Dzimwe nguva unongorwadziwa nemudumbu here? Kana kuti unonzwa kuneta zvisina kujairika pasina chikonzero chaicho? Pamwe unofunga kuti zvine chekuita nezvauri kudya mazuva ano, kana kuti pamwe inyaya ye gastritis. Ndizvo zvinogona kuitika muzviitiko zvakawanda. Asi, kunyangwe zvisingawanzoitiki, zviratidzo izvi zvinogonawo kuva chiratidzo chegomarara risingawanzoitiki, risingawanzoitiki. Ndizvo zvatichataura nezvazvo nhasi. Ndiyo GIST, kana Gastrointestinal Stromal Tumor. Usatye kana ukanzwa zita racho, tichataura nezvese zviri nyore uye zvakajeka.
Zvichitaurwa zviri nyore, chii chinonzi GIST iyi?
GIST inomiririra Gastrointestinal Stromal Tumor . Ngatitsanangure mashoko aya.
- Matumbu: Izvi zvinoreva sisitimu yedu yekugaya chikafu. Kureva, nzira inofamba chikafu chatinodya - muromo, gurokuro, dumbu, ura diki, uye ura hukuru.
- Stromal: Izvi zvinoreva rudzi rwakakosha rwenyama inowanikwa mumadziro enhengo dzedu uye inoshanda sechitsigiro chenhengo idzodzo.
- Bundu: Pamwe wakambonzwa nezverino. Izvi zvinoreva bundu.
Zvichitaurwa zviri nyore, GIST igomarara rinotanga mumhando chaiyo yesero mumadziro enhengo iri mudumbu redu (kazhinji mudumbu kana muura hudiki).
Iyi imhando yegomarara isingawanzoonekwi iri muboka remasarcoma enyama dzakapfava. Mumadziro edumbu redu, mune masero akakosha anonzi ``interstitial cells of Cajal``. Funga nezvemasero aya seanogadzirisa mafambiro edumbu redu. Masero aya anobatsira kudzora rhythmic contractions inodiwa kuti chikafu chipinde mudumbu. Matumbu eGIST anoumbwa kana paine chikanganiso mumasero aya, zvichiita kuti apatsanuke zvisingadzoreki.
Ma cysts aya dzimwe nguva anogona kuva madiki sepenzura. Kana ari madiki, anogona kugara kwemakore asingaratidzi zviratidzo. Zvisinei, mamwe ma cysts anokura zvishoma nezvishoma uye anotanga kukonzera zviratidzo zvinotikonzera kusagadzikana.
Ndezvipi zviratidzo zvinogona kukonzera GIST?
Kazhinji, bundu iri rinowanikwa netsaona panguva yekuongororwa kana kuvhiyiwa kunoitwa nechimwe chikonzero, pasina zviratidzo. Asi kana zviratidzo zvikaitika, zvinogona kutaridzika seizvi. Ngatizviisei patafura iri nyore kunzwisisa.
| Chiratidzo | Manzwiro aungaita |
|---|---|
| Kurwadziwa kwemudumbu kana kusagadzikana | Zvinogona kungova kurwadziwa mudumbu, kunzwa kuguta, kana kunzwa sekunge chimwe chinhu chakabatirira panzvimbo imwe chete. |
| Kubuda ropa kana uchienda kuchimbuzi | Izvi zvinogona kuva zvitsvuku, seropa. Kana kuti zvinogona kuva zvitema, zvitete, uye zvinonamira. Izvi zvinokonzerwa nekubuda ropa mudumbu. |
| Kurutsa ropa | Kana uchirutsa, unogona kuona ropa dzvuku kana chimwe chinhu chitema chakaita sekofi yakakuyiwa. |
| Kuneta | Uku hakusi kuneta chete. Kunzwa kuneta kwezuva rese kusingapere kunyangwe mushure mekurara zvakanaka husiku. Dambudziko iri rinogona kukonzerwa nekushaya ropa, inova chirwere chinokonzerwa nekubuda ropa mukati memuviri. |
| Kuderedza uremu pasina kuedza | Kana ukangoerekana wadzikira uremu usina kudya zvakanaka kana kurovedza muviri, kunyangwe uri kudya zvakajairika, chinhu chekufunga nezvacho. |
| Kurasikirwa nechido chekudya uye kuvimbiwa | Ungasada kudya, kunzwa kuguta kunyangwe mushure mekudya zvishoma, kana kunetseka kuenda kuchimbuzi. |
Yeuka, havasi vese vane zviratidzo izvi vane GIST. Izvi zvinoitika kune zvimwe zvirwere zvakawanda. Asi kana zviratidzo izvi zvikaramba zviripo, zvakanaka kuti uone chiremba kuti aongororwe.
Sei GIST iyi ichikura? Chii chinokonzera?
Kazhinji, chikonzero chikuru cheGIST kuchinja kwemajini edu. Funga nezvemajini ari mumuviri wedu sebhuku remirairo yemuviri wedu kuti ukure uye ushande. Pane peji mubhuku remirairo iri rinonzi `(KIT gene)`. Sekureva kwemirairo iri papeji rino, masero anonzi `(interstitial cells of Cajal)` atakataura nezvawo kare anoumbwa uye anodzorwa.
Asi dzimwe nguva, bhii kana shoko rinopereterwa zvisirizvo papeji iri rekuti `(KIT gene)`. Zvakafanana nekukanganisa kwekunyora. Mukurapa, izvi zvinonzi `(mutation)`. Nekuda kwekukanganisa uku, jini reKIT rinopa mirairo isiriyo yekugadzira puroteni yakakosha inonzi `(KIT CD117)`. Nekuda kwepuroteni iyi isiriyo, masero iwayo anogara achiwana chiratidzo chekuti "ramba uchipatsanura, ramba uchipatsanura." Ndipo apo masero iwayo anokura zvisingadzoreki uye ogadzira bundu.
Kuchinja kwemajini uku kunowanzoitika zvisina tsarukano muhupenyu hwedu. Kureva kuti, hazvisi zvinhu zvatinozvarwa nazvo.
Zvisinei, kashoma, chirwere ichi chinogona kusanganiswa nemamiriro ezvinhu emumajini anopfuudzwa kubva kuchizvarwa kuenda kune chimwe. Zvimwe zvezviitiko izvi zvinosanganisira:
- Chirwere cheGIST chemhuri: Ichi chirwere chisingawanzoitiki. Muchiitiko ichi, mwana anogara nhaka gene reKIT rakakanganisika kubva kumubereki mumwe chete. Muchiitiko ichi, mabundu eGIST anogona kukura achiri mudiki, kana kuti mabundu anopfuura rimwe chete anogona kukura.
- Neurofibromatosis rudzi 1: Ichi chirwere chinokonzerwawo nemajini. Chinokonzera bundu mutsinga dzemuviri. Vanhu vane chirwere ichi vane mukana wakakura wekuva neGIST kupfuura vanhu vose.
- Carney-Stratakis syndrome: Ichi chirwere chisingawanzoitiki, chinogara nhaka. Vanhu vane chirwere ichi vari panjodzi yakakura yekubatwa neGIST.
Vanachiremba vanoongorora sei chirwere cheGIST?
Paunoenda kunoona chiremba ane zviratidzo zvataurwa pamusoro apa, anotanga akubvunza nezvezviratidzo zvako. Kuti zvagara kwenguva yakareba sei, kuti zvinonzwa sei, nezvimwewo. Zvadaro achakuongorora. Pamusoro pezvo, achakurudzira bvunzo dzinoverengeka kuti aone chikonzero chaicho chechirwere.
Miedzo mikuru yakaitwa
- Endoscopy yepamusoro: Iyi ndiyo bvunzo yekutanga inotorwa. Muchidimbu, chubhu ine kamera diki yakabatana nayo inopinzwa nemuromo uye gurokuro, dumbu, uye chikamu chekutanga cheura hudiki zvinoongororwa. Izvi zvinogona kutarisa zvakananga bundu uye kubuda ropa.
- CT scan: Izvi zvinotora mifananidzo yemukati memuviri wedu. Zvakafanana nekucheka chidimbu chechingwa. Izvi zvinogona kuratidza zvakajeka kukura kwebundu, nzvimbo yaro, uye kana rakapararira kune dzimwe nhengo, dzakadai sechiropa.
- Kuongororwa kwemuviri:Iyi ndiyo bvunzo inonyanya kukosha yekusimbisa chirwere ichi 100% yenguva. Panguva ye endoscopy kana imwe nzira, chidimbu chidiki chenyama chinotorwa kubva mubundu rinofungidzirwa. Zvadaro, nyama yacho inoongororwa pasi pemakroskopu murabhoritari kuti ione kana iri masero eGIST.
- Kuongororwa kwePET: Mune zvimwe zviitiko, kunyanya kana paine fungidziro yekuti kenza yapararira kune dzimwe nhengo dzemuviri, bvunzo iyi inogona kuitwa.
Ndezvipi zvirongwa zvekurapa GIST?
Kurapwa kweGIST kunoenderana nehukuru hwebundu, nzvimbo yaro, uye kana rapararira kune dzimwe nzvimbo. Kune mhando mbiri huru dzekurapa.
1. Kuvhiyiwa:
Kazhinji, mushonga wakanakisa weGIST bundu ndekubvisa bundu racho zvachose nekuvhiyiwa. Kana bundu iri diki uye risati rapararira kune dzimwe nzvimbo, kuvhiyiwa chete ndiko kunogona kurapa chirwere chacho zvachose.
2. Kurapa Kwakanangwa:
Ichi ndicho chinhu chinochinja-chinja pakurapa kweGIST. Kusiyana nechemotherapy yenguva dzose, mishonga iyi yakaita se "smart bombs." Inonanga zvakananga protein yeKIT isina kunaka yatakambotaura nezvayo. Nokudaro, hapana kukuvara kudiki kumasero ane hutano.
- Usati wavhiyiwa: Kana bundu iri rakakura zvikuru uye rakaoma kuvhiyiwa, kurapwa uku kwakanangana kunotanga kwaitwa uye kuvhiyiwa kunoitwa mushure mekunge bundu radzikira.
- Mushure mekuvhiyiwa: Kana paine njodzi yekuti chirwere ichi chidzokezve mushure mekuvhiyiwa, mishonga iyi inopihwawo kuderedza njodzi iyoyo.
- Kana kenza yapararira: Kana bundu rapararira zvakanyanya zvekuti haringabviswi, ungangoda kutora mishonga iyi kweupenyu hwako hwese kuti udzore chirwere uye uderedze zviratidzo.
Chii chaungatarisira kana uchirarama nechirwere cheGIST?
Mushure mekurapwa, zviratidzo zvinogona kuvandudzika, uye dzimwe nguva chirwere chinogona kupora zvachose. Zvisinei, GIST chirwere chine mukana wekudzoka. Saka, zvakakosha kuti ugare uchitaurirana nachiremba wako wekenza uyo achakutarisira kunyangwe mushure mekurapwa.
Uchasangana nachiremba wako mwedzi mitatu kusvika mitanhatu yega yega. Munguva iyi, bvunzo dzichaitwa kuti uone kana paine zviratidzo zvekudzokera shure kwechirwere.
- `CT scans`
- `Kuongororwa kweMRI`
- `Kuongorora PET`
Tinoita bvunzo dzakadai kuti tive nechokwadi chekuti zvese zviri kufamba zvakanaka.
Kana uchitaura nezvegomarara, ungangove wakanzwa nezvenhamba dzakadai se "Survival Rate". Pamusoro peGIST, data rinoratidza kuti 85% yevanhu vapenyu makore mashanu mushure mekuonekwa vaine chirwere ichi. Asi usavhunduke nenhamba dzakadaro. Idzi ingori avhareji chete zvichibva panhamba kubva kuzviuru zvevarwere. Mamiriro ako ezvinhu anogona kunge akasiyana zvakanyanya. Saka, taura pachena nachiremba wako nezvechirwere chako, kubudirira kwekurapwa kwako, uye zvaunotarisira. Iye achakupa ruzivo rwakasiyana newe.
Nekuti GIST chirwere chisingawanzoitiki, zvakajairika kunzwa kushamisika uye kutya paunonzwa nezvazvo. Asi yeuka, ikozvino kune mishonga inoshanda kwazvo yechirwere ichi. Hausi wega. Chikwata chako chekurapa, mhuri, neshamwari dziripo kuti dzikubatsire. Dzidza nezvechirwere ichi, bvunza mibvunzo, uye tarisa kurapwa zvakanaka.
Mharidzo Yekuenda Nayo Kumba
- GIST (Gastrointestinal Stromal Tumor) ibundu regomarara risingawanzoitiki rinoumba madziro emudumbu medu.
- Kazhinji hapana zviratidzo, asi zviratidzo zvakaita sekurwadziwa mudumbu, kuneta, ropa mutsvina, uye kudzikira kwehuremu zvinogona kuitika.
- Kana uine zviratidzo izvi, usavhunduka wobva waona chiremba nekukasika.
- Chikonzero chikuru cheGIST kuchinja (mutation) mumajini.
- Chirwere ichi chinogona kudzorwa uye kurapwa kuburikidza nekuvhiyiwa uye kurapwa kwakanangana nepfungwa kunoshanda zvikuru.
- Kunyangwe mushure mekurapwa, zvakakosha zvikuru kuteverwa panguva yakatarwa.
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