi umubwize ukuri kuri ibi kandi ntutinye kubaza ibibazo.

Ese PTCL ishobora kwirindwa?

Ikibabaje ni uko oya, uko tubizi, nta buryo bwihariye bwo kwirinda ibi . Iyi lymphoma iterwa n'uturemangingo twa T twitwara nabi tukaba kanseri. Nta cyo twakora ngo tuyirinde. Ariko, kwirinda ibintu bimwe na bimwe bishobora gutera ibyago (urugero: virusi ya HTLV-1) bishobora kugabanya ibyago byo kurwara ubwoko bwa PTCL bufitanye isano.

Niyitaho nte? (Kuba muri PTCL)

Lymphoma ya T-cell lymphoma ni ubwoko bwa kanseri idakunze kugaragara kandi ikura vuba. Niba ufite PTCL, dore inama zimwe na zimwe zagufasha kwihanganira iyi ndwara:

• Tekereza ku buvuzi bugabanya ububabare: Ubu buvuzi bushobora kugufasha guhangana n'ibimenyetso n'ingaruka mbi zo kuvurwa. Ikindi kandi, itsinda ryawe ryita ku buvuzi bugabanya ububabare rishobora kugufasha guhangana n'ibibazo by'amarangamutima (agahinda, ubwoba, guhangayika) bizanwa no kubaho ufite indwara ikomeye nk'iyo.
• Shaka ubufasha: Kubera ko PTCL ari kanseri idakunze kugaragara, ushobora kumva ko ari wowe wenyine uyirwaye. Ariko ntugomba kuyirwanya wenyine. Vugana n'itsinda ry'abaganga bawe maze umenye amatsinda y'abaterankunga aho ushobora guhuzwa n'abandi bahura n'ibintu nk'ibyawe. Gusangiza abandi ubunararibonye no kubona ubufasha ni ingirakamaro cyane muri iki gihe.
• Fata umwanya wawe (Kwitaho): Kanseri ni indwara itera stress. Kwitaho ni ingenzi cyane iyo ubana na PTCL. Vugana n'itsinda ry'abaganga ku buryo bwo gucunga stress (kwita ku byo utekereza, imyitozo ngororamubiri yo guhumeka, gukora ibintu wishimisha), n'uburyo bwo gukora indyo yuzuye kugira ngo ugumane imbaraga mu gihe cyose uvurwa. Gira ibitotsi bihagije.

Ni ibihe bibazo ngomba kubaza muganga wanjye?

Ntukibagirwe kubaza ibi bibazo igihe ugiye kwa muganga wawe:

• Ni ubuhe bwoko bwa lymphoma ya Peripheral T-cell mfite? Yitwa iki?
• Indwara yanjye igeze ku kihe cyiciro? Yakwirakwiriye igeze he?
• Ni ubuhe buryo bwo kuvura mfite? Ni ibihe byiza n'ibibi bya buri buryo bwo kuvura?
• Ni ubuhe bwoko bw'intsinzi bushobora kwitegwa muri ubu buryo bwo kuvura?
• Ingaruka mbi zo kuvurwa ni izihe? Ni gute zishobora gukemurwa?
• Ese nkwiye gutekereza ku buryo bushya bwo kuvura bushingiye ku bushakashatsi (`(igerageza ry'ubuvuzi)`)? Ese birakwiriye kuri njye?
• Ni izihe mpinduka ngomba kugira mu mibereho yanjye?

Ubutumwa bwa nyuma bwo kujyana mu rugo

Kanseri ya T-cell lymphoma (PTCL) ni ubwoko budasanzwe ariko bw'ingenzi bwa kanseri y'amaraso. Ibaho iyo uturemangingo twa T turinda imibiri yacu duhinduka tukaba kanseri. Nubwo dusangiye impamvu imwe, imiterere ya buri wese iratandukanye. Kubera ko PTCL igira ingaruka ku bice bitandukanye by'umubiri, rimwe na rimwe bishobora kugorana kuyisuzuma no kuyivura.

Ariko, komeza kugira icyizere! Abashakashatsi mu by'ubuvuzi bahora bashaka uburyo bushya kandi bufite akamaro bwo kuvura bugamije impinduka mu miterere y'uturemangingo muri PTCL. Niba urwaye PTCL, ntugatinye, kandi vugana n'itsinda ry'abaganga bawe mu buryo bweruye . Baza niba hari uburyo bushya bwo kuvura bushingiye ku bushakashatsi (igeragezwa ry'ubuvuzi) bujyanye n'uburwayi bwawe. Ufite amakuru akwiye n'inkunga y'abakunzi bawe, uzahabwa imbaraga zo guhangana n'iki kibazo!

Lymphoma y'uturemangingo twa T , PTCL, Lymphoma, lymphoma y'uturemangingo twa T, Kanseri, Kanseri y'amaraso, Lymphoma, Ibimenyetso bya PTCL, Ubuvuzi bwa PTCL