Pamwe wakambonzwa nezvemishonga yakaita seViagra. Vanhu vazhinji vanoziva kuti iyi mishonga inopihwa kune vanhu vane dambudziko rekusashanda zvakanaka pabonde. Asi waiziva here kuti mishonga iri muboka rakasiyana, inonzi Phosphodiesterase Inhibitors, inoshandiswa kurapa zvirwere zvakasiyana-siyana, kubva kuzvirwere zvemwoyo kusvika kuzvirwere zvemapapu, chirwere cheganda, uye zvirwere zvemajoini? Nhasi, ngatitaurei nezvemhando iyi inoshamisa yemishonga. Ngatingonzwisisai kuti chii, kuti inoshanda sei, uye zvakanakira nezvakaipa.
Zvichitaurwa zviri nyore, chii chinonzi Phosphodiesterase Inhibitors (PDE inhibitors)?
Iyi imhando yemushonga unokudza mitsipa yeropa mumuviri wedu, unoderedza kuoma kwayo, uye unoita kuti ropa rifambe zviri nyore. Fungidzira kuti kana pombi yemvura yavharika, kana ukaiita hombe zvishoma, mvura inoyerera zviri nyore. Izvi zvinoderedza BP uye zvinovandudza kuyerera kweropa kunzvimbo dzakasiyana-siyana dzemuviri. Nekuda kwehunyanzvi uhwu, rudzi urwu rwemushonga runoshandiswa kurapa zvirwere zvakasiyana-siyana.
Mushonga uyu unoshanda sei?
Kuti tinzwisise izvi, tinofanira kutanga taziva nezvechinhu chidiki chinotakura kemikari mumuviri wedu. Zita racho rinonzi Phosphodiesterases , kana kuti PDE muchidimbu. PDE iyi imhando yeenzyme . MaEnzymes akafanana nevabatsiri vadiki vanokurumidzisa uye vanorerutsira mamwe maitiro ekemikari mumuviri wedu.
Kune mhando dzakasiyana dzema enzymes ePDE mumiviri yedu. Masayendisiti akashandisa nhamba kuti asiyanise. Chinhu chakakosha ndechekuti mhando yega yega yePDE inonyanya kushanda munzvimbo dzakatarwa dzemuviri.
- PDE-3: Rudzi urwu runonyanya kuwanikwa mumoyo mako nemutsinga dzeropa . Runobatanidzwawo mukuita kwekugwamba kweropa.
- PDE-4: Izvi zvinonyanya kuwanikwa mumapapu . Zvinoshanda nekusimbisa tsandanyama dziri munzira dzekufema.
- PDE-5: Rudzi urwu runowanikwa mumapapu nenhengo dzesikarudzi dzevarume .
Saka, mishonga inonzi Phosphodiesterase Inhibitors (PDE inhibitors) inoshanda nekudzivirira mashandiro ema enzymes ePDE ataurwa pamusoro apa. Zvakafanana nekuvhara musuwo. Mimwe mishonga inodzivirira PDE inoshanda nekusarudza zvakanyanya. Kureva kuti, inongonanga rudzi rwakati, senge PDE-5. Kune mimwe mishonga inoshanda isina kusarudza . Kureva kuti, inogona kukanganisa marudzi ese ePDE kusvika pamwero wakati.
Ndezvipi zvirwere zvinorapwa nemushonga uyu?
Rudzi rwemishonga inonzi PDE inhibitors yakatenderwa nemasangano akaita seU.S. Food and Drug Administration (FDA) kurapa zvirwere zvinopfuura gumi nezviviri. Heano mamwe acho.
| Rudzi rwezvirwere | Dambudziko rehutano uye tsananguro iri nyore |
|---|---|
| Kutenderera kweropa nemoyo |
|
| Zvirwere zvinozvimba |
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| Zvirwere zvenhengo dzekubereka dzevarume |
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| Zvirwere zvemudumbu |
|
Ndezvipi zvakanakira PDE Inhibitors?
Rudzi urwu rwemushonga runobatsira zvikuru pakurapa mamwe matambudziko ehutano. Pane zvikonzero zvakawanda zvinoita izvi.
- Zviri nyore kushandisa: Mishonga iyi inouya mumhando dzakasiyana-siyana. Inowanikwa semapiritsi ekunwa, mafuta ekuzora, uye jekiseni remutsinga. Mimwe mishonga inofanira kutorwa zuva nezuva, asi mimwe inogona kutorwa chete kana ichidikanwa.
- Kurapwa kwakanangana: Sezvandambotaura, mimwe mishonga inongonangana nerudzi rwakati rwePDE, saka hainyanyi kukonzera migumisiro isingadiwe (migumisiro) kune dzimwe nhengo dzemuviri. Zvakafanana nemushonga unoshanda chaizvo panzvimbo chaiyo iri chirwere.
- Mabhenefiti akati wandei emushonga mumwe chete: Dzimwe nguva zvirwere zviviri zvine chekuita nazvo zvinogona kuitika mumunhu mumwe chete. Semuenzaniso, benign prostatic hyperplasia (BPH) uye erectile dysfunction (ED) zvinogona kuitika pamwe chete. Tadalafil inodzivisa PDE-5 inotenderwa kurapa zvirwere zvese zviri zviviri. Saizvozvowo, kune mishonga inogona kurapa gout uye arthritis inobatanidzwa nayo.
Ndezvipi migumisiro nenjodzi zvemushonga uyu?
Chinhu chakakosha ndechekuti mishonga iyi yese inofanira kutorwa chete kana yapihwa mazano nachiremba. Mikana yemigumisiro inogona kusiyana kubva pamushonga kuenda kumushonga uye kubva kumunhu kuenda kumunhu.
Migumisiro mikuru inoenderana nekuti mushonga uyu ndewerudzii rwePDE inhibitor.
| Rudzi rwePDE Inhibitor | Migumisiro midiki uye ine mwero | Migumisiro inogona kunge yakakomba (udza chiremba wako nekukasika) |
|---|---|---|
| PDE-3 Inhibitors (inokanganisa mwoyo netsinga dzeropa) | Musoro, kushaya simba, kuzvimba, kuda kurutsa, kurutsa, kurwadziwa mudumbu, dzungu, mapundu paganda. | Kusarongeka kwemutinhimira wemoyo (arrhythmia), kurwadziwa pachipfuva, BP yakaderera, kubuda ropa kusingawanzoitiki kana mavanga, kukuvara kwechiropa. |
| PDE-4 Inhibitors (inokanganisa mapapu nekuzvimba) | Kudzikira kwehuremu, kuda kurutsa, kurutsa, manyoka, hutachiona hwemudumbu, musoro, kushaya hope, kuzvimba panzvimbo yekubaiwa jekiseni. | Kuora mwoyo kuripo, kufunga nezvekuzviuraya, reactions dzekunzwa kushushikana (kuvaviwa, kuzvimba, mapundu). |
| Zvidziviriro zvePDE-5 (zvinokanganisa kushaya simba pabonde uye BP yemapapu) | Musoro, kusviba, mhino yakazadzwa, kurwadziwa nemusana, kurwadziwa kwetsandanyama, kuda kurutsa, dzungu, uye pamwe kuona chiedza sebhuruu (kwenguva pfupi). | Kuzvimba kwenhengo yemurume (Priapism): Kumira kwenhengo yemurume kunorwadza kunotora maawa anopfuura mana pasina kukurudzirwa pabonde. Iyi idambudziko rehutano. Kuchinja-chinja/kurasikirwa nekuona kana kunzwa kamwe kamwe, kukuvara kwechiropa. |
| Zvidziviriri Zvisingasarudze (semuenzaniso caffeine, theophylline) | Kusagadzikana, kushaya hope, kudedera, kuda kurutsa, manyoka, dzungu, musoro. | Kurova kwemoyo nekukurumidza, kurova kwemoyo kusina kurongeka, kurwadziwa kwechipfuva, pfari. |
Yambiro inokosha: Kana uri kutora mushonga wakaita senitroglycerin pasi perurimi wekurwadziwa pachipfuva, uye ukatanga kurwadziwa pachipfuva mukati memaawa makumi maviri nemana mushure mekutora mushonga wePDE-5 inhibitor (semuenzaniso Sildenafil, Tadalafil), enda kuchipatara nekukurumidza. Kusanganisa mishonga iyi miviri kunogona kukonzera kuderera kweropa zvine njodzi.
Ndiani asingafaniri kutora mushonga uyu?
Kune vamwe vanhu, mhando iyi yemushonga inonzi PDE inhibitors ingasakodzera nekuda kwemamwe matambudziko avo ehutano kana mimwe mishonga yavari kutora. Tinoti izvi zvinopesana . Kune mhando mbiri dzazvo:
1. Zvipingamupinyi zvachose:
- Kune chero chinhu chinodzivirira PDE: Kana wakambova neallergy yakanyanya (hypersensitivity) kumushonga uyu kana wakafanana nawo.
- YeCilostazol: Kana uine chero rudzi rwechirwere chemwoyo.
- Kune vanodzivirira PDE-5 (vakadai seSildenafil, Tadalafil): chirwere chemwoyo chakakomba, kurwadziwa kwechipfuva kusina kugadzikana (angina isina kugadzikana), kurwara kwemoyo kwazvino kana sitiroko.
2. Zvinopesana nekushandiswa kwemishonga iyi:
- Kune vanodzivirira PDE-5: Kana uri kutora nitrates kana alpha-blockers, unofanira kutaura nachiremba wako sezvo zvinogona kukonzera kuderera kweropa rako zvine njodzi.
- YeCilostazol: Kana uine matambudziko ekubuda ropa.
- YePentoxifylline: Kana wachangobva kubuda ropa muuropi kana muziso.
Kana uine pamuviri, uchiedza kubata pamuviri, kana kuyamwisa, gara uchitaura nachiremba wako usati watora chero mushonga. Pane humbowo hwekuti mamwe maPDE inhibitors anogona kukanganisa mwana ari mudumbu muongororo dzemhuka.
Unofanira kuona chiremba rini?
Kana zviratidzo zvako zvikachinja kana kukanganisa mabasa ako ezuva nezuva, zvakanaka kuudza chiremba wako. Zvisinei, kana ukasangana nechimwe chezvinotevera , enda kuchipatara kana kuchipatara chekukurumidzira (ETU) nekukasika.
- Zviratidzo zvechirwere chemwoyo: kurwadziwa pachipfuva, kufema zvishoma, kudikitira, dzungu, kuda kurutsa.
- Kuzvikudza: Kumira kwenhengo yemurume kunorwadza kunotora maawa anopfuura mana pasina kukurudzirwa pabonde. Izvi zvinogona kukonzera kukuvara zvachose kana zvikasarapwa nekukasika.
- Kurasikirwa nekuona kana kunzwa kamwe kamwe: Kana ukarasikirwa nekuona kamwe kamwe, kurasikirwa nekuona, kana kurasikirwa nekunzwa, tsvaga rubatsiro rwechiremba nekukasika. Kunonoka kunogona kukonzera kukuvara zvachose.
Mharidzo Yekuenda Nayo Kumba
- Mishonga inodzivirira phosphodiesterase (PDE inhibitors) inobatsira zvikuru kwete chete pakurapa matambudziko epabonde, asiwo pazvirwere zvakasiyana-siyana zvine chekuita nemwoyo, mapapu, ganda, uye majoini.
- Mishonga iyi yese inofanira kungotorwa kana yakurudzirwa nachiremba.Udza chiremba wako nezvezvimwe zvirwere zvaunazvo uye mimwe mishonga yaunotora.
- Migumisiro inogona kuitika, saka ziva nezvazvo usati watanga mushonga.
- Kana ukaona zviratidzo zvakakomba zvakaita sekurwadziwa pachipfuva, kushaya mweya kwenguva inopfuura maawa mana, kana kurasikirwa nekuona/kunzwa kamwe kamwe, enda kuDhipatimendi reEmergency (ETU) nekukasika.
- Kushandisa mushonga uyu usina kunyorerwa nachiremba, nekubvunza vamwe kana kubvunza kuma pharmacy, kunogona kuva nemigumisiro yakakomba, inotoisa upenyu panjodzi.
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