Dzimwe nguva mushure mekudya, dumbu redu rinonzwa raguta uye rakazvimba, handiti? Zvinonzwa sekunge chikafu hachisi kunyura mudumbu medu. Kana kuti tinonzwa kusagadzikana sekunge kugara tichinzwa kurwadza, chirungurira, uye kurutsa. Chimwe chikonzero chezvinhu izvi chingave chekuti kugaya kwako, kureva ura hwako, kunononoka zvishoma. Nhasi, tiri kutaura nezvemhando yakakosha yemishonga inobatsira panguva dzakadaro.
Zvichitaurwa zviri nyore, chii chinonzi maProkinetic Agent aya?
Mishonga yeprokinetic imhando yemishonga inosimudzira tsandanyama dziri mudumbu mako kuti dziite kuti dziome, kana kuti "dzisundire," uye dzinobatsira kufambisa chikafu zviri nyore.
Fungidzira, patinomedza chikafu, tsandanyama dzinobva pagurokuro kuenda mudumbu nemuura hwedu dzinongogumira dzozorora semafungu, dzichisundira chikafu mberi. Tinoti izvi zvinongoerekana zvaitika peristalsis . Zvakafanana nekudzvanya nekudzvanya chimwe chinhu mukati mechubhu wochitumira mberi. Nekuti izvi zvinoitika nemazvo, muviri wedu unokwanisa kutora zvinovaka muviri zvaunoda kubva muchikafu.
Zvisinei, kana nekuda kwechimwe chikonzero maitiro aya ekufamba akaderedzwa simba, chikafu chinogona kugara mudumbu kwenguva yakareba. Izvi zvinogona kukonzera kusagadzikana kwakadai sekuzvimba, kuvimbiwa, uye chirungurira. Ndipo apo mishonga inonzi Prokinetic Agents inobatsira kupa dumbu redu "kusunda" zvishoma uye kudzorera maitiro iwayo.
Mushonga uyu unoshanda sei mumuviri?
Zvinoita kuti tsinga dzemudumbu dzishande nekukurudzira tsinga dziri muura hwedu, zvichiita kuti tsandanyama dzimire. Izvi zvinoita zvinhu zvishoma zvakakosha:
- Zvinowedzera kuzvimba kwegurokuro: Izvi zvinoita kuti chikafu chifambe nekukurumidza mudumbu.
- Simbisa Lower Esophageal Sphincter (LES): Iri ndiro "gedhi" riri pakati pegurokuro redu nedumbu. Kana risisina simba, acid yemudumbu inogona kuyerera ichidzokera mugurokuro. Izvi ndizvo zvatinodaidza kuti chirungurira, kana kuti GERD . Mishonga yeprokinetic inosimbisa gedhi iri uye inomisa acid kuti isadzokere mudenga.
- Zvinowedzera kurwadziwa kwemudumbu: Izvi zvinoita kuti chikafu chiri mudumbu chifambe nekukurumidza chichipinda muura hudiki. Kana dumbu rikangobuda nekukurumidza, mikana yekuti ridzoke zvakare hainyanyi kukwira.
- Zvinoderedza nguva inotorwa kuti dumbu ribude: Izvi zvinobatsirawo zvikuru mukutonga mamiriro akaita seGERD ataurwa pamusoro apa.
Mishonga yeprokinetic inoshandiswa mumamiriro api ezvinhu?
Rudzi urwu rwemushonga runowanzo kurudzirwa navanachiremba kana mamwe marapirwo asina kubatsira, sezvo izvi zvichigona kuva nemigumisiro yakaipa.
| Dambudziko rehutano | Zvichitaurwa zviri nyore... | Mushonga uyu unobatsira sei? |
|---|---|---|
| Gastroparesis | Kugayiwa kwezvokudya kunononoka nekuti tsandanyama dzemudumbu hadzishande zvakanaka. Dambudziko iri rinowanzoitika kuvanhu vane chirwere cheshuga. | Inowedzera marwadzo emudumbu, zvichiita kuti dumbu ribude nekukurumidza. Metoclopramide mushonga mukuru unotenderwa kuita izvi. |
| GERD (kurwadziwa kwemoyo/kurwadziwa kwechipfuva) | Chirwere chenguva refu chinokonzerwa neacid yemudumbu inogara ichiyerera mugurokuro. | Mishonga iyi haisi mushonga weGERD yoga. Zvisinei, kana kunonoka kubvisa zvinhu mudumbu kuchikonzerawo GERD, chiremba wako anogona kuinyora pamwe chete nemimwe mishonga. |
| Kushanda kweDyspepsia | Zviratidzo zvekusagadzikana kwekugaya chikafu zvinoramba zvichienderera mberi mushure mekudya, asi hapana chikonzero chakajeka chinowanikwa. | Zvinobatsira kuderedza zviratidzo nekuwedzera kurwadziwa kwemudumbu, zvichiita kuti zvibude nekukurumidza. |
| Kusvotwa nekurutsa | Kurutsa nguva dzose uye kuda kurutsa izvo zvakaoma kudzora nedzimwe nzira dzekurapa. Inoshandiswawo kurapa kurutsa kunokonzerwa ne chemotherapy inopiwa varwere vegomarara. | Zviratidzo izvi zvinodzorwa nekuchinja nzvimbo dzinoshandiswa kurutsa muuropi uye kukurumidzisa kubuda kwechinhu mudumbu. |
Ndedzipi mhando huru dzemishonga yeprokinetic?
Mishonga iyi inogona kukamurwa kuita mapoka maviri makuru zvichienderana nemashandiro ayo: Agonists neAntagonists .
- MaAgonists: Ava vanoita sema neurotransmitters mumuviri wedu uye vanoita zvimwe chete zvavanoita. Kureva kuti, vanotumira shoko kutsandanyama dziri muura kuti dziome.
- Zvinorwisa: Izvi zvinoshanda nekumisa kemikari inotakura mashoko etsinga anononotsa mashandiro emudumbu kusvika patsinga. Kureva kuti, zvinovhara mashoko anoita kuti ura "hunonoke."
Kune mhando dzakasiyana dzemishonga pasi peizvi:
- Zvinopikisa dopamine: Dopamine, kemikari inowanikwa muuropi nemudumbu, inoderedza mashandiro emudumbu. Mishonga iyi inoshanda nekudzivisa mashandiro edopamine. Mienzaniso: Metoclopramide, Domperidone .
- Serotonin agonists: Inoshanda sekemikari inonzi serotonin uye inokurudzira marwadzo emudumbu. Mienzaniso: Prucalopride .
- Motilin agonists: Motilin ikemikari inodzora marwadzo emudumbu medu madiki. Aya ndiwo mashandiro anoita mishonga iyi. Zvinoshamisa kuti boka iri rinosanganisira mishonga inorwisa mabhakitiriya yakaita seErythromycin .
- Mishonga yeCholinergic: Inoshanda se neurotransmitter acetylcholine uye inokonzera tsandanyama dziri muura kuti dziome. Mienzaniso: Bethanechol, Neostigmine .
Zvakakosha zvikuru: Migumisiro yemushonga uyu
Ichi ndicho chikamu chakakosha chechinyorwa chino. Mishonga yeProkinetic haisi mushonga sePanadol wemusoro unowanzo shandiswa. Inogona kuva nemigumisiro yakakomba uye haifanirwe kutorwa chero chikonzero pasina kurairwa nachiremba.
Vanachiremba vanongopa mishonga iyi kana mimwe mishonga yakundikana, uye inowanzopihwa muhuwandu hushoma uye kwenguva pfupi.
Migumisiro inowanzoonekwa:
- Marwadzo emudumbu
- Kusvotwa nekurutsa
- Manyoka
- Kuona kusina kujeka
- Musoro
- Kuneta kwakanyanya, hope
- Kuora Mwoyo uye Kunetseka
Migumisiro yakaipa yekutarisira:
Zviratidzo izvi zvakakosha zvikuru. Kana ukasangana nechimwe chezviratidzo izvi paunenge uchitora mushonga weprokinetic, unofanira kuzivisa chiremba wako nekukasika.
- Dystonia: Ichi chirwere apo tsandanyama dzemuviri dzinoita sedzinokweverwa nenzira isingadzoreki, senge mutsipa unodhonzwa kudivi rimwe chete, maziso achimonereka, kana kuti rurimi rwunobuda panze.
- Kufamba-famba kwenhengo dzechiso pasina chikonzero (Tardive Dyskinesia): Ichi chirwere chinogona kuitika mushure mekutora mushonga kwenguva yakareba. Zvikamu zvechiso, zvakaita semuromo, rurimi, neshaya, zvinofamba zvisina chinangwa. Dambudziko iri dzimwe nguva harina kunaka kunyangwe mushure mekumira kushandisa mushonga.
- Matambudziko emwoyo: Mimwe mishonga, kunyanya Domperidone , inogona kukonzera kurova kwemoyo zvisina kurongeka (arrhythmias) uye kurwiswa kwemoyo. Nekuda kweizvi, kushandiswa kwemishonga iyi kwakarambidzwa mune dzimwe nyika.
Nekuda kwenjodzi idzi, kana chiremba wako akakunyorera mushonga uyu , taura naye nokungwarira nezvezvakanakira nezvakaipira. Iva nechokwadi chekuudza chiremba wako nezvezvimwe zvirwere zvaunazvo uye mimwe mishonga yauri kutora.
Mharidzo Yekuenda Nayo Kumba
- Mishonga yeprokinetic imhando yemushonga unosimudzira kugaya chikafu "kunonoka", zvichiita kuti chikafu chifambe zviri nyore.
- Izvi zvinoshandiswa kurapa zvirwere zvakaita se gastroparesis (kusashanda zvakanaka kwemudumbu) uye GERD yakanyanya.
- Izvi hazviwanzo shandiswa senzira yekutanga yekurapa nekuda kwenjodzi yemigumisiro yakaipa.
- Usamboshandisa mishonga iyi usina kupiwa mazano nachiremba.
- Kana ukaona zviratidzo zvisingawanzoitiki paunenge uchitora mushonga uyu, kunyanya kugwinha kwetsandanyama kumeso kana mumuviri, taurira chiremba wako nekukasika.
- Kana chiremba wako akakunyorera mushonga uyu, imhaka yekuti akaona kuti mabhenefiti acho akakura kupfuura njodzi dzingangoitika. Saka, tevera mirairo yachiremba wako nemazvo.
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