Unodawo kuziva nezvebvunzo yeANCA here? Ngatikurukurei zvakadzama!

Wakambonzwa nezve `(bvunzo yeANCA)` here? Pamwe chiremba wako akakuudza kuti uite bvunzo iyi, kana kuti pamwe wakangoona zita racho pane imwe nzvimbo ukatanga kuda kuziva. Saka, chii chinonzi `(bvunzo yeANCA)`? Chii chaizvo chinotsvagwa? Munyaya ino, tichawana mhinduro dzemibvunzo yakadaro yaungave uchifunga.

Chii chinonzi bvunzo yeANCA? Ngatizvinzwisise zviri nyore!

Muchidimbu, bvunzo yeANCA ibvunzo yeropa inotora sampuli yeropa rako yotsvaga zvinhu zvinonzi Antineutrophil Cytoplasmic Antibodies, kana kuti ANCA muchidimbu.

Zvino ungave uchishamisika kuti, chii chinonzi `(ANCA)`? `(ANCA)` rudzi rwe `(autoantibodies)` . `(Autoantibodies)` rudzi rweprotein inogadzirwa neimmune system yemuviri wedu (ndiko kuti, system inotidzivirira kubva kuzvirwere). Zvisinei, dambudziko ne `(autoantibodies)` aya nderekuti anorwisa masero nematishu ane hutano mumuviri wedu zvisirizvo. Zvakafanana neuto redu rinorwisa nyika yedu.

Aya ma `(ANCA)` anonyanya kunanga mapuroteni anowanikwa mumasero machena eropa anonzi `(neutrophils) . `(Neutrophils)` akafanana nemasoja madiki mumiviri yedu. Ndiwo anorwisa utachiona uye anotibatsira kuzvidzivirira kubva kuzvirwere. Saka, iyi `(ANCA test)` inogona kuona kana une aya ma `(autoantibodies)` muropa rako, uye kana zvakadaro, mangani.

Kuongororwa kweANCA kunoshandiswa kuona chirwere cherudzii?

Vanachiremba vanoshandisa bvunzo yeANCA zvakanyanya kubatsira kuona zvimwe zvirwere zve autoimmune, zviri muboka rezvirwere zvinonzi vasculitis .

Chii chinonzi `(vasculitis)`?

Fungidzira, mumiviri yedu yese, kune zvinhu zvidiki zvakaita sechubhu zvinotakura ropa? Ndizvo zvatinodaidza kuti mitsipa yeropa. Mumamiriro ezvinhu aya anonzi "vasculitis," chinoitika ndechekuti masoja edu emuviri anorwisa mitsipa iyi yeropa uye anoita kuti izvimbe, kureva kuti, kuzvimba . Zvakafanana neronda remukati.

Kune mhando dzakasiyana dzevasculitis dzakabatana neANCA:

• `(Granulomatosis ine polyangiitis)` (yaimbozivikanwa se`(Wegener granulomatosis)`).
• `(Microscopic polyangiitis)` .
• Eosinophilic granulomatosis ine polyangiitis (yaimbozivikanwa seChurg-Strauss syndrome).

Mitsipa yeropa ndiyo inotakura ropa kubva pamwoyo wedu kuenda kune dzimwe nhengo dzese nematishu. Saka, kana mitsipa iyi yeropa ikazvimba, ropa harifambi zvakanaka. Izvi zvinogona kukuvadza nhengo dzedu dzinokosha, uye dzimwe nguva zvinotokonzera mamiriro ezvinhu ane njodzi akadai sekuputika kwetsinga yeropa (aneurysm) . Ndosaka zvichikosha kuona mamiriro akadaro nekukurumidza.

Kune mhando huru dze (ANCA) here?

Ehe, kune mhando mbiri huru dzeANCA. Kuongororwa uku kweANCA kunogona kuona kana uine imwe kana dzese dziri mbiri.

• `cANCA` : Izvi zvinonanga puroteni inonzi `(proteinase 3)` kana `(PR3)` .
• `pANCA` : Izvi zvinonanga puroteni inonzi `(myeloperoxidase)` kana `(MPO)` .

Mhando dzese idzi dze `(protein)` dzinowanikwa mukati memasero machena eropa anonzi `(neutrophils)` ambotaurwa. Kuziva kuti rudzii rwe `(ANCA)` ruripo kunobatsira chiremba mukuongorora chirwere ichi uye kuronga kurapwa.

Ndiani anoita bvunzo yeANCA? Inoedzwa sei murabhoritari?

Kazhinji, mukoti, chiremba, kana nyanzvi yezvekurabhoritari inotora ropa rako, iro rinozotumirwa kurabhoritari kunoongororwa.

Chii chinoitika murabhoritari (`lab`)?

Vanotora sampuro yeropa rako voisanganisa nema neutrophils ari paslide. Zvino, kana paine maANCA muropa rako, anonamira kuma neutrophils. Zvadaro dhayi yakakosha (stain) inowedzerwa paslide. Zvadaro, paunoitarisa uchishandisa maikorosikopu, unogona kuona zvakajeka maitiro emaANCA akabatanidzwa paslide.

Rabhoritari inoratidza masero aya se cANCA (cytoplasmic pattern) kana pANCA (perinuclear pattern) zvichibva pane fluorescence pattern chaiyo inoonekwa mumasero aya.

Rabhoritari inogona kushandisa mhando imwe kana mbiri dzebvunzo dzeANCA:

• `(Indirect immunofluorescence) (IIF)` : Bvunzo iyi inongokuudza chete kana une `(autoantibodies)` iyoyo kana kuti kwete. Kureva kuti, mhedzisiro yacho `(positive)` kana `(negative)`.
• Kuyedza immunosorbent assay (ELISA) kwakabatana neenzyme : Iyi nzira yekuyedza inoshandiswa kuona kuti protein iri kudiwa (kureva PR3 kana MPO) chii chiri mukati mema neutrophils.

Pane gadziriro yakakosha inodiwa here bvunzo yeANCA isati yaitwa?

Kazhinji , hapana kugadzirira kwakakosha kunodiwa pakuongororwa kweANCA. Zvisinei, dzimwe nguva zvinhu zvakawanda zvinogona kuongororwa neropa rimwe chete. Muzviitiko zvakadaro, mimwe miedzo ingada kuti utsanye kwemaawa masere kusvika gumi nemaviri, zvichireva kuti haufanirwe kudya kana kunwa chero chinhu kunze kwemvura. Zvisinei, chiremba wako achakupa mirairo chaiyo pane izvi. Saka usazvidya moyo nazvo.

Chii chaunofanira kutarisira paunenge uchiita bvunzo yeANCA?

Zvinongotora maminetsi mashoma chete kuti ropa rako riongororwe. Zvinowanzoitwa muhofisi, kiriniki, kana murabhoritari. Heino maitirwo eropa:

• Kutanga, tambo yekutamba kana bhandi yakaputirwa zvakasimba paruoko rwako rwepamusoro (pamusoro pedumbu rako).
• Zvadaro, ganda richatorwa ropa rinocheneswa nemushonga unouraya utachiona.
• Tevere, tsono inopinzwa mutsinga iri pedyo negokora. Panguva iyi , unogona kunzwa kurwadziwa kana kukwenya zvishoma . Izvi zvakajairika.
• Chubhu diki inonamirwa patsono uye ropa rinodiwa rinounganidzwa.
• Zvadaro, vanobvisa tepi netsono, vobata nzvimbo yakapinzwa tsono nedonje kuti vamise kubuda ropa.
• Pakupedzisira, bhandiji diki (plaster) rinoiswa panzvimbo yacho.

Chii chinoitika mushure mekuongororwa kweANCA?

Chiremba wako angangokuudza kuti ugare wakapfeka bhandeji kwemaawa mashoma. Vangangokuudzawo kuti usaite maekisesaizi anorema kwemaawa mashoma mushure mekupa ropa. Kunze kweizvozvo, hapana chakakosha.

Pane njodzi here neizvi (bvunzo yeANCA)?

Kuongororwa kweropa kwakachengeteka zvikuru uye njodzi dzacho dzakaderera .

Unogona kunzwa kukuvara kudiki pakaiswa tsono. Izvi zvinowanzopera zvega mumazuva mashoma. Kashoma, tsinga inogona kuzvimba zvishoma. Kana izvi zvikaitika, madzvinyiriro anodziya anogona kubatsira. Izvi hazvina basa.

Zvinotora nguva yakareba sei kuti uwane mhedzisiro yekuongororwa kweANCA?

Bvunzo yeANCA ibvunzo yakasarudzika, saka inoitirwa murabhoritari yakasarudzika. Saka, zvinogona kutora chero nguva kubva pamazuva mashoma kusvika pavhiki kuti mhinduro dzidzoke. Chiremba wako achakuzivisa.

Zvinorevei zvabuda mubvunzo dzeANCA? Ndinonzwisisa sei?

Ichi ndicho chinhu chinonyanya kukosha. Chiremba wako ndiye achataura newe nezvemhedzisiro yekuongororwa kweANCA uye kuti inokanganisa sei hutano hwako.

• Kana mhinduro dziri ``negative``: Izvi zvingangoreva kuti hauna chirwere che``autoimmune vasculitis`` chataurwa kare.
• Kana mhinduro dziri ``dzakanaka``: Zvingareva kuti une ``autoimmune vasculitis``.

Zvisinei, pane chimwe chinhu chakakosha kunzwisisa pano. Kuongororwa kweANCA hakurevi kuti une chirwere ichi. Chiremba wako anogona kuraira mimwe miedzo , yakaita se biopsy (sampuli yenyama inotorwa kuti iongororwe), kana kumwe kuongororwa kweropa. Pamusoro pezvo, kuongororwa kunoitwa zvichibva pazvinhu zvakawanda, kusanganisira zviratidzo zvako uye mhedzisiro yeimwe bvunzo.

Zvakakosha: Mhedzisiro yebvunzo yeANCA ingori chikamu chimwe chete chekuongorora chirwere. Haingooni kuvapo kwechirwere chega. Chiremba wako achafunga izvi pamwe chete nezvimwe zvinhu zvakawanda, zvakaita sezviratidzo zvako, mhedzisiro yemimwe miedzo, uye nhoroondo yako yehutano.

Saka, chii chinonyanya kukosha chatinofanira kuyeuka kubva pane izvi?

Kuongororwa kwe "Antineutrophil Cytoplasmic Antibodies", kana kuti "ANCA", inzira inokosha yekuongorora ropa inobatsira vanachiremba kuona mhando dzakasiyana dze "autoimmune vasculitis", mamiriro ezvinhu umo masoja edu emuviri anorwisa mitsipa yedu yeropa.

Chiremba wako achakutsanangurira kuti sei uchifanira kuongororwa uku uye kuti mhedzisiro yacho icharevei kwauri. Saka, usatya kana kufungira. Kana uine mibvunzo kana kuti usinganzwisise chimwe chinhu, bvunza chiremba wako nekukasika. Zvakanaka kuti uzive zvakawanda paunenge uchiita sarudzo nezvehutano hwako.

(Kuongororwa kweANCA), Kuongororwa kweANCA, kuongororwa kweropa, vasculitis, zvirwere zve autoimmune, masoja ekudzivirira muviri , ma neutrophils, kuzvimba kwetsinga dzeropa