Chii chinonzi G-CSF (Granulocyte-Colony Stimulating Factor)? Sei ichikosha pakurapa kenza?

Ungave wakaona mumwe munhu mumhuri yako, hama kana shamwari achirapwa gomarara. Unofanira kunge wakanzwa nezvekurapa kunonzi "Chemotherapy" pakurapa kwakadaro. Pamwe unozivawo kuti panguva yekurapwa kwechemo, huwandu hwemasero machena eropa anorwisa zvirwere mumuviri hunoderera. Mumamiriro ezvinhu akadaro, munyaya ino, tichataura nezvemushonga unoshandiswa navanachiremba kubatsira dziviriro yemuviri wedu. Ndiyo G-CSF.

Chii chaizvo chinonzi G-CSF?

Zvichitaurwa zviri nyore, G-CSF mushonga unobatsira miviri yedu kugadzira masero machena eropa akawanda, kunyanya rudzi runonzi "neutrophils."

Fungidzira kuti muviri wedu wakaita senyika. Saka ma neutrophils aya akafanana nemasoja ari munyika iyoyo. Masoja aya anonzi ma neutrophils anorwisa utachiona hwekunze, kureva vavengi vakaita semabhakitiriya nemavhairasi, uye anotidzivirira kubva kuzvirwere nehutachiona. Saka chii chinoitika kana masoja aya akadzikira? Nyika yedu, kureva muviri wedu, inova nyore kubatwa nezvirwere.

Kunyange zvazvo zita rekuti G-CSF ringaita serakaoma zvishoma, kana tikatsanangura zvarinoreva, zviri nyore kwazvo.

• Granulocyte: Iri ndiro zita rinopiwa rudzi rwemasero machena eropa. MaNeutrophils rudzi rwegranulocyte zvakare.
• Chinhu Chinosimudzira Matumbu: Ichi chinhu "chinoraira" kana "kukurudzira" masero. Kufanana nemaneja wefekitori anopa mabasa kuvashandi, puroteni iyi inoenda kumongo wedu wemapfupa yoti, "Zvakanaka, tanga kugadzira ma neutrophils izvozvi."

Saka mushonga uyu unonzi G-CSF unoenda kumapfupa emapfupa , inova chikamu chakaita sechipanji chiri mukati memapfupa edu, uye unoudza masero emuviri aripo kuti, "Imi varume munofanira kukurumidza kuva ma neutrophils, uye ma neutrophils aripo anofanira kupatsanurana nekuwanda." Zvadaro varwi ava vatsva vema neutrophil vanobatana neropa votanga kushanda kutidzivirira.

Mumamiriro api ezvinhu apo G-CSF inoshandiswa?

G-CSF inonyanya kushandiswa kurapa nekudzivirira chirwere chinonzi "neutropenia." Neutropenia ingori nhamba yakaderera pane yakajairika yema neutrophils muropa.

Mukurapa kenza (Chemotherapy)

Mishonga yechemotherapy inoshandiswa mukurapa kenza yakagadzirirwa kuuraya masero ekenza anokamura nekukurumidza. Zvisinei, mishonga iyi haigone kuziva masero ekenza chete, asiwo masero ane hutano anokamura nekukurumidza mumuviri wedu. Saka, sezvo ma neutrophils, anogadzirwa mumongo wemapfupa, ariwo rudzi rwemasero anokamura nekukurumidza, anokuvadzwawo nemishonga yechemotherapy.

Izvi zvakafanana nekupfapfaidza mushonga wesora kuti ubvise sora, asi zvinokuvadzawo zvirimwa zvakanaka.

Ndosaka neutropenia ichiwanzoitika mushure me chemotherapy. Kana chirwere ichi chikanyanya kuipa, kunyangwe hutachiona hudiki hunogona kuisa hupenyu panjodzi. Muzviitiko zvakadaro, vanachiremba vanokurudzira G-CSF kuderedza njodzi yekutapukirwa uye kudzoreredza dziviriro yemuviri.

Mukuisa stem cell

Mune mamwe marudzi egomarara nezvirwere zveropa, kuisirwa stem cell kunoda kuitwa. G-CSF inoshandiswa usati waita izvi uye mushure mazvo.

• Usati waisirwa: Kana murwere akapihwa G-CSF, mupfupa unoburitsa huwandu hwakawanda hwemasero ekutanga uye unoaburitsa muropa. Vanachiremba vanobva vatora masero ekutanga iwayo ane hutano kubva muropa.
• Panguva yekuisirwa masero: Tevere, kurapwa ne chemotherapy yakawanda kana nemwaranzi kunoparadza chero masero asina kujairika asara mumuviri.
• Mushure mekuisirwa masero eropa: Pakupedzisira, masero eropa akange aunganidzwa kare anozodzorerwa mumuviri. Masero aya anozova masero eropa matsva ane hutano.

Kana uri munhu anopa masero ekutanga emuviri, ungangodawo kubaiwa jekiseni reG-CSF usati watanga kurapwa.

Zvimwe zvirwere zvinokonzera kuderera kwemasero machena eropa

Mazinga eNeutrophil anogonawo kuva akaderera nekuda kwemamwe mamiriro ezvinhu aripo pakuzvarwa (neutropenia yakanyanya yekuzvarwa nayo) kana muzviitiko apo chikonzero chisingazivikanwi (idiopathic neutropenia). Muzviitiko zvakadaro, G-CSF inoshandiswa kuwedzera mazinga eNeutrophil.

Mhando dzeG-CSF uye kuti dzinopihwa sei

G-CSF inowanikwa pamusika nemazita akasiyana-siyana. Mhando mbiri dzinonyanya kushandiswa ndeidzi:

1. Filgrastim: Iyi imhando yemushonga unoshanda kwenguva pfupi. Inowanzo fanirwa kupihwa jekiseni zuva nezuva.

2. Pegfilgrastim: Uyu mushonga unoshanda kwenguva refu, saka kazhinji zvakakwana kuti munhu abaiwe jekiseni rimwe chete pakati pemakemikoro maviri ekurapa chemotherapy.

Mishonga iyi inowanikwa pasi pemazita akasiyana-siyana emhando dzakasiyana uye biosimilars. Semuenzaniso, chiremba wako anogona kukuudza nezvemazita akaita seNeupogen®, Neulasta®, Nivestym®, uye Zarxio®.

Mushonga uyu unopihwa sei mumuviri?

G-CSF inowanzopihwa jekiseni repasi peganda , asi mune dzimwe nguva inogonawo kupihwa semushonga wemutsinga .

• Ungangofanira kuenda kukiriniki zuva rega rega kuti upihwe majekiseni.
• Kana kuti, mukoti achakudzidzisa zvakajeka iwe kana nhengo yemhuri mashandisirwo ekubaiwa jekiseni kumba. Hazvina kuoma kudaro.

Munhu wese anoda G-CSF here?

Kwete. G-CSF haipiwi kune wese munhu ari kurapwa nechemotherapy kana ane ma neutrophils mashoma. Kufanana nemushonga upi zvawo, G-CSF ine mabhenefiti pamwe nenjodzi dzemigumisiro. Chiremba wako achafunga nezvezvinhu zvakati wandei asati akupa mushonga uyu.

• zera rako
• Hutano hwako hwese
• Rudzi rwegomarara raunaro
• Rudzi rwe chemotherapy yauri kugamuchira
• Kana uchitova nezviratidzo zve neutropenia (zvakadai sefivha)

Mabhenefiti uye migumisiro inogona kuitika yeG-CSF

Kana G-CSF ikakurudzirwa, yeuka kuti mabhenefiti acho anopfuura njodzi dziripo.

Zvakanakira zvikuru:

• Njodzi yezvirwere zvakakomba, zvinogona kuisa hupenyu pangozi inoderera zvakanyanya.
• Kuderera kwemazinga e neutrophil kunogona kudzivirira chemotherapy kuti isanonoke kana kuderedzwa kwemushonga , zvichiita kuti kurapwa kwegomarara kurambe kuripo sezvakarongwa.

Migumisiro inogona kuitika

Migumisiro yakawanda inongoitika kwenguva pfupi uye inonyangarika mushure mekunge G-CSF yamiswa.

Zvinhu zvekurangarira kana uchitora G-CSF

• Udza chiremba wako nhoroondo yako yese yezvekurapa. Iva nechokwadi chekumuzivisa nezvezvimwe zvirwere zvaunazvo uye mimwe mishonga yauri kutora (kusanganisira mavhitamini).
• Hazvikurudzirwi kutora G-CSF kana uine pamuviri, uchiedza kuva nepamuviri, kana kuti uchiyamwisa . Taura nachiremba wako nezvenyaya iyi.
• Usazvidya mwoyo nezvemigumisiro yakaipa. Kana ukasangana nemigumisiro yakaipa, udza chiremba wako kana nesi. Vachakubatsira kuigadzirisa.
• Ongororo dzeropa rako nenguva. Chiremba wako achaongorora huwandu hwema neutrophil ako uye achaona kuti mushonga unodiwa kwenguva yakareba sei.

G-CSF chinhu chakakosha zvikuru mukurapa kenza. Inopa simba guru rekuita kuti kurapwa kwechemotherapy kuve kwakachengeteka uye kubudirire. Kana muine mimwe mibvunzo nezveizvi, ndapota musazeza kubvunza chiremba wenyu ari kurapa.