Chii chinonzi Glucagonoma? Ngatitaurei nezvechirwere ichi chisingawanzoitiki!

Chirwatata inhengo diki asi inokosha zvikuru mumuviri wako. Inoburitsa mahormone akati wandei anodiwa nemuviri wedu. Saka, dzimwe nguva, mhando isingawanzoitiki yekenza inokura murwatata inogona kukonzera matambudziko. Ndiyo inonzi chirwere ichi Glucagonoma . Pamwe wakangoerekana wava nechirwere cheshuga, kana kuti wakaita mapundu asinganzwisisike paganda rako, zvakakosha kuti uzive izvi.

Chii chinonzi glucagonoma? Zvichitaurwa zviri nyore...

Glucagonoma igomarara risingawanzoitiki rinokura mupancreas yako. Gomarara iri rinoburitsa hormone yakawandisa inonzi glucagon. Iye zvino ungangove uchishamisika kuti glucagon iyi chii.

Glucagon ihormone inokosha zvikuru inobatsira kudzora huwandu hweshuga mumuviri wedu, ndiko kuti, huwandu hweshuga muropa . Inogadzirwa nemasero ealpha, rudzi rwakakosha rwesero mupancreas yako. Fungidzira kana usati wadya kwenguva yakati, kana ukaita maekisesaizi akaomarara, kana ukadya chikafu chine mapuroteni akawanda, huwandu hweshuga muropa rako hunogona kudzikira, handiti? Ndipo panopinda glucagon iyi, inoburitsa shuga yakachengetwa muchiropa chako, ndiko kuti, glycogen , uye inodzosa huwandu hweshuga muropa. Zvakafanana nemunhu anobatsira kuchengetedza chiyero cheshuga mumuviri wedu.

Zvisinei, kana paine glucagonoma, iyi hormone yeglucagon inogadzirwa yakawandisa. Ipapo muviri wedu haugone kuigadzirisa. Musanganiswa wezviratidzo zvinoitika nekuda kweizvi unonzi Glucagonoma Syndrome . Izvi zvinogona kutungamira kumatambudziko akawanda akadai sematambudziko eganda uye chirwere cheshuga.

Rudzi urwu rwegomarara, runonzi glucagonoma, rwuri muboka rematumbu epancreatic neuroendocrine , kana kuti matumbu eislet cell . Kazhinji, aya anomuka mumuswe kana pakati pepancreas.

Ko iyi igomarara zvechokwadi here?

Ehe, kazhinji, glucagonoma ikenza . Chinhu chinosuwisa ndechekuti, kunyangwe ikaonekwa, muzviitiko zvingangoita 50%, kureva kuti, munhu mumwe chete pavanhu vaviri, kenza iyi inogona kunge yakapararira (yakapararira) kune dzimwe nhengo dzemuviri, kunyanya chiropa .

Dambudziko iri rakajairika zvakadii?

Glucagonoma chirwere chisingawanzoitiki . Vanhu vashoma pane miriyoni vanobatwa nechirwere ichi gore rega rega. Chinowanzo bata vanhu vane makore ari pakati pe50 ne70 .

Ndezvipi zviratidzo zveizvi?

MaGlucagonoma anowanzo kukura zvishoma nezvishoma . Saka, kana muviri wako usingagadzire glucagon yakakwana kukonzera matambudziko, ungasava nezviratidzo.

Zvisinei, kana glucagonoma ikaburitsa glucagon yakawandisa uye muviri usingakwanise kuigadzirisa, chirwere cheglucagonoma chataurwa kare chinoitika.Zvinoitika. Zvadaro, uchaona zviratidzo zvakajeka. Kana uine zviratidzo izvi, zvakakosha zvikuru kuona chiremba nekukurumidza.

Mapundu paganda (Necrolytic Migratory Erythema - NME)

Ichi ndicho chiratidzo chikuru uye chinowanzoonekwa che glucagonoma syndrome. Vanhu vanosvika 90% vane chirwere ichi vanowana dambudziko iri reganda. Chinonzi necrolytic migratory erythema (NME) .

Fungidzira, ganda rako, kunyanya muzvikamu zvakavanzika, magaro, nemakumbo epasi, rinotanga kuita mavanga matsvuku, anokwenya, uye dzimwe nguva anorwadza. Aya anozopedzisira ava maronda, mavanga, uye goko. Kunyangwe mushure mekupora, donda rebrown rinogona kuramba riripo. Izvi zvinogona kuumbwa panzvimbo imwe, zvopora, uye zvozoonekwazve pane imwe nzvimbo. Zvakafanana nemapundu anofamba kubva panzvimbo imwe kuenda kune imwe.

Zvimwe zvinhu zveNME:

• Izvi zvinogona kuuya zvoenda, uye zvinogona kufamba-famba mumuviri wese .
• Zvinogona kuvava uye kurwadza pakutanga.
• Mapundu anotsvuka obva aita maronda oita goko. Mushure mekupora, donda rebrown rinogona kuramba riripo.
• Izvi zvinogona kutungamira kuzvinhu zvakaita semaronda erurimi (glossitis ), maronda emuromo, miromo yakakuvara, uye angular cheilitis .
• Kuzvimba kwemaziso ( blepharitis ), kurasikirwa nebvudzi, uye matambudziko ezvipikiri zvinogonawo kuitika.

Zviratidzo zvechirwere cheshuga

Chirwere ichi chinokonzera huwandu hweshuga muropa ( hyperglycemia ), izvo zvinogona kukonzera chirwere cheshuga. Zviratidzo zvechirwere cheshuga zvinosanganisira:

• Kuonda pasina chikonzero.
• Nyota yakawandisa (Polydipsia) .
• Kuita weti kakawanda ( polyuria ), kunyanya husiku.
• Nzara yakawandisa ( Polyphagia ).

Zvimwe zviratidzo zve (glucagonoma syndrome)

Kune zvimwe zviratidzo zvakawanda:

• Manyoka asingarapiki .
• Hemoglobin yakaderera muropa (anemia ). Izvi zvinogona kukonzera kuneta uye dzungu.
• Kugwamba kweropa, kunyanya mutsinga dzakadzika dzemakumbo ( Deep Vein Thrombosis (DVT) ).

Zviratidzo zvine chekuita nepfungwa uye nervous system

Dzimwe nguva, unogona kuonawo zviratidzo zvine chekuita nepfungwa netsinga, zvakaita se:

• Kuora mwoyo
• Dementia
• Kutsamwa
• Hyperreflexia (kukurumidza kwemhinduro dzemuviri)
• Kufamba kusingafadzi (ataxia )
• Matambudziko epfungwa ( Psychosis))
• Kutya kusina musoro uye kufungidzira ( Paranoid Delusions )

Chii chinokonzera glucagonoma?

Kazhinji, vanachiremba havazivi chikonzero chaicho cheglucagonoma. Zvisinei, muzviitiko zvinenge gumi muzana, kenza iyi inobatanidzwa nechirwere chemajini chinonzi Multiple Endocrine Neoplasia type 1 (MEN type 1) .

Zvisinei, havasi vese vane MEN type 1 vanowana glucagonoma. Izviwo inhamba diki kwazvo.

Unozviziva sei izvi?

Kana uine chirwere cheganda chinonzi necrolytic migratory erythema (NME) chambotaurwa, chiremba anogona kufungidzira kuti une glucagonoma. Vanogona kuita bvunzo dzakadai se:

• Kuongororwa kweShuga Yeropa Yekutsanya: Kana huwandu hweshuga hwakakwira, glucagonoma inogona kufungidzirwa uye chirwere cheshuga chinogona kusimbiswa.
• Kuongororwa kweGlucagon Yekutsanya: Huwandu hweGlucagon hwakakwira zvisingawanzoitiki muglucagonoma - kazhinji hunopfuura 500 picograms pa milliliter (pg/mL). Huwandu hweGlucagon yekutsanya hwakajairwa huri pasi pe150 pg/mL.
• Kuongororwa kweAmino Acid Ropa: Glucagonoma inowanzo kukonzera mazinga mashoma emaamino acids muropa ( hypoaminoacidemia ).
• Kuverengwa Kweropa Rakazara (CBC): Izvi zvinoongorora kusakwana kweropa , sezvo kusakwana kweropa kunogona kuitika neglucagonoma.

Kuongororwa kwemifananidzo yakaita seiyi kunogona kubatsira kusimbisa kana bundu riripo:

• Kuskena kweCT
• Kuskena kweMRI
• Ultrasound yeEndoscopic

Inorapwa sei?

Kurapwa kweglucagonoma kunonyanya kuenderana nekuti kenza yacho yakangogumira papancreas (yakawanikwa munzvimbo imwe chete) here kana kuti yakapararira kune dzimwe nhengo dzemuviri (yakapararira) .

Maitiro ekutanga ekudzora zviratidzo

Danho rekutanga ndere kudzora zviratidzo nematambudziko anokonzerwa nekuwanda kweglucagon. Izvi zvinorapwa seizvi:

• Mishonga yekudzora glucagon yakawandisa: Majekiseni anonzi Octreotide naLanreotide anobatsira kuderedza migumisiro yeglucagon yakawandisa uye kumisa kugadzirwa kweglucagon. Mishonga iyi inogona kutononotsa kukura kwebundu. Inopawo zororo kubva kuzviratidzo zveNME, chirwere cheshuga, manyoka, uye zvirwere zvetsinga.
• Kurapa chirwere cheshuga: Ungangoda mushonga wechirwere cheshuga kana jekiseni re insulin kuti shuga yako yeropa irambe iri pakati pehuwandu hwakakodzera.
• Rutsigiro rwezvekudya:Mishonga yeTotal Parenteral Nutrition (TPN) , amino acid uye zinc supplements zvinogona kupihwa kuderedza migumisiro yekushaya chikafu chakakwana.
• Kurapa chirwere cheganda cheNME: Mishonga inorwisa mabhakitiriya ne corticosteroids inogona kuvandudza NME.
• Kurapa Nemishonga Inoderedza Kubuda Kweropa: Mishonga inoomesa ropa yakaita seheparin inobatsira kudzivirira deep vein thrombosis (DVT) .

Kana zvichingogumira padumbu repancreas...

Kana kenza iri mupancreas chete, kuvhiyiwa ndiko kurapwa kukuru . Kana chiremba akakwanisa kubvisa bundu zvachose, chirwere chacho chinowanzo poreswa . Mushure mekunge glucagonoma yabviswa, huwandu hweglucagon yako hunofanira kudzokera pahunhu hwakajairika. Zviratidzo zvako zvinofanirawo kupera.

Kana yapararira kune dzimwe nzvimbo (yakapararira)...

Pose pazvinogoneka, vanachiremba vanokurudzira kubviswa kwebundu kuvhiyiwa. Izvi zvinogona kusanganisira kubviswa kwebundu riri mupancreas, lymph nodes dziri pedyo, uye chiropa.

Asi kana chiremba akasakwanisa kubvisa bundu rose kana kuti bundu rose, timu yenyu yezvekurapa inogona kukurudzira imwe kana kupfuura yemishonga iyi:

• Kurapa nemakemikari: Kurapa uku kunoshanda nekuparadza masero ekenza uye kudzivirira kukura kwawo.
• Kubviswa kwemasaisai emagetsi: Izvi zvinoshandisa kupisa kunobva kumasaisai emagetsi kuuraya masero ekenza.
• Kubvisa masero ekenza (Cryosurgical Ablation): Izvi zvinoshandisa makemikari anotonhora zvikuru, akadai se liquid nitrogen, kuparadza masero ekenza.
• Kurapa kweChemoembolization: Kurapa uku kunovhara ropa rinoenda kugomarara.

Chii chiri fungidziro yekuti munhu achapora kubva mudambudziko iri?

Maonero emunhu ane glucagonoma anoenderana nezvinhu zvakati wandei:

• Zera rako nehutano hwako hwese .
• Kukura kwebundu rekenza .
• Kana gomarara rapararira kana kuti kwete .

Kana kenza iri mupancreas chete, tarisiro yacho inowanzova yakanaka . Kuvhiyiwa kwekubvisa bundu kunowanzo rapa, asi izvi zvinoitika kune vanenge 20% chete yevarwere vane glucagonoma.

Nekuti glucagonoma haiwanzoitiki, hapana ruzivo rwakakwana rwekutaura kuti unogona kurarama kwenguva yakareba sei kana kuti mhedzisiro yacho ichava yei kana kenza ikapararira. Chikwata chenyu chekurapa chichakwanisa kupa rumwe ruzivo zvichienderana nemamiriro ako chaiwo.

Izvi zvinogona kudzivirirwa here?

Nekuti masayendisiti haazivi chikonzero chezvirwere zvakawanda zveglucagonoma, hapana chaunogona kuita kudzivirira chirwere ichi .

Zvisinei, kana mumwe wehama dzako dzekutanga (vabereki vako vekutanga nevanin'ina vako) akaonekwa aine chirwere cheMEN (Multiple Endocrine Neoplasia) , taura nachiremba wako nezvekuongororwa kwemajini. Kana uinewo MEN, kuongororwa kwemajini kunogona kubatsira kuona kenza padanho rayo rekutanga.

Kuonekwa uine kenza chinhu chinoshungurudza zvikuru. Kana chiri chinhu chisingawanzoitiki seglucagonoma, zvinotonyanya kuoma. Asi yeuka, timu yako yezvekurapa iripo kuti ipindure mibvunzo yako uye ikutsigire. Kana uchinzwa uri wega mupfungwa nemupfungwa nepamuviri neglucagonoma, bvunza chiremba wako nezvezvirongwa nemasevhisi anogona kukubatsira.

Pakupedzisira, zvinhu zvekurangarira (Mharidzo Yekuenda Kumba)

Saka, kunyangwe glucagonoma iri chirwere chisingawanzoitiki, zvakakosha kuti uzive nezvacho. Kunyanya kana ukangoerekana wava nezviratidzo zvakafanana nechirwere cheshuga pamwe chete nekuputika kweganda kusinganzwisisike (NME), sezvataurwa, ona chiremba nekukurumidza. Kana zvikaonekwa nekukurumidza, zvinogona kurapwa. Kunyangwe izvi zvisingawanzoitiki, kune mishonga.

Usazvidya moyo, hausi wega. Chiremba wako nechikwata chevanachiremba vachakubatsira murwendo urwu. Ramba wakasimba uye tevera mazano avanokupa.

Glucagonoma , kenza yepancreas, glucagon, chirwere cheshuga, zviratidzo zveganda, mahormone, kenza dzisingawanzoitiki