Mwana wako anowanzo rwara nefivha here? Zvingave zvichikonzerwa neSAIDs (Systemic Autoinflammatory Diseases) here?

Oh, mwana wako anowanzo rwara nefivha mazuva ano here? Paunenge uchifunga kuti wapora, inomuka zvakare here? Dzimwe nguva chikonzero cheizvi chingasave hutachiona kana mabhakitiriya akajairika. Nhasi tichataura nezvechirwere chakaoma zvishoma, asi chakakosha kuziva nezvacho. Izvi zvinonzi SAIDs, izvo zvinomirira Systemic Autoinflammatory Diseases . Kare, izvi zvainzi `(Periodic Fever Syndromes)` kana `(Recurrent Fever Syndromes)`.

Chii chinonzi SAIDs? Ngatizvinzwisise zviri nyore.

Zvichitaurwa zviri nyore, SAIDs iboka rezvirwere zvinokonzerwa nekusashanda zvakanaka kana dambudziko rekutonga mumuviri wedu . Ndosaka mwana achigona kugara achirwara nefivha kunyangwe asina hutachiona (hwakadai sehutachiona kana mabhakitiriya).

Chinhu chinonyanya kukosha ndechekuti zvirwere izvi zvinonzi SAIDs hazvifanirwe kuvhiringidzwa ne `(Autoimmune Diseases)` (semuenzaniso `(Rheumatoid Arthritis)` kana `(Lupus)` zvamungave makambonzwa nezvazvo. Muzvirwere zve `(Autoimmune)`, nekuda kwekukanganisa kuri mu `(adaptive immune system)` yemuviri wedu, iyo system inorwisa masero ayo ane hutano. Asi muSAIDs, chimwe chinhu chakasiyana chinoitika.

MaSAID haawanzo kuwanikwa pane zvirwere zve autoimmune. Anowanzo gara nhaka uye anokonzerwa nekuchinja kwemajini .

Kazhinji, asi kwete nguva dzose, zviratidzo zveSAID zvinotanga mwana achiri mudiki, kungave ari mucheche kana mwana mudiki . Mwana wako anogona kunge aine "nguva" dzefivha nezvimwe zviratidzo zvine chirwere ichi. Pakati penguva idzi, mwana wako anogona kunge asina zviratidzo zvachose. Kunyangwe pasina mushonga weSAIDs, kazhinji pane marapirwo anobatsira kudzora zviratidzo zvemwana wako.

Ndeapi marudzi makuru eSAIDs?

Vaongorori vakaona mhando dzeSAIDs dzinosvika makumi matanhatu, uye itsva dzichiri kuwanikwa. Heano mamwe emhando dzeSAIDs dzinozivikanwa zvikuru:

• Fevha yeMediterranean yemhuri (FMF): Iyi ndiyo inonyanya kurwara nefivha inogarwa nhaka, inodzokororwa. Inogona kukonzera kuzvimba kunorwadza kwedumbu, chipfuva, uye majoini muvana.
• Fivha yenguva nenguva, aphthous-stomatitis, pharyngitis, adenitis (PFAPA): Izvi zvinowanzotanga muvana vadiki vasati vasvitsa makore mana. Dzimwe nguva, chirwere ichi chinogona kunaya chega mushure memakore gumi.
• Tumor necrosis factor receptor-associated periodic syndrome (TRAPS): Izvi zvinogona kuitika muhudiki, kuyaruka, kana kunyange kukura.
• Kushaikwa kweMevalonate kinase (MKD): Kare kwainzi ``Hyper-IgD syndrome'', izvi zvinowanzotanga mwana asati asvitsa gore rimwe chete.
• Zvirwere zvinozvimba zve autoimmune zvinosanganisirwa neNLRP3:Izvi zvaimbonzi `(Cryopyrin-associated periodic syndromes - CAPS)`. Kune mamwe marudzi matatu mukati meizvi.
• Chirwere cheAdult-onset Still's (AOSD): Sezvinoratidzwa nezita racho, ichi chirwere chevana chinonzi "Systemic Juvenile Idiopathic Arthritis (JIA)" chinoitika kuvanhu vakuru.
• Chirwere chegranulomatous chinokonzerwa neNOD-2 (Blau syndrome): Izvi zvinowanzotanga mwana asati asvitsa makore mana. Zvinonyanya kukanganisa ganda, maziso, uye majoini.

Ndezvipi zviratidzo zveSAIDs?

Zviratidzo zveSAID zvinowanzotanga muhudiki. Chiratidzo chikuru uye chinowanzoonekwa ifivha inongogara iripo . Munguva yefivha, vanhu vanowanzova vakagwinya uye vasina zviratidzo. Zvisinei, panogona kunge paine zvimwe zviratidzo zvakanangana nerudzi rumwe nerumwe rweSAID. Ngationei kuti ndezvipi:

• FMF: Izvi zvinogona kukonzera kuzvimba uye kurwadziwa kwakanyanya mudumbu remwana, pachipfuva, uye pamapfundo . Panogonawo kuva nemapundu pamakumbo epasi kana muzviziso.
• PFAPA: Izvi zvinogona kukonzera kurwadziwa pahuro, maronda mumuromo, uye kuzvimba kwema lymph nodes mumutsipa . Semuenzaniso, kana mwana wako achiratidza zviratidzo zvakaita se tonsillitis uye maronda mumuromo, zvinogona kunge zviri PFAPA.
• MISUNGO: Izvi zvinogona kukonzera kutonhora uye kurwadziwa kwetsandanyama muhudyu/muviri nemaoko . Zvinogonawo kukonzera mapundu matsvuku anorwadza anotanga pamaoko nemakumbo opararira nemuviri wese.
• MKD: Izvi zvinogona kukonzera zviratidzo zvakaita sechando, musoro, kurwadziwa mudumbu, kurasikirwa nechido chekudya, uye zviratidzo zvakaita sefuruu .
• Zvirwere zveNLRP3: Chirwere ichi chinogona kukonzera mapundu paganda, musoro, kusagadzikana, kurwadziwa kwemajoini, uye maziso matsvuku/conjunctivitis .
• AOSD: Ichi chirwere chinoratidzwa nemapundu eganda, kurwadziwa kwemajoini, uye kurwadziwa kwetsandanyama . Vamwe vanhu vanogonawo kunzwa kurwadziwa pahuro, kurwadziwa mudumbu, kuneta, uye kusagadzikana.
• Blau syndrome: Izvi zvinogona kukonzera maronda paganda remwana wako, maoko, makumbo, kana pakati pedumbu . Zvinogonawo kukonzera kurwadziwa kwemajoini nekurwadziwa kwemaziso .

Ndezvipi zvinokonzera SAIDs?

Mazhinji maSAID zvirwere zvemajini . Kureva kuti, shanduko chaiyo (variant) mujini chaiyo inokonzera chirwere chega chega. Fungidzira kuti muviri wedu une seti yemirairo (majini) inotiudza maitiro ekuita basa rega rega, saka kana bhii rimwe chete mubhuku iroro risiri iro, rinogona kukonzera kusashanda zvakanaka.

Heano marudzi makuru eSAIDs nemajini anobatanidzwa nawo:

• FMF:Jini rinonzi `MEFV` ndiro rinopa mirayiridzo yekuti puroteni `(pyrin)` ingagadzirwa sei.
• PFAPA: Chikonzero chaicho cheizvi hachisati chazivikanwa .
• MISUNGO: Jini `TNFRSF1A`. Izvi zvinorayira kugadzirwa kwepuroteni inonzi `(tumor necrosis factor receptor - TNFR)`.
• MDK: Jini rinonzi `MVK`. Izvi zvinorayira kugadzirwa kwepuroteni inonzi `(mevalonic kinase)`.
• Zvirwere zveNLRP3: Jini `NLRP3`. Izvi zvinorayira kugadzirwa kwepuroteni inonzi `(cryopyrin)`.
• AOSD: Chikonzero chaicho cheizvi hachisati chawanikwa .
• Blau syndrome: Jini `NOD2`. Izvi zvinorayira kugadzirwa kwepuroteni inonzi `(NOD2)`.

Zvakakosha kunzwisisa kuti kana izvi zvichikonzerwa nezvinhu zvinokonzerwa nemajini, haisi mhosva yevabereki. Aya maitiro akaomarara emuviri.

Matambudziko anokonzerwa neSAIDs

Zvakakosha zvikuru kuwana kurapwa kwakakodzera kwezvirwere izvi. Nekuti, kana kuzvimba kukaramba kuripo mumuviri, kunogona kutungamira kuchirwere chinonzi `(Amyloidosis). `(Amyloidosis)` ipuroteni inowanikwa muitsvo . Izvi zvinogona kukonzera kukuvara kusingaperi kweitsvo . Saka, kana paine zviratidzo, zvakakosha kutsvaga rubatsiro rwechiremba nekukasika.

MaSAID anoonekwa sei?

Kutaura chokwadi, kuongorora SAIDs kunogona kuoma nekuti zviratidzo zvinogona kufanana nezvezvimwe zvirwere zvakakomba, zvakaita se lupus kana lymphoma. Saka, zvakakosha kuona chiremba ane hunyanzvi hwezvirwere zvinozvimba (rheumatologist) kuti aongorore uye agadzirise mamiriro emwana wako nemazvo.

Chiremba wemapfupa emwana wenyu achashandisa zvinhu zvakati wandei kuongorora SAIDs. Achabvunza nezvezviratidzo zvemwana wenyu uye kana paine mumwe munhu mumhuri menyu akambova nematambudziko aya (nhoroondo yemhuri). Chiremba anogona kufungidzira kuti mwana wenyu ane Periodic Fever Syndrome kana:

• Kana uchigara uchirwara nefivha
• Kana paine munhu mumhuri ane nhoroondo yefivha yakaita seiyi nguva nenguva
• Kana uri weboka revanhu vane fivha yakadaro

Miedzo ipi inoshandiswa?

Chiremba anogona kukurudzira bvunzo dzinoverengeka kuti asimbise chirwere chacho. Izvi zvinogona kusanganisira:

• Kuongororwa kwemurabhoritari: Kuongororwa kwakadai se `(C-reactive protein - CRP)` uye `(Complete Blood Count - CBC)` kunogona kutarisa kuzvimba mumuviri. Kuongororwa uku kunova `(positive)` kana paine fivha, uye kunodzokera pahunhu hwakajairika kana fivha yapera.
• Kuongororwa kweweti:Kuongororwa kweprotein yemuweti kunogona kuitwa kuti paonekwe huwandu hwakawanda hweprotein muweti. MuMKD, kuongororwa kwe organic acids weti kucharatidza huwandu hwakakwira hwe mevalonic acid.
• Kuongororwa kwemajini: Izvi zvinogona kutarisa magene akasiyana. Zvisinei, vamwe vana vane SAIDs vanogona kusawana magene akasiyana. Saka, kunyangwe mhinduro dzebvunzo dziri ``negative``, mukana weSAID haugone kurambwa.

MaSAID anorapwa sei?

Kurapwa kweSAIDs kunosiyana zvichienderana nerudzi uye kuoma kwechirwere . Kunyangwe zvirwere izvi zvisingarapike zvachose, zviratidzo zvemwana zvinogona kudzorwa zvakanaka nekushandisa mishonga . Semuenzaniso, kana mwana wako achingowana dzihwa iri kashoma pagore, mishonga inoderedza marwadzo uye mishonga isingarwisi kuzvimba (NSAIDs) inogona kudzora zviratidzo. Zvisinei, kana chirwere chacho chakanyanya kuipa, chiremba anogona kupa mamwe marapirwo.

Heano mamwe marapirwo akadaro:

• FMF: Izvi zvinogona kurapwa nemushonga unonzi `(Colchicine)` kuderedza kuzvimba. Kana usingakwanise kutora `(Colchicine)`, unogona kuedza mushonga wemhando ye`(Biologic)` unonzi `(Canakinumab)`.
• PFAPA: Kukurumidza kwePFAPA kunogona kupfupikiswa nekupa mishonga inonzi steroid (kazhinji inonzi prednisone). Vamwe vana vakakwanisa kudzora zviratidzo zvavo nekushandisa cimetidine, mushonga unoshandiswa kurapa maronda emudumbu.
• TRAPS: Mushonga wekuti `(Canakinumab)` unoshanda zvikuru paTRAPS. Zvakare, mishonga inorapwa nechiremba yekudzivirira kuzvimba yakaita se`(Glucocorticoids)` inogonawo kubatsira kuderedza zviratidzo.
• MKD: `(Canakinumab)` isarudzo yakanaka yekurapa MKD. Kushandisa `(NSAIDs)` kana `(Steroids)` panguva yefivha kunogonawo kubatsira.
• Zvirwere zveNLRP3: Mamwe ma immunomodulators akadai seCanakinumab neRilonacept, Anakinra, anoshanda zvakanaka mukurapa zvirwere zveNLRP3.
• AOSD: Mhando dzakasiyana dzemishonga inoderedza kuzvimba dzinoshandiswa paAOSD. Izvi zvinosanganisira `(Steroids)`, `(Disease-Modifying Anti-Rheumatic Drugs - DMARDs)`, uye `(Biologics)`.
• Blau syndrome: Zvichienderana nezviratidzo zvemwana, mishonga inodzvinyirira immune, tumor necrosis factor (TNF) inhibitors, uye/kana mishonga yemaziso inogona kuyedzwa.

Ko mamiriro eSAIDs anozvigadzirisa ega here?

Mamwe maSAID anogona kugara kweupenyu hwese . Mamwe anogona kugara kwemakore mashoma uye anova nani nekukura. Kunyange zvazvo mamwe matambudziko achigara kweupenyu hwese, kuwanda kwefivha kunogona kudzikira nekufamba kwenguva uye zviratidzo zvinogona kudzikira . Chiremba wako anogona kukupa ruzivo rwakananga nezvemamiriro chaiwo emwana wako.

Kuchengeta mwana ane SAID kunogona kuoma. Pamwe wakambozvitaura wega, asi unogona kushandisa ruzivo rwako pachako kubatsira mwana wako uye kumubatsira kurarama nedambudziko iri rehupenyu hwese.

Chinhu chinonyanya kukosha ndechekutsvaga kurapwa kubva kunyanzvi dzinonyatsoziva kuomarara kweSAIDs. Vanogona kubatsira kudzora zviratidzo zvemwana wako uye kumubatsira kuti ave nehudiki hwakanaka.

Zvinhu zvakakosha zvekurangarira (Mharidzo Yekuenda Kumba)

Zvakanaka, ngatipfupisei zvimwe zvezvinhu zvaunofanira kurangarira kubva pane zvatataura nezvazvo.

• Kana mwana wako achigara achirwara nefivha , taura nachiremba nezvazvo. Izvi zvinogona kuva chiratidzo cheSAID.
• MaSAID idambudziko remuviri wedu rekudzivirira zvirwere , kwete chirwere chinotapukira chinowanzoitika.
• Izvi zvakasiyana nezvirwere zve "Autoimmune" .
• Kazhinji, izvi zvinokonzerwa nezvinhu zvinokonzerwa nemajini .
• Zvakakosha kuona chiremba weRheumatologist kuti uwane chirwere chakakodzera.
• Kurapwa kunogona kudzora zviratidzo zvakanaka .
• Kurapwa nekukurumidza kwakakosha kudzivirira kukuvara kweitsvo.

Kana muine mimwe mibvunzo nezvenyaya iyi, musatya kubvunza chiremba wemhuri yenyu kana chiremba wevana. Vachakwanisa kukubatsirai zvakanyanya.

` SAIDs, fivha inogarwa nhaka, fivha inowanzo itika, fivha muvana, masoja ekudzivirira muviri, zvirwere zvemajini, rheumatologist