Kukundikana kweBone Morrow: Ngatikurukurei izvi zvakadzama!

Mupfupa ndiwo musimboti mukuru wekugadzira ropa mumuviri wako. Wakafanana nefekitori. Fekitori iyi inogadzira zvinhu zvakaita semasero matsvuku eropa, masero machena eropa, uye maplatelet anobatsira miviri yedu kugadzika. Fungidzira kuti chii chingaitika kana fekitori iyi ikangoerekana yamira kushanda, kana kuti ikasashanda nemazvo? Ndizvo zvinoreva kukundikana kwemupfupa. Ngatitaurei nezvazvo zvakadzama .

Chii chinonzi Bone Marrow Failure?

Zvichitaurwa zviri nyore, kutadza kushanda kwemubofu kunoitika kana mubofu wako usingakwanise kugadzira masero matsvuku eropa, masero machena eropa, kana maplatelet akakwana mumuviri. Rudzi rumwe nerumwe rwemasero aya rune basa rarwo mumuviri wedu.

• Masero matsvuku eropa ndiwo anotakura okisijeni mumuviri wese. Kana ari mashoma, unogona kunzwa kuneta uye kucheneruka.
• Masero machena eropa akafanana neuto riri mumuviri wedu. Anorwisa hutachiona. Kana ari mashoma, mikana yekurwara yakakura.
• Maplatelet anobatsira kuti ropa rigwambe, zvinoreva kuti anomira kubuda ropa kana wakuvara. Kana huwandu hwemaplatelet ako hukadzikira, kunyange ronda diki rinogona kukonzera kubuda ropa kwakawanda.

Kukundikana kwemapfupa kunowanzova dambudziko rechimwe chirwere. Asi dzimwe nguva zvinogona kuitika pasina chikonzero chakajeka. Vanachiremba vanogona kugadzirisa zviratidzo nekushandisa mishonga uye nzira dzakasiyana-siyana dzekurapa. Zvisinei, kurapwa kwenguva refu kwechirwere ichi kungoiswa mumasero emuviri anokonzera allogeneic .

Ndeapi marudzi makuru echirwere ichi?

Kune mhando mbiri huru dzekutadza kushanda zvakanaka kwemubofu:

1. Zvakawanikwa: Nyanzvi hadzizivi kuti chii chinokonzera chirwere ichi. Asi tsvakiridzo yakaratidza kuti chinogona kukonzerwa nezvimwe zvirwere, kusangana nemamwe makemikari, kana kushandisa mimwe mishonga. Rudzi urwu runokura zvishoma nezvishoma nekufamba kwenguva.

2. Kugara nhaka: Izvi zvinoitika kana ukagara nhaka shanduko dzemajini (kuchinja kwemajini) kubva kune mumwe wevabereki vako kana vese. Vanachiremba vanodana izvi kuti Bone Marrow Failure Syndrome .

Dambudziko iri rakajairika zvakadii?

Ichi hachisi chirwere chinowanzoitika. Semuenzaniso, vana vanosvika 65 kubva pamamiriyoni ega ega vanozvarwa muUnited States gore rega rega vane chirwere chegomarara remapfupa chinotapukira. Mumwe muenzaniso chirwere chegomarara chinonzi "Fanconi Anemia." Chinokanganisa munhu mumwe chete pavashanu pamamiriyoni ega ega. Saka unogona kuona, izvi hazviwanzoitiki.

Ndezvipi zviratidzo zvinogona kunge zviri?

Zviratidzo zvinogona kusiyana zvichienderana nechikonzero chekukundikana kwemapfupa. Semuenzaniso, munhu ane kutadza kwemapfupa ekuzvarwa nakwo anogona kutanga kuratidza zviratidzo achiri nemakore maviri ekuberekwa. Zvisinei, tsvakurudzo inoratidza kuti munhu ane rudzi rwechirwere ichi anogona kutanga kuratidza zviratidzo ari pakati pemakore makumi maviri nemakumi maviri nemashanu, kana kunonoka kusvika makore makumi matanhatu nemashanu. Pasinei nekuti chinotanga riini, zviratidzo zvinonyanya kuzivikanwa ndeizvi:

• Kurwadziwa mumapfupa
• Kubuda ropa rakawanda (semuenzaniso kubuda ropa mumhino, kubuda ropa mumazino, kubuda ropa rakawanda panguva yekuenda kumwedzi)
• Kuneta kwakanyanya uye kuneta
• Fivha inowanzo itika
• Kutapukirwa nehutachiona kakawanda
• Musoro
• Kutadza kufema zvakanaka (Dyspnea)
• Ruvara rweganda rwuchichenuruka kupfuura zvakajairika
• Mavara matsvuku pasi peganda (Petechiae)
• Kukuvara pamuviri pasina chikonzero chinozivikanwa

Kana ukaramba uine chimwe chezviratidzo izvi kana kupfuura, iva nechokwadi chekuona chiremba.

Sei mapfupa aya achikundikana kushanda? Ndezvipi zvinokonzera?

Zvinhu zvinotevera zvinogona kukonzera njodzi yekukundikana kwemapfupa:

• Une Bone Marrow Failure Syndrome (iyo inogarwa nhaka).
• Une kenza yeropa, chimwe chirwere cheropa, kana zvimwe zvirwere zveropa, kenza, kana hutachiona (izvi zvinotanga gare gare, kureva kuti, ndezverudzi rwe `(Zvakawanikwa)`).
• Kusangana nemamwe makemikari nemishonga (izvi zvinowirawo pasi pechikamu che `(Zvakawanikwa)`).

Dzimwe nguva, chirwere ichi chinogona kuitika pasina chikonzero chakajeka. Vanachiremba vanochidanawo kuti " idiopathic bone marrow failure." Vaongorori vanotenda kuti pane hukama pakati pe autoimmunity ne bone marrow failure. Autoimmunity inguva apo masoja emuviri wako anorwisa bone marrow yako zvisizvo.

Zviratidzo zveKukundikana kweBone Marrow Zvakagara Nenhaka

Aya ndiwo mamwe ematambudziko anogarwa nhaka, ane hukama, kana ane zviratidzo zvakafanana:

• Congenital Agranulocytosis (Kostmann Syndrome): Izvi zvinokanganisa rudzi rwemasero machena eropa anonzi neutrophils.
• Congenital Amegakaryocytic Thrombocytopenia (CAMT): Mumamiriro ezvinhu aya, pane kudzikira kwehuwandu hwemasero anonzi megakaryocytes, anobatsira kugadzira maplatelet, mumongo wemapfupa ako.
• Diamond-Blackfan Anemia (Diamond-Blackfan Anemia): Ichi chirwere chisingaperi chinokanganisa kugadzirwa kwemasero matsvuku eropa.
• Dyskeratosis Congenita (Dyskeratosis Congenita - `(Dyskeratosis Congenita)`):Zviratidzo zvechirwere ichi zvinosanganisira kuchinja kweganda, izvo zvinogona kuva chiratidzo chekutanga chekukundikana kwemapfupa.
• Fanconi Anemia (Fanconi Anemia): Iyi ndiyo inowanzoonekwa sechirwere chebone marrow failure syndrome.
• Kusagadzikana kwemasero emuviri (Reticular Dysgenesis): Iyi imhando yeSevere Combined Immunodeficiency (SCID). Mumamiriro ezvinhu aya, muviri wako haugadziri T-cells dzakakura zvakakwana.
• Kurwara Kwakanyanya Kwepamuviri (Severe Congenital Neutropenia): Mumamiriro ezvinhu aya, ma neutrophils ako, rudzi rwemasero machena eropa, akaderera pane zvakajairika.
• Shwachman-Diamond Syndrome (Shwachman-Diamond Syndrome): Dambudziko iri rinokanganisa pancreas yako, bone marrow, nemapfupa.

Kana mumwe wevabereki vako aine chirwere ichi nezviratidzo (izvi zvinonzi ``Autosomal Dominant''), une mukana we50% wekuva nechirwere ichi uye kutanga bone marrow failure syndrome.

Zvisinei, kana vabereki vako vese vaine gene mutation ine chekuita nerudzi rumwe chete rwe bone marrow failure syndrome, asi hapana kana mumwe wavo ane zviratidzo (izvi zvinonzi ``Autosomal Recessive''), njodzi yako yekuva nechirwere ichi inoderedzwa kusvika pa25%.

Kenza dzeropa

Uri panjodzi huru yekukundikana kwemapfupa kana uine imwe yemhando dzekenza dzinotevera:

• Lymphoma
• Multiple Myeloma
• Chirwere cheMyelodysplastic

Zvimwe Zvirwere zveRopa

Vamwe vanhu vanozvarwa vaine zvirwere izvi. Vamwe vanokura nazvo nekufamba kwenguva. Izvi zvinosanganisira:

• Aplastic Anemia (Aplastic Anemia): Ichi chirwere cheropa chisingawanzoitiki. Chinokuvadza mupfupa wako uye chinoudzivirira kugadzira masero matsva eropa nemaplatelet. Vanachiremba vanogona kushandisa izwi rekuti "aplastic anemia" pavanotaura nezvekukundikana kwemupfupa.
• Cytopenias (Cytopenias): Izvi zvinosanganisira zvirwere zvakaita se autoimmune neutropenia, idiopathic neutropenia, uye large granular lymphocyte leukemia.
• Paroxysmal Nocturnal Hemoglobinuria (Paroxysmal Nocturnal Hemoglobinuria): Mumamiriro ezvinhu aya, masoja emuviri wako anoparadza masero matsvuku eropa.
• Aplasia Yemasero Matsvuku Akachena (Aplasia Yemasero Matsvuku Akachena): Ichi chirwere chinogara nhaka chinokanganisa kugadzirwa kwemasero matsvuku eropa.

Utachiona hwehutachiona

Utachiona hunotevera hunogonawo kuwedzera njodzi yako:

• Cytomegalovirus `(Cytomegalovirus)`
• Utachiona hweEpstein-Barr
• Virusi reHuman Immunodeficiency Virus (HIV)
• Parvovirus B19 `(Parvovirus B19)`
• Chiropa Chinokonzerwa neHutachiona

Kurapwa nemakemikari kana kuti nemwaranzi yegomarara kunogonawo kuwedzera njodzi yekukundikana kwemapfupa. Uyewo, kusangana nemakemikari nezvinonyungudutsa zvinoshandiswa mune mimwe mishonga yezvipembenene nezvipembenene zvinogona kuwedzera njodzi yako.

Ndezvipi zvinetso zvechirwere ichi?

Ichi chirwere chakakomba chinogona kuisa hupenyu panjodzi . Kunyangwe mushure mekurapwa, matambudziko anotevera anogona kuitika:

• Utachiona hwehutachiona kana hwehutachiona
• Kubuda ropa
• Kenza yeropa, semuenzaniso, acute myeloid leukemia kana myelodysplasia
• Mamwe mabundu ane kenza, semuenzaniso osteosarcoma uye rhabdomyosarcoma
• Kansa yeSquamous Cell

Unoona sei izvi?

Chiremba achatanga nekukubvunza nezvezviratidzo zvako, nhoroondo yako yezveutano, uye nhoroondo yezveutano hwemhuri yako. Vachakubvunzurudzawo. Vanogonawo kuraira kuongororwa kweropa uye kuongororwa kwemifananidzo.

Kuongororwa kweRopa

Kuongororwa kweropa kunogona kusanganisira:

• Kuedzwa kweCeruloplasmin
• Kuwanda Kweropa Rakazara (CBC)
• Kuedzwa kweFerritin
• Kuedzwa kweKushomeka kweFolate
• Bvunzo yeKushaikwa kweVitamin B12

Miedzo yeKufungidzira

Miedzo yekufungidzira inogona kusanganisira:

• Kufungidzira Magadzirirwo Emagineti (MRI - `(Kufungidzira Magadzirirwo Emagineti)` scan)
• Positron Emission Tomography (PET - `(Positron Emission Tomography)` scan)
• Kuongororwa kweUltrasound `(Ultrasound)`

Zvichibva pamhedzisiro yekuongororwa kweropa uye kuongororwa kwemifananidzo, chiremba wako anogona kukurudzira kuti uongorore mapfupa emubofu . Anogonawo kukurudzira kuti uongorore majini kuti uone shanduko dzemajini dzinokonzera kutadza kushanda kwemapfupa emubofu.

Chiremba wako anogonawo kuraira bvunzo dzekuongorora hutachiona hwakati kana kubvisa zvimwe zvirwere. Vachakutsanangurira kuti sei vari kuita bvunzo yega yega uye kuti bvunzo dzinogona kuratidza chii.

Ndezvipi zviri kurapwa?

Kurapwa kwaunowana kunoenderana nezvinhu zvakati wandei, zvinosanganisira:

• Rudzi rwekukundikana kwemupfupa (kureva kuti, kungave kuri kwenhaka kana kuti kwakawanikwa).
• Kuoma kwemamiriro ako ezvinhu.
• Zera rako nehutano hwako hwese.
• Zviratidzo zvako.

Sarudzo dzekurapa dzingasanganisira:

• Mishonga inorwisa mabhakitiriya , mishonga inorwisa fungus, uye mishonga inorwisa mavhairasi yekurwisa hutachiona.
• Kuwedzerwa ropa kuti kuwedzere huwandu hwemasero matsvuku eropa uye kuderedza zviratidzo zvakaita sekubuda ropa uye kuneta.
• Zvinokurudzira mapfupa emumaronda zvinobatsira mapfupa ako kugadzira masero eropa akawanda.
• Mishonga inodzvinyirira muviri inobatsira kudzivirira masoja emuviri wako kurwisa mupfupa wako.
• Kudyara Sero reAllogeneic Stem (Bone Marrow) .

Pane migumisiro kana matambudziko ekurapwa here? (Matambudziko Ekurapwa)

Matambudziko nemigumisiro inosiyana zvichienderana nekurapwa, asi kuisirwa masero emuviri (bone marrow) ndiko kunonyanya kukonzera matambudziko makuru. Izvi zvinosanganisira chirwere chegraft-versus-host (GVHD) uye hutachiona.

Hupenyu huchava hwakaita sei kana paine dambudziko iri? (Kufungidzira)

Zvaungatarisira mushure mekurapwa (kufanotaura chirwere) zvinoenderana nezvinhu zvakati wandei, zvinosanganisira rudzi rwechirwere, zera rako uye hutano hwako hwese, uye kuti muviri wako unopindura sei kurapwa.

Kazhinji, vanhu vane kutadza kushanda zvakanaka kwemapfupa vanoda rubatsiro rwechiremba nguva dzose . Asi havasi vese vakafanana. Ziva mamiriro ako chaiwo, uye bvunza chiremba wako kuti chii chinozoitika mushure mekurapwa kwako kwekutanga.

Kukundikana kwemubofu kunokonzera rufu here? (Chirwere chinouraya here?)

Ichi chirwere chakakomba zvikuru uye chinoisa hupenyu panjodzi . Vanhu vazhinji vane kutadza kushanda zvakanaka kwemapfupa vanorapwa nenyanzvi dzine ruzivo dzakadai sevanachiremba vekenza nevanoongorora ropa.

Chii chingataurwa nezvenguva yekurarama kwevarwere ava? (Kutarisira Kurarama)

Nguva inotarisirwa kurarama inofungidzirwa kuti munhu achararama kwenguva yakareba sei mushure mekurapwa kwechimwe chirwere. Nguva inotarisirwa kurarama yevanhu vane kutadza kushanda kwemapfupa inogona kubva pamwedzi mishoma kusvika kuhupenyu hwese.

Asi, iwe wakakosha, uye ruzivo rwako runogona kusiyana nerwevamwe vese. Bvunza chiremba wako nezvezvaungatarisira, uye kuti ungatarisira kurarama kwenguva yakareba sei. Ndivo vanonyanya kukupa ruzivo, nekuti vanoziva iwe nemamiriro ako ezvinhu.

Njodzi inogona kuderedzwa here? (Kuderedza Njodzi)

Zvinosuwisa kuti hapana nzira yekuderedza njodzi yekukundikana kwemapfupa emupfupa. Zvisinei, kudzivisa makemikari anozivikanwa kuti anoderedza kushanda kwemapfupa emupfupa kunogona kuderedza njodzi yekukundikana kwemamwe mapfupa emupfupa. Uyewo, kurapwa kwekutanga kunogona kubatsira kuderedza zviratidzo zvako uye kuvandudza hupenyu hwako.

Ndingazvitarisira sei? (Kuzvitarisira)

Chinhu chakanakisa chekuita ndechekuchengetedza hutano hwako hwese . Semuenzaniso, usashandise fodya, usazvidya mwoyo kana kurega kunwa doro. Heano mamwe mazano:

• Ona chiremba wako nguva dzose. Kusashanda zvakanaka kwemapfupa kunogona kuva chirwere chehupenyu hwese. Ungangoda kurapwa nguva dzose. Zvinogonawo kukonzera matambudziko matsva ehutano. Saka zvakakosha kuti ugare uchiongororwa. Chiremba wako achaongorora hutano hwako hwese uye acharapa matambudziko matsva.
• Idya chikafu chine hutano. Zviratidzo zvako nemigumisiro yekurapwa kwako zvinogona kuita kuti zvikuomere kudya kana kurasikirwa nechido chako chekudya. Kana usina chokwadi kana uri kuwana chikafu chaunoda, taura nenyanzvi yezvekudya. Vanogona kukupa mazano akakodzera.
• Ita maekisesaizi. Kuva nechirwere chakakomba chehutano chakadai sekutadza kushanda zvakanaka kwemapfupa kunogona kunetsa. Kuekisesaiza inzira yakanaka yekuderedza kushushikana. Iva nechokwadi chekutaura nachiremba wako usati watanga maitiro matsva ekurovedza muviri.

Unofanira kuenda kuEmergency Treatment Unit (ETU) riini?

Kana uine dambudziko remapfupa, uri panjodzi huru yekutapukirwa nezvirwere uye matambudziko ekubuda ropa. Unofanira kuenda kuchipatara kana ukasangana nechimwe chezvinotevera:

• Kuva nefivha isingaderere kunyangwe mushure mekutora mushonga unowanzo rwadza
• Kunzwa kutonhora uye kudedera (kutonhora)
• Kubuda ropa kusingadzivisiki

Mibvunzo ipi yandinofanira kubvunza chiremba?

Ungave uine kutadza kushanda zvakanaka kwemapfupa nekuda kwezvimwe zvirwere zvawakazvarwa uri wega. Asi dzimwe nguva zvinogona kuitika pasina chikonzero chakajeka. Unogona kubvunza chiremba wako mibvunzo yakaita seiyi:

• Unoziva here kuti sei ndiine dambudziko iri remabhonzo?
• Ndedzipi nzira dzekurapa dzandinadzo?
• Ndichazofanira kurapwa nekusingaperi here?
• Izvi zvinogona kurapwa here?

Kana uine dambudziko remapfupa asina kusimba, ungave watove nedambudziko guru rehutano, rakadai sechirwere chekuzvarwa nacho, chirwere cheropa, kana kenza. Kuongororwa uku kutsva kunogona kunge kuri kukonzera mibvunzo mitsva yakawanda uye zvinokunetsa, izvo zvinogona kukuremera. Zvakajairika kuti unzwe kunetseka nekuti ichi chinogona kuva chirwere chinoisa hupenyu panjodzi. Taura nechikwata chako chekurapa nezvezvaunotarisira uye zvekuita zvinotevera. Vachafara kupindura mibvunzo yako.

Rangarira sechidimbu (Mharidzo Yekuenda Kumba)

Kukundikana kwemapfupa emapfupa chirwere chakakomba uye chakaoma kunzwisisa . Asi yeuka, kune zvikonzero zvakawanda zvinogona kukonzera, uye kune nzira dzakasiyana siyana dzekurapa uye nzira dzekutarisira. Chinhu chakakosha ndechekuwana chirwere nekukurumidza, kutsvaga kurapwa kubva kune nyanzvi dzakakodzera, uye kuramba uchitevera mirairo iyoyo.Kana muine mibvunzo kana zvinokunetsai nezvenyaya iyi, musatya kutaura nachiremba wenyu. Varipo kuti vakubatsirei.

Kukundikana kweBone Morrow, Masero Matsvuku Eropa, Masero Machena Eropa, Maplatelet, Kudyara Masero Ekutanga, Zvirwere zveBone Morrow