Kurwadziwa kwemudumbu hakusi kungorwadziwa nemudumbu chete here? Ngatitaurei nezve GIST (Gastrointestinal Stromal Tumor)!

Dzimwe nguva une dambudziko remudumbu here, kana kurwadziwa nemudumbu, kana kunzwa kuremerwa? Dzimwe nguva tinofunga kuti chikafu chakaipa, "gastric upset", kana kungoti "flatulence". Asi, funga nezvazvo, dzimwe nguva panogona kunge paine nyaya yakakomba iri shure kwezviratidzo zvidiki zvakadaro. Chimwe chakadaro, chisingawanzoitika, asi chakakosha kuziva nezvechirwere chegomarara iGIST, iyo inomiririra Gastrointestinal Stromal Tumor . Ngatitaurei nezveizvi zvakadzama, asi zviri nyore, zvakanaka here?

Chii chinonzi bundu iri remudumbu (GIST)?

Zvichitaurwa zviri nyore, maGIST mabundu ekenza anoumbwa mumadziro enzira yako yekugaya chikafu —chikamu chemuviri wako umo chikafu nechinwiwa zvinofamba kubva mumuromo mako zvichienda mudumbu mako uye zvobva zvapinda muura hwako kuti zvigayiwe. Mabundu aya, kutaura chokwadi, anowira mune chinonzi nachiremba ' soft tissue sarcoma.'

Zvino funga nezvazvo, mamwe mabundu eGIST madiki zvikuru, sepenzura kana pizi. Kana riri bundu diki kwazvo, ungasatomboriona kana kunzwa kurwadziwa. Zvisinei, mamwe mabundu anotanga kukura nekufamba kwenguva. Ndipo apo maGIST aya anogona kutanga kukukonzera zviratidzo zvakasiyana-siyana nezvimwe zvinetso zvehutano. Kazhinji, vanachiremba vanorapa chirwere ichi cheGIST nekuvhiya kubvisa bundu kana mabundu zvachose.

Chirwere ichi chinonzi GIST chakajairika zvakadii?

Kutaura zvazviri, GIST rudzi rwegomarara rusingawanzoonekwi . Kunyangwe kana ichienzaniswa nedzimwe nyika pasi rose, zvakafanana. Semuenzaniso, munyika yakaita seUnited States, vanhu vanosvika 4,000 kusvika 6,000 chete vanobatwa neGIST gore rega rega. Saka unogona kufungidzira kuti chirwere ichi hachiwanzoonekwi. Ndosaka zvichikosha kuti uzive nezvazvo, kuitira kuti kana ukaona zviratidzo, ugone kutsvaga rubatsiro rwechiremba nekukurumidza.

Ndezvipi zviratidzo zveGIST?

Sezvatakambotaura, kana bundu reGIST riri diki, ungasaona zviratidzo. Kazhinji, bundu reGIST rinowanikwa netsaona panguva yekuedzwa, senge kuskena mudumbu, kana panguva yekuvhiyiwa kumwe.

Zvisinei, bundu parinokura, kana zvichienderana nenzvimbo yaro, zvimwe zviratidzo zvinogona kuoneka. Izvi ndizvo zviratidzo zvinonyanya kuzivikanwa:

• Kunzwa kurwadziwa mudumbu kana kusagadzikana . Izvi zvinogona kungova kunzwa kuguta kana chimwe chinhu chakanamira mudumbu mako.
• Ropa riri mutsvina yako kana tsvina ine ropa. Dzimwe nguva tsvina inogona kunge yakasviba, izvo zvinoratidzawo kubuda ropa mukati.
• Kuzvimba zvinoreva kusaita tsvina kwemazuva akati wandei.
• Nguva dzoseKunzwa kuneta zvakanyanya uye kuneta . Sekunge pasina hupenyu mumuviri.
• Kuderedza uremu pasina kuedza.
• Kushaya chikafu zvinoreva kusada kudya.
• Kurutsa ropa . Ichi chiratidzo chakakomba.

Kana wave uine chimwe chezviratidzo izvi kwenguva yakati, kuchenjera kuona chiremba woongororwa, pane kungozvibvunza kuti, "Chii ichocho?"

Ndezvipi zvikonzero zveGIST?

Kazhinji, GIST inokura kana paine shanduko, kana kuti mutation, mu gene inonzi KIT mumuviri wedu. Funga nezvazvo, gene iyi yeKIT yakaita semutumwa mudiki anoudza mamwe masero ari mudumbu redu kuti "aparadzane uye awedzere." Saka, kana paine chikanganiso mu gene iyi, masero iwayo anotanga kupatsanurana nekuwanda nekukurumidza uye zvisingadzoreki. Bundu iroro, kana kuti GIST, rinoumbwa kana masero iwayo achikura zvisingadzoreki. Kuchinja kwemajini uku kunowanzoitika mushure mekuzvarwa kwedu, munguva yehupenyu hwedu. Haisi chinhu chinogarwa nhaka kubva kuvabereki kuenda kuvana.

Jini reKIT iri rinoudza masero kuti agadzire puroteni inonzi KIT CD117 . Puroteni iyi inokurudzira kupatsanurwa kwemasero mugadziriro yekugaya chikafu. MuGIST, maitiro aya anoenda zvisina kunaka, zvichikonzera bundu.

Zvisinei, kunyange zvazvo zvisingawanzoitiki, mamwe mamiriro ezvinhu anogarwa nhaka anogona kuwedzera zvishoma njodzi yekubatwa neGIST. Mamwe ematambudziko aya anosanganisira:

• Familyal GIST syndrome: Izvi hazviwanzoitiki. Chinoitika pano ndechekuti chikanganiso mujini reKIT chinotorwa kubva kuvabereki kuenda kuvana. Kana izvi zvikaitika, njodzi yekubatwa neGIST inowedzera. Uyewo, GIST inogona kukura pazera diki kupfuura zvakajairika uye bundu rinopfuura rimwe chete rinogona kukura.
• Neurofibromatosis rudzi 1: Ichi chirwere chinokonzerwa nemajini. Chinokonzera kuti mamwe marudzi emasero akure asingadzoreki uye agadzire mamota muzvikamu zvakasiyana zvemuviri. GIST imwe yemhando yemota inogona kukura nenzira iyi.
• Carney-Stratakis syndrome: Ichi chirwere chisingawanzoitiki, chinogara nhaka. Vanhu vane chirwere ichi vari panjodzi huru yekubatwa neGIST kupfuura vamwe.

GIST inoonekwa sei?

Paunoenda kunoona chiremba ane zviratidzo zvataurwa pamusoro apa, anotanga akubvunza nezvezviratidzo zvako, kuti zvagara kwenguva yakareba sei, uye ozoongorora muviri wako . Izvi zvinoreva zvinhu zvakaita sekunzwa dumbu rako.

Pamusoro pezvo, chiremba wako anogona kuraira mimwe miedzo yakawanda kuti aone kana une GIST, saizi yayo, uye kana yapararira. Mimwe mikuru ndeiyi:

• Endoscopy yepamusoro:Izvi zvinosanganisira kuisa chubhu ine kamera diki mumuromo mako woongorora mukati mehuro mako, gurokuro (pombi yechikafu), uye dumbu. Izvi zvinokutendera kuti uone zvakananga kana paine chimwe chinhu, senge bundu.
• CT scan: Izvi zvinoshandisa X-rays kutora mifananidzo yakadzama yemukati medumbu rako. Izvi zvinogona kubatsira kuona saizi nenzvimbo yebundu.
• Kuongororwa kwePositron emission tomography (PET): Uku kuongororwa kwakasiyana-siyana. Kunobatsira kuona kuti masero egomarara anoshanda zvakadii uye kana akapararira kune dzimwe nhengo dzemuviri.
• Biopsy: Iyi ndiyo bvunzo inoshandiswa kuona kana uine GIST. Izvi zvinosanganisira kutora chidimbu chidiki chenyama kubva pabundu wochiongorora uchishandisa maikorosikopu nachiremba wezvirwere . Izvi zvinobatsira kuona kana iri GIST kana chimwe chinhu. Dzimwe nguva biopsy inogona kuitwa panguva imwe chete ne endoscopy.

GIST inorapwa sei?

Munhu mukuru anorapa GIST ndichiremba wekenza . GIST inowanzo shandiswa kuvhiya kubvisa bundu. Zvisinei, mhando yekurapa yakakunakira inoenderana nezvinoonekwa nebvunzo. Izvi zvinoreva kuti vanachiremba vachatarisa zvinhu zvakaita sehukuru hwebundu, kuti riri kupi, uye kana rakapararira (rakabva papi) kubva parakatangira.

Semuyenzaniso:

• Kana bundu riri diki kwazvo, chiremba wako wekenza anogona kukwanisa kuribvisa zvachose nekuvhiyiwa. Zvadaro, hapana kumwe kurapwa kungadiwa.
• Asi kana bundu iri rakakura zvikuru kana kuti riri munzvimbo yakaoma kuvhiyiwa, chiremba wako wekenza angasarudza kukupa mushonga unonzi targeted therapy kuti uderedze bundu usati wavhiyiwa. Mishonga iyi inotarisa uye inorwisa zvinhu zvakananga zvinobatsira masero eGIST kukura. Izvi zvinoderedza bundu uye zvinoita kuti zvive nyore kuvhiya. Dzimwe nguva, mishonga iyi inogona kuenderera mberi mushure mekuvhiyiwa kudzivirira GIST kudzoka.

Yeukai kuti havasi varwere vese veGIST vanowana kurapwa kwakafanana. Chikwata chenyu chekurapa chichakurukura nemi nzira yakanakisisa yekurapa mamiriro enyu ezvinhu.

Ndezvipi migumisiro yekurapwa?

Sezvinoita chero kurapwa kupi zvako, kurapwa kweGIST kunogona kukonzera mimwe migumisiro yakaipa.

Mimwe migumisiro inogona kuitika yekurapa kwakanangwa:

• Kuvharirwa
• Manyoka (kurwadziwa kwemudumbu)
• Kuneta uye kuneta
• Kurwadziwa kwetsandanyama
• Kusvotwa (kunzwa kuda kurutsa)

Migumisiro inowanzoonekwa panguva yekuvhiyiwa:

• Maitiro ekurwadziwa nekurwadziwa (semuenzaniso, dzungu, kurutsa)
• Marwadzo panzvimbo yekuvhiyiwa
• Kubuda ropa

Migumisiro iyi haiitike kune wese munhu nenzira imwe chete. Vamwe vanhu vanogona kusangana nemimwe yacho, nepo vamwe vasingasangane nayo. Kana uchinzwa kusagadzikana, iva nechokwadi chekuudza chiremba wako kana nesi. Migumisiro yakawanda inogona kugadziriswa.

Chii chandinofanira kutarisira kana ndine GIST?

Kunyangwe mushure mekunge kurapwa kwapera, chiremba wako wekenza acharamba achikutarisa. Izvi zvinoreva kuti uchakumbirwa kuti uuye kuzoongororwa nguva nenguva kuti utarise kupora kwako uye hutano hwako. Kuongororwa uku kunowanzoitwa mwedzi mitatu kusvika mitanhatu yega yega.

Munguva yekushanya uku, chiremba wako achakubvunza nezvezviratidzo zvako, okuongorora, uye anogonawo kuita mimwe miedzo, yakaita sekuskena, kuti aone kana GIST yadzoka kana kuti iri kupindura sei pakurapwa. Miedzo inowanzo sanganisira:

• Kuongororwa kwechiropa nechiuno neCT scan .
• Kuongororwa kweMRI (magnetic resonance imaging (MRI) scans) .
• PET scans kuti ione mhinduro yekurapa kwakanangana.

Chiremba wako ndiye achasarudza kuti unofanira kuita bvunzo idzi kangani, zvichienderana nemamiriro ako ezvinhu.

Chii chinonzi chiyero chekupona neGIST?

Iyi inyaya inonetsa kunzwisisa. Mwero wekurarama kwemunhu ane GIST unosiyana kubva pamunhu kusvika pamunhu. Pane zvinhu zvakawanda zvinoonekwa pakuongorora izvi. Semuenzaniso, kukura kwegomarara kana GIST yaonekwa, kuti inoshanda sei, hutano hwako hwese, uye kuti gomarara racho rinopindura sei pakurapwa.

Zvichienderana nedata rakaunganidzwa kubva kumasangano akaita seUS National Cancer Institute (NCI) , vanhu vanosvika 85% vane GIST vachiri vapenyu makore mashanu mushure mekuonekwa kwechirwere ichi.

Zvisinei, kana ukaona nhamba dzakadai, unofanira kurangarira zvinhu zvishoma:

• Izvi zvinongova fungidziro chete: zvakavakirwa pazviitiko zvevanhu vazhinji vakambobatwa neGIST kare. Mamiriro ako ezvinhu anogona kunge akasiyana zvikuru. Semuenzaniso, zera rako uye kana uine zvimwe zvirwere zvinogona kukanganisa nhamba idzi.
• Nhamba idzi ndedzekare: data rinounganidzwa anenge makore mashanu ega ega. Saka, simba remishonga mitsva haribatanidzwi munhamba idzi. Nemishonga mitsva, nhamba idzi dzinogona kutowedzera kuvandudzika.
• Mwero wekupona uye wenguva yekurarama zvinhu zviviri zvakasiyana: Mwero wekupona hautauri kuti uchararama kwenguva yakareba sei. Ruzivo rwenguva yekurarama rwakanyanya kuoma kuwana kune vanhu vane GIST.

Saka, usanyanya kunetseka nenhamba idzi. Kana uine mibvunzo, bvunza chiremba wako wekenza. Iye achakwanisa kutsanangura kuti nhamba idzi dzinoshanda sei pamamiriro ako ezvinhu.

Unozvitarisira sei?

Kutarisira hutano hwako ndicho chinhu chakanakisa chaunogona kuzviitira, panguva yekurapwa kweGIST uye mushure mekurapwa.

• Idya zvakanaka: Edza kudya zvakasiyana-siyana zvine mapuroteni akawanda, mafuta mashoma, uye zvakawanda sezvinobvira. Isa miriwo, miriwo, nemichero mukudya kwako kwezuva nezuva. Kudya kwakaringana kuchapa muviri wako simba rekupora nekukurumidza.
• Ita maekisesaizi: Kurwara kunogona kukushungurudza. Paunenge uchipora kubva mukurapwa, maekisesaizi akareruka (sekufamba netsoka) anogona kukubatsira kuderedza kushushikana. Zvisinei, unofanira kugara uchitaura nachiremba wako usati watanga maekisesaizi matsva kana usati watangazve maekisesaizi awanga uchiita.
• Dzivisa kusvuta zvachose: Kushandisa chero rudzi rwefodya (kusanganisira fodya dzemagetsi) kunowedzera njodzi yekubatwa nekenza itsva, pamwe nenjodzi yekuti GIST idzoke zvakare.

Chirwere chakadai seGIST chingasakonzera zviratidzo zvikuru pakutanga. Kunyangwe zvikaitika, ungafunga kuti kungori kugaya chikafu kana furuu yemudumbu. Saka, kuziva kuti une bundu rekenza risingawanzoitiki rakadai kunogona kukushamisa zvikuru. Kana uine chirwere ichi, tora nguva yekuzvidzidzisa nezvechirwere ichi chisingawanzoitiki uye nzira dzekurapa nadzo. Kazhinji, kurapwa kunogona kuderedza zviratidzo zvako uye kutorapa GIST. Uchava nemibvunzo yakawanda. Chikwata chako chekurapa chichavapo kuti chipindure zvese uye chikutsigire.

Pakupedzisira, zvinhu zvekurangarira

Kunyange zvazvo GIST iri chinhu chekutya, chirwere chinogona kuva nemigumisiro yakanaka kana ukachiziva uye ukabatsirwa nenguva.

• Usaregeredza: Kana uine kurwadziwa kwemudumbu kusingawanzoitiki, zviratidzo zvekubuda ropa, kana kudzikira kwehuremu kusingatsananguriki, tsvaga rubatsiro rwechiremba.
• Kuongorora chirwere nemazvo kwakakosha: Kuongororwa kwakakosha kunodiwa kuti uongorore GIST. Saka, tsvaga pfungwa dzenyanzvi.
• Kune mishonga: Kune mishonga inoshanda yeGIST, yakadai sekuvhiyiwa uye kurapwa kwakanangana.
• Hausi wega: timu yako yezvekurapa, mhuri, neshamwari vachakubatsira parwendo urwu.

Chinhu chinonyanya kukosha ndechekugara wakasimba uye kutevedzera mazano echiremba.

Bundu remudumbu, GIST, kenza, sisitimu yekugaya chikafu , jini reKIT, kuvhiyiwa, kurapwa kwakanangana