Mushonga wauri kutora une njodzi here? Ngatidzidzei nezveSerotonin Syndrome?

Nhasi tichataura nezvechirwere chakakomba zvishoma, asi chinogona kudzorwa zviri nyore kana uchiziva nezvacho. Ungave uchitora mishonga yekuora mwoyo kana chimwe chirwere. Dzimwe nguva mishonga iyi inogona kukonzera shanduko mumiviri yedu uye kukonzera matambudziko ataisagona kufungidzira. Chimwe chezvirwere zvakadaro i serotonin syndrome.

Chii chinonzi Serotonin Syndrome?

Zvichitaurwa zviri nyore, Serotonin Syndrome idambudziko rinokonzerwa nemishonga rinogona kutyisidzira hupenyu, rinoitika kana paine kemikari inonzi serotonin yakawandisa mumuviri wako.

Funga nezvazvo, serotonin ikemikari inotumirwa nemasero etsinga muuropi hwedu nedzimwe nhengo dzemuviri. Kutaura chokwadi, inhume inotakura mameseji pakati pemasero etsinga. Tinoidaidza kuti neurotransmitter . Iyi serotonin inokanganisa zvinhu zvakawanda, zvakaita semanzwiro edu, kurara, uye kuda kudya.

Vanhu vazhinji vanogona kutora mishonga inokanganisa serotonin (serotonergic) zvakachengeteka pamipimo inokurudzirwa, sezvakarairwa nachiremba wavo. Zvisinei, serotonin syndrome inowanzoitika kana ukatanga mushonga mutsva kana kuwedzera uwandu hwemushonga wauri kutotora, kunyanya kana mushonga wacho ukawedzera mazinga ako e serotonin. Kana muviri wako ukachinja mashandisiro aunoita serotonin, kana kuti ukasakwanisa kubata mazinga e serotonin akawedzera, unogona kutanga zviratidzo zve serotonin syndrome.

Dambudziko iri rinogona kubva pazviratidzo zvisina kunyanya kuoma zvakaita semanyoka uye kuda kurutsa kusvika pazviratidzo zvakakomba zvakaita sefivha yakanyanya uye pfari. Mune zvimwe zviitiko, severe serotonin syndrome inogona kuisa upenyu panjodzi kana ikasaonekwa uye ikarapwa nekukurumidza.

Vanachiremba vakatanga kuona serotonin syndrome muma1960, mushure mekunge mishonga yekutanga yekudzora kuora mwoyo yabvumidzwa. Nhasi uno, sezvo mishonga yakawanda iripo inokanganisa serotonin, nyaya dze serotonin syndrome dziri kutaurwa kakawanda.

Ndiani anogona kukudziridza izvi?

Kutaura zvazviri, chero munhu anogona kuzviwana, zvisinei nezera rake. Kana ukashandisa mishonga yakanyorerwa nachiremba, mishonga inotengeswa muzvitoro, mishonga yemishonga kana yekudya, kana mishonga isingabvumirwe inokanganisa huwandu hweserotonin mumuviri wako, uri panjodzi yekubatwa neserotonin syndrome.

Ndezvipi zviratidzo zvinonyanya kuitika zveizvi?

Zviratidzo uye kuoma kwechirwere cheserotonin zvinogona kusiyana kubva pamunhu kuenda kumunhu. Zvinogona kuva zvishoma, zvine mwero, zvakakomba, uye zvinotouraya.

Kana uri kutora mushonga unokanganisa serotonin uye uine chimwe chezviratidzo izvi, fonera chiremba wako nekukasika kana kuenda kuchipatara.

Zviratidzo zvidiki

• Kunzwa kutya zvishoma uye kusagadzikana.
• Kunzwa kuda kurutsa uye kurutsa.
• Dumbu rinozvimba (manyoka).
• Mavara matema ari mumaziso anokura (mapepa akakura).
• Kunzwa sekunge nhengo dzako dziri kudedera (Kudedera).

Zviratidzo zviri pakati nepakati

• Ndinonzwa kusagadzikana uye kushushikana.
• Kugwinha kwetsandanyama, kugwinha kwetsandanyama kusingatarisirwi, kugwinha kwetsandanyama, kusimba kwetsandanyama.
• Kudikitira zvakanyanya, kudedera nekuda kwechando.
• Maziso anofamba zvisina kujairika kubva kurutivi kuenda kurutivi.

Zviratidzo zvakakomba

• Kuvhiringidzika kukuru, sekunge pfungwa dziri kukanganiswa, munhu anokanganwa kuti ari kupi uye kuti inguvai (Kuvhiringidzika, kuvhiringidzika, kupenga).
• Kurova kwemoyo kunowedzera zvakanyanya (kukurumidza kwemoyo).
• Kukwira kweropa.
• Kupisa kwemuviri kwakanyanya kupfuura 38.5 degrees Celsius (101.3 degrees Fahrenheit).
• Kubatwa nepfungwa kuri kuuya.
• Kurova kwemoyo kunova kusina kurongeka.
• Ndinorasikirwa nepfungwa uye ndinodonha.

Zviratidzo zvinoonekwa nekukurumidza sei?

Zviratidzo izvi zvinowanzotanga kuonekwa mukati memaawa mashoma , kungave mushure mekutanga mushonga mutsva unokanganisa huwandu hweserotonin kana mushure mekuwedzera mushonga wauri kutora parizvino. Munhu wese anowanzoona zviratidzo mukati memaawa makumi maviri nemana mushure mekutora mushonga kana chigadzirwa chinokanganisa serotonin.

Sei izvi zvichiitika? Ndezvipi zvikonzero?

Chikonzero chikuru che serotonin syndrome kuwedzera kwemazinga e serotonin mumuviri wako. Izvi zvinogona kuitika mumamiriro ezvinhu anotevera:

• Kana uchishandisa mishonga inopfuura imwe chete, zvinokanganisa huwandu hweserotonin mumuviri.
• Paunotanga mushonga mutsva unowedzera serotonin, kana kuti paunowedzera mushonga wauri kutora parizvino.
• Kana ukatora mushonga wakawandisa une chekuita neserotonin, zvichida netsaona kana nemaune.
• Kana uchishandisa mimwe mishonga isingabvumidzwe nemutemo, mishonga yemiti , kana mishonga inotengeswa kunze kwemutemo inokanganisa huwandu hweserotonin mumuviri.

Ndeipi mishonga nezvimwe zvinhu zvinokanganisa mazinga e serotonin?

Iye zvino ngationei kuti ndeapi marudzi emishonga anogona kukanganisa huwandu hweserotonin uye kukonzera serotonin syndrome.

Mishonga yekuderedza kushushikana

Pakati peizvi, mishonga inorwisa kuora mwoyo ndiyo inonyanya kukosha. Iyi ndiyo mishonga inonyanya kukanganisa huwandu hweserotonin. Dambudziko iri rinowanzoitika kana mishonga iyi ikashandisa pamwe chete nemimwe mishonga inokanganisa serotonin, yakadai setriptans yemigraines kana opioids yekuderedza marwadzo.

Heano mamwe mapoka emishonga inorwisa kuora mwoyo nemienzaniso:

• `Selective serotonin reuptake inhibitors (SSRIs): Boka iri rinosanganisira mishonga yakaita se`fluoxetine (Prozac®), `citalopram (Celexa®), `sertraline (Zoloft®), `paroxetine (Paxil®)` uye `escitalopram (Lexapro®).` Aya ndiwo anonyanya kushandiswa uye nekudaro ndiwo anonyanya kusanganiswa neserotonin syndrome.
• Mishonga inodzivirira kutorwa kweSerotonin-norepinephrine (SNRIs): Mienzaniso inosanganisira duloxetine (Cymbalta®), venlafaxine (Effexor®), desvenlafaxine (Pristiq), levomilnacipran (Fetzima), uye milnacipran (Savella).
• `Mishonga yekuora mwoyo yeTricyclic`: Boka iri rinosanganisira mishonga yakaita se`amitriptyline (Elavil®)`, `clomipramine (Anafranil®)`, uye `nortriptyline (Pamelor®).`
• `Monoamine oxidase inhibitors (MAOIs): Mishonga yakaita se`phenelzine (Nardil®)`, `selegiline (Emsam®)` uye `tranylcypromine (Parnate®)` iri muchikamu ichi.
• Zvinogadzirisa serotonin: zvakaita se nefazodone ne trazodone (Desyrel®).
• Muenzaniso weizvi ndi `Norepinephrine reuptake inhibitor`: `bupropion (Wellbutrin®).`

Mimwe Mishonga

Kuwedzera kune mishonga inorwisa kuora mwoyo, kune mimwe mishonga inokanganisa huwandu hwe serotonin mumuviri. Njodzi yacho yakanyanya kana ikasanganiswa nemimwe mishonga inokanganisawo serotonin. Mishonga iyi inoshandiswa ku:

• Kumarwadzo akanyanya: Mishonga inouraya marwadzo inobva mukirasi yeopioid, yakaita setramadol (Ultram®), meperidine (Demerol®), tapentadol (Nucynta®), hydrocodone (Hysingla ER®), oxycodone (Oxycontin®), fentanyl (Actiq®), uye methadone.
• Kukosora: Mimwe mishonga yekukosora nedzihwa inotengeswa kunze kwemushonga wechiremba (OTC), yakadai sedextromethorphan, inogona kukanganisa huwandu hweserotonin mumuviri.
• Kune migraine inotapukira: Triptans dzinosanganisira almotriptan (Axert®), eletriptan (Relpax®), uye sumatriptan (Imitrex®).
• Kune HIV/AIDS: `ritonavir (Norvir®)`.
• Mishonga inorwisa mabhakitiriya: linezolid (Zyvox®).
• Mishonga yekurutsa nekurutsa: yakaita se `metoclopramide (Reglan®)`, `granisetron (Sustol®)`, `ondansetron (Zofran®)`.
• Chinosimbisa mafungiro: lithium (Lithobid®).

Zvimwe Zvigadzirwa

Kuwedzera kumishonga, mimwe mishonga yechivanhu, mishonga yekuwedzera, uye mishonga isingabvumirwe zvinogona kukanganisawo huwandu hweserotonin uye kukonzera chirwere ichi.

• Mishonga yekuwedzera: Izvi zvinogona kusanganisira zvinhu zvakaita seginseng, St. John's wort, Syrian rue, uye nutmeg.
• Mishonga isiri pamutemo: Zvinhu zvakaita se ecstasy, LSD, cocaine, amphetamines, uye methamphetamines.
• Zvekudya zvinovaka muviri:Tryptophan.

Nyanzvi dzezvekurapa dzichiri kudzidza zvakawanda nezve serotonin syndrome. Kana muine mibvunzo nezvemishonga yamunotora uye kana iine chekuita ne serotonin, taurai nachiremba wenyu kana munhu ari pa pharmacy kwamunowana mishonga yenyu.

Vanachiremba vanoziva sei izvi?

Iye zvino ngationei kuti vanachiremba vanoongorora sei izvi. Hapana bvunzo chaiyo yekusimbisa serotonin syndrome. Chiremba wako anowanzoongorora nekukuongorora, kubvunza nezvezviratidzo zvako, uye kudzidza nezvemishonga yauri kutora inokanganisa huwandu hweserotonin mumuviri wako.

Unogona kubatsira chiremba wako nekujekesa zvese zvauri kutora (mishonga inotorwa nachiremba, mishonga inotengeswa pasina kunyoreswa nechiremba, mishonga yekuwedzera, mishonga yemiti, kunyangwe mishonga isingabvumirwe nemutemo). (Iva nechokwadi, usatya. Chiremba aripo kuti akubatsire, kwete kukutonga.)

Chiremba wako anogonawo kuita bvunzo dzakadai sedzinotevera:

• Kuongororwa ropa neweti kuti uone huwandu hwemishonga yauri kutora.
• Kuongororwa kuti uone kana mimwe nhengo yako iri kushanda nemazvo.
• Kuongororwa kuti vaone kana paine hutachiona mumuviri, pamwe kutoti pombi yemusana.
• Kuongororwa kweX-ray yechipfuva kana CT scan kunogona kuitwa kuti pave nechokwadi chekuti hapana zvimwe zvirwere (zvine zviratidzo zvakafanana) kana kuti kutarisa zvimwe zvinetso.

Izvi zvinorapwa sei?

Kurapwa kwaunowana kunoenderana nekuti zviratidzo zvako zvakakomba sei.

• Zviratidzo zvidiki: Kana zviratidzo zviri zvidiki, kurega mushonga kana kuchinja mushonga kunowanzo gadzirisa zviratidzo mukati memaawa makumi maviri nemana kusvika makumi manomwe nemaviri . Kana zviratidzo zvikasapera nekukurumidza, mushonga unovhara serotonin wakaita se cyproheptadine (Periactin®) unogona kunyorerwa.
• Zviratidzo zviri pakati nepakati: Kana zviratidzo zvako zviri pakati nepakati, uchachengetwa muchipatara kwemaawa makumi maviri nemana kuti uone kana zviratidzo zvako zvichivandudzika nekurapwa.
• Zviratidzo zvakakomba: Kana zviratidzo zvakanyanya, uchaendeswa kuIntensive Care Unit (ICU) uko mashandiro emuviri wako nenhengo dzemuviri wako achanyatsoongororwa.

Zvichienderana nezviratidzo, mishonga inotevera inogona kupihwa:

• Mushonga wekunyaradza wakaita se benzodiazepine unogona kuderedza zviratidzo zvakaita sekushungurudzika, kuomarara kwetsandanyama, uye pfari.
• Mushonga weSaline `(IV fluids)` unopihwa kuderedza kuchengetwa kwemvura mumuviri uye fivha, uye oxygen inopihwa kuburikidza ne`(mask)` kumeso kuti oxygen ive nani muropa.
• Mushonga wekudzora kurova kwemoyo neBP.
• Kuti kuderedze fivha yakanyanya (41.1 degrees Celsius / 106 degrees Fahrenheit), pombi yekufema inoiswa kana paine matambudziko ekufema, mushonga wekunyaradza unopiwa, uye mushonga wekuzorodza tsandanyama unopihwa.
• Kana mamwe marapirwo asingape zororo nekukurumidza, mushonga unodzivisa serotonin unonzi cyproheptadine unopihwa.

Kana chirwere chako che serotonin chakakonzerwa nemushonga unorwisa kuora mwoyo, zvinogona kutora mavhiki akati wandei kuti mushonga wacho ubve mumuviri wako zvachose uye kuti zviratidzo zvako zvipere zvachose.

Chinonyanya kukosha: Usarega kutora chero mushonga kana kuchinja dosage usina kutaura nachiremba wako. Zvisinei, kana uine zviratidzo zvakakomba kana zviratidzo zvako zvikawedzera, tsvaga rubatsiro rwechiremba nekukurumidza. Serotonin syndrome inogona kuisa hupenyu panjodzi.

Ndezvipi zvinetso zvinogona kuitika?

Kana ikasarapwa, serotonin syndrome inogona kukonzera matambudziko akadai se:

• Kubatwa nepfari.
• Kutadza kufema zvakanaka.
• Kukundikana kweitsvo. Kana zvinhu zvinopwanyika tsandanyama zvikaungana muropa zvoseferwa neitsvo, zvinogona kukonzera kukuvara kwakanyanya kweitsvo kana zvikasarapwa.
• Nyika yeComa.
• Kunyangwe rufu runogona kuitika.

Tinoponeswa sei kubva pane izvi?

• Zvakakosha kunyatsoteerera chero mushonga waunotora. Verenga yambiro dzese dziri papakeji yemishonga kana pepa reruzivo rinouya nawo. Richakuudza kana paine njodzi ye serotonin syndrome.
• Usarega kushandisa chero mushonga usina kutaura nachiremba wako.
• Ramba uchiziva chiremba wese anokurapa nezvemishonga yese yauri kutora (mishonga yakanyorerwa nachiremba, mishonga inotengeswa pasina kunyoreswa nechiremba, mishonga yechivanhu, mishonga yekuwedzera, kunyangwe mishonga isingabvumirwe nemutemo).
• Kana uri kutora triptan yekurwadziwa kwemusoro pamwe chete nemishonga yekuora mwoyo (kunyanya SSRIs kana SNRIs), chiremba wako anofanira kukutarisa zvakanyanya. Njodzi yacho inofungidzirwa kuti idiki kwazvo, pamwe haitombopo. Asi yeuka, une basa: Kana ukaona chimwe chezviratidzo zvataurwa munyaya ino, fonera chiremba wako nekukasika.
• Kutevera matanho aya kuchakubatsira iwe nachiremba wako kuziva zviratidzo zve serotonin syndrome nekukurumidza. Kuonekwa nekukurumidza kunogona kubatsira kudzivirira zviratidzo zvakakomba.

Chii chatinofanira kutarisira mumamiriro ezvinhu aya?

Kana zvikaonekwa uye zvikarapwa nekukurumidza, zviratidzo zvevanhu vazhinji zvinopera zvachose mukati memaawa makumi maviri nemana kusvika makumi manomwe nemaviri.

Mushure mekupora, chiremba wako anogona:

• Deredzai mushonga wakakonzera chirwere ichi kusvika padanho rakaderera rinoshanda.
• Rega kupa mishonga miviri ine mwero wepamusoro inokanganisa serotonin pamwe chete.
• Chinja kune imwe mishonga isingakanganisi serotonin.

Ndinofanira kufonera chiremba wangu rini?

• Kana uine zviratidzo zve serotonin syndrome (kana zviratidzo zvichiwedzera kuipa), fonera chiremba wako nekukasika kana kuenda kuchipatara che emergency. Chenjerera zvikuru kana watanga mushonga mutsva, wakawedzera mushonga uripo, kana kuti uri kutora mishonga yaunoziva kuti inokanganisa huwandu hwe serotonin mumuviri.
• Usarega kutora mishonga kana kuchinja mwero wemushonga usina kutaura nachiremba wako.
• Iva nechokwadi chekuti vanachiremba vako vese vanoziva nezvemishonga yese yaunotora.
• Verenga nyevero nemapepa eruzivo anouya nemushonga wako nokungwarira.
• Dzidza nezvezviratidzo zve serotonin syndrome. Nyatsocherechedza zviratidzo izvi kana uri kutora mishonga inorwisa kuora mwoyo.
• Kana muine mibvunzo nezvemushonga wenyu kana zviratidzo zvechirwere ichi, bvunzai chiremba wenyu kana murapi wemishonga.
• Kana ukaona zviratidzo, kana zviratidzo zvako zvikawedzera, usakanganwa kufonera chiremba wako nekukasika kana kuenda kuchipatara che emergency.

Ndeipi meseji yatinoda kuunza kubva munyaya iyi?

• Serotonin Syndrome chirwere chinogona kuva chakakomba, asi chinogona kurapwa kana chikarapwa nemazvo.
• Taura pachena nachiremba wako nezvemushonga waunotora, kunyanya kana uri kutanga mumwe mushonga mutsva kana kuchinja mwero wemushonga wacho.
• Ziva zviratidzo. Kana usina chokwadi , tsvaga rubatsiro rwechiremba usingatambise nguva.
• Yeuka kuti unoziva hutano hwako zvakanyanya, saka zvakakosha kuziva nezvekuchinja kupi zvako.

Serotonin syndrome, serotonin, mishonga inorwisa kushushikana, migumisiro yemishonga, makemikari europi, neurotransmitters, maitiro emishonga