Zvakajairika kuti munhu wese anzwe kutya kukuru uye kuvhunduka paanonzwa mazwi ekuti "kenza yemudumbu". Zvisinei, nekuda kwekufambira mberi kwekurapa nhasi, kune nzira dzakawanda itsva uye dzinobudirira dzinogona kutibatsira kurarama nezvirwere zvakadaro. Nhasi, tichataura nezvenzira ye "targeted therapy" yakasiyana nechemotherapy yechinyakare uye inonyanya kurwisa masero ekenza.
Zvichitaurwa zviri nyore, maMonoclonal Antibodies aya chii?
Tisati tanzwisisa izvi, ngatitarisei nzira inoshamisa yekudzivirira muviri ine miviri yedu. Kana utachiona, hwakaita sebhakitiriya kana hutachiona, huchipinda mumiviri yedu, immune system yedu inogadzira mapuroteni akakosha anogona kuziva zvipembenene izvi, kuzvinamatira, uye kuzviparadza. Tinozvidaidza kuti "bodyguards," kana kuti antibodies kuti zvive pachena.
Zvino, aya ma "Monoclonal Antibodies" rudzi rwema "anogadzira" ma antibodies akagadzirwa murabhoritari uchishandisa tekinoroji yakakosha. Aya akagadzirwa kurwisa chinangwa chimwe chete. Kutaura chokwadi, akagadzirwa kuti aone puroteni chaiyo pamusoro pesero rekenza, oinamatira, uye oparadza sero rekenza iroro .
Izvi zvakafanana nemukuru wemauto akadzidziswa zvakakwana anogona kuwana muvengi munzvimbo yakazara vanhu ongorwisa muvengi iyeye chete asingakuvadzi mumwe munhu. Saka, pachinzvimbo chekukuvadza masero akanaka mumuviri sekurapa chemotherapy nguva dzose, nzira iyi yekurapa inogona kutarisirwa kuti isabate migumisiro mishoma nekuti inonyanya kujeka.
Mishonga inomisa kukura kwetsinga dzeropa mukenza (Angiogenesis Inhibitors)
Gomarara harisi chinhu chinongokura chete. Rakafanana nemuti. Rinoda chikafu kuti rirarame, rikure, uye rikure. Kuti riwane chikafu ichi, masero egomarara anokura mitsipa mitsva yeropa yakaipoteredza. Tinodana maitiro aya kuti "angiogenesis." Saka, kana tikamisa mitsipa yeropa inopa izvi "chikafu nechinwiwa" kugomarara, tinogona kumisa kukura kwegomarara, handiti? Ndizvo zvatinodaidza kuti kirasi yemishonga inoita izvozvo.
Aya ndiwo mashandiro anoita Bevacizumab (Avastin):
Bevacizumab (zita rechiratidzo: Avastin) mushonga unonyanya kushandiswa mukirasi iyi. Masero egomarara anotumira chiratidzo chinoaudza kuti "avake mitsipa yeropa." Chiratidzo ichi chinonzi vascular endothelial growth factor, kana kuti VEGF. Chinoitwa naAvastin ndechekuvhara chiratidzo ichocho kuti chisasvike panzvimbo yacho. Muchidimbu, inobvisa "tsamba yekuvaka mitsipa yeropa" inotumirwa negomarara yoiparadza.
Izvi zvinomisa kenza kuti isagadzire mitsipa mitsva yeropa, izvo zvinononotsa kukura kwekenza. Mushonga uyu unotenderwa kenza yemuura yakapararira (yakapararira) kune dzimwe nhengo dzemuviri. Kunyangwe isingakwanise kurapa kenza zvachose, zvidzidzo zvakawana kuti Avastin, kana ikashandiswa pamwe chete nechemotherapy, inogona kuwedzera nguva yekurarama kwevarwere nemwedzi mishanu .
`Fruquintinib (Fruzaqla)`, `ramucirumab (Cyramza)`, uye `ziv-aflibercept (Zaltrap)` mimwe yemishonga mitsva yakanangana ne `VEGF`.
Avastin inopihwa sei? Ndezvipi zvinokonzeresa?
Avastin ijekiseni remutsinga (IV). Inowanzo pihwa mavhiki maviri kusvika matatu ega ega pamwe chete nechemotherapy.
Zvakakosha zvikuru kuziva nezvemigumisiro inogona kuitika kubva pamushonga uyu.
| Rudzi rwemhedzisiro yakaipa | Tsananguro |
|---|---|
| Migumisiro yakajairika |
|
| Migumisiro yakaipa |
|
Mishonga inokanganisa kukura kwemasero ekenza
Cetuximab (Erbitux) nepanitumumab (Vectibix) mamwe marudzi maviri ema antibodies e monoclonal. Aya anoshanda zvakasiyana. Anotarisa puroteni inonzi epidermal growth factor receptor (EGFR) pamusoro pemasero ekenza.
Funga nezve 'EGFR' iyi se 'On' switch inoudza sero rekenza kuti 'riparare nekukurumidza uye rikure zvakanyanya.' Zvinoitwa nemishonga 'Erbitux' na 'Vectibix' ndezvekugara pa switch iyi woivharira. Zvadaro, chiratidzo chechisikigo chinoudza sero kuti rikure hachigone kuvhura switch. Nenzira iyi, kukura kwemasero ekenza kunodzorwa.
Mushonga uyu unopihwa kunaani?
Mishonga yeErbitux neVectibix inotenderwa kurapa kenza yemuura yakapararira kune dzimwe nhengo dzemuviri.
Jekiseni reErbitux rinopihwa kamwe chete pasvondo, kungave kuri kwega kana nemushonga wechemotherapy irinotecan (Camptosar). Jekiseni reVectibix rinopihwa mavhiki maviri ega ega pamwe chete nemimwe mishonga yechemotherapy.
Zvakakosha kuti usati wapa mushonga uyu, bvunzo yekuchinja kwemajini inoitwa pamasero ako egomarara kuti uone kana mushonga uyu uchizoshanda kune gomarara iroro. Izvi hazvina kukodzera kune ese magomarara. Saka, bvunzo iyi inotoitwa.
Ndezvipi migumisiro yakaipa yeErbitux neVectibix?
Mishonga iyi inewo migumisiro chaiyo.
| Zvinowanzoitika mhedzisiro yeErbitux uye Vectibix | |
|---|---|
| Matambudziko eganda | Mapundu akafanana neapundu, mapundu paganda, uye ganda rakaoma. Asi chinoshamisa ndechekuti, dzimwe nguva maitiro aya eganda anoreva kuti mushonga uyu unoshanda zvakanaka pakurwisa kenza. |
| Mimwe migumisiro yakaipa |
|
Mharidzo Yekuenda Nayo Kumba
- Ma antibodies eMonoclonal mushonga wepamusoro unonyanya kurwisa masero ekenza. Akasiyana nekurapa chemotherapy nguva dzose.
- Mimwe mishonga inodzivisa ropa rinoenda kugomarara, nepo mimwe ichivhara nzira yekuzivisa kenza inokonzeresa kukura kwemasero egomarara.
- Mishonga yese iyi ine migumisiro yayo. Taura nachiremba wako nezveizvi usati watanga kurapwa.
- Kurapa uku hakuna kukodzera munhu wese. Chiremba wako ndiye achasarudza kuti ndeipi nzira yekurapa yakakunakira zvichienderana nerudzi rwegomarara raunaro, kuti rapararira kusvika papi, uye mhedzisiro yekuongororwa kwemajini.
- Kana iwe kana mumwe munhu mumhuri mako aine kenza, musavhunduka. Taura nachiremba wako wekenza nezvenzira dzese dzekurapa dziripo, zvakanakira nezvadzinokanganisa, uye shingai kutarisana nekurapwa kwacho.
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