Unowanzo sangana neallergies ine mavara matsvuku uye kuvaviwa mumuviri wako wese here? Izvi zvinogona kunge zviri Mastocytosis!

Unowanzo sangana nemapundu matsvuku, anokwenya, uye dzimwe nguva akanyanya mumuviri wako here? Kana kuti unotambura neallergy yakanyanya kunyangwe pazvinhu zvidiki diki kwemazuva? Ungafunga kuti, "Ndiri kuita allergy zvakare." Zvisinei, dzimwe nguva zviratidzo izvi zviri shure kwezviratidzo izvi, panogona kunge paine chirwere chisingawanzoitika chatisati tanzwa nezvacho. Chimwe chezvirwere zvakadaro ndi '(Mastocytosis)'. Kunyangwe zita racho ringanzwika serisinganzwisisike, ngatitaurei nezvazvo zviri nyore.

Chii chinonzi Mastocytosis? Zvichitaurwa zviri nyore...

Fungidzira, mukati memiviri yedu mune masero akaita sevarindi vadiki. Tinoadaidza kuti "mast cells." Aya "mast cells" chikamu che "immune system" yedu. Akafanana nemauto ekuchengetedza enyika yedu. Kana vavengi vakaita semajemusi, mabhakitiriya, uye zvinhu zvinokonzera allergy vachipinda mumuviri, aya "mast cells" anouya kuzorwa.

Kana aya `(mast cells)` apindura vavengi, anoburitsa kemikari inonzi `(histamine).` Iyi `(histamine)` ndiyo inokonzera zviratidzo zvekurwara mumuviri wedu (semuenzaniso, kuvaviwa, kutsvuka kweganda, kuzvimba). Aya `(mast cells)` anobatsirawo kugadzira acid mudumbu.

Kazhinji, aya `(mast cells)` anoita basa rawo uye anotonga vavengi uye obva anyarara zvakare. Zvisinei, zvinoitika mumuviri wemunhu ane `(Mastocytosis)` ndezvekuti aya `(mast cells)` anowedzera zvisina kujairika uye zvisingadzoreki. Paanowedzera seizvi, masero aya anoburitsa `(histamine) yakawandisa. Ndipo paunowana allergy yakakura kunyangwe kuchinhu chidiki, kana kuti paunowana allergy, inotonyanya kuipa kupfuura mumunhuwo zvake, uye inogara kwenguva refu.

Chinonyanya kukosha ndechekuti munhu wese ane Mastocytosis ari panjodzi yakakura yekubatwa ne anaphylaxis , chirwere chinongoerekana chaitika, chakakomba, uye chinogona kutyisidzira hupenyu . Saka, zvakakosha kuziva izvi.

Kunyange hazvo vanachiremba vasingakwanise kurapa Mastocytosis zvachose, vanogona kudzora zviratidzo uye kurapa chero matambudziko angamuka.

Ndeapi marudzi makuru eMastocytosis?

Kune mhando mbiri huru dzechirwere ichi:

1. Cutaneous Mastocytosis: Izvi zvinowanzoitika muvacheche nevana vadiki . Zvisinei, zvinogonawo kuitika muvakuru. Chinoitika pano ndechekuti "mast cells" asingawanzoitiki anoungana muganda, zvichikonzera maronda nemavanga anokwenya matsvuku, matsvuku akasviba, mashava, kana mavara akasiyana-siyana. Zvinoita sekuti mwana mudiki anongoerekana ava nemavanga matsvuku akawanda pamuviri wake uye anoakwenya nguva dzese.

2. Systemic Mastocytosis: Rudzi urwu runonyanya kuonekwa muvanhu vakuru.Pano, "masero emudumbu" asina kujairika anoungana munhengo dzemukati dzakadai semupfupa, mapfupa, sisitimu yedu yekugaya chikafu, nemapapu. Fungidzira, kana masero aya akaungana akawandisa mumupfupa, zvinogona kukanganisa kuumbwa kwemasero edu eropa. Uyewo, kana masero aya akawedzera mudumbu, anogona kugadzira acid yakawandisa mudumbu uye kukonzera maronda emudumbu.

Ichi chirwere chinowanzoitika here?

Kwete, ichi chirwere chisingawanzoitiki. Sekureva kweongororo, zvinonzi munhu mumwe chete pavanhu zviuru gumi (10,000) kana mumwe pavanhu zviuru makumi maviri (20,000) anorwara nechirwere ichi. Saka, zvakajairika kuti havasi vese vanoziva nezvacho.

Ndezvipi zviratidzo zvinogona kukonzera Mastocytosis?

Sezvo aya "mast cells" achiwedzera zvisingawanzoitiki, zviratidzo zvakasiyana-siyana zvinogona kuitika. Kunyange zvazvo zviratidzo izvi zvingave zvishoma kune vamwe vanhu, zvinogona kuva zvakanyanya kune vamwe.

• Kurwadziwa kwemapfupa: Kunzwa sekunge mapfupa ako ari kurwadza.
• Manyoka (kurwadziwa nemudumbu): Kuenda kuchimbuzi nguva nenguva.
• Kufenda (sekurasikirwa nepfungwa): Kamwe kamwe, maziso anoshanduka kuita bhuruu uye unoita seuri kurasikirwa nepfungwa.
• Kugara uchinetseka uye uchitya: Kunzwa uchinetseka pasina chikonzero.
• Kutsvuka: Kutsvuka kamwe kamwe kweganda muviri wese.
• Mapundu kana mavanga anokwenya paganda: Sezvatakambotaura.
• Musoro: Kurwadziwa nemusoro nguva nenguva.
• Dzungu rinokonzerwa neBP yakaderera: Kunzwa dzungu kana wakamira wakamira.
• Kurwadziwa kwemajoini: Kurwadziwa kwemajoini.
• Mavara matsvuku kana mashava paganda: Aya anogona kunge achikwenya kana kusakwenya.

Mastocytosis inotanga pazera ripi?

Zvinosiyana zvichienderana nerudzi rwechirwere. Kazhinji:

• Mastocytosis yeganda: Izvi zvinogona kukanganisa kunyange vacheche vachangoberekwa.
• Systemic Mastocytosis: Inowanzo bata vanhu vakuru vane makore anopfuura makumi mashanu.

Chikonzero cheizvi chii?

`(Mastocytosis)` hachisi chinhu chatinozvarwa nacho. Chinokonzerwa nekuchinja kwemajini kunonzi `(majini eKIT)`. Aya `(majini eKIT)` majini anobatsira mamwe marudzi emasero, akadai semasero edu eropa, `(mast cells)`, kukura. Mu`(Mastocytosis), aya majini eKIT akachinja anopa chiratidzo chisina kunaka ku`(mast cells)` kuti "awande zvakanyanya uye akure zvisingadzoreki."

Ndezvipi zvinokonzera mastocytosis?

Izvi zvinogona kusiyana kubva pamunhu nemunhu. Havasi vanhu vese vane zvikonzero zvakafanana. Zvisinei, pane zvimwe zvinhu zvinogona kuwedzera zviratidzo:

• Kukwesha kana kukwenya ganda: Izvi zvinogonawo kuitika kune vamwe vanhu nekungopfeka mbatya dzakasimba.
• Kurovedza muviri uye kuita maekisesaizi akawandisa.
• Kurumwa nezvipembenene:Kunyanya mhuka dzakadai semasvosve, mago, uye nyuchi.
• Kunwa doro.
• Zvimwe zvekudya: Zvikuru chikafu chine zvinonhuwira, chine munyu wakawanda.
• Mimwe mishonga: Semuenzaniso, mishonga inoderedza marwadzo inonzi ``NSAIDs`` (Nonsteroidal anti-inflammatory drugs), mishonga inozorodza tsandanyama, uye mishonga inonyaradza marwadzo ``(anesthesia)``.
• Kuchinja kamwe kamwe kwekushisa: Sekusvetukira mumvura inotonhora zvikuru.
• Kushushikana kwemuviri kana kwepfungwa: Izvi zvinowanzova nemigumisiro yakakura.

Ndezvipi zvinetso zvinogona kuitika nekuda kweMastocytosis?

Chirwere ichi chinogona kukonzera mamwe matambudziko ehutano, anosanganisira:

• Osteoporosis: Izvi zvinoita kuti mapfupa asashande zvakanaka uye aputsike nyore nyore.
• Matambudziko echiropa: Chirwere chekuti chiropa chinozvimba uye hachishande zvakanaka.
• Cytopenia: Kusakwanisa kwemuviri kugadzira masero eropa akakwana.
• Kubatwa nezvirwere kakawanda.

Mastocytosis inoonekwa sei?

Chiremba wako achakubvunza nezvezviratidzo zvako uye achaongorora ganda rako. Pamusoro pezvo, vanogona kuita bvunzo dzakadai se:

• Kuongororwa kweropa: Tarisa huwandu hweenzyme inonzi ``tryptase`` muropa rako. Iyi ``tryptase`` chinhu chinoburitswa ne``mast cells`` kana ichipindura vavengi.
• Kuongororwa kwemapfupa: Kuongorora kana mapfupa akakuvara.
• Kuongororwa kwemapfupa emubofu: Muenzaniso wemapfupa emubofu unotorwa woongororwa kuti hauna masero emubofu asina kujairika.
• Kuongororwa kwemajini: Kana uine Systemic Mastocytosis, unogona kuongororwa kuti uone kana paine shanduko mumajini eKIT.

Ndeipi mishonga yekurapa Mastocytosis?

Nzira dzekurapa dzinosiyana zvichienderana nerudzi rwechirwere uye zviratidzo zvako. Vanachiremba vanowanzo shandisa mishonga nedzimwe nzira dzekurapa kuderedza zviratidzo.

Mhando dzemishonga inoshandiswa pakurapa Mastocytosis:

• Mishonga inoderedza asidhi (H2 blockers) yematambudziko emudumbu: Kune zvinhu zvakaita sekuzvimba kwemudumbu uye gastritis.
• Antihistamines: Kuderedza zviratidzo zveganda zvekurwara zvakaita sekurumwa nekutsvuka.
• Bisphosphonates ye osteoporosis: Simbisa mapfupa.
• Corticosteroids: Deredza kuzvimba.
• Ma antibodies eMonoclonal: kunyanya mishonga yakaita se omalizumab (Xolair®).
• Mishonga yekurwadziwa .

Mamwe marapirwo:

• Kurapa nechiedza cheUltraviolet (UV): Deredza mavara matema paganda.
• Kurapa kwakanangana .
• Epinephrine ye anaphylaxis:Kurapwa kwekukurumidzira kana paine allergy yakanyanya.
• Kurapa nemakemikari: Izvi hazviwanzoitiki uye zvinongoitwa chete kana Mastocytosis ikashanduka kuita kenza.
• Kuisirwa kwemasero emuviri (mumafupa) eAllogeneic: Izvi zvinoonekwawo muzviitiko zvakakomba zvemastocytosis. Vanhu vazhinji havadi izvi.

Pane matambudziko kana migumisiro yekurapwa here?

Ehe, sekurapa kupi zvako, kune mimwe migumisiro inogona kuitika pakurapwa kweMastocytosis. Mimwe inogona kunge iri midiki, asi mimwe inogona kunge yakakomba. Kana uine Mastocytosis, chiremba wako achakutsanangurira marapirwo auri kugamuchira uye migumisiro inogona kuitika.

Ko Mastocytosis inogona kurapwa zvizere here?

Kazhinji, Mastocytosis inoonekwa sechirwere chisingarapike zvachose, asi chinogona kudzorwa nekudzora zviratidzo uye kurapa matambudziko .

Mushonga wega ungangorapa izvi ndewe "allogeneic stem cell (bone marrow) transplantation" yambotaurwa. Zvisinei, kunyange izvozvo zvinongokurudzirwa chete kune varwere vane zvirwere zvakanyanya uye zvakaoma.

Ko mastocytosis inotowedzera kuipa nekufamba kwenguva here?

Kana zvikasarapwa, zviratidzo zvinogona kuwedzera nekufamba kwenguva, kunyanya kumunhu ane systemic mastocytosis , sezvo mast cells asina kujairika achiramba achikanganisa bone morrow nenhengo dzemukati.

Mastocytosis inogona kudzivirirwa here?

Zvinosuwisa kuti kwete. Sezvo zvichikonzerwa nekuchinja kwemajini eKIT, hapana nzira yekuzvidzivirira. Zvisinei, kana uine Mastocytosis, unogona kudzora zviratidzo zvako nekuziva chaizvo zvinokonzera allergic reactions yako uye kudzivirira zvakanyanya sezvinobvira.

Semuenzaniso, kana uine chikonzero chekushandisa mimwe mishonga, zvakanaka kupfeka bracelet yekuzivisa nezvekurapa yakanyorwa nezvayo. Izvi zvichazivisa vamwe mishonga yausingafaniri kunwa kana paine emergency.

Kana uine Systemic Mastocytosis, zvakakosha kugara uine sirinji inozvibaya ine epinephrine. Iyi inogona kushandiswa kurapa zvirwere zvakakomba, zvinouraya zvakadai se anaphylactic shock.

Ndinozvitarisira sei? (Mastocytosis) Pandinenge ndichigara ne...

Sezvo Mastocytosis iri chirwere chisingarapiki zvachose, ungangofanira kurarama nacho kwenguva yakati. Chinogona kuva chakaoma. Zvisinei, hezvino zvimwe zvinhu zvinogona kukubatsira:

• Ziva chaizvo zvinokonzera zviratidzo zvako.Zvinhu zvinokonzeresa chirwere ichi zvakasiyana. Ungangoda kunyora pasi kuti zviratidzo zvako zvanyanya kuipa riini, zvawakadya nezvawakanwa, uye zvawakaita panguva iyoyo.
• Kushushikana kunogona kuwedzera zviratidzo izvi. Kana uchida rubatsiro rwekugadzirisa kushushikana, bvunza chiremba wako nezvezvirongwa zvekugadzirisa kushushikana. Zvinhu zvakaita sekufungisisa neyoga zvinogona kubatsira.
• Pfeka bracelet yekuzivisa nezvekurapa. Inofanira kuratidza mamiriro ako ehutano uye chero mishonga yausingafaniri kunwa.
• Gara uine tsono ye epinephrine auto-injector. Izvi zvinogona kuponesa hupenyu kana paine allergy yakanyanya.

Ndinofanira kuona chiremba wangu rini?

Uchaongororwa nachiremba wako nguva nenguva . Vachaongorora zviratidzo zvako uye vachachinja marapirwo ako kana zvichidikanwa. Kana ukatanga zviratidzo zvitsva, kana zviratidzo zvako zvikawedzera, taurira chiremba wako nekukurumidza.

Ndinofanira kuenda kuEmergency Room riini?

Kana uine allergy yakanyanya isingagone kudzorwa nemishonga, enda kuchipatara nekukurumidza. Kureva kuti, kana ukaona zviratidzo zvakaita sekuoma kufema, pahuro pakaoma, dzungu rakasimba, kana kurasikirwa nepfungwa.

Mibvunzo ipi yandinofanira kubvunza chiremba wangu?

Kana uine Mastocytosis, zvakanaka kubvunza chiremba wako mibvunzo yakaita seiyi:

• Ndine rudzii rweMastocytosis?
• Ndeapi marapirwo anowanikwa erudzi rwandinarwo?
• Kurapwa uku kuchabvisa zviratidzo zvangu zvachose here?
• Ndezvipi zvimwe zviratidzo zvingaratidza kuti mamiriro angu ari kuipa?
• Ndichazofanira kurapwa nekusingaperi here?
• Kana ndine chimiro chisina kusimba, fungidziro yangu ndeyei?
• Pane here miedzo yekiriniki yandinogona kutora chikamu mairi?

Pakupedzisira, zvekurangarira (Mharidzo Yekuenda Kumba)

Mastocytosis chirwere chisingawanzoitiki chinokonzera kukura kusingadzoreki kwemasero emuviri. Chinogona kukanganisa ganda nenhengo dzemukati. Vanhu vazhinji vanogona kudzora zviratidzo zvavo nekuziva nekudzivirira zvinovakonzera uye kutora mishonga. Zvakakoshawo kuchengetedza jekiseni re epinephrine riri pedyo nekurapa allergy yakanyanya.

Kunyangwe ichi chirwere chisingarapiki zvachose, kana ukapihwa mazano ekurapa uye kurapwa kwakakodzera, unogona kuedza kudzora zviratidzo uye kurarama hupenyu hwakajairika. Kana uine mimwe mibvunzo nezveizvi, usazeza kutaura nachiremba wako. Vachakubatsira.

Mastocytosis, mast cells, histamine, allergy , zvirwere zveganda, immune system, anaphylaxis