Une Peripheral T-cell Lymphoma (PTCL) here? Usazvidya moyo, ngatitaure nezvazvo!

Dzimwe nguva, tinogona kuwana zvirwere zvatisingatombofungi nezvazvo, handiti? Peripheral T-cell Lymphoma, kana kuti PTCL muchidimbu, chirwere chakaoma kunzwisisa, asi zvakakosha kuti uzive nezvazvo. Hachisi chirwere chimwe chete, asi musanganiswa wezvirwere zvakawanda. Tinofanira kutaura nezvazvo zviri nyore, nenzira yaunogona kunzwisisa here?

Peripheral T-cell Lymphoma (PTCL) haisi chirwere chimwe chete. Iboka remhando dzakasiyana-siyana dzegomarara reropa. Zvikuru sei, inokanganisa sisitimu yedu yelymphatic . Ungave wakambonzwa nezvayo se "Non-Hodgkin lymphoma", uye ndizvo zvazviri. Chimwe chinhu nezvePTCL ndechekuti inogona kupararira (metastasize) kubva kune imwe nhengo yemuviri kuenda kune dzimwe nhengo . Izvi zvinoreva kuti inogona kukanganisa chero nhengo yemuviri, saka zviratidzo zvinogona kusiyana.

Mashoko akanaka ndeekuti vanachiremba vanogona kudzora mhando dzakawanda dzePTCL. Zvisinei, dzimwe nguva chirwere ichi chinogona kudzoka . Ndosaka vaongorori vezvekurapa vachigara vachitsvaga mishonga mitsva inogona kubatsira vanhu kurarama kwenguva yakareba nePTCL.

Chirwere ichi chinonzi PTCL chinowanzoitika here?

Kwete, ichi hachisi chirwere chinowanzoitika . Ongororo yakaitwa pasi rose inoratidza kuti vanhu vanosvika mazana maviri ezviuru vanowana PTCL. Vanenge 10% yeavo vanowana `(Non-Hodgkin lymphoma)` vane PTCL.

Dambudziko iri rinowanzoonekwa munyika dzedu dzeAsia, Africa, neCaribbean kupfuura muUnited States. Rinowanzoonekwa nevanhu vane makore anopfuura makumi matanhatu. Zvisinei, mamwe marudzi echirwere ichi anogonawo kuonekwa muvana vadiki nevechidiki .

Ndedzipi mhando huru dzePTCL?

Sangano reWorld Health Organization (WHO) rakaona mhando dzePTCL dzinopfuura makumi maviri. Imwe neimwe yeidzi ine zviratidzo zvayo zvemajini. Ngatitarisei dzimwe dzemhando dzakajairika.

Peripheral T-cell lymphoma, isina kutaurwa neimwe nzira (PTCL-NOS)

Uyu ndiwo rudzi rwechirwere runonyanya kuzivikanwa . ``(PTCL-NOS)`` chikamu chinosanganisira zvirwere zvisinganyatsotsanangurwa uye zvisingaenderane nemamwe marudzi akajeka. Vanenge 30% yevarwere vese vePTCL vanowira muchikamu ichi. Zvinogona kukanganisa zvakanyanya ma lymph nodes ako, bone marrow, spleen , kana chiropa .

Angioimmunoblastic T-cell lymphoma (AITL)

Izvi zvinoitikawo mu15% kusvika 30% yevarwere vePTCL pasi rose. AITL inogonawo kukanganisa chiropa chako, mubofu, chiropa, kana chiropa.

Anaplastic large cell lymphoma (ALCL)

Kunewo marudzi akasiyana e `(ALCL)`.

• Kune imwe inonzi primary cutaneous ALCL , iyo inokanganisa ganda .
• Kune imwezve.Systemic ALCL, iyo inokanganisa mapapu, ganda, nedzimwe nhengo dzemuviri. Iyi systemic ALCL dzimwe nguva inoiswa muzvikamu zvakasiyana zvichienderana nekuchinja kuri kuita jini rinonzi ALK (anaplastic lymphoma kinase) . Inenge 15% yePTCL inowira murudzi urwu rwe "(ALCL)``.

Extranodal natural killer/T-cell lymphoma, mhando yemhino

Uyu wakasiyana zvishoma. Rudzi urwu runowanzo buda munyama dzemhino dzako , maburi emusana , nepahuro repamusoro . Asi dzimwe nguva rinogona kupararira kuganda, mudumbu , nedzimwe nhengo dzemuviri. Rudzi urwu runoumba inenge 10% yePTCL.

Matumbu eT-cell lymphomas

Zita racho rinoratidza izvozvo, handiti? Izvi zvinokanganisa kugaya chikafu . Zvinoita 6% yePTCL. Zvine mhando dzinonzi enteropathy-associated T-cell lymphoma (EATL) uye monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) .

T-cell lymphoma/leukemia yevakuru (ATLL)

Inogona kukanganisa ganda nemapfupa. Kune mhando ina dzeATLL: acute, lymphoma, chronic, uye smoldering . Mhando mbiri dzakajairika ndedzeacute nelymphoma, idzo dzine hukasha. Mhando dzechirwere chechronic nesmoldering dzinokura zvishoma nezvishoma. Rudzi rumwe nerumwe rweATLL runokanganisa nhengo dzakasiyana dzemuviri.

Ndezvipi zviratidzo zvePTCL?

Kunyangwe rudzi rumwe nerumwe rwePTCL rune zviratidzo zvakananga, kune zvimwe zvakajairika. Ngatitarisei kuti ndezvipi:

• Ma lymph nodes akazvimba: Unogona kuzvimba mumutsipa, muhapwa, kana muzvidya zvisina kurwadziwa . Fungidzira bundu diki mumutsipa wako rinonzwa sekunge riri kukura nekufamba kwenguva, asi risingarwadzi. Ndizvo chete.
• Kudzikira kwehuremu kusingatsananguriki: Kana ukaderedza huremu hwako hwese ne10% mukati memwedzi mitanhatu, usingaedze nesimba, chinhu chekufunganya nezvacho.
• Kurwadziwa mudumbu kana kuzvimba: Izvi zvinogona kuitika kana chiropa chako chakakura. Zvinogona kunzwa kusagadzikana, sekunge dumbu rako rakazara.
• Kuneta kunogara kwenguva refu: Kunzwa kuneta zvisina kujairika kwemazuva akati wandei pasina chikonzero chakajeka. Zvinoita sekunge kuneta hakuperi zvisinei nekuti unorara zvakadii.
• Fivha isina kutsanangurwa: Kazhinji, fivha inoitika kana muviri uchirwisa hutachiona. Zvisinei, kana fivha inopfuura 39.5 degrees Celsius (103 Fahrenheit) ikaramba iripo kwemaawa anopfuura maviri mushure mekurapwa kumba, kana fivha ikaramba iripo kwemazuva anopfuura maviri, zvinogona kuva chiratidzo chechimwe chinhu chakakomba.

Chinhu chinonyanya kukosha ndechekuti usazvidya mwoyo nezvekuva nePTCL nekuda kwekuti une zviratidzo izvi. Zvinogona kunge zvichikonzerwa nezvimwe zvikonzero zviri nyore. Asi kana zviratidzo izvi zvikaramba zviripo,Zvakakosha kuona chiremba uye kuwana mazano.

Iye zvino ngationei kuti zviratidzo zvipi zvinouya nezvimwe zvinhu zvakasiyana-siyana.

Zvimwe zviratidzo zve peripheral T-cell lymphoma, zvisina kutaurwa neimwe nzira (PTCL-NOS)

Kuwedzera kune zviratidzo zvakajairika, unogona zvakare kuona:

• Kuderera kwemasero matsvuku eropa (Anemia) - Izvi zvinogona kukonzera kucheneruka uye kuneta kwakanyanya.
• Kuwanda kwemaplatelet muropa (Thrombocytopenia) - Izvi zvinogona kukonzera kuti munhu ade kubuda ropa.
• Mavara matsvuku anokwenya paganda .
• Kana kenza iri muchipfuva , kurwadziwa pachipfuva kana kuoma kufema (kushaya simba).

Zvimwe zviratidzo zve angioimmunoblastic T-cell lymphoma (AITL)

Kuwedzera kune zviratidzo zvakajairika:

• Kudikitira husiku - Kudikitira zvakanyanya paunenge wakarara zvekuti machira anonyorova.
• Mapundu paganda .
• Matambudziko e autoimmune akadai se "Autoimmune hemolytic anemia" .

Zvimwe zviratidzo zve anaplastic large cell lymphoma (ALCL)

ALCL yeganda rekutanga (rudzi rwunokanganisa ganda)

• Zvinhu zvakaita sekutsvuka kana kutsvukuruka-kutsvuka kweganda, mapundu anokura nekufamba kwenguva.
• Maronda makuru, akaita sedenderedzwa, anokwenya .
• Mapundu aya anogona kuvava uye kupwanyika.

Systemic ALCL (rudzi runokanganisa nhengo dzemukati)

Muchiitiko ichi, zviratidzo zvinowanzoonekwa paPTCL zvinoonekwa.

Extranodal natural killer/T-cell lymphoma, mhando yemhino

• Mhino dzakavharika, kunzwa sekunge mhino yavharika.
• Kubuda ropa mumhino .
• Mukati memhino munova negoko .
• Kuzvimba kunorwadza kwechiso .
• Matambudziko emaziso akadai sekubuda ropa mumaziso uye kurwadziwa kwemaziso.

T-cell lymphoma/leukemia yevakuru (ATLL)

Zviratidzo zvePTCL zvakajairika kune marudzi ese mana eATLL.

Ndezvipi zvikonzero zvePTCL?

Zvichitaurwa zviri nyore, peripheral T-cell lymphoma inoitika kana masero eT mumuviri wedu achichinja (`(mutate)`) kuita masero ekenza. Sezvamunoziva, masero eT aya rudzi rwemasero machena eropa anotidzivirira kubva kuhutachiona hwakaita sehutachiona hunopinda mumuviri wedu. Saka, kana masero aya eT achichinja, anova masero ekenza uye anotanga kuwanda zvisingadzoreki . Paanowanda seizvi, anoungana mumapapu edu, spleen, chiropa, nedzimwe nhengo dzemuviri uye anoumba bundu rekenza .

Nyanzvi hadzisati dzawana chikonzero chaicho chinoita kuti maT-cell aya achinje seizvi.Zvisinei, tsvakiridzo yakawana kuti ine chekuita nemamwe matambudziko ehutano.

Semuyenzaniso:

• Ongororo yepasi rose yakaratidza kuti vanhu vane chirwere chinonzi celiac disease vanogona kunge vaine njodzi yakakura yekubatwa nemarudzi akasiyana-siyana ePTCL, kusanganisira ALCL.
• Uyewo, vanhu vane hutachiona hweEpstein-Barr vanogona kunge vaine njodzi yakakura yekubatwa ne extranodal natural killer/T-cell lymphoma.
• Vanhu vane hutachiona hwe `(Human T-cell lymphotropic virus Type 1 (HTLV-1))` vari panjodzi yakakura yekubatwa ne `(acute T-cell lymphoma/leukemia)`.

PTCL inoonekwa sei?

Vanachiremba vangangoda kuita bvunzo dzakasiyana-siyana kuti vawane rudzi rwePTCL ruri kukonzera matambudziko ehutano hwako. Izvi zvinogona kusanganisira kuongororwa kweropa, kuongororwa kwemifananidzo, kuongororwa kwe biopsy , uye bvunzo dzemajini kuti vadzidze nezvemajini emasero ekenza.

Kuongororwa kweropa

Vanachiremba vanoongorora ropa kuti vaone kana paine mavhairasi angave akabatana nePTCL. Izvi zvinogona kusanganisira:

• Kuverengwa kweropa rose (CBC)
• Paneri yakazara yemetabolism (CMP)
• Kuedzwa kweLactate dehydrogenase (LDH)
• Kuongororwa kweHepatitis B neHepatitis C
• Kuongororwa kwehutachiona hweHIV (Human immunodeficiency virus)
• Miedzo yehutachiona hweT-cell lymphotropic Type 1 (HTLV-Type 1) yemunhu

Miedzo yemifananidzo

Kuongororwa uku kunoita kuti vanachiremba vawane ruzivo nezvemukati memuviri wako, kunyanya pane mapundu ane kenza.

• Kuongororwa kweCT nekombiyuta
• Kuongorora kwePositron emission tomography (PET)
• Kuskena kwemagnetic resonance imaging (MRI)

Kuongororwa kwemuviri

Izvi zvinosanganisira kutora chidimbu chidiki chenyama kubva panzvimbo inofungidzirwa wochiongorora uchishandisa maikorosikopu. Iyi ndiyo nzira huru yekusimbisa chirwere chacho .

• Kuongororwa kweLymph node
• Kuongororwa kweganda
• Kuongororwa kwemwongo wemapfupa

Matanho ePTCL ndeapi?

Vanachiremba vanoshandisa nzira yekuongorora kenza kuronga kurapwa uye kukupa pfungwa yezvaungatarisira kubva mukurapwa (kufanotaura). Danho iri rinotsanangurwa nerudzi rwePTCL uye kuti masero eT-cell ane kenza apararira kupi. Heano matanho mana makuru ePTCL:

• Danho I: Masero eT ane gomarara anowanikwa musero rimwe chete kana muboka rimwe chete remasero.
• Danho rechipiri: Gomarara rakanganisa ma lymph nodes maviri kana kupfuura ari kurutivi rumwe chete rwemuviri wako (semuenzaniso, kurutivi rumwe nerumwe rwemutsipa wako, kana kurutivi rumwe chete pamusoro kana pasi pe diaphragm).
• Danho rechitatu: Kenza yapararira kusvika munyama dziri pamusoro nepasi pe diaphragm yako.
• Danho rechina: Kuwedzera kumachende, kenza iyi yakakanganisawo dzimwe nhengo dzemuviri, dzakadai semapapu, chiropa, mupfupa, kana kugaya chikafu.

Ndeapi marapirwo ePTCL?

Nekuti kune mhando dzakawanda dzePTCL uye danho regomarara, hapana mushonga mumwe chete unokodzera zvese . Sarudzo dzekurapa dzinogona kusiyana kubva pamunhu nemunhu. Chiremba wako ndiye achasarudza mushonga wakanakira iwe. Heano mamwe emishonga yakajairika:

• Kurapa nemakemikari: Musanganiswa wemhando dzakasiyana dzemishonga yechemotherapy. Uku ndiko kurapwa kukuru kunonyanya kushandiswa.
• Kurapa nemwaranzi: Dzimwe nguva izvi zvinoshandiswa pamwe chete nechemotherapy, kunyanya kana kenza iri panzvimbo imwe chete.
• Kurapa kwakanangana: Uku kurapa kunonangana nekuchinja kwemajini (kuchinja kwemajini) uko kunoita kuti masero ane hutano ave masero ekenza. Izvi zvakasiyana nekurapa kwemishonga yechinyakare.
• Kurapa nemakemikari uye kuisirwa kwemasero emuviri anokonzera allogeneic: Kurapa uku kunogona kushandiswa kune PTCL isingapindure kurapwa nemakemikari nemwaranzi, kana kuti inodzoka mushure mekurapwa. Uku kurapa kwakaoma zvishoma.

Dzimwe nguva unogona kukwanisa kutora chikamu mukuyedzwa kwekiriniki kwemishonga mitsva yePTCL. Taura nachiremba wako nezveizvi.

Ndezvipi migumisiro inowanzoonekwa yekurapwa?

Kurapa gomarara kwakawanda kunogona kukonzera mimwe migumisiro. Zvisinei, havasi vese vanowana migumisiro iyi yese, uye kuoma kwayo kunogona kusiyana. Semuenzaniso, migumisiro yechemotherapy neradiation therapy inogona kusanganisira:

• Kuneta
• Mhute yeuropi inokonzerwa nekurapwa nemakemikari - kunzwa kwemhute yeuropi, kurasikirwa nendangariro, uye kuoma kwekuisa pfungwa pachinhu chimwe chete.
• Kusvotwa nekurutsa
• Kudonha kwebvudzi
• Maronda emuromo
• Zviri nyore kubatwa nezvirwere

Pari zvino kune nzira dzakawanda dzekudzora migumisiro iyi, saka taura nachiremba wako nezvazvo zvakare.

Chii chinonzi fungidziro yePTCL?

Izvi zvinoenderana nerudzi rwePTCL, danho rekenza, hutano hwako hwese, uye kana kenza iri kupora (``remission``) nekurapwa."Kurerutsirwa kwechirwere" zvinoreva kuti hauna zviratidzo uye hapana zviratidzo zvegomarara zvinowanikwa pakuongororwa. Mune zvimwe zviitiko, PTCL inogona kurapwa zvakakwana nekurapwa kwakajairika.

Zvisinei, mhando dzakawanda dze peripheral T-cell lymphoma dzinogona kudzoka (`(dzinodzokororwa)`) . Kana izvi zvikaitika, ungangoda kurapwa kwakawedzerwa kana imwe mhando yekurapwa.

Zvingori zvechisikigo kuti ude kuziva zvaunotarisira kubva mukurapwa kwako. Chiremba wako ndiye munhu akakodzera kuziva nezvechirwere chako. Saka taura naye pachena uye mutendeseke nezvenyaya iyi uye usatya kubvunza mibvunzo.

Ko PTCL inogona kudzivirirwa here?

Zvinosuwisa kuti kwete, sekuziva kwedu, hapana nzira chaiyo yekudzivirira izvi . Iyi lymphoma inokonzerwa nemasero eT asingashande zvakanaka uye anova kenza. Hapana chatingaita kuti tisaitike. Zvisinei, kudzivirira zvimwe zvinhu zvine njodzi (semuenzaniso, hutachiona hweHTLV-1) kunogona kuderedza njodzi yekuve nerudzi rwePTCL rwunobatanidzwa.

Ndinozvitarisira sei ? (Kurarama nePTCL)

Peripheral T-cell lymphoma igomarara risingawanzoitiki uye rinokura nekukurumidza. Kana uine PTCL, heano mamwe matipi ekukubatsira kurarama nechirwere ichi:

• Funga nezvekuchengetedzwa kwevarwere vane marwadzo ekurwadziwa: Kutarisirwa uku kunogona kukubatsira kudzora zviratidzo nemigumisiro yekurapwa. Uyezve, timu yako yekuchengetedzwa kwevarwere inogona kukutsigira mukugadzirisa matambudziko emanzwiro (kusuruvara, kutya, kuzvidya mwoyo) anouya nekurarama nechirwere chakakomba kudaro.
• Tsvaga rutsigiro: Nekuti PTCL igomarara risingawanzoitiki, unganzwa sekuti ndiwe wega uri kurwisana naro. Asi haufanirwe kuzviita wega. Taura nechikwata chako chekurapa uye tsvaga ruzivo nezvemapoka ekutsigirana kwaunogona kubatana nevamwe vari kusangana nematambudziko akafanana newe. Kugovana ruzivo uye kuwana rutsigiro kubva kune vamwe kunokosha panguva ino.
• Zvipe nguva yekuzvitarisira (Kuzvitarisira): Gomarara chirwere chinoshungurudza. Kuzvitarisira kwakakosha zvikuru kana uchirarama nePTCL. Taura nechikwata chako chehutano nezvenzira dzekugadzirisa kushushikana (kufungisisa, kurovedza muviri kufema, kuita chimwe chinhu chinokuvaraidza), uye maitiro ekugadzira kudya kunovaka muviri kuti urambe wakasimba panguva yekurapwa. Wana hope dzakakwana.

Mibvunzo ipi yandinofanira kubvunza chiremba wangu?

Usakanganwa kubvunza mibvunzo iyi kana waona chiremba wako:

• Rudzii rwePeripheral T-cell lymphoma rwandinarwo? Runonzi chii?
• Danho rechirwere changu nderei? Rapararira kusvika papi?
• Ndedzipi nzira dzekurapa dzandinadzo? Ndezvipi zvakanakira nezvakaipa zvekurapa kwega kwega?
• Rudzii rwekubudirira runogona kutarisirwa kubva mukurapa uku?
• Ndezvipi migumisiro yekurapwa? Zvingagadziriswa sei?
• Ndinofanira kufunga nezvekurapa kutsva kwakavakirwa patsvagurudzo (`(kuyedzwa kwekiriniki)`) here? Kwakakodzera kwandiri here?
• Ndezvipi zvandinofanira kuchinja muhupenyu hwangu?

Mharidzo Yekupedzisira Yekuenda Kumba

Peripheral T-cell lymphoma (PTCL) igomarara reropa risingawanzoitiki asi rinokosha. Rinoitika kana maT-cell anodzivirira miviri yedu achichinja-chinja ova gomarara. Kunyangwe aine chikonzero chimwe chete, majini erimwe nerimwe akasiyana. Nekuti PTCL inokanganisa nhengo dzakasiyana dzemuviri, dzimwe nguva zvinogona kuoma kuongorora nekurapa.

Asi, ramba uine tariro! Vaongorori vezvekurapa vanogara vachitsvaga mishonga mitsva, inoshanda zvakanyanya inotarisa shanduko dzemajini muPTCL. Kana ukaonekwa uine PTCL, usavhunduke, uye taura pachena nechikwata chako chezvekurapa . Bvunza kana paine mishonga mitsva yakavakirwa pakutsvaga (miedzo yekiriniki) yakakodzera mamiriro ako chaiwo. Neruzivo rwakakodzera uye rutsigiro rwevadikani vako, uchasimbiswa kutarisana nedambudziko iri!

` Peripheral T-cell Lymphoma, PTCL, Lymphoma, T-cell lymphoma, Kenza, Kenza yeropa, Lymphoma, Zviratidzo zvePTCL, Kurapwa kwePTCL