Unonzwa sekuti muviri wako uri kukurwisa kubva mukati here? Inogona kunge iri Antisynthetase Syndrome!

Dzimwe nguva unonzwa sekuti pane chiri kukunetsa kubva mukati here? Zvingave kuti majoini ako ari kungorwadza, uri kunetseka kufema, kana kuti uri kungoona shanduko diki paganda rako. Usazvitore sezviri kuitika. Dzimwe nguva pane nyaya yakaoma shure kwazvo. Nhasi tichataura nezvechirwere chisingawanzoitiki asi chinogoneka chinonzi Antisynthetase Syndrome.

Chii chinonzi Antisynthetase Syndrome? Zvichitaurwa zviri nyore...

Antisynthetase Syndrome chirwere chisingawanzoitiki. Chinoitika apa ndechekuti kune kuzvimba mumuviri wedu wese, kureva kuti, chirwere chakaita sekuzvimba. Ichi chirwere che autoimmune. Iye zvino uri kubvunza kuti chirwere che autoimmune chii.

Fungidzira, muviri wedu une immune system . Zvakafanana neuto rinodzivirira nyika yedu. Masero nenhengo dziri musystem iyi zvinotidzivirira kubva kuhutachiona, mabhakitiriya, nemavhairasi anokonzera zvirwere. Zvisinei, muchirwere che autoimmune, iyi immune system inotadza kushanda zvakanaka. Inofunga kuti masero edu ane hutano nenyama "vavengi" uye inotanga kuarwisa. Zvakafanana neuto redu richirwisa misha yedu. Kunyangwe vanachiremba vachiri kutadza kuziva kuti nei izvi zvichiitika.

MuAntisynthetase Syndrome, masoja edu emuviri anogona kukanganisa nzvimbo dzinotevera dzemuviri wedu:

• Tsandanyama
• Majoini
• Mapapu
• Ganda
• Mitsipa yeropa

Chinhu chinonyanya kukosha ndechekuona chiremba kana ukaona kurwadziwa kwemajoini, shanduko dzeganda, kana kuoma kwekufema, usingazviregerere.

Chirwere ichi hachiwanzoitiki kangani?

Ichi chirwere (Antisynthetase Syndrome) chirwere chisingawanzoitiki . Zvakaoma kutaura kuti vanhu vangani vanochiwana. Nekuti vanhu vashoma chete ndivo vanobatwa nacho gore rega rega. Dzimwe nguva, zviratidzo izvi zvakafanana nezviratidzo zvezvimwe zvirwere, uye zvinogona kusaonekwa.

Ndezvipi zviratidzo zveAntisynthetase Syndrome?

Zviratidzo zvaunoona zvinoenderana nekuti masoja emuviri wako ari kushanda zvakanaka sei uye kuti ari kuukuvadza zvakanyanya sei.

Kazhinji, vanhu vane Antisynthetase Syndrome vane zviratidzo zvinosanganiswa nezvimwe zvirwere zvakawanda. Ngationei kuti ndezvipi:

• Myositis: Uku kuzvimba kwemhasuru kwenguva refu. Izvi zvinokonzera kurwadziwa kwemhasuru uye kushaya simba.Zvinoitika. Fungidzira, unonzwa usina simba zvekuti haugone kutombosimudza maoko ako. Dzimwe nguva tsandanyama dziri pahuro pako dzinopera simba, zvichiita kuti zviomere kumedza chikafu nechinwiwa. Tinozvidaidza kuti dysphagia .

• "Maoko emakanika": Iri harisi zita risinganzwisisike here? Apa ndipo panobva ganda rezvanza nemativi eminwe rinokora uye rinotsemuka. Rinotaridzika semaoko emakanika anoshanda nemafuta zuva rese.

• Chirwere chemapapu chinonzi Interstitial Lung Disease (ILD): Apa ndipo panokuvara nyama iri pakati pemasagi madiki emhepo (alveoli) mumapapu edu netsinga dzeropa dzakaapoteredza. Izvi zvinogona kukonzera kushaya mweya (dyspnea) , kukosora kwakaoma , kuneta , uye kusagadzikana pachipfuva . Zvakafanana nekudonha pasi pematanho.

• Polyarthritis: Izvi zvinoitika kana majoini mashanu kana kupfuura achibatwa panguva imwe chete. Izvi zvinokonzera kurwadziwa, kuomarara, uye kuzvimba mumajoini . Unogona kunzwa kuomarara paunomuka mangwanani.

• Raynaud's phenomenon (secondary Raynaud's syndrome): Muizvi, zvigunwe zvemaoko nezvigunwe zvinochinja ruvara (zvinoshanduka kuchenuruka, zvobva zvaita bhuruu, zvobva zvatsvuka) zvobva zvaita chiveve, kunyanya kana zvabatwa nechando. Zvakafanana neminwe yako inoshaya chiveve mushure mekubvisa ice cube mufiriji.

• Fivha: Vamwe vanhu vanogona kungova nefivha vasina hutachiona mumuviri wavo. Izvi zvinoreva kuti tembiricha yemuviri inokwira nekuda kwekushanda kwemasoja emuviri uku.

Chii chinokonzera Antisynthetase Syndrome?

Chikonzero chaicho chechirwere ichi hachisati chazivikanwa . Asi vanachiremba vakaona kuti vanhu vazhinji vane chirwere ichi vane mhando chaiyo yema antibodies muropa ravo. Ma antibodies aya anoratidza kuti masoja avo emuviri ari kurwisa miviri yavo pachinzvimbo chekuadzivirira. Tinoadaidza kuti (autoantibodies) , zvinoreva kuti "self-antibodies".

Zvino, tarisai, ma antibodies mapuroteni anotidzivirira kana chimwe chinhu chakaipa chikapinda mumiviri yedu. Akafanana nezviratidzo zvemakemikari zvinoshandiswa nemasoja edu ekudzivirira muviri. Ma antibodies aya anoratidza zvinokuvadza zvakaita semabhakitiriya nemavhairasi se "njodzi." Asi kana uine chirwere che autoimmune, masoja ako ekudzivirira muviri anogadzira nekuburitsa ma antibodies anorwisa tishu dzine hutano.

Vanhu vane Antisynthetase Syndrome vanowanzova nema autoantibodies anorwisa ma enzymes anonzi tRNA synthetases . Aya ma tRNA synthetases ma enzymes akakosha uye anobatsira ayo miviri yedu inoda kuti ishande zvakanaka.

Hazvisati zvanyatsojeka kuti sei masoja edu emuviri achitanga kugadzira maautoantibodies aya. Zvisinei, kana uine humbowo hwemaautoantibodies aya muropa rako, zvingangoita kuti une Antisynthetase Syndrome.

Zvakaita seizvi, fungidzira mumwe munhu achitungidza mafirecracker pamberi pemba yako. Paunozvitarisa mangwanani akatevera, kune zvidimbu zvemafirecracker nenzira dzakatsva dzakapararira pasi rese. Ungasaziva kuti ndiani akatungidza mafirecracker, kuti akatungidzwa riini, kana kuti nei. Asi pane humbowo hwekuti zvakaitika. MuAntisynthetase Syndrome, pachinzvimbo cheruzha rwaunonzwa paunotungidza mafirecracker uye imbwa dzichitya, unosangana nezviratidzo zvatakambotaura nezvazvo.

Ndiani ari panjodzi huru yekubatwa nechirwere ichi?

Munhu wese anogona kuwana chirwere cheAntisynthetase Syndrome. Zvisinei, vakadzi nevanhu vane makore anopfuura makumi mashanu vane mukana wakakura wekuwana chirwere ichi. Vakadzi vane mukana wakapetwa kaviri wekuwana chirwere ichi pane varume.

Antisynthetase Syndrome inoonekwa sei?

Chiremba anoongorora chirwere ichi zvichienderana nezviratidzo zvako, kuongororwa kwemuviri, uye mimwe miedzo yakati wandei.

Ungangoda kuona chiremba ane ruzivo nezvezvirwere zve autoimmune, anonzi rheumatologist . Iye achakuongorora uye achakubvunza nezvezviratidzo zvako. Uchafanira kuudza chiremba kuti zviratidzo zvako ndezvipi, kuti wakatanga kuzviona riini, uye kana paine chimwe chinhu chinoita kuti zviwedzere kuipa.

Pamusoro pezvo, uchafanirwa kuongororwa kakawanda kuti usimbise kuti une Antisynthetase Syndrome uye kuti uzive zvimwe zvirwere zvinogona kukonzera zviratidzo zvakafanana.

Ndezvipi zviedzo zvinoshandiswa kuongorora chirwere ichi?

Iyi haisi bvunzo imwe chete inogona kusimbisa chirwere ichi. Izvi zvinowanzova chikamu chemaitiro anonzi differential diagnosis . Izvi zvinoreva kuti chiremba wako achaita bvunzo dzinoverengeka kuti aone kuti chii chiri kukonzera zviratidzo zvako, kubvisa zvimwe zvirwere, uye pakupedzisira aongorore kuti une Antisynthetase Syndrome. Mimwe yebvunzo dzaungave uine ndeiyi:

• Kuongororwa kweropa: Kutarisa mashandiro ari kuita masoja emuviri wako uye kuona kana uine maautoantibodies, ayo ari chiratidzo cheAntisynthetase Syndrome. Kuongororwa kweropa kunogonawo kutarisa huwandu hwakawanda hwemamwe ma enzymes anoburitswa muropa kana tsandanyama dzakuvara.
• Kuongororwa kweweti: Kuongorora mashandiro eitsvo uye kuongorora hutachiona kana mamwe matambudziko ari muweti anogona kunge achikonzera zviratidzo zvako.
• Kuongororwa kwebasa remapapu: Tarisa kuti uone kana mapapu ako kana hurongwa hwekufema hwakakanganiswa.
• Kuongororwa kweCT (computed tomography) kana kumwe kuongorora mifananidzo: Tora mifananidzo yenyama nenhengo dziri mukati memuviri.
• (Electromyography - EMG):Tarisa mashandiro emhasuru.
• Kuongororwa kwemagnetic resonance imaging (MRI) kwetsandanyama dzakakanganiswa: kutarisa kuzvimba.
• Kuongororwa kweropa (biopsy) inzira yekuongorora tsandanyama kana mapapu.

Antisynthetase Syndrome inorapwa sei?

Hapana mushonga weAntisynthetase Syndrome. Zvisinei, chiremba wako anogona kukubatsira kuwana mishonga yakasiyana-siyana inogona kubatsira kudzora zviratidzo zvako, kuderedza kukanganisa kwazvinoita pahupenyu hwako hwezuva nezuva, uye kuderedza kukuvara kwenhengo dzako dzemuviri.

Rudzi rwekurapwa kwaunoda runoenderana nekuti zviratidzo zvako zviri papi uye kuti zvakanyanya sei. Heano mamwe emishonga inonyanya kushandiswa:

• Corticosteroids: Iyi mishonga inonyorerwa nachiremba inoderedza marwadzo nekuzvimba. Vanachiremba vanowanzo nyora mishonga yecorticosteroid pamwe chete nemishonga inonzi immunosuppressants.
• Mishonga inodzvinyirira muviri: Mishonga iyi inoshanda nekumisa masoja emuviri wako kurwisa masero nematishu ane hutano. Rudzi rwemishonga yaunoda runoenderana nekuti ndeapi nhengo dziri kukanganiswa. Mishonga inonyanya kuderedza muviri inonzi methotrexate, azathioprine, uye mycophenolate . Ungangodawo cyclophosphamide, rituximab, kana tacrolimus .
• Kurapa Chirwere Chemapapu Chemukati (ILD): Unogona kupihwa mushonga wekuti zvive nyore kufema, kana kuti oxygen therapy kana uchida oxygen yakawedzerwa. Uchafanira kushanda nachiremba wemapapu kuti ugadzirise matambudziko ako ekufema.
• Kurapa kwemuviri: Nyanzvi yekurapa muviri inogona kukubatsira kuvandudza kufamba kwemuviri wako. Vanogona kubatsira kudzora zviratidzo zvine chekuita netsandanyama kana kukupa mazano ekurovedza muviri kuti usimbise mapapu ako. Ungangodawo kurapwa kwemapapu .

Chii chinoitika kana ndiine Antisynthetase Syndrome?

Chiremba wako anogona kukubatsira kuwana musanganiswa wemishonga inogona kugadzirisa zviratidzo zvako.

Antisynthetase Syndrome chirwere chisingaperi . Izvi zvinoreva kuti uchafanira kudzora zviratidzo kwenguva yakareba (zvichida hupenyu hwako hwese).

(Antisynthetase Syndrome) inouraya here?

Antisynthetase Syndrome haisi chirwere chinouraya . Nguva yekurarama kwevanhu vanorarama nechirwere ichi haiwanzo kanganiswa zvakanyanya. Vanhu vazhinji vanorarama nechirwere ichi kweupenyu hwavo hwese, asi vanogona kudzora zviratidzo zvavo nekurapwa.

Zvisinei, kana uine chirwere chakakomba chemukati memapapu kana chimwe chirwere chinokanganisa kufema kwako, chinogona kuuraya. Asi hazviwanzoitiki. Chiremba wako achakuudza zvekutarisira, uye zviratidzo zvinochinja zvingave zviratidzo zvekutanga zvekufema kwakanyanya.

Ndinogona here kudzivirira kukura kweAntisynthetase Syndrome?

Hapana nzira yekudzivirira Antisynthetase Syndrome, sezvo nyanzvi dzisiri kunyatsoziva kuti chii chinokonzera kana kuti chii chinowedzera njodzi yacho.

Ndinofanira kuona chiremba rini?

Kana ukaona zviratidzo zvitsva, kunyanya kana zvikawedzera kuipa, enda kuna chiremba . Kana uchinzwa sekuti zviratidzo zvako hazvisi kudzorwa sezvazvaimboita pakurapwa kwako, kana kuti kana zviratidzo zvako zviri kuita kuti zvikuomere kuita mabasa ako ezuva nezuva, taura nachiremba wako.

Ndinofanira kuenda kuchipatara riini?

Kana uine chimwe chezviratidzo izvi, enda kuchipatara nekukurumidza kana kufonera 911 (kana nhamba yako yekukurumidzira yemuno) :

• Kutadza kufema kamwe kamwe.
• Kushaya mweya zvakanyanya (kunzwa sekunge haugone kufema).
• Ruvara rwebhuruu rweganda, miromo, kana nzara (cyanosis).
• Kurwadziwa pachipfuva kana kurema.

Mibvunzo ipi yandinofanira kubvunza chiremba wangu?

• Ndine chirwere cheAntisynthetase Syndrome here kana chimwe chirwere che autoimmune?
• Ndedzipi mhando dzebvunzo dzandichafanira kuita?
• Ndeapi marapirwo akanakisa ekudzora zviratidzo zvangu?
• Ndichada kurapwa kwemuviri here kana kuti kurapwa kwekufema?
• Ndiri panjodzi yakakura sei yekuva nematambudziko makuru emapapu?

Ndeapi mamwe mazita eAntisynthetase Syndrome?

Dzimwe nguva vanachiremba vanodana Antisynthetase Syndrome nemamwe mazita. Semuenzaniso:

• (Dambudziko reAntisynthetase Deficiency)
• (AS syndrome)
• (Anti-Jo1 syndrome)

Aya mazita ese akasiyana emamiriro akafanana.

Pakupedzisira, zvekurangarira (Mharidzo Yekuenda Kumba)

Antisynthetase Syndrome chirwere chisingawanzoitiki apo masoja emuviri wako anorwisa muviri wako pachinzvimbo chekukudzivirira. Taura nachiremba wako nezvemishonga inogona kubatsira kuderedza kukanganisa kunoita zviratidzo zvako pahupenyu hwako hwezuva nezuva.

Kurarama nechirwere che autoimmune kunogona kunetsa zvikuru - zvinogona kunzwa sekunge muviri wako uri kukunyengera. Kana uchida rubatsiro rwekugadzirisa shanduko muhupenyu hwako kana kurarama nechirwere ichi, bvunza chiremba wako nezvenzira dzekuwana mazano ehutano hwepfungwa. Kunzwa kusuruvara uye kuora mwoyo zvakajairika, asi haufanirwe kuzviita wega.

'Antisynthetase Syndrome, chirwere che autoimmune, myositis, chirwere che interstitial lung, chiitiko chaRaynaud, autoantibodies, kurwadziwa kwemajoini, kushaya simba kwetsandanyama