Tose tinogara tichitaura nezve cholesterol, uye tinozvidya mwoyo nazvo, handiti? Asi funga nezvazvo, wakambonzwa nezvechirwere chinogarwa nhaka umo huwandu hwe cholesterol hwakakwira zvisingawanzoitiki kubvira paudiki, pamwe kunyange muhudiki? Nhasi tichataura nezvechimwe chirwere chisingawanzoitiki asi chakakosha zvikuru. Ichi chinonzi Homozygous Familyal Hypercholesterolemia (HoFH). Kunyangwe zita racho rakaoma zvishoma, ngatirinzwisise zviri nyore.
Chii chinonzi Homozygous Familyal Hypercholesterolemia?
Zvichitaurwa zviri nyore, ichi chirwere chemajini chinoita kuti zviomere miviri yedu kubvisa cholesterol "yakaipa", kureva cholesterol yeLDL (Low-Density Lipoprotein), kubva muropa redu. Tese tinoziva kuti cholesterol chinhu chine wakisi chinodiwa nemasero edu. Basa reLDL cholesterol nderekutakura cholesterol iyi mumuviri wese kuburikidza neropa.
Asi kana huwandu hweLDL hwakwira zvakanyanya, cholesterol iyi inotanga kuungana mutsinga dzeropa dzinopa ropa kumwoyo wedu, tsinga. Nekufamba kwenguva, zvinhu izvi zvinogona kuvhara tsinga, zvichibvisa ropa neokisijeni kumoyo, uye zvichiwedzera njodzi yekurwara nemoyo .
Chirwere ichi chinoitika kuzvarwa nacho. Izvi zvinoreva kuti unogona kuva necholesterol yakakwira kubva paudiki. Ichi chirwere chakakomba chisingarapiki uye chinofanira kutarisirwa kwehupenyu hwako hwese.
Kana vakasarapwa, varume vane chirwere ichi vanogona kubatwa nechirwere chemwoyo vari mumakore avo ekuma40 uye vakadzi vari mumakore avo ekuma50. Saka, zvakakosha zvikuru kuziva izvi uye kutsvaga kurapwa kwakakodzera.
Chikonzero cheizvi chii?
Tinoti chirwere ichi chirwere chemajini. Kutaura chokwadi, unowana chirwere ichi chete kana ukagara nhaka makopi maviri ejini risingashande zvakanaka, rimwe kubva kuna amai vako nerimwe kubva kuna baba vako .
Kazhinji, chiropa chedu chinobvisa cholesterol yakawandisa yeLDL muropa. Chiropa chine 'LDL receptors' dzakakosha dzeizvi. Izvi zvakafanana nemagineti anobata cholesterol oibvisa muropa. Asi kune munhu ane chirwere ichi, nekuda kwejini rakakanganisika raakagara nhaka, ma receptors aya haashande nemazvo. Mugumisiro wacho ndewekuti huwandu hwecholesterol hunokwira zvisingadzoreki.
Ungave wakambonzwawo nezve 'Heterozygous' Familyal Hypercholesterolemia. Apa ndipo apo jini risina kunaka rinogarwa nhaka kubva kumubereki mumwe chete. Dambudziko iri harina kunyanya kuipa se 'Homozygous'.
Ndezvipi zviratidzo zvechirwere ichi?
Kune zviratidzo zvikuru zvakawanda zvinogona kushandiswa kuziva chirwere ichi. Ngatizvitarisei patafura.
| Hunhu | Tsananguro |
|---|---|
| Cholesterol yakakwira zvikuru | Huwandu hwecholesterol muropa hunogona kuva 600 mg/dL kana kupfuura (huwandu hune hutano husingasviki 200). |
| Zvidimbu zveganda (Xanthomas) | Mapundu eyero, akaita senakisi pasi peganda pamagokora, mabvi, nemagaro. Aya ndiwo mafuta akaunganidzwa mumuviri. |
| Madonhwe emaziso (Xanthelasmas) | Mafuta eyero anodonhera pamaziso. |
| Kuchinja kweziso (Arcus cornealis) | Mhete yegrey kana chena yakakomberedza ziso dema. |
| Zviratidzo zvemwoyo | Zviratidzo zvakaita sekurwadziwa pachipfuva (angina), kushaya mweya, uye kurova kwemoyo nekukurumidza zvinogona kuitika pazera diki. |
Nzira yekuziva sei chirwere ichi?
Kana uine zviratidzo izvi, zvakakosha kuti uone chiremba wako. Chiremba achatanga akuongorora muviri wako uye achakubvunza mibvunzo mishoma.
- Wakaona chimwe chinhu chakaita semavanga eyero paganda rako here?
- Une kurwadziwa pachipfuva here?
- Uri kunzwa kushaya mweya here?
- Vabereki vako vanewo cholesterol yakakwira here?
Zvadaro, chiremba wako achakuongororwa ropa kuti aone huwandu hwecholesterol yako mumuviri. Vanogonawo kukuongororwa majini kuti vaone kana uine jini risina kunaka rinokonzera chirwere ichi. Chiremba wako anogonawo kuongororwa nhengo dzemhuri yako yepedyo.
Nzira dzekurapa uye manejimendi
Chinangwa chikuru chekurapa ndechekuderedza huwandu hweLDL cholesterol mumuviri wako uye kuderedza njodzi yekurwara nemwoyo.Unowanzo tumirwa kuna chiremba ane ruzivo rwezvirwere zvecholesterol zvakaita seizvi (Lipidologist).
Kuchinja kwemararamiro uye kudya
Danho rekutanga nderekudya zvine hutano pamoyo zvine mafuta akawandisa, cholesterol, uye shuga shoma. Zvakakoshawo kurega kusvuta, kunwa doro zvishoma, uye kurovedza muviri zuva nezuva.
Mishonga
Nekuti huwandu hwecholesterol yako hwakakwira zvisingaite, unogona kutanga kutora mishonga yakawanda yestatins , iyo inoshanda nekumisa chiropa kugadzira cholesterol.
Pamwe chete neizvozvo, mimwe mishonga inoderedza huwandu hwecholesterol inotorwa kubva muchikafu (semuenzaniso Ezetimibe , PCSK9 inhibitors , Lomitapide ) inogona kuwedzerwa.
Kurapa kwakananga
Kana cholesterol isingagone kudzorwa nemishonga chete, dzimwe nzira dzekurapa dzichafanira kufungwa nezvadzo.
- Apheresis: Iyi inzira yakafanana nedialysis yevarwere veitsvo. Wakabatana nemuchina uri muchipatara, ropa rako rinotorwa mumuviri wako, cholesterol yeLDL inoseferwa, uye ropa rakacheneswa rinodzoserwa mumuviri wako. Iyi inzira yekurapa inotora maawa akati wandei uye inofanira kuitwa nguva nenguva.
- Kuisirwa Chiropa: Kana pasina kana imwe yenzira dzataurwa pamusoro apa inobudirira, kuisirwa chiropa kungave ndiyo nzira yekupedzisira. Chiropa chitsva chine hutano chine ma LDL receptors, anogona kubatsira kudzora cholesterol. Uku kuvhiyiwa kwakakomba, uye kupora kunogona kutora mwedzi mitanhatu kusvika pagore.
Kana uri kurapwa zvakakomba kudaro, zvakakosha zvikuru kutsvaga rutsigiro rwepfungwa kubva kumhuri neshamwari. Taura pachena nezvazvo nachiremba wako.
Mharidzo Yekuenda Nayo Kumba
- Homozygous Familyal Hypercholesterolemia chirwere chakakomba, asi chisingawanzoitiki, chemajini chinokonzera cholesterol yakakwira zvakanyanya.
- Izvi zvinodaro nekuti vanogara nhaka majini maviri asina kunaka kubva kuna amai vavo nababa vavo.
- Nekuziva nekutanga kurapwa vachiri vadiki, njodzi yekubatwa nechirwere chemwoyo vachiri vadiki inogona kuderedzwa.
- Kurapwa ndekwehupenyu hwese uye kunogona kusanganisira mishonga, kudya, kurovedza muviri, uye pamwe kurapwa kwakasarudzika (apheresis).
- Kana mumwe munhu mumhuri yako akambova nechirwere chemwoyo kana kuti cholesterol yakakwira achiri mudiki, zvakanaka kuti iwe uongororwe cholesterol yako sezvakarairwa nachiremba wako.
- Hausi wega uri parwendo urwu. Shanda nachiremba wako, mhuri yako, nemapoka ekutsigirana kuti ubudirire kubata chirwere ichi.
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