Ngatidzidzei nezvemamwe matambudziko ane chekuita nehurongwa hwegland remuviri wenyu? - Multiple Endocrine Neoplasia (MEN)

Muviri wedu wakaita semuchina unoshamisa, handiti? Kuti muchina uyu ushande zvakanaka, chikamu chimwe nechimwe chinofanira kushanda pamwe chete uye kushanda pamwe chete zvakanaka. Kune sisitimu yakakosha kwazvo mumuviri wedu, inonzi endocrine system . Matumbu ari musisitimu iyi anogadzira mahormone anodzora mabasa mazhinji mumuviri wedu. Zvisinei, dzimwe nguva sisitimu iyi inogona kusashanda zvakanaka. Nhasi tichataura nezvemamiriro asingawanzoitiki asi akakosha ekuziva. Ndiyo Multiple Endocrine Neoplasia , inozivikanwawo se `(MEN)` muchidimbu.

Saka chii chinonzi endocrine system iyi?

Zvichitaurwa zviri nyore, sisitimu yedu yeendocrine inetwork yemagland nenhengo dziri mumuviri wedu. Idzi ndidzo dzinogadzira makemikari anonzi mahormone uye dzinoaburitsa muropa. Funga nezvemahormone aya senhume diki dzinotakura mashoko mukati memiviri yedu. Mashoko aya anoudza nhengo dzedu, ganda, netsandanyama zvekuita uye nguva yekuzviita.

Kune matumbu makuru akawanda nenhengo dziri muhurongwa hwedu hwe endocrine:

• Hypothalamus: Iyi iri pasi pehuropi hwedu. Inodzora zvinhu zvakawanda muhurongwa hwe endocrine.
• Gland repituitary: Gland diki iri, rakabatana nehypothalamus, rinogadzira mahormone anodzora mamwe magland akawanda, anosanganisira gland rethyroid, gland readrenal, maovari, uye machende.
• Gland reGland: Gland iri rakaita seshavishavi riri pamberi pemutsipa rinodzora mashandiro emuviri wedu, ndiyo nzira yatinoshandisa simba rinobva muchikafu chatinodya.
• Parathyroid glands: Aya magland madiki mana, anowanzo kuwanikwa pedyo nethyroid gland, anodzora huwandu hwecalcium nephosphorus mumuviri wedu.
• Matumbu eAdrenal: Matumbu maviri aya, ari pamusoro peitsvo, anodzora mashandiro emuviri, BP, kukura kwepabonde, uye kushushikana.
• Pineal gland: Gland iyi inogadzira hormone inonzi melatonin uye inotarisira kurara kwedu.
• Pancreas: Apa ndipo panogadzirwa insulin. Yakakosha zvikuru pakugadzirisa muviri uye kudzora shuga muropa. Inhengo yemuviri wedu wekugaya chikafu.
• Mazai: Apa ndipo panogadzirwa mahormone epabonde echikadzi anonzi estrogen, progesterone, uye testosterone.
• Maende: Pakuburitsa urume muvarume, hormone inonzi testosterone inogadzirwawo pano.

Saka chii chinonzi Multiple Endocrine Neoplasia (MEN)?

Multiple Endocrine Neoplasia (MEN) chirwere chisingawanzoitika mumajini umo mabundu anokura mumasero akawanda emudumbu, zvatakakurukura kare. Dzimwe nguva mabundu aya anogona kuita kenza.

Kune mhando mbiri huru dzemamiriro aya ekuti `(MEN)`:

1. Multiple endocrine neoplasia type 1 (MEN type 1): Ichi chirwere chinoita kuti bundu riwande mumagland akasiyana e endocrine system. Izvi zvinonziwo MEN-1 uye Wermer's syndrome.

2. Multiple endocrine neoplasia type 2 (MEN type 2): Ichi chirwere chegomarara remajini chinokanganisa magland akasiyana-siyana. Vanhu vane MEN2 vanowana rudzi rwegomarara rethyroid rinonzi medullary thyroid cancer (MTC) . Vanewo mukana mukuru wekuva nemagomarara mune mamwe magland e endocrine system. Izvi zvinonziwo MEN-2 uye Sipple syndrome.

Sei mamiriro ezvinhu aya ekuti '(VANHU)' achiitika?

Mhando dzese idzi dze `(MEN)` dzinokonzerwa nekuchinja kwemajini edu, kureva, kuchinja . Fungidzira kuti muviri wedu une chimwe chinhu chakafanana nebhuku remirairo, kureva majini. Kana bhii rimwe chete mubhuku remirairo iri risiri iro, kureva kuti, kana jini rikachinja, mamwe mabasa emuviri anogona kukanganiswa.

• (MEN type 1) inokonzerwa nekuchinja kwejini rekuti `MEN1` . Iri jini rekuti `MEN1` ijini rinodzivirira bundu . Kureva kuti, jini rinobatsira kudzora kupatsanurwa kwemasero nekudzivirira bundu kuti risaumbwe. Kana jini iri rikasashanda zvakanaka, mamwe masero anogona kukura asingadzoreki uye kuumba bundu.
• (RUDZI RWEMEN rwechipiri) runokonzerwa nekuchinja kwejini re'RET' . Iri jini re'RET' ijini rine chekuita nekukura kwegomarara. Kana jini iri rikachinja, masero ari mune dzimwe nhengo dzemuviri nemasero emudumbu anokura zvisingadzoreki uye anoumba bundu.

Kuchinja kwemajini uku kunogona kutorwa kubva kuvabereki kana kuti kunogona kuitika zvisina tsarukano panguva yekukura kwemwana ari mudumbu. Kana mubereki mumwe aine MEN, pane mukana we50% wekuti mwana achava nechirwere ichi.

Ngatidzidzei zvakawanda nezve `(MEN)` rudzi 1 (`MEN rudzi 1`)

Vanhu vane chirwere cheMEN type 1 vanowana bundu mumatumbu akawanda e endocrine system. Nzvimbo dzinowanzo batwa nadzo ndedzinotevera:

• Parathyroid glands: Iyi ndiyo inonyanya kuwanikwa.
• Gastroenteropancreatic tract: Izvi zvinoreva kuti bundu rinogona kuumbwa mupancreas, mudumbu, nedzimwe nzvimbo dzemudumbu, dzakadai seduodenum.
• Gland repituitary.

Kazhinji, mapundu anowanikwa neMEN type 1 haasi ekenza (asina kuipa) . Zvisinei, mamwe mapundu anogona kuva ekenza (anokuvadza).Inogonawo kupararira (metastasize) kune dzimwe nhengo dzemuviri. Matumbu ane bundu anowanzo buritsa mahormone akawandisa muropa. Izvi ndizvo zvinokonzera zviratidzo zvakasiyana-siyana nematambudziko ehutano.

Vanachiremba vakaona mhando dzinopfuura makumi maviri dzematumbu emudumbu neasiri emudumbu muvanhu vane MEN type 1. Kune dzimwe mhando dzematumbu dzisinganyanyi kuwanda, dzakadai se:

• Mabundu eNeuroendocrine anokura muthymus (lymph node iri muchipfuva) uye bronchi (nzira dzekufema mumapapu).
• Matumbu eAdrenocortical anoumbwa muchikamu chekunze cheadrenal glands.
• Mapundu ane mafuta (Lipomas) anoumbwa pasi peganda.
• Kenza yemazamu.
• Mamota akadai se meningiomas ne ependymomas anogona kuitika muuropi kana musana.

Ndezvipi zviratidzo zve `(MEN type 1)`?

Zviratidzo zveMEN type 1 zvinogona kusiyana zvikuru kubva pamunhu kusvika pamunhu. Zvinoenderana nekuti ndeapi magland akanganiswa uye kuti anogadzira mahormone akawanda sei. Vamwe vanhu vanogona kunge vasina zviratidzo zvachose, vamwe vanogona kunge vaine zviratidzo zvishoma, uye vamwe vanogona kunge vaine zviratidzo zvakakomba, zvinotouraya. Zviratidzo zvinogona kusiyana kubva pamunhu kusvika pamunhu, kunyangwe mumhuri imwe chete, kunyangwe pakati pemapatya.

Ngatitarisei mamwe emhando huru dzemapundu uye zviratidzo zvawo:

• Nekuda kwematambudziko ane parathyroid glands (hyperparathyroidism):

90% yevanhu vane `(MEN type 1)` vanowana chirwere ichi pavanosvika makore makumi mashanu. Mukuita izvi, magland eparathyroid anotanga kushanda zvakanyanya.

• Zviratidzo zvishoma: kurwadziwa kwemajoini, kushaya simba kwemhasuru, kuneta, kuora mwoyo, kuoma kuisa pfungwa pachinhu chimwe, kushaya chishuwo chekudya.
• Zviratidzo zvakakomba: kuda kurutsa, kurutsa, kuvhiringidzika, kukanganwa, nyota yakawandisa uye kuita weti nguva nenguva, kuvimbiwa, kurwadziwa kwemapfupa.

• Nekuda kwebundu riri mupancreas nechikamu chekutanga cheura diki (Gastrinomas):

Vanhu vakuru vanosvika 40% vane chirwere cheMEN type 1 vanowana tumors dzinonzi gastrinomas. Izvi zvinogadzira hormone inonzi gastrin, iyo inokonzera kuti mudumbu mubudise acid yakawandisa.

• Zviratidzo: Kurwadziwa kwemudumbu, manyoka, chirungurira (acid reflux), maronda emudumbu (peptic ulcers).
• Rimwe bundu rinoonekwa muchikamu ichi i insulinoma . Izvi zvinoburitsa insulin, iyo inogona kukonzera kuderera kweshuga muropa (hypoglycemia).
• Zviratidzo: kuvhiringidzika, kudedera, kudikitira, nzara yakawandisa, kushaya zororo, kurova kwemoyo nekukurumidza, kuchinja kwekuona kwenguva pfupi.

• Nekuda kwebundu repituitary (prolactinomas):

Vanhu vanosvika 25% vane chirwere cheMEN type 1 vanowana bundu repituitary. Anonyanya kuwanikwa iprolactinomas, iyo inogadzira hormone inonzi prolactin .

• Zviratidzo kuvakadzi: kusaenda kumwedzi zvakanaka kana kurega kuenda kumwedzi (amenorrhea), kunetseka kubata pamuviri, kubuda kwemukaka muzamu kana usina pamuviri kana kuyamwisa (galactorrhea), kudzikira kwechido chebonde.
• Zviratidzo muvarume: Kudzikira kwechido chebonde nekuda kwekudzikira kwemazinga e testosterone, kusashanda zvakanaka kwepabonde (ED), uye kuoma kubata pamuviri.
• Kana bundu rakakura: musoro, kuda kurutsa/kurutsa, kuchinja kwekuona (kuona kaviri, kuona zvishoma).

Zvakakosha: Havasi vese vanozosangana nezviratidzo zvakafanana. Rondedzero iyi haina kukwana. Kune mamwe marudzi akawanda emapundu anogona kukura mu `(MEN type 1)`.

Ngatidzidzeiwo nezve `(VANHU)` rudzi rwechipiri (`VANHU rudzi rwechipiri`)

Munhu wese ane MEN type 2 anowana mhando yegomarara rethyroid rinonzi medullary thyroid cancer (MTC) . Rudzi urwu rwegomarara runokura mumhando yakakosha yesero mugland rethyroid rinonzi C cells. Masero aya anogadzira hormone inonzi calcitonin. MTC inogona kupararira kuma lymph nodes nedzimwe nhengo dzemuviri. Kurapa kukuru kubviswa kwegland rethyroid (thyroidectomy).

Uyewo, vanhu vane `(MEN type 2)` vanogona kusangana nechimwe chezvirwere zvinotevera kana zvese zviri zviviri:

• Pheochromocytoma: Iri bundu risingawanzoitiki rinokura pakati peimwe kana ese ari maviri adrenal glands (adrenal medulla). Kazhinji, aya haasi kenza. Vanhu vanosvika 10%-15% vanogona kuita kenza uye kupararira.
• Hyperparathyroidism: Kuwanda kwecalcium muropa kunowedzera nekuda kwekuwanda kweparathyroid hormone (PTH) inogadzirwa neparathyroid glands.

Ndezvipi zviratidzo zve `(MEN type 2)`?

Zviratidzo pano zvakasiyanawo. Zviratidzo zvinowanzo kukonzerwa nehuwandu hwakawanda hwemahormone anogadzirwa nekenza (MTC) uye mamwe mabundu.

• Zviratidzo zvegomarara remudumbu (MTC):
• Bundu riri pamberi pemutsipa, kurwadziwa kwemutsipa, kushanduka kwezwi (kuchema), kukosora, kuoma kumedza, kuoma kufema.

• Zviratidzo zvinokonzerwa nePheochromocytoma: (zvinoitika muzviitiko zvinenge 50%)
• Zviratidzo zvinongoitika chete kana bundu iri richiburitsa mahormone akawandisa, akadai seadrenaline. Mamwe bundu hariburitse mahormone uye rinogona kusaratidza zviratidzo.
• Zviratidzo zvinowanzoonekwa (zvinowanzo buda uye zvichienda muzvitsinga): BP yakakwira (BP), musoro unotemwa nemusoro, kudikitira zvakanyanya pasina chikonzero, kurova kwemoyo nekukurumidza kana kusina kurongeka, kudedera.

• Zviratidzo zvinokonzerwa ne hyperparathyroidism:
• Sezviri mu`(MEN type 1)`, zviratidzo zvakaita sekurwadziwa kwemajoini, kushaya simba kwetsandanyama, kuneta, kuora mwoyo, kuoma kwekutarisa, kushaya chido chekudya, kuda kurutsa, nyota yakawandisa uye kuita weti nguva nenguva, kuvimbiwa, uye kurwadziwa kwemapfupa zvinogona kuitika.

Ndiani anogona kuva nechirwere ichi chinonzi `(VANHU)`? Chinowanzoitika sei?

Chirwere che `(MEN)` chinogona kubata varume nevakadzi zvakaenzana. Zera iro chirwere che `(MEN type 1)` chinoratidzika rinosiyana zvikuru. Chakaonekwa muvana vane makore masere nevakuru vane makore makumi masere.

`(VANHU)` chirwere chisingawanzoitiki .

• `(MEN type 1)` inobata munhu mumwe chete pavanhu zviuru makumi matatu.
• `(MEN type 2)` inobata munhu mumwe chete pavanhu 35,000.

Vamwe vaongorori vanotenda kuti huwandu chaihwo hwevanhu vane zvirwere izvi hunogona kunge hwakakwira nekuda kwekunge vasina kuongororwa zvakakwana kana kuti vasina kuongororwa zvisizvo.

Vanachiremba vanoongorora sei chirwere chinonzi `(MEN)`? (Kuongororwa)

Kuziva chirwere chinonzi `(MEN)` kunogona kuoma zvishoma, nekuti kunokanganisa magland akasiyana.

• Kuzivikanwa kwe `(MEN type 1)`:

Munhu anowanzoonekwa aine chirwere cheMEN type 1 kana aine maviri emabundu matatu makuru eendocrine ataurwa pamusoro apa (parathyroid bundu, pituitary bundu, uye/kana mabundu emudumbu), kana kana aine rimwe remabundu iwayo uye nhengo yemhuri ine MEN type 1.

• Miedzo:
• Kuongororwa kweropa: Tarisa huwandu hwakanyanya hwemahormone (semuenzaniso parathyroid hormone (PTH), calcium).
• Kuongororwa kwemifananidzo: Izvi zvinogona kubatsira kuwana nzvimbo dzine mapundu, akadai seCT scan (computed tomography scan) kana MRI (magnetic resonance imaging scan).
• Kuongororwa kwemajini: Kutarisa kana paine shanduko mujini rekuti 'MEN1'.

• Kuzivikanwa kwe `(MEN type 2)`:

Munhu anoonekwa aine chirwere cheMEN type 2 kana aine medullary thyroid cancer (MTC) pamwe chete nepheochromocytoma uye/kana hyperplasia kana adenoma yemagland eparathyroid.

• Miedzo:
• Kuongororwa kweropa: Tarisa huwandu hwemahormone akadai se calcitonin (yeMTC), parathyroid hormone (PTH), uye catecholamines (ye pheochromocytoma).
• Miedzo yekufungidzira: `CT scan` kana `MRI scan` zvinoshandiswa.
• Kuongororwa kwemajini: Kutarisa kana paine shanduko mujini re'RET'.

Ndezvipi zvinorapwa zve `(VANHU)`?

Kurapwa kweMEN kunoenderana zvachose nekuti ndeapi ma "endocrine glands" nenhengo dzemuviri dzinokanganiswa. Kazhinji kunosanganisira timu yevanachiremba vane hunyanzvi hwakasiyana-siyana, kusanganisira vanachiremba ve "endocrinologists" , vanachiremba vekuvhiya , uye vanachiremba vekenza .

Panogona kuva nesarudzo dzakasiyana-siyana dzekurapa:

• Mishonga: Dzora zviratidzo uye uderedze migumisiro yemahormone akawandisa.
• Kuvhiyiwa: Bvisa bundu kana gland rese rakakanganiswa (semuenzaniso, gland re thyroid).
• Kurapa kwekutsiva mahormone: Kana endocrine gland ikabviswa nekuvhiyiwa, mahormone anogadzirwa nayo anopihwa kunze.
• Kurapa kenza: Kana kenza yapararira kune dzimwe nzvimbo (yakapararira), mishonga yakaita sechemotherapy neradiation therapy .

Nekuti murwere wese we `(VANHU)` akasiyana, chirongwa chekurapa chinoshanda kune wese munhu chakasiyana. Usatya kutaura nachiremba wako nezvesarudzo dzekurapa dzakakunakira.

`(VANHU)` vanogona kuporeswa zvizere here? Vanogona kudzivirirwa here?

Zvinosuwisa kuti pari zvino hapana mushonga wechirwere ichi chinonzi `(MEN)`. Zvisinei, chinogona kurapwa . Vanachiremba vanorapa shanduko dziri mugland rega rega nekuvhiyiwa kana mishonga sezvakakodzera panguva iyoyo.

Hazvigoneki kudzivirira kukura kwe `(MEN)`, nekuti kunokonzerwa nekuchinja kwemajini. Kuchinja kwemajini uku kunogona kugarwa nhaka kubva kuvabereki kana kuitika zvisina tsarukano panguva yekukura kwemwana.

Zvisinei, kana hama yepedyo (mubereki, munin'ina kana hanzvadzi) yaonekwa kuti ine chirwere cheMEN, zvakakosha kutaura nachiremba wako nezvekuongororwa kwemajini eMEN. Kuita izvi kunogona kubatsira kuona bundu nekukurumidza kana uine chirwere ichi.

Chii chinoitika kana uchigara ne `(VARUME)`? (Kufungidzira)

Kufanotaura kweMEN kunoenderana nezvinhu zvakawanda:

• Kuti `(MEN)` yakakurumidza sei kuzivikanwa.
• Ndezvipi zvirwere zve endocrine zvinokanganiswa?
• Kuti bundu iri rine kenza here kana kuti kwete.
• Rudzi rwekurapa rwunoshandiswa.
• Kana bundu regomarara rakapararira kune dzimwe nhengo dzemuviri (rakaita metastasized) zvinodanwa.

Kana wakamboonekwa uine chirwere cheMEN, chiremba wako anogona kukupa zano rakanakisisa rekurapwa kwako uye nzira yekufambira mberi.

Nguva yekuona chiremba uye mibvunzo inokosha yekubvunza

Kana wakamboonekwa uine chirwere cheMEN, unofanira kuona chiremba wako nguva nenguva kuti utarise mamiriro ako uye uve nechokwadi chekuti kurapwa kwako kuri kushanda nemazvo.

Uyewo, kana nhengo yemhuri yepedyo mumhuri yako ine `(MEN)`, taura nachiremba wako nezvekuongororwa kwemajini, sezvambotaurwa.

Kana uine `(MEN)`, zvingabatsira kubvunza chiremba wako mibvunzo yakaita seiyi:

• Ndine rudzii rwe `(VANHU)`?
• (VANHU VEMUNHU) vanokanganisa sei muviri wangu?
• Ndezvipi zviratidzo zvandinofanira kutarisa?
• Ndedzipi nzira dzekurapa dzandinadzo?
• Ndezvipi zvakanakira nekuipira kwenzira dzakasiyana dzekurapa?
• Zvinotora nguva yakareba sei kuti kurapwa kubudirire?
• Vamwe vese vemhuri yangu vanofanira kuongororwa (VANHU) here?

Pakupedzisira, zvinhu zvekurangarira (Mharidzo Yekuenda Kumba)

Chirwere che multiple endocrine neoplasia (MEN) chirwere chisingawanzoitiki. Uyewo, nekuti MEN inogona kukonzera zviratidzo zvakasiyana-siyana uye mamiriro emunhu wese haana kufanana, dzimwe nguva zvinogona kuoma kuziva kana uine chirwere ichi.

Kana ukaona zviratidzo zvitsva zvinokunetsa, kana kuti ukaona shanduko mumuviri wako, chinhu chakanakisa chekuita ndechekuona chiremba.

Kunyangwe zvimwe zviitiko zve `(MEN)` zvichiitika zvisina tsarukano, zvinogonawo kuitika mumhuri. Kana mumwe wehama dzako dzepedyo aine `(MEN)`, zvakakosha kuti uedze majini kuti uone kana uri panjodzi. Taura nachiremba wako nezvemibvunzo yako nezvenjodzi yako yekuva ne `(MEN)`. Varipo kuti vakubatsire. Usatya, usatya, uye usatya kubvunza mibvunzo.

` Multiple endocrine neoplasia, MEN, endocrine system, mahormone, bundu, kenza, MEN rudzi 1, MEN rudzi 2, parathyroid, pituitary, pancreas, thyroid, MTC, pheochromocytoma, genetic condition, zviratidzo, kuongororwa, kurapwa