Une chirwere chechiropa chinonzi PBC here, kana kuti Primary Biliary Cholangitis? Kana zvakadaro, mushonga wekutanga wawakanyorerwa nachiremba wako ungasashanda sezvawaitarisira. Usazvidya moyo nazvo. Vanhu vazhinji vakasanganawo nedambudziko rakafanana. Chinhu chakakosha ndechekugara uine tariro uye kuziva zvaunogona kuita zvinotevera. Nhasi, ngatitaurei nezvezvaunogona kuita panguva yakaita seiyi uye mishonga mitsva iripo.
Kutanga, chii chinonzi PBC mumashoko akareruka?
PBC chirwere chakaoma uye chinogara kwenguva refu apo masoja emuviri wedu anorwisa migero midiki ye bile iri muchiropa chedu. Funga nezvemigero iyi semapaipi madiki ari muchiropa chedu. Basa rayo guru nderekutakura bile, mvura inobatsira kugaya chikafu, kubva muchiropa.
Zvino, kana tichitarisa PBC, masero edu ekudzivirira muviri anokuvadza mapaipi aya. Ipapo mapaipi aya anovharika, uye bile harifambi zvakanaka uye rinonamira muchiropa. Kungofanana nemota dzinonamira mumotokari. Kana bile rikaungana nenzira iyi, rinotanga kukuvadza masero echiropa. Nekufamba kwenguva, kukuvara uku kunogona kukonzera mavanga pachiropa. Tinodana izvi kuti fibrosis . Kana chirwere ichi chikanyanya kuipa, chinogona kutungamira kunjodzi ye cirrhosis, chirwere chinonzi kutadza kwechiropa.
Izvi zvakasiyana zvishoma nezvimwe zvirwere zve autoimmune. Nekuti PBC haipinduri zvakanaka nemishonga inodzvinyirira masoja emuviri inoshandiswa kune zvimwe zvirwere zve autoimmune. Chimwe chikonzero chingave chekuti chiropa chinenge chatokuvara kusvika pamwero wakati panguva iyo chirwere chinoonekwa. Asi musazvidya mwoyo, nekufambira mberi kwesainzi, ikozvino kwava nemishonga yakanaka yekurapa izvi.
Danho rekutanga mukurapa: mushonga weUDCA
Pane zvinangwa zvikuru zvakawanda mukurapa PBC: kuderedza kufambira mberi kwechirwere, kudzora zviratidzo, uye kudzivirira matambudziko anokonzerwa nekukuvara kwechiropa.
Kana wangoonekwa uine PBC, mushonga wekutanga waunotanga kushandisa chiremba wako iUrsodeoxycholic acid , kana kuti UDCA muchidimbu. Unogona kuiziva nezita rekuti Ursodiol. Mushonga uyu unoshanda nekubatsira chiropa kuburitsa bile rakanamira muchiropa uye kuderedza kuumbwa kwemavanga (fibrosis) muchiropa. Izvi zvakakosha, nekuti mavanga ndiwo anogona kupedzisira akonzera cirrhosis uye kutadza kushanda kwechiropa.
Asi chokwadi ndechekuti, UDCA haishandire munhu wese. Iri ndiro pfungwa huru yatiri kutaura nezvayo nhasi.
Sei UDCA yoga isina kukwana?
Ongororo yakawana kuti pakati pe25% ne50% yevarwere vanotora UDCA havawani mhedzisiro inotarisirwa kubva pamushonga uyu. Izvi zvinoreva kuti bvunzo dzavo dzekushanda kwechiropa hadziratidzi kuvandudzika kukuru.
Nenzira iyi, munhu asingapindure zvakanaka kuUDCA ane mukana wakapetwa kashanu wekuva nechirwere checirrhosis. Uye mukana wekufa nechirwere ichi wakapetwa katatu . Saka kana UDCA isiri kushanda, zvakakosha kutaura nachiremba wako nezvematanho anotevera, pane kungoramba uchiishandisa.
Uri kushamisika here kuti sei UDCA isiri kushanda nemazvo? Panogona kunge paine zvikonzero zvakawanda zveizvozvo.
| Zvikonzero zvekukundikana kwekurapa kweUDCA | Tsananguro iri nyore |
|---|---|
| Vatova nemavanga echiropa (cirrhosis) | Kana chiropa chatove chakakuvara kusvika pamwero wakati apo chirwere chacho chinoonekwa, zvingave zvakaoma kuchidzora neUDCA chete. |
| Mazinga eGGT akakwira | Kana kuongororwa kweropa rako kukaona huwandu hwakawanda hweenzyme yechiropa inonzi gamma-glutamyl transferase (GGT) paunotanga kuonekwa uine chirwere ichi, izvozvo zvinogonawo kuva chikonzero chekusagamuchira kurapwa zvakanaka. |
| Muviri haugone kushivirira mushonga. | Miviri yevamwe vanhu haigone kushivirira UDCA, zvichireva kuti havagone kutora mushonga uyu panguva yakatarwa nekuda kwemigumisiro yakaipa. |
Kana uine chimwe chezvikonzero izvi kana kupfuura, inguva yekufunga nezvekurapa kwechipiri . Chinangwa pano hachisi chekungovandudza mhinduro dzeropa rako. Zvakakoshawo kudzora zviratidzo zviri kukanganisa hupenyu hwako, zvakaita sekuvaviwa kusingatsungiririki , kuneta zvakanyanya, uye kushaya hope . Nekuti UDCA haipe zororo rakawanda pazviratidzo izvi.
Kurapa kwemutsara wechipiri: Ndedzipi sarudzo itsva idzi?
Nzira dzekurapa PBC dziri kuchinja nekukurumidza. Mishonga mitsva yakati wandei iri muchikamu chekupedzisira chekubvumidzwa. Ngatitarisei mishonga iripo uye iri kuuya.
Obeticholic acid (OCA)
Kana UDCA isingashande zvakanaka, kana kuti kana usingakwanise kushivirira UDCA, mushonga mukuru unotevera wauchazoshandisa chiremba wako iobeticholic acid , kana kuti OCA . Kazhinji unouya pasi pezita rekuti Ocaliva.
Dzimwe nguva OCA inogona kupihwa pamwe chete neUDCA. Kureva kuti, mishonga yese inoshandiswa pamwe chete. OCA iri muboka remishonga inonzi farnesoid X receptor agonists . Muchidimbu, basa rayo nderekuti,
1. Inoderedza huwandu hwenyongo inogadzirwa nechiropa.
2. Inobatsira kusunda nyongo kubva muchiropa.
Nenzira iyi, kana OCA ikashandiswa yoga kana neUDCA, mashandiro echiropa anovandudzika uye mwero wemavanga echiropa unoderera.
Asi chimwe chezvikonzero zvikuru zveOCA ndechekuti inogona kuwedzera kuvaviwa muvarwere vane PBC. Saka, kana kuvaviwa kukawedzera mushure mekutanga mushonga uyu, unofanira kuudza chiremba wako nezvazvo. Ipapo anogona kuchinja dosi kana kukupa imwe nzira yekurapa.
Basa rekurapa kwePBC riri kuramba richichinja, saka zvakakosha kuti hutano hwako hugare huchitaurirana nachiremba wako uye kukurukura nezvekurapa kutsva.
Mharidzo Yekuenda Nayo Kumba
- PBC chirwere chechiropa chinotora nguva refu chinoda kurapwa. Usachiregeredza.
- UDCA mushonga wekutanga unokosha zvikuru pakurapa izvi, asi ungasapa mhedzisiro yakafanana kune wese munhu.
- Kana usingawane mhedzisiro yakanaka kubva kuUDCA kana kuti usingakwanise kutsungirira migumisiro yacho, hakusi kuguma kwekurapwa. Iye zvino kune mishonga yechipiri inoshanda, yakaita seOCA.
- Usasarudza kurapwa uri wega. Gara uchitaurirana nachiremba wako pachena nezvekurapa kwako, kuongororwa kweropa, uye zviratidzo.
- Kuongororwa nachiremba uye kuongororwa ropa (kunyanya kuongororwa mashandiro echiropa) nenguva kwakakosha pakurapa chirwere ichi.
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